Electroretinogram changes before and after silicone oil removal in eyes with macula-off rhegmatogenous retinal detachment

Evita Evangelia Christou, P. Zafeiropoulos, E. Bagli, A. Katsanos, I. Asproudis, M. Stefaniotou
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引用次数: 1

Abstract

Background: Pars plana vitrectomy (PPV) with silicone oil (SO) injection for rhegmatogenous retinal detachment (RRD) repair may adversely affect electroretinographic responses. This study was aimed at assessing retinal function using electrodiagnostic testing after successful PPV with SO tamponade in the eyes with macula-off RRD. Methods: In this interventional comparative study, eligible participants were recruited prospectively over 1 year. We included the eyes that underwent a single successful three-port PPV with SO tamponade for the primary repair of macula-off RRD. Full-field electroretinogram (ffERG) and multifocal electroretinogram (mfERG) were recorded 1 day before and 3 days after SO removal. The amplitude and implicit time of the a- and b-waves for ffERG and P1 and N1 waves for mfERG were evaluated. The unaffected fellow eyes of the patients were selected as controls. Results: We included the ten eyes of ten patients (seven men and three women) with a mean (standard deviation) age of 58.8 (6.2) years. The mean (SD) interval between the diagnoses of macula-off RRD and PPV was 11.7 (3.6) days. The mean (SD) duration of SO tamponade was 147.8 (34.9) days. Using ffERG, significantly lower a- and b-wave amplitudes were found in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P < 0.05). Using the mfERG, treated eyes had significantly lower P1 amplitudes in the central R1+R2+R3 rings and in the R4 and-R5 peripheral rings of the macular area in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P < 0.05). The wave implicit time in ffERG and mfERG did not differ significantly in the eyes before and after SO removal or compared to the unaffected fellow eyes (all P > 0.05). Conclusions: The electrical retinal response density in ERG waveforms increased following SO removal, indicating amelioration of the electrical activity of the retina and macula. These results indicate that the adverse effects of SO tamponade on electroretinography responses may be reversible with removal. In addition, ffERG and mfERG can be used to monitor retinal function in the eyes with macula-off RRD and SO tamponade. Further clinical trials are required to verify the preliminary findings of this study.
无黄斑孔源性视网膜脱离去除硅油前后视网膜电图的变化
背景:玻璃体切割(PPV)联合硅油(SO)注射治疗孔源性视网膜脱离(RRD)可能会对视网膜电图反应产生不利影响。本研究旨在通过电诊断测试评估无黄斑RRD患者的视网膜功能。方法:在这项干预性比较研究中,前瞻性地招募符合条件的参与者超过1年。我们纳入了接受单次成功的三孔PPV与SO填塞的眼睛,用于黄斑脱落的RRD的初级修复。取SO术前1 d、术后3 d分别记录全视场视网膜电图(ffERG)和多焦视网膜电图(mfERG)。评估了ffERG的a波和b波以及mfERG的P1波和N1波的振幅和隐含时间。选择患者未受影响的同伴眼睛作为对照。结果:我们纳入了10例患者(7男3女)的10只眼睛,平均(标准差)年龄为58.8(6.2)岁。黄斑脱落型RRD与PPV诊断的平均(SD)间隔为11.7(3.6)天。SO填塞的平均(SD)持续时间为147.8(34.9)天。使用ffERG,在SO去除前后或与未受影响的眼睛相比,眼睛的a波和b波振幅显著降低(均P < 0.05)。使用mfERG,在SO去除前后或与未受影响的眼睛相比,治疗的眼睛在黄斑区域的R1+R2+R3中心环和R4和r5周围环的P1振幅显著降低(均P < 0.05)。摘除SO前后眼ffERG和mfERG的波隐时间与未受影响眼比较差异均无统计学意义(P > 0.05)。结论:去SO后视网膜电反应密度增加,视网膜和黄斑电活动有所改善。这些结果表明,SO填塞对视网膜电图反应的不良影响可能在移除后是可逆的。此外,ffERG和mfERG可用于监测黄斑脱落性RRD和SO填塞眼的视网膜功能。需要进一步的临床试验来验证本研究的初步结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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