Medical hypothesis, discovery & innovation in optometry最新文献

{"title":"Pediatric cycloplegic refraction","authors":"Mahmoud Eltagoury, Ehab Ghoneim","doi":"10.51329/mehdioptometry170","DOIUrl":"https://doi.org/10.51329/mehdioptometry170","url":null,"abstract":"Background: Cycloplegic refraction is an essential part of the pediatric ophthalmic assessment and is the cornerstone of strabismus evaluation. This narrative review aimed to ascertain the current scope of practice for cycloplegic refraction in the pediatric population. \u0000Methods: An extensive literature review was conducted using ScienceDirect, PubMed/MEDLINE, Scopus, and Google Scholar databases using the following search terms: cyclopentolate, tropicamide, pediatric cycloplegia, atropine, homatropine, manual retinoscope, handheld autorefractometer, spherical errors, and no spherical errors of refraction in articles published from January 2000 to December 2022. Relevant retrieved references and practical points concerning pediatric cycloplegic refraction were summarized. \u0000Results: Atropine has the most potent cycloplegic effect and is best used in cases of severe accommodative esotropia. Because of the unfavorable side effects and risks associated with atropine, cyclopentolate has been found to provide quite effective cycloplegia, even for moderate to severe hyperopia, and has become the standard agent for traditional pediatric cycloplegic exams. Tropicamide has also been shown to provide adequate cycloplegia while being less toxic and causing fewer side effects. Tropicamide has the fewest side effects and toxicity of all agents, while atropine has the most. Cyclopentolate is an exceptionally safe cycloplegic agent. To detect spherical and non-spherical refractive errors, refraction can be performed using a handheld autorefractometer or a manual retinoscope, as well as under general anesthesia in some cases. The optimal time to wear eyeglasses to maintain binocular vision and avoid amblyopia is also considered. \u0000Conclusions: Accommodative power in children is at its maximum, and this interferes with reliable - assessment of refraction. Therefore, the use of cycloplegic refraction is mandatory during childhood to obtain actual refraction, which is considered the cornerstone for eyeglass prescription. Knowledge of the various cycloplegic agents used in childhood refraction is important for ophthalmologists and optometrists to obtain safe and effective cycloplegia. High refractive errors, as well as the presence of anisometropia or squint, necessitate the use of eyeglasses as early as childhood to maintain binocularity and depth perception.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery & innovation in optometry","volume":"267 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123252501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal topography and higher-order aberrations in patients with type 2 diabetes mellitus","authors":"Amir Asharlous, A. Riazi, A. Jamali, S. Rajabi, Masoud Rahimi, Alireza Akbarzadeh, M. Khabazkhoob, Samira Janani, Taghi Naghdi","doi":"10.51329/mehdioptometry168","DOIUrl":"https://doi.org/10.51329/mehdioptometry168","url":null,"abstract":"Background: Changes in blood sugar levels cause alterations in the anterior segment and retina of the eye. This study was aimed at evaluating corneal topography, aberrometry, and corneal asphericity in patients with treatment-naive type 2 diabetes mellitus (T2DM). \u0000Methods: Participants with treatment-naive T2DM were enrolled in this cross-sectional study. The inclusion criteria were glycated hemoglobin A1c (Hb A1c) greater than or equal to 7.5% and absence of other ocular or systemic diseases. Patients who refused to participate or had a history of topical or systemic steroid use, hyperlipidemia, hypertension, anemia, prior ocular disorder or surgery, diabetic retinopathy, glaucoma, cataract, active ocular inflammatory or infectious disease, or contact lens use were excluded. All participants underwent a comprehensive ophthalmic examination. The Pentacam HR Scheimpflug tomography system (Pentacam High Resolution; Oculus, Wetzlar, Germany) was used to measure the anterior-segment parameters. \u0000Results: Sixty eyes of 30 patients with a male-to-female ratio of 1:1 were included; the mean (standard deviation [SD]) age and Hb A1c were 51.63 (6.73) years and 8.82% (1.31%), respectively. The mean (SD) values of central corneal thickness, root mean square (RMS) of total aberration, RMS of lower-order aberrations, RMS of higher-order aberrations, spherical aberration, 0° coma, 90° coma, flat anterior keratometry (K), steep anterior K, mean anterior K, anterior topographic astigmatism, flat posterior K, steep posterior K, mean posterior K, posterior topographic astigmatism, anterior corneal asphericity, and posterior corneal asphericity were 540.22 (24.47) µm, 1.72 (0.73) µm, 1.63 (0.73) µm, 0.51 (0.17) µm, + 0.31 (0.09) µm, - 0.06 (0.15) diopters (D), 0.003 (0.21) D, 43.87 (1.49) D, 44.69 (1.50) D, 44.28 (1.44) D, + 0.82 (0.83) D, - 6.25 (0.27) D, - 6.55 (0.31) D, - 6.40 (0.28) D, - 0.30 (0.15) D, - 0.32 (0.12) Q-value, and - 0.47 (0.17) Q-value, respectively. \u0000Conclusions: We presented the mean values of Pentacam parameters for aberrometry, keratometry, and corneal asphericity in patients with treatment-naive T2DM. These values could serve as a baseline for prospective monitoring of the ocular health status of this cohort and for comparison with future cohorts of patients with well-controlled T2DM. Further studies are required to assess the presence and applicability of ocular changes following intensive blood glucose control in T2DM and further understand the related pathophysiology.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery & innovation in optometry","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128709991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography epithelial mapping for keratoconus screening","authors":"Sana Niazi, F. Doroodgar","doi":"10.51329/mehdioptometry166","DOIUrl":"https://doi.org/10.51329/mehdioptometry166","url":null,"abstract":"Letter to the Editor \u0000Note: letters have no abstract.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery & innovation in optometry","volume":"217 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131458387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior-segment optical coherence tomography for tacrolimus therapy response monitoring of vernal keratoconjunctivitis","authors":"Mahmoud Eltagoury, W. A. Abou Samra, Ehab Ghoneim","doi":"10.51329/mehdioptometry164","DOIUrl":"https://doi.org/10.51329/mehdioptometry164","url":null,"abstract":"Background: Vernal keratoconjunctivitis (VKC), a chronic bilateral eye disease, is a severe form of allergic conjunctivitis. Anterior-segment optical coherence tomography (AS-OCT) is a rapid, noninvasive, in vivo visualization modality for the anterior segment structures that has been used in diagnosing and staging diseases and assessing the treatment efficacy. We used anterior-segment optical coherence tomography (AS-OCT) to monitor the efficacy of the tacrolimus eye ointment in managing VKC. \u0000Methods: In this prospective follow-up study, we included patients with active symptomatic VKC. All patients were treated with the 0.03% tacrolimus ophthalmic ointment twice daily for 2 months and then once daily for 1 month. All patients underwent AS-OCT before and 3 months after treatment as an objective method to assess the treatment efficacy. \u0000Results: We included 20 eyes of ten patients (nine men and one woman) with active symptomatic VKC. The mean age was 17.3 (range: 11 – 36) years, with nine patients having a palpebral type and one patient having a mixed type of VKC. Substantial flattening and reduction in the papilla size were observed in all patients at the post-treatment follow-up. AS-OCT measurements revealed significant reductions in the vertical, horizontal, and total diameters of the palpebral papillae and limbal conjunctival thickness after 3 months of treatment compared to baseline measurements (all P < 0.001). No serious adverse effects attributable to tacrolimus administration were observed in the study period. \u0000Conclusions: AS-OCT is a suitable objective method for evaluating the treatment efficacy of the 0.03% tacrolimus eye ointment in patients with VKC. Future large-scale studies including a wide range of age groups with longer follow-up periods and AS-OCT monitoring at multiple post-treatment visits are required to confirm our preliminary results. Moreover, the diagnostic accuracy of AS-OCT in monitoring patients with active VKC should be tested in comparison with objective scoring by an experienced corneal fellowship.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125143581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vision correction on the visual impairment status and quality of life score in patients with type II diabetes mellitus","authors":"Noor Suriani Mohamad, C. Majumder, R. Omar","doi":"10.51329/mehdioptometry163","DOIUrl":"https://doi.org/10.51329/mehdioptometry163","url":null,"abstract":"Background: Visual impairment (VI) in patients with diabetes mellitus (DM) worsens as the disease progresses. Therefore, quality of life (QOL) may also be affected. Furthermore, in the absence of macular involvement, some patients may benefit from visual intervention. However, not many Malaysians with known DM had their eyes screened or used correctable spectacles. Consequently, the QOL and VI status of patients with DM in Malaysia remain unclear. This study was aimed at determining the impact of optometric intervention on the QOL and VI status of adults with type II DM. \u0000Methods: This was a quasi-self-controlled, experimental study involving adults with known type II DM. We conducted face-to-face interviews using the low vision quality-of-life questionnaire (LVQOL). The habitual visual acuity (VA) of all participants was recorded. All participants underwent fundus photography to grade diabetic retinopathy (DR) in both eyes. Correctable VA was determined following subjective refraction when the best-corrected distance visual acuity (BCDVA) was 6 /9 and better. After a 3-week adaptation to the prescribed refractive error correction, LVQOL was repeated via a phone interview. \u0000Results: A total of 47 participants with type II DM, including 16 (34%) men and 31 (66%) women, with a mean (standard deviation [SD]) age of 49.0 (7.9) years were recruited. The age range was 32 – 59 years, and the baseline mean (SD) habitual binocular VA was 0.52 (0.31) decimal. Only 15% (n = 7 patients) of the participants had their vision tested and wore glasses; however, some were uncomfortable with the current corrections. All patients had undercorrected or uncorrected refractive errors, namely, hyperopic astigmatism (47%), myopic astigmatism (38%), hyperopia (6%), myopia (4%), and antimetropia (4%). Among the 47 participants, 89% (n = 42) had uncorrected presbyopia. The mean (SD) LVQOL score at baseline was 91.9 (17.3), which improved significantly with visual intervention to 122.8 (3.2) (P < 0.05). Refractive error corrections significantly improved the VI status (P < 0.05), as all participants achieved a BCDVA of 6 / 9 and better. \u0000Conclusions: Our findings indicate that optometric intervention is effective in improving the LVQOL and VI status of adults with type II DM. Further clinical optometric studies on type II DM with DR with a longer follow-up should be carried out to understand the clinical characteristics of this cohort and the impact of meticulous refractions on QOL in providing better services in the future.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128350041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopia progression in children before and after the coronavirus disease lockdown","authors":"P. Chande, N. Dave, Mumtaz Qazi, Priyanka Bapat Vora","doi":"10.51329/mehdioptometry162","DOIUrl":"https://doi.org/10.51329/mehdioptometry162","url":null,"abstract":"Background: The worldwide spread of the coronavirus disease (COVID-19) pandemic in 2020, followed by lockdowns, forced children to be in home confinement with increased screen time, leading to rapid progression of myopia and an increase in the prevalence of myopia. This study was aimed at determining if myopia progression seen in evidence-based practice resulted from the COVID-19 lockdown or delayed follow-ups. \u0000Methods: A retrospective review of case sheets of patients visiting the pediatric department of a tertiary care eye hospital in Mumbai, India, was conducted from 2017 onwards. We enrolled all children with myopia who had attended at least one follow-up visit before the COVID-19 lockdown and at least one follow-up visit post-lockdown. The spherical equivalent (SEQ) of refractive error values at baseline and pre- and post-COVID-19 lockdown follow-ups (hereinafter referred to as the “first” and “second” follow-ups, respectively) were recorded. The duration between baseline and the first follow-up visit and between the first and second follow-up visits were noted. \u0000Results: We enrolled 112 eyes of 56 children, including 35 (62.5%) boys and 21 (37.5%) girls, with a mean (standard deviation [SD]) age of 9.54 (2.82) years. The mean (SD) SEQ values at baseline and first and second follow-ups were - 4.74 (3.83), - 5.46 (3.81), and - 6.42 (3.66) D, respectively. The mean change in SEQ, mean SEQ myopia progression, and rate of myopia progression per month differed significantly between the baseline and the first follow-up visit versus between the first and second follow-ups (all P < 0.05). However, the change in myopia degree did not differ significantly between these two periods in eyes with low, moderate, or high myopia (all P > 0.05). The mean (SD) duration between the baseline and the first follow-up visit was 14.57 (5.68) months, while that between the first and second follow-ups was 27.96 (9.18) months, showing a significant difference (P < 0.05). \u0000Conclusions: Our findings suggest that a longer gap between follow-up visits and myopia progression per month should be factored into the management of myopia. Considering that young children are more vulnerable, preventive measures and school reforms should be urgently implemented in India. Further retrospective multicenter studies with a larger sample size of eyes, including various refractive errors over a longer period, are required to verify these findings.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127219249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seven-year experience in a low vision rehabilitation clinic at a tertiary referral center","authors":"A. Riazi, Reza Gharebaghi MD MPH FAAO PhDc, A/Prof. Fatemeh Heidary MD, MPH, FAAO, FICO","doi":"10.51329/mehdioptometry161","DOIUrl":"https://doi.org/10.51329/mehdioptometry161","url":null,"abstract":"Background: Low vision is a major public health concern worldwide. This study was aimed at describing the characteristics of patients who had visited a low-vision rehabilitation clinic. \u0000Methods: In this retrospective study, we reviewed the medical records of patients with low vision attending a low-vision rehabilitation clinic at a tertiary referral center over 7 years. Inclusion criteria were a diagnosis of vision impairment and availability of complete records. We extracted the following data from each record: age, sex, education level, employment status, chief complaints concerning vision, associated ocular diseases, uncorrected distance and near visual acuities, best-corrected distance and near visual acuities, statuses of previous and current prescribed optical devices, and cooperation status of patients during the optometric examination. \u0000Results: We enrolled a total of 567 patients, including 338 (59.6%) men and 229 (40.4%) women, with a mean (standard deviation) age of 40.46 (28.34) years. Most (98.4%) participants were cooperative, with a high rate of unemployment (90.5%) and low education level. Half (49.2%) of the patients had moderate visual impairment. Retinal pathologies, mainly congenital (28.4%), and age-related macular degeneration (ARMD; 26.5%) were common causes of low vision. Difficulty in reading was the most frequent complaint (22.9%), and a combination of difficulties in reading, writing, and facial recognition was recorded in 54.7% of the patients. Other functional complaints were reported by at least 5% of the patients. Our multivariate logistic regression analysis revealed that the likelihood of difficulties in performing in-house activities, reading, facial recognition and social interaction, and driving increased per 10-year increment in age, with odds ratios of 1.39, 1.31, 1.24, and 1.22, respectively (all P < 0.05). The likelihood of reporting three complaints (reading, writing, and facial recognition together) increased per 0.1-logarithm of the minimum angle of resolution increment in the best-corrected distance visual acuity of the better eye, with an odds ratio of 2.05 (P < 0.05). In addition, men were more likely to experience difficulties in driving and reading, while women were more likely to experience difficulties in facial recognition and social interaction or in-house activities (all P < 0.05). Optical devices for distance or near vision were prescribed to most patients. \u0000Conclusions: Most patients were men and unemployed. The most common category of low vision was moderate impairment. Retinal conditions, mainly congenital ones and ARMD, were the most frequent causes. A combination of difficulties in reading, writing, and facial recognition was the most common complaint. Optometrists should address these findings during rehabilitation therapy to treat patients with low vision.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127805885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vortex keratopathy after photorefractive keratectomy in a patient on long-term clozapine treatment","authors":"Samir S Shoughy, Hosam Elgemie, Waleed Nasif","doi":"10.51329/mehdioptometry165","DOIUrl":"https://doi.org/10.51329/mehdioptometry165","url":null,"abstract":"Background: Vortex keratopathy is a corneal entity characterized by corneal deposits at the level of the basal epithelium in the form of a whorl-like pattern in the interpalpebral portions of the cornea. Medications such as amiodarone, chloroquine, hydroxychloroquine, indomethacin, phenothiazines, ibuprofen, and naproxen bind to the cellular lipids of the basal epithelial layer of the cornea, producing a characteristic whorl pattern. Here, we report a case of bilateral central vortex keratopathy with slight vision impairment 3 weeks after uneventful photorefractive keratectomy (PRK) in a woman on long-term clozapine treatment. \u0000Case Presentation: A 42-year-old woman presented to the outpatient clinic for refractive surgery for the correction of bilateral moderate myopia. Her best-corrected distance visual acuity was 20 / 20 in both eyes. She had been on antipsychotic clozapine tablets 400 mg / day for the past 6 years to manage a psychiatric disorder. On detailed preoperative slit-lamp examination, her corneas were clear, with perilimbal conjunctival pigmentations. Other ocular examination results were unremarkable. At the 3-week follow-up after an uneventful PRK, her uncorrected distance visual acuity was 20 / 25 in the right eye and 20 / 20 in the left eye, with complaints of slightly unclear vision in both eyes. Slit-lamp examination revealed bilateral corneal subepithelial deposits in a whorl-like pattern reminiscent of vortex keratopathy. The deposits were restricted to the epithelial and subepithelial regions and did not extend to the stroma without evident stromal haze. Dilated fundus examination results were normal bilaterally. Despite excellent refractive outcomes and visual acuity in both eyes, she was dissatisfied and complained of unclear vision. She was administered with lubricating eye drops and placed on regular follow-ups. At the 4-month follow-up, the vortex lines were cleared centrally, and she reported improvement in vision. Anterior-segment optical coherence tomography of the cornea revealed no epithelial deposits in the central part of the cornea and residual deposits in the temporal peripheral cornea, indicating clearing of the deposits from the central cornea and explaining the subjective improvement in vision. Her final best-corrected distance visual acuity was 20/20 in both eyes with an unremarkable ocular examination. \u0000Conclusions: Our case indicates a potential causal relationship between long-term clozapine treatment and development of temporary, visually significant vortex keratopathy after uneventful PRK. Further large-scale studies are required to verify the causal relationship between the long-term clozapine administration and the development of vortex keratopathy following surface ablation photorefractive procedures.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125783373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroretinogram changes before and after silicone oil removal in eyes with macula-off rhegmatogenous retinal detachment","authors":"Evita Evangelia Christou, P. Zafeiropoulos, E. Bagli, A. Katsanos, I. Asproudis, M. Stefaniotou","doi":"10.51329/mehdioptometry160","DOIUrl":"https://doi.org/10.51329/mehdioptometry160","url":null,"abstract":"Background: Pars plana vitrectomy (PPV) with silicone oil (SO) injection for rhegmatogenous retinal detachment (RRD) repair may adversely affect electroretinographic responses. This study was aimed at assessing retinal function using electrodiagnostic testing after successful PPV with SO tamponade in the eyes with macula-off RRD. \u0000Methods: In this interventional comparative study, eligible participants were recruited prospectively over 1 year. We included the eyes that underwent a single successful three-port PPV with SO tamponade for the primary repair of macula-off RRD. Full-field electroretinogram (ffERG) and multifocal electroretinogram (mfERG) were recorded 1 day before and 3 days after SO removal. The amplitude and implicit time of the a- and b-waves for ffERG and P1 and N1 waves for mfERG were evaluated. The unaffected fellow eyes of the patients were selected as controls. \u0000Results: We included the ten eyes of ten patients (seven men and three women) with a mean (standard deviation) age of 58.8 (6.2) years. The mean (SD) interval between the diagnoses of macula-off RRD and PPV was 11.7 (3.6) days. The mean (SD) duration of SO tamponade was 147.8 (34.9) days. Using ffERG, significantly lower a- and b-wave amplitudes were found in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P < 0.05). Using the mfERG, treated eyes had significantly lower P1 amplitudes in the central R1+R2+R3 rings and in the R4 and-R5 peripheral rings of the macular area in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P < 0.05). The wave implicit time in ffERG and mfERG did not differ significantly in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P > 0.05). \u0000Conclusions: The electrical retinal response density in ERG waveforms increased following SO removal, indicating amelioration of the electrical activity of the retina and macula. These results indicate that the adverse effects of SO tamponade on electroretinography responses may be reversible with removal. In addition, ffERG and mfERG can be used to monitor retinal function in the eyes with macula-off RRD and SO tamponade. Further clinical trials are required to verify the preliminary findings of this study.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125978025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveitis in spondyloarthropathies","authors":"H. Khan, Q. A. Khan, Muhammad Aamir Shahzad","doi":"10.51329/mehdioptometry155","DOIUrl":"https://doi.org/10.51329/mehdioptometry155","url":null,"abstract":"Background: Uveitis is associated with several systemic disorders. It may be the initial presentation or manifestation of a systemic disease. It is the most common ocular complication and is sometimes the earliest manifestation of spondyloarthropathies. This study aimed to review the current literature on spondyloarthropathies and associated uveitis. \u0000Methods: A narrative review was performed using various combinations of the keywords spondyloarthropathies, seronegative spondylarthritis-related uveitis, and human leukocyte antigen-associated uveitis using PubMed/MEDLINE and Google Scholar from January 1, 2000, to September 30, 2022. We describe the disease mechanisms, genetics, and classification of spondyloarthropathies, the clinical patterns of their related ocular diseases, and the current modalities for the management of their ocular or systemic manifestations. \u0000Results: Seronegative spondyloarthropathies are a group of rheumatic disorders including ankylosing spondylitis, reactive arthritis, psoriatic arthritis, inflammatory bowel disease-related spondyloarthropathy, juvenile-onset spondyloarthritis, and undifferentiated spondyloarthritis. These are characterized by enthesitis in the absence of serum rheumatoid factor and have a strong association with human leukocyte antigen B27. The clinical courses and features of spondyloarthropathies are remarkably diverse. Ocular inflammation is common in spondyloarthropathies, often precedes the onset or diagnosis of systemic disease, and responds well to topical therapy. Timely diagnosis of systemic diseases may improve quality of life and help avoid ocular and skeletal complications. Recurrence of ocular inflammation is frequent; on occasion, it may be associated with etanercept administration. \u0000Conclusions: Eye care professionals should be able to recognize spondyloarthropathies, manage ocular disease, and collaborate with related specialties for modification of systemic treatment if associated with ocular complications. Timely referral and early management could attenuate or prevent ocular or systemic morbidities associated with spondyloarthropathies.","PeriodicalId":370751,"journal":{"name":"Medical hypothesis, discovery &amp; innovation in optometry","volume":"PP 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126528163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}