Current Pathobiology Reports最新文献_第5页

High-resolution microscopy for imaging cancer pathobiology. 高分辨率显微成像癌症病理生物学。

Current Pathobiology Reports Pub Date : 2019-01-01 Epub Date: 2019-07-11 DOI: 10.1007/s40139-019-00201-w

Yang Liu, Jianquan Xu

引用次数: 9

Cancer Foraging Ecology: Diet Choice, Patch Use, and Habitat Selection of Cancer Cells 癌症觅食生态：癌症细胞的饮食选择、贴片使用和生境选择

Current Pathobiology Reports Pub Date : 2018-11-27 DOI: 10.1007/s40139-018-0185-7

S. Amend, R. Gatenby, K. Pienta, Joel s. Brown

引用次数: 12

Hepatic Manifestations in Glycogen Storage Disease Type III 糖原贮积病III型的肝脏表现

Current Pathobiology Reports Pub Date : 2018-11-05 DOI: 10.1007/s40139-018-0182-x

Aditi Korlimarla, S. Austin, Baodong Sun, P. Kishnani

引用次数: 0

Nanotechnology Enabled Inhalation of Bio-therapeutics for Pulmonary Diseases: Design Considerations and Challenges 纳米技术实现肺部疾病生物疗法的吸入：设计考虑和挑战

Current Pathobiology Reports Pub Date : 2018-10-24 DOI: 10.1007/s40139-018-0183-9

N. Joshi

引用次数: 1

Nanoparticles Based Drug Delivery for Tissue Regeneration Using Biodegradable Scaffolds: a Review 基于纳米颗粒的生物可降解支架组织再生药物递送研究进展

Current Pathobiology Reports Pub Date : 2018-10-22 DOI: 10.1007/s40139-018-0184-8

Nitin Sahai, N. Ahmad, M. Gogoi

引用次数: 19

Perioperative Developments in Biliary Atresia Treatment 胆道闭锁治疗的围手术期进展

Current Pathobiology Reports Pub Date : 2018-10-17 DOI: 10.1007/s40139-018-0181-y

O. Madadi-Sanjani, C. Petersen

引用次数: 3

Effects of Partial Gravity on the Function and Particle Handling of the Human Lung. 局部重力对人体肺功能和颗粒处理的影响

Current Pathobiology Reports Pub Date : 2018-09-01 Epub Date: 2018-07-13 DOI: 10.1007/s40139-018-0174-x

G Kim Prisk

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引用次数: 0

Evolutionary Stem Cell Poker and Cancer Risks: The Paradox of The Large And Small Intestines. 进化干细胞扑克和癌症风险:大肠和小肠的悖论。

Current Pathobiology Reports Pub Date : 2018-09-01 Epub Date: 2018-07-16 DOI: 10.1007/s40139-018-0176-8

Darryl Shibata

{"title":"Evolutionary Stem Cell Poker and Cancer Risks: The Paradox of The Large And Small Intestines.","authors":"Darryl Shibata","doi":"10.1007/s40139-018-0176-8","DOIUrl":"https://doi.org/10.1007/s40139-018-0176-8","url":null,"abstract":"Purpose of review: Recent studies demonstrate that normal human tissues accumulate substantial numbers of somatic mutations with aging, to levels comparable to their corresponding cancers. If mutations cause cancer, how do tissues avoid cancer when mutations are unavoidable?Recent findings: The small intestines (SI) and colon accumulate similar numbers of replication errors, but SI adenocarcinoma is much rarer than colorectal cancer. Both the small and large intestines are subdivided into millions of small neighborhoods (crypts) that are maintained by small numbers of stem cells. To explain the SI cancer paradox, four fundamental evolution parameters (mutation, drift, selection, and population size) are translated to crypts.Summary: The accumulations of driver mutations in a single stem cell may be analogous to an evolutionary poker game. The rarity of SI cancer may reflect that SI crypts are smaller and have fewer stem cells than the colon, which reduces the numbers of cells at risk for mutation and perhaps selection efficiency. Tissue microarchitecture may physically modulate cancer evolution by controlling the numbers of directly competing neighboring cells. A better understanding of the SI cancer paradox may illuminate how tissues naturally avoid cancers when mutations are unavoidable.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":"6 3","pages":"193-198"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40139-018-0176-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36925336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Musculoskeletal Injuries in Astronauts: Review of Pre-flight, In-flight, Post-flight, and Extravehicular Activity Injuries 宇航员的肌肉骨骼损伤:飞行前、飞行中、飞行后和舱外活动损伤综述

Current Pathobiology Reports Pub Date : 2018-07-28 DOI: 10.1007/s40139-018-0172-z

V. Ramachandran, Sawan Dalal, R. Scheuring, J. Jones

引用次数: 12

The Challenge of Human Pathobiology in Space 人类病理生物学在太空中的挑战

Current Pathobiology Reports Pub Date : 2018-07-26 DOI: 10.1007/s40139-018-0177-7

R. Kerschmann

引用次数: 1