Sleep Medicine: X最新文献

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Short slow wave sleep latency in patients with disorders of arousal 觉醒障碍患者的短慢波睡眠潜伏期
Sleep Medicine: X Pub Date : 2023-01-23 DOI: 10.1016/j.sleepx.2023.100063
Carlo Perretti, Ana Gales, Smaranda Leu-Semenescu, Pauline Dodet, Isabelle Arnulf
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引用次数: 0
Response to Letter to Editor of Perretti et al. re disorders of arousal and timing of the first period of slow wave sleep: Clinical and forensic implications. Sleep Medicine X 2022:4: 100057 致Perretti等编辑的信的回复。慢波睡眠第一阶段的觉醒和时间紊乱:临床和法医意义。睡眠医学,2022:4:100057
Sleep Medicine: X Pub Date : 2023-01-20 DOI: 10.1016/j.sleepx.2023.100062
Mark R. Pressman
{"title":"Response to Letter to Editor of Perretti et al. re disorders of arousal and timing of the first period of slow wave sleep: Clinical and forensic implications. Sleep Medicine X 2022:4: 100057","authors":"Mark R. Pressman","doi":"10.1016/j.sleepx.2023.100062","DOIUrl":"10.1016/j.sleepx.2023.100062","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"5 ","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10736062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical application of a previously validated pregnancy-specific screening tool for sleep apnea in a cohort with a high prevalence of obesity 妊娠期睡眠呼吸暂停筛查工具在肥胖高发人群中的临床应用
Sleep Medicine: X Pub Date : 2023-01-08 DOI: 10.1016/j.sleepx.2023.100061
Sakshi Bajaj , A. Lauren Rice , Payden White , Abigail M. Wiedmer , Natalie M. Jacobson , Nathan R. Jones , Mihaela H. Bazalakova , Kathleen M. Antony
{"title":"Clinical application of a previously validated pregnancy-specific screening tool for sleep apnea in a cohort with a high prevalence of obesity","authors":"Sakshi Bajaj ,&nbsp;A. Lauren Rice ,&nbsp;Payden White ,&nbsp;Abigail M. Wiedmer ,&nbsp;Natalie M. Jacobson ,&nbsp;Nathan R. Jones ,&nbsp;Mihaela H. Bazalakova ,&nbsp;Kathleen M. Antony","doi":"10.1016/j.sleepx.2023.100061","DOIUrl":"10.1016/j.sleepx.2023.100061","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this project was to determine the positive predictive value of existing obstructive sleep apnea (OSA) screening tools in clinical use, in a real-world clinical population of gravidae, and to explore the development of a new questionnaire for screening for OSA during pregnancy.</p></div><div><h3>Methods</h3><p>Pregnant people were administered sleep screening questionnaires as part of routine clinical care. These included Facco's four variable OSA screening tool, the STOP-BANG, and the Epworth Sleepiness Scale. Those who screened positive were referred for diagnostic sleep testing, typically with a type III home monitoring device. Here we analyzed the screening responses used by those who completed diagnostic testing to determine the positive predictive value of the existing tools.</p></div><div><h3>Results</h3><p>159 pregnant people completed diagnostic OSA testing and were included in this analysis. The positive predictive value of Facco's four variable sleep screening tool was 74.3%, STOP-BANG was 75.3%, and the Epworth Sleepiness Scale was 69.8%. Our sample size was insufficient to create a new screening tool.</p></div><div><h3>Conclusions</h3><p>Here we calculated the positive predictive value of Facco's 4 variable screening tool for screening for OSA in pregnancy in a real-world pregnant population. While we were not able to generate a new screening tool for screening for OSA during pregnancy, both STOP-BANG and Facco's four variable tool had positive predictive values over 70% in our population which was characterized by high BMI and advanced maternal age. Increased clinical use of the pregnancy-specific tool may be warranted.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"5 ","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/66/main.PMC9845998.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10586904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Factors associated with poor sleep quality in midlife Singaporean women: The Integrated Women’s Health program (IWHP) 新加坡中年妇女睡眠质量差的相关因素:综合妇女健康计划(IWHP)
Sleep Medicine: X Pub Date : 2022-12-09 DOI: 10.1016/j.sleepx.2022.100060
Beverly W.X. Wong , Yiong Huak Chan , Michael S. Kramer , Inger Sundström-Poromaa , Susan Logan , Jane A. Cauley , Eu-Leong Yong
{"title":"Factors associated with poor sleep quality in midlife Singaporean women: The Integrated Women’s Health program (IWHP)","authors":"Beverly W.X. Wong ,&nbsp;Yiong Huak Chan ,&nbsp;Michael S. Kramer ,&nbsp;Inger Sundström-Poromaa ,&nbsp;Susan Logan ,&nbsp;Jane A. Cauley ,&nbsp;Eu-Leong Yong","doi":"10.1016/j.sleepx.2022.100060","DOIUrl":"10.1016/j.sleepx.2022.100060","url":null,"abstract":"<div><h3>Objective</h3><p>To examine factors associated with poor sleep quality in community-dwelling midlife women.</p></div><div><h3>Methods</h3><p>Healthy women (aged 45–69 years) of Chinese, Malay and Indian ethnicities attending well-women clinics at the National University Hospital, Singapore, completed the Pittsburgh Sleep Quality Index (PSQI). A PQSI score &gt;5 denoted poor sleep quality. The women filled out validated questionnaires covering menopausal and genito-urinary symptoms, and mental health. Physical performance was measured. Bone mineral density and visceral adiposity were assessed by dual energy X-ray absorptiometry. Binary logistic regression analyses assessed independent factors for poor sleep.</p></div><div><h3>Results</h3><p>Poor sleep quality was reported in 38.2% of women (n = 1094, mean age: 56.4 ± 6.2 years). Indian women had higher sleep disturbance scores than Chinese women (mean ± SD: 1.33 ± 0.58 vs 1.17 ± 0.49). Malays experienced more daytime dysfunction (0.54 ± 0.60 vs 0.33 ± 0.55) and had a higher overall PSQI score (6.00 ± 3.31 vs 5.02 ± 2.97) than the Chinese. A low education level (aOR: 1.76, 95% CI: 1.01–3.05), feelings of irritability (2.67, 1.56–4.60) and vaginal dryness (1.62, 1.03–2.54) were associated with poor sleep quality in the adjusted multivariable model. Women with moderate to severe disability were ∼3 times (2.99, 1.20–7.44) more likely to experience less than ideal sleep quality, while urinary incontinence (1.53, 1.08–2.17) and breast cancer history (2.77, 1.36–5.64) were also associates of poor sleep quality.</p></div><div><h3>Conclusion</h3><p>Self-reports of education level, irritability, vaginal dryness, disability, urinary incontinence, and breast cancer history were independently related to poor sleep. Ethnic differences suggest the need for targeted interventions among the ethnic groups.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"5 ","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/57/main.PMC9772553.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10802851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study 血清25-羟基维生素D与北极人群主观睡眠测量的关联:来自基于人群的特罗姆瑟研究的见解
Sleep Medicine: X Pub Date : 2022-12-01 DOI: 10.1016/j.sleepx.2022.100056
A.U. Larsen , L.A. Hopstock , R. Jorde , G. Grimnes
{"title":"Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study","authors":"A.U. Larsen ,&nbsp;L.A. Hopstock ,&nbsp;R. Jorde ,&nbsp;G. Grimnes","doi":"10.1016/j.sleepx.2022.100056","DOIUrl":"10.1016/j.sleepx.2022.100056","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N).</p></div><div><h3>Methods</h3><p>Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents missing data on s-25(OH)D (n = 161) and/or subjective sleep measures (including sleep duration, insomnia, and daytime sleepiness)(n = 490). Based on s-25(OH)D (assessed using LC-MS/MS), participants were grouped as deficient (&lt;30 nmol/L), insufficient (30–49.9 nmol/L), sufficient (50–75 nmol/L), or high (&gt;75 nmol/L). Sleep duration was grouped as inadequate (ISD) if &lt; 7 or ≥9 h. Linear and logistic regression were used to calculate unstandardized <em>β</em>-values and odds ratios [95% confidence intervals]. The analyses were adjusted for season, age, BMI, lifestyle factors and relevant comorbidities.</p></div><div><h3>Results</h3><p>In both men and women, s-25(OH)D was positively associated with sleep duration, and compared to the sufficient s-25(OH)D group, the insufficient s-25(OH)D group reported significantly shorter sleep duration in both sexes. There was an increased odds of ISD in both men and women but adjusted for confounding factors this was only significant in women (1.16 [1.03, 1.32], <em>p</em> = .017). In men, there were no significant associations between s-25(OH)D and the remaining sleep measures. Women in the high s-25(OH)D group had lower ESS-scores (−0.28 [-0.47, −0.08], <em>p</em> = .006), but higher odds of insomnia (1.16 [1.01, 1.33], <em>p</em> = .036) compared to women in the sufficient group.</p></div><div><h3>Conclusions</h3><p>In this Arctic population, a tenuous association was found between s-25(OH)D and subjective sleep measures, predominantly in women.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"4 ","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/52/main.PMC9579360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Disorders of Arousal and timing of the first period of slow wave sleep: Clinical and forensic implications 慢波睡眠第一阶段的觉醒和时间紊乱:临床和法医意义
Sleep Medicine: X Pub Date : 2022-12-01 DOI: 10.1016/j.sleepx.2022.100057
Mark R. Pressman
{"title":"Disorders of Arousal and timing of the first period of slow wave sleep: Clinical and forensic implications","authors":"Mark R. Pressman","doi":"10.1016/j.sleepx.2022.100057","DOIUrl":"10.1016/j.sleepx.2022.100057","url":null,"abstract":"<div><p>The timing of first period of slow wave sleep (SWS) is often used as a proxy for determining if and when Disorders of Arousal (DOA) such as sleepwalking are likely to occur or did occur in the past. In criminal cases employing a “sleepwalking defense” the prosecution may argue that nocturnal violence or sexually aggressive behavior occurred too early in the sleep period to be associated with SWS. Expert witness opinion on the expected latency to SWS (LSWS) has varied from minutes after sleep onset to ≥60 min. A search of PubMed was conducted for LSWS and for any reports of DOAs occurring from stage N2. A total of 21 studies reported LSWS in normal controls, clinically diagnosed sleepwalkers, in otherwise normal sleepers following different types of sleep deprivation and due to the effects of alcohol. Five studies reported episodes of DOA from N2 sleep. The shortest mean LSWS of 6.4 min was found with a combination of total sleep deprivation and alcohol. In a group of normal research subjects, a LSWS mean of 10.7 min was noted. LSWS in DOA patients occurred as early as a mean of 12.4 min. Two sleep studies performed on Kenneth Parks, acquitted of the murder of his mother-in-law by a sleepwalking defense, reported LSWSs of 9.7 and 10 min. Sleep deprivation but not alcohol was found to decrease LSWS significantly. Expert opinions on LSWS should be based on scientific peer reviewed publications documenting empirical sleep evidence and can be much shorter than is generally reported.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"4 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/81/main.PMC9520070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40391309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Association of food intake with sleep disorders in children and adolescents with obesity 肥胖儿童和青少年食物摄入与睡眠障碍的关系
Sleep Medicine: X Pub Date : 2022-12-01 DOI: 10.1016/j.sleepx.2022.100053
Raquel S.M. Zarpellon , Dra Regina M. Vilela , Fernando Mazzilli Louzada , Dra Rosana B. Radominski , Dra Ana Chrystina de Souza Crippa
{"title":"Association of food intake with sleep disorders in children and adolescents with obesity","authors":"Raquel S.M. Zarpellon ,&nbsp;Dra Regina M. Vilela ,&nbsp;Fernando Mazzilli Louzada ,&nbsp;Dra Rosana B. Radominski ,&nbsp;Dra Ana Chrystina de Souza Crippa","doi":"10.1016/j.sleepx.2022.100053","DOIUrl":"10.1016/j.sleepx.2022.100053","url":null,"abstract":"<div><h3>Introduction</h3><p>the great increase in childhood obesity rates is well documented in the scientific literature. However, the influence of diet on sleep quality in children and adolescents still needs further research in order to be better understood. The objective of this study was to evaluate the association between diet and sleep characteristics and in children and adolescents with obesity.</p></div><div><h3>Methods</h3><p>observational analytical cross-sectional study with prospective data collection. Forty-three children and adolescents aged between 6 and 13 years diagnosed with obesity and treated at a public tertiary care institution participated in the study. The 6-day Food Intake Registry was used to evaluate the intake of energy and macronutrients. To investigate the risk of sleep disturbances and to know the routine and characteristics of sleeping habits, the Sleep Disturbance Scale for Children (SDSC) questionnaire was used.</p></div><div><h3>Results</h3><p>and discussion: Food intake showed association with Sleep Breathing Disorders (SBD) and Sleep Wake Transition Disorders (SWTD). The sum of all SDSC factors demonstrated the presence of pathological sleep in most patients (n = 25).</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"4 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33448503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The association between sleep deprivation and arterial pressure variations: a systematic literature review 睡眠剥夺与动脉压变化之间的关系:系统的文献综述
Sleep Medicine: X Pub Date : 2022-12-01 DOI: 10.1016/j.sleepx.2022.100042
Alécio Vinícius Sá Gomes e Farias, Mariana Peixoto de Lima Cavalcanti, Marcelo Alcântara de Passos Junior, Bruna del Vechio Koike
{"title":"The association between sleep deprivation and arterial pressure variations: a systematic literature review","authors":"Alécio Vinícius Sá Gomes e Farias,&nbsp;Mariana Peixoto de Lima Cavalcanti,&nbsp;Marcelo Alcântara de Passos Junior,&nbsp;Bruna del Vechio Koike","doi":"10.1016/j.sleepx.2022.100042","DOIUrl":"10.1016/j.sleepx.2022.100042","url":null,"abstract":"<div><h3>Objectives</h3><p>Arterial hypertension is a cardiovascular disease defined as a sustained high blood pressure, constituting an important risk factor for the development of heart diseases, such as coronary heart disease and heart failure. At the same time, pathophysiological pathways underlying sleeping deprivation provides biological plausibility for a causation connection between sleep deprivation and acute or chronic blood pressure elevation, such as the mechanism behind blood pressure dipping at night, which strongly relies on reduced sympathetic activity provided by sleep, besides empirical and clinical evidence suggesting that sleep disorders incidence is correlate with posterior development of arterial hypertension. The aim of this study was to systematically review published studies analyzing the possible relationship between sleep deprivation and variations in blood pressure during nighttime and daytime.</p></div><div><h3>Methods</h3><p>The research was carried out in the second semester of 2020 following the PRISMA model and using the LILACS, MEDLINE and COCHRANE (CENTRAL) databases. The keywords used were associated using the Boolean method. Only trials and studies in humans unrelated to sleep apnea were included, in an attempt to answer the question proposed. Duplications and articles outside the topic were excluded.</p></div><div><h3>Results</h3><p>After the selection processes, fourteen studies were left, which were classified, depending on the findings, in four categories: 1) blood pressure differences only in sleep deprivation's night; 2) blood pressure differences only in the following day after sleep deprivation's night; 3) blood pressure differences in both nights and 4) those that found no blood pressure differences.</p></div><div><h3>Conclusion</h3><p>It was found an increase in blood pressure on the night of sleep deprivation, suggesting a possible causality with an acute increase in blood pressure depending on the population studied. In general, sleep deprivation is acutely associated with blood pressure elevation or acute elevation of markers that suggest the role of compensatory mechanisms, such as increased natriuresis and increased parasympathetic activity.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"4 ","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39803552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Sleep body position correlates with cognitive performance in middle-old obstructive sleep apnea subjects 中老年阻塞性睡眠呼吸暂停受试者睡眠体位与认知表现的关系
Sleep Medicine: X Pub Date : 2022-12-01 DOI: 10.1016/j.sleepx.2022.100050
Sara Girolami, Marta Tardio, Serpetti Loredana, Nadia Di Mattia, Pamela Micheletti, Mario Di Napoli
{"title":"Sleep body position correlates with cognitive performance in middle-old obstructive sleep apnea subjects","authors":"Sara Girolami,&nbsp;Marta Tardio,&nbsp;Serpetti Loredana,&nbsp;Nadia Di Mattia,&nbsp;Pamela Micheletti,&nbsp;Mario Di Napoli","doi":"10.1016/j.sleepx.2022.100050","DOIUrl":"10.1016/j.sleepx.2022.100050","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"4 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/9f/main.PMC9241099.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40581205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children 唐氏综合症儿童睡眠呼吸障碍的特征——与正常发育儿童的比较
Sleep Medicine: X Pub Date : 2022-12-01 DOI: 10.1016/j.sleepx.2022.100045
Hiroyuki Sawatari , Anita Rahmawati , Nobuko Moriyama , Kanae Fujita , Tomoko Ohkusa , Tomoko Nao , Nobuko Hashiguchi , Mari Nishizaka , Shin-ichi Ando , Akiko Chishaki
{"title":"Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children","authors":"Hiroyuki Sawatari ,&nbsp;Anita Rahmawati ,&nbsp;Nobuko Moriyama ,&nbsp;Kanae Fujita ,&nbsp;Tomoko Ohkusa ,&nbsp;Tomoko Nao ,&nbsp;Nobuko Hashiguchi ,&nbsp;Mari Nishizaka ,&nbsp;Shin-ichi Ando ,&nbsp;Akiko Chishaki","doi":"10.1016/j.sleepx.2022.100045","DOIUrl":"10.1016/j.sleepx.2022.100045","url":null,"abstract":"<div><h3>Background</h3><p>Compared with typically developing control children (CC), children with Down syndrome (DS) frequently exhibit sleep-disordered breathing (SDB) and unusual sleep postures (USPs). No studies have directly compared SDB-related signs and symptoms, SDB-related parameters, and USPs between children with DS and CC. This study aimed to evaluate the prevalences of SDB and USPs in children with DS and CC.</p></div><div><h3>Methods</h3><p>We analyzed SDB-related parameters measured via overnight pulse oximetry and questionnaires administered to parents on SDB-related signs and symptoms, including sleeping postures. Estimated SDB was defined as a 3% oxygen desaturation index (ODI) ≥5 dips/h.</p></div><div><h3>Results</h3><p>Fifty-one children with DS (4–5 years: N = 12, 6–10 years: N = 23, 11–15 years: N = 16) and sixty-three CC (4–5 years: N = 18, 6–10 years: N = 27, 11–15 years: N = 18) were included. The prevalence of estimated SDB and observed USPs was higher in children with DS than in CC (p &lt; 0.0001). Among children aged 11–15 years old, but not those aged 4–5 and 6–10 years old, frequency of arousal and apnea (p = 0.045 and p = 0.01, respectively) were higher in children with DS than in CC. Multivariate analyses showed that DS was associated with SDB-related signs and symptoms, estimated SDB, 3% ODI, average oxygen saturation (SpO<sub>2</sub>), and nadir SpO<sub>2</sub>, while USPs were associated only with higher values of SpO<sub>2</sub> &lt;90%.</p></div><div><h3>Conclusions</h3><p>Estimated SDB tended to increase in children with DS but decreased in CC with growth. USPs were more frequent in children with DS than in CC, especially in older children. USPs might indicate severe hypoxemia due to SDB in DS.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"4 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142722000040/pdfft?md5=99f9bd1267bc1a746f6ee4a550beb46b&pid=1-s2.0-S2590142722000040-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49241442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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