CJC OpenPub Date : 2025-03-01DOI: 10.1016/j.cjco.2024.11.019
Emily E. Ellis MPH , Hena Quereshi MSc , Douglas C. Dover PhD , M. Patrice Lindsay RN, PhD , Sean Virani MD , Anique Ducharme MD, MSc , Nathaniel M. Hawkins MD , Robert McKelvie MD, PhD, FRCPC , Padma Kaul PhD
{"title":"Economic Burden of Heart Failure Hospitalizations in Canada: A Population-based Study","authors":"Emily E. Ellis MPH , Hena Quereshi MSc , Douglas C. Dover PhD , M. Patrice Lindsay RN, PhD , Sean Virani MD , Anique Ducharme MD, MSc , Nathaniel M. Hawkins MD , Robert McKelvie MD, PhD, FRCPC , Padma Kaul PhD","doi":"10.1016/j.cjco.2024.11.019","DOIUrl":"10.1016/j.cjco.2024.11.019","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure (HF) is associated with significant mortality and morbidity and accounts for substantial health care resources. We examined hospitalization costs of patients with HF in Canada (excluding patients from Quebec and the Territories) between 2010/2011 and 2018/2019 and estimated future costs to 2039/2040.</div></div><div><h3>Methods</h3><div>We identified hospitalization records with a primary diagnosis of HF between 2010/2011 and 2018/2019. Concurrent hospitalizations were combined to identify episodes of care. Total hospitalization costs and costs per HF patient were calculated for each fiscal year of the study. All costs are presented in 2022 CAD$. Generalized linear models were used to project primary HF hospitalization episodes and costs to 2039/2040 on the basis of population projections from Statistics Canada.</div></div><div><h3>Results</h3><div>There were 436,160 hospitalization episodes with a primary diagnosis of HF. Between 2010/2011 and 2018/2019, HF episodes increased from 43,114 to 54,743, and number of patients increased from 34,960 to 44,567, and total hospitalization costs increased from $684.3 million to $776.0 million, resulting in a cumulative cost of $6.65 billion. Between 2019/2020 and 2039/2040, there are projected to be 1.69 million HF hospitalization episodes, costing the Canadian health care system $19.5 billion.</div></div><div><h3>Conclusions</h3><div>HF places a substantial economic burden on the Canadian health care system, which is likely to increase in the coming decades. Health system planning and policy solutions to identify, and reduce barriers to, HF therapies that are effective in preventing hospitalizations; and improved access to community-based services are needed to mitigate future costs.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 3","pages":"Pages 279-286"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CJC OpenPub Date : 2025-03-01DOI: 10.1016/j.cjco.2024.11.021
Zhiepng Wei MD , Enjun Zhu MD , Zhiyong Shi MD , Tong Tan MD , Ke Zhang MD , Zhihui Zhu MD , Shengwei Wang MD , Xiaoli Zhang MD , Yongqiang Lai MD
{"title":"Predictive Value of Viable Myocardium of Papillary Muscle-Ventricular Wall Complex for Improvement in Moderate Ischemic Mitral Regurgitation","authors":"Zhiepng Wei MD , Enjun Zhu MD , Zhiyong Shi MD , Tong Tan MD , Ke Zhang MD , Zhihui Zhu MD , Shengwei Wang MD , Xiaoli Zhang MD , Yongqiang Lai MD","doi":"10.1016/j.cjco.2024.11.021","DOIUrl":"10.1016/j.cjco.2024.11.021","url":null,"abstract":"<div><h3>Background</h3><div>Performing a mitral valve procedure during coronary artery bypass grafting (CABG) in patients with coronary artery disease complicated by moderate ischemic mitral regurgitation (IMR) remains controversial. This study aimed to assess the benefit of isolated CABG and to develop a new index of viable myocardium within the papillary muscle-ventricular wall complex (VM-PM-VWC) to predict the improvement of IMR by CABG alone.</div></div><div><h3>Methods</h3><div>In total, 122 patients (age, 62.34 ± 8.53 years; 78.70% male) with moderate IMR who underwent CABG alone at Beijing Anzhen Hospital were retrospectively analyzed. All patients underwent <sup>99m</sup>Tc-sestamibi single-photon emission computed tomography (SPECT) and <sup>18</sup>-fluorine fluorodeoxyglucose positron emission tomography (<sup>18</sup>F-FDG PET) to evaluate the VM-PM-VWC. Based on the postoperative echocardiography results at 1-year follow-up, patients were divided into IMR-unimproved (moderate or severe IMR, n = 38) and IMR-improved (no or mild IMR, n = 84) groups. Factors associated with improvement were analyzed by multivariate logistic regression.</div></div><div><h3>Results</h3><div>The VM-PM-VWC was an independent factor for moderate IMR improvement (odds ratio, 1.16; 95% confidence interval [CI], 1.09-1.24; <em>P</em> < 0.001). The cutoff value for moderate IMR improvement was 12.50%, with a sensitivity and specificity of 76.32% and 80.95%, respectively (area under the curve [AUC] 0.830; 95% CI, 0.741-0.919; <em>P</em> < 0.001). During a median follow-up of 3.71 (interquartile range: 2.17-5.10) years, major cardiovascular and cerebrovascular event-free survival was higher in the improved group than in the unimproved group (<em>P</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>Most patients with moderate IMR improved from isolated CABG. The VM-PM-VWC was an independent predictor of IMR improvement, which could help surgical decision making.</div></div><div><h3>Clinical Trial Registration</h3><div>ChiCTR2100042454.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 3","pages":"Pages 351-361"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trends in Global Burden and Socioeconomic Profiles of Atrial Fibrillation and Atrial Flutter: Insights from the Global Burden of Disease Study 2021","authors":"Samuel Chin Wei Tan MD , Mae-Ling Tang MD , Hongyuan Chu MD , Yun-Tao Zhao MD , Cuilian Weng MD","doi":"10.1016/j.cjco.2024.11.017","DOIUrl":"10.1016/j.cjco.2024.11.017","url":null,"abstract":"<div><h3>Background</h3><div>Understanding trends in atrial fibrillation (AF) and atrial flutter (AFL) is crucial for effective prevention. This study quantifies the burden and identifies key risk factors for AF/AFL across 204 countries and territories from 1990 to 2021.</div></div><div><h3>Methods</h3><div>Using data from the Global Burden of Disease (GBD) study 2021, we employed average annual percentage change (AAPC) and Bayesian Age Period Cohort (BAPC) modelling to assess trends and future projections, with a focus on disparities across Socio-Demographic Index (SDI) levels.</div></div><div><h3>Results</h3><div>In 2021, AF/AFL remained the most common arrhythmia globally, with a prevalence of 52.55 million, 8.36 million disability-adjusted life years (DALYs), and 0.34 million deaths. For each 0.1 increase in SDI, age-standardized mortality rates increased by 4.94%, DALYs by 2.56%, and prevalence rates by 2.40%, highlighting the significant impact of socioeconomic development on AF/AFL burden. AAPC analysis indicated slight increases in deaths, prevalence, and DALYs, along with a decline in incidence, reflecting the impact of public health strategies. However, significant inequalities were observed across SDI levels, with a higher burden in high-SDI regions because of aging populations and improved detection, whereas lower SDI regions faced higher age-standardized mortality rates because of resource constraints.</div></div><div><h3>Conclusions</h3><div>By 2035, we project a 4.07% increase in incidence despite a 6.84% decrease in mortality. Nearly one-half of the AF/AFL burden is linked to modifiable risk factors, underscoring the importance of tailored prevention strategies and improved health care access, especially in lower SDI countries, to mitigate rising disease rates and reduce health care disparities.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 3","pages":"Pages 247-258"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CJC OpenPub Date : 2025-03-01DOI: 10.1016/j.cjco.2024.12.006
Julius Jelisejevas MD , Ali Husain MBBCh , Brian Chiang MD , Howard Paje RN , Hassan Ogran MD , Desiree Nadine Wussler MD , Stephanie L. Sellers MSc, PhD , Jonathon A. Leipsic MD , Philipp Blanke MD , Richard Cook MD , Janarthanan Sathananthan MBCHB, MPH , John G. Webb MD , David A. Wood MD
{"title":"Managing Multivalvular Bioprosthetic Failure and a Hidden Aortic Root–Left Ventricular Outflow Tract Fistula With a Transcatheter Approach: Balancing Risk and Intervention","authors":"Julius Jelisejevas MD , Ali Husain MBBCh , Brian Chiang MD , Howard Paje RN , Hassan Ogran MD , Desiree Nadine Wussler MD , Stephanie L. Sellers MSc, PhD , Jonathon A. Leipsic MD , Philipp Blanke MD , Richard Cook MD , Janarthanan Sathananthan MBCHB, MPH , John G. Webb MD , David A. Wood MD","doi":"10.1016/j.cjco.2024.12.006","DOIUrl":"10.1016/j.cjco.2024.12.006","url":null,"abstract":"","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 3","pages":"Pages 304-306"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}