Journal of Experimental Orthopaedics最新文献

{"title":"Characteristics of gait pelvic jerk in individuals with femoroacetabular impingement syndrome","authors":"Satoshi Machida,&nbsp;Masahiro Tsutsumi,&nbsp;Hajime Utsunomiya,&nbsp;Takuya Ibara,&nbsp;Shintarou Kudo","doi":"10.1002/jeo2.70373","DOIUrl":"https://doi.org/10.1002/jeo2.70373","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Despite a consensus on gait kinematic changes caused by femoroacetabular impingement (FAI), the characteristics of kinetic changes in patients with FAI remain unclear. Therefore, this study aimed to investigate whether pelvic jerk, which can be assessed by inertial sensors, can detect kinetic differences between individuals with FAI and asymptomatic controls and the association between pelvic jerk and patient-reported outcome measures in individuals with FAI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty patients with FAI and 30 asymptomatic controls participated in this study. To obtain the pelvic jerk time series, all participants walked 10 m at a self-selected speed using a third lumbar internal sensor. The peak values of the pelvic jerk in the first and second halves of the stance phases (1st- and 2nd-peak pelvic jerks) were also analysed. The patient-reported outcome measures of individuals with FAI were the international hip outcome tool-33, hip outcome score-activities of daily living, and modified Harris hip score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The FAI group showed lower pelvic jerk than the control group in the first (3%–18% gait cycle) and second halves (42%–54%, 57%–67%) of the stance phase based on the statistical parametric mapping analysis (<i>p</i> &lt; 0.05), and also lower peak values corresponding to the respective gait cycles (1st-peak pelvic jerk, <i>p</i> &lt; 0.001; 2nd-peak pelvic jerk, <i>p</i> = 0.002). Multivariate linear regression analysis showed that 1st-peak pelvic jerk was positively associated with all patient-reported outcome measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Gait kinetic changes in the FAI group were characterised by reduced 1st- and 2nd-peak pelvic jerks. The reduced 1st-peak pelvic jerk is associated with hip function disability in individuals with FAI. Pelvic jerk may be a simple and quantitative indicator of FAI, although the relevance of this metric must be confirmed in the future studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III, case–control study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70373","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative activity, postoperative flexion contractures, and degree of medial cartilage damage affects achievement of high physical activity after open wedge high tibial osteotomy","authors":"Fumiyoshi Kawashima,&nbsp;Jun Oike,&nbsp;Kazuyuki Segami,&nbsp;Koji Kanzaki","doi":"10.1002/jeo2.70372","DOIUrl":"https://doi.org/10.1002/jeo2.70372","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To investigate factors that affect return to physical activities after open wedge high tibial osteotomy (OWHTO), and to determine whether an optimal correction angle exists for return to physical activities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with medial osteoarthritis of the knee who underwent OWHTO at our institution were evaluated. Radiographic evaluations were performed using bilateral weight bearing long leg radiographs. The clinical evaluation consisted of the Tegner activity scale, the Knee Injury and Osteoarthritis Outcome Score (KOOS) Sports/Rec subscore, and the presence of residual flexion contracture of 10° or more in unstable hinge fractures. In addition, the degree of cartilage damage in the medial compartment was evaluated via arthroscopic surgical findings according to the ICRS classification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty patients (70 knees; 25 males and 45 females; mean age, 55.2 [32–75] years; mean follow-up, 8.5 [3.8–12.4] years) were included in the study. The preoperative alignment defined by mean WBLR (%) was significantly higher in the Return to High Physical Activity Group (H Group: 31.0 ± 18.6) than the Return to Low Physical Activity Group (L Group: 15.9 ± 13.9). Logistic analysis showed that low preoperative WBLR and the absence of severe cartilage damage to the medial compartment, postoperative flexion contracture, and unstable hinge fracture were factors affecting return to sport. In addition, the cutoff values using the Youden Index based on ROC analysis were preoperative Tegner activity score of 4.0 and preoperative KOOS (Sports/Rec) of 35.0.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Preoperative KOOS (Sports/Rec) was a useful index for predicting postoperative return to high physical activities. Depending on the degree of arthroscopic cartilage damage, the under-collection of cases with severe cartilage damage should be avoided.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV, retrospective case series.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of pericapsular nerve group block in hip arthroscopy: A systematic review and meta-analysis","authors":"Jeroen den Breejen,&nbsp;Justin van Loon,&nbsp;Inger N. Sierevelt,&nbsp;Michel H. Klaver,&nbsp;Daniel Haverkamp","doi":"10.1002/jeo2.70303","DOIUrl":"https://doi.org/10.1002/jeo2.70303","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>In hip arthroscopy, regional anaesthesia techniques are gaining importance for pain management. A side effect of nerve blocks can be unintended motor block, affecting early post-operative mobilization. Pericapsular nerve group (PENG) block is a technique that may address this issue. This review compares the clinical effects of the PENG block with current pain management practices in hip arthroscopy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature search was conducted in PubMed, Embase and the Cochrane Library, following the PRISMA guidelines. The primary outcome was post-operative pain. Secondary outcomes included duration of hospital stay, opioid use, post-operative motor function and complications. Outcomes were presented in subgroups categorized by study design (randomized controlled trials and retrospective comparative cohort studies). Risk of bias was assessed with both the Cochrane checklist and MINORS. Quality of evidence was evaluated using the Grades of Recommendation Assessment, Development and Evaluation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This systematic review included four RCTs and six retrospective comparative cohort studies, comprising 900 patients in total. The RCTs reported lower mean pain scores at 24 h post-operatively and lower maximum pain scores at the post anaesthesia care unit (PACU) in the PENG group, with no differences observed in PACU time, opioid usage at the PACU or post-operative nausea and vomiting (PONV). The retrospective cohort studies revealed lower maximum and mean PACU pain scores, reduced PACU time, decreased opioid usage and a lower incidence of PONV in the PENG group. One RCT reported better quadriceps strength in PENG, whereas one RCT and cohort study reported no motor impairment in this group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PENG block holds promise for post-operative pain relief, decreased opioid consumption, shorter PACU stay and potentially less PONV without affecting motor function. No differences in hospital stay or PACU opioid use were found, necessitating further research. Due to minimal risks and potential advantages, PENG could be a viable option for analgesia in hip arthroscopy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III, review including Level I–III studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, indications, and risk factors for revision tibial tubercle osteotomy: A national database study","authors":"Julia S. Retzky,&nbsp;William ElNemer,&nbsp;Nathan H. Varady,&nbsp;Vincentius J. Suhardi,&nbsp;Sabrina M. Strickland","doi":"10.1002/jeo2.70339","DOIUrl":"https://doi.org/10.1002/jeo2.70339","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The aims of the present study are to describe the (1) incidence, (2) indications, and (3) risk factors for revision tibial tubercle osteotomy (rTTO) in a national sample of patients in the United States.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A retrospective review of the Mariner PearlDiver database was performed. Patients who underwent unilateral primary tibial tubercle osteotomy (TTO) from 2015 to 2021 with a minimum 2-year follow-up were included, and patients who required revision TTO were identified. Patients with insufficient information, history of total knee arthroplasty (TKA), or lower extremity fracture as indication for primary TTO excluded. Demographic variables including age, sex, Elixhauser comorbidity index (ECI), diagnosis and comorbidities were compared between the no revision (NR) and revision TTO groups. Continuous variables were compared via Student's &lt;i&gt;t&lt;/i&gt;-test, and dichotomous variables were compared via chi-squared test. Multivariate Cox-proportional hazard modelling was utilized to identify predictors of revision TTO.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;4919 patients who underwent TTO were included, 105 of whom required revision TTO. The average age was 26.5 ± 11.5 years, and 3782 (77%) patients were female. The median follow-up time was 4.3 years (interquartile range [IQR]: 3.1–5.6 years). The most common indications for primary TTO included instability (62%) and chondromalacia/pain (33%). The most common indications for rTTO were instability (38%), chondromalacia/pain (28%) and fracture (24%). The median time to rTTO was 91 days [IQR: 20–219 days]. The following variables were associated with an increased risk for revision TTO: hypothyroidism (hazard ratio [HR] 1.8 [range: 1.1–3.0], &lt;i&gt;p&lt;/i&gt; = 0.028), renal disease (HR = 3.3 [1.3–8.7], &lt;i&gt;p&lt;/i&gt; = 0.014) and stroke (HR = 2.8 [1.3–5.8], &lt;i&gt;p&lt;/i&gt; = 0.007).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Instability is the most common indication for rTTO, and most rTTO occur within 91 days of the primary procedure. History of hypothyroidism, renal disease and stroke are all independent risk factors for rTTO. These results highlight the importance close management of higher risk patients in the perioperative period following primary TTO. Preoperative medical optimisation of conditions such as hypothyroidism may mitigate postoperative complications following primary TTO.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Level of Evidence&lt;/h3&gt;\u0000 \u0000 ","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femoral components are positioned in greater external rotation using functional alignment in robot-assisted total knee arthroplasty compared to mechanical alignment","authors":"Anne Ruth van Meijeren,&nbsp;Danielle Langeloo,&nbsp;Hans-Peter van Jonbergen,&nbsp;Marrigje Meijer","doi":"10.1002/jeo2.70362","DOIUrl":"https://doi.org/10.1002/jeo2.70362","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Objective of this study was to evaluate the effect of functional alignment on femoral component rotation compared to mechanical alignment in knees with a constitutional tibial varus alignment classified as coronal plane alignment of the knee (CPAK) types I, II and IV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included patients undergoing conventional total knee replacement (TKR) (<i>n</i> = 64) and robot-assisted TKR (<i>n</i> = 84). Coronal and axial measurements were performed manually and automatically using pre- and postoperative computed tomography images in the conventional group and robot-assisted group respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Femoral component rotation was statistically significant more external rotated in the conventional group versus robot-assisted group (1.3° ± 2.7° vs. 0.76° ± 1.4°, <i>p</i> &lt; 0.001). Also, the tibial plateau was placed statistically significant more in varus in the robot-assisted group compared to the conventional group (87.6° ± 2.5° vs. 88.9° ± 1.4°, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Functional alignment leads to more varus of the tibial component and less external rotation of the femoral component compared to mechanical alignment in TKR in patients with a constitutional tibial varus alignment. Since this is a radiological analysis, further research is needed to understand how these differences affect clinical outcomes as faster recovery, adequate patellar tracking and longer survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70362","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of arthroscopy in intra-articular adipose tissue-derived mesenchymal stem cells for the treatment of early-stage knee osteoarthritis: A bicentric retrospective comparative study","authors":"Simone Giusti,&nbsp;Ezio Adriani,&nbsp;Kristian Samuelsson,&nbsp;Alice Laudisio,&nbsp;Alexandra Horvath,&nbsp;Biagio Zampogna,&nbsp;Rocco Papalia","doi":"10.1002/jeo2.70368","DOIUrl":"https://doi.org/10.1002/jeo2.70368","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To determine the difference in clinical scores and re-intervention rates in patients receiving intra-articular adipose-derived mesenchymal stromal cells (AD-MSCs) as a stand-alone treatment for knee osteoarthritis (OA) compared to patients receiving the same treatment following arthroscopic debridement and lavage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Internal records at two orthopaedic centres were reviewed, and all consecutive patients with Kellgren–Lawrence II–III knee OA who had received intra-articular AD-MSC during 2017–2018 were included. The patients were stratified into two cohorts depending on whether they also received debridement arthroscopy. Patients were evaluated with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS) scores as well as re-intervention rates with a last available follow-up of 5 years after the intra-articular AD-MSC injection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 135 patients were enroled, 66 (49%) patients were male and 69 (51%) were female. The mean age at the time of intervention was 66 (range: 43–81) years. About half of the cohort (<i>n</i> = 68) received a diagnostic and therapeutic arthroscopy (intervention) procedure in the same setting, whereas the other half (<i>n</i> = 67) received intra-articular AD-MSCs without an arthroscopic procedure (control). Totally, 94% reported improved VAS scores post-operatively. Seventy-two patients (53%) had good symptomatic control at 5 years after the intra-articular AD-MSCs injection (VAS score range 0–3). Within this group, 57% of the patients had also received arthroscopy as part of their treatment, whereas the remaining patients had only received the intra-articular injection of AD-MSCs. Overall, WOMAC (46 arthroscopy + AD-MSC, 58 AD-MSC, <i>p</i> &lt; 0.0001) and functionality (34 arthroscopy + AD-MSC, 43 AD-MSC, <i>p</i> &lt; 0.0001) scores were superior in the cohort who also received debridement arthroscopy at the 5-year follow-up. Conservative re-intervention rates, such as hyaluronic acid injections, were comparable amongst the cohorts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, debridement arthroscopy with AD-MSC is favoured over stand-alone MSC in Kellgren–Lawrence I–III knee OA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III, retrospective comparative study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of cellular activity and gene expression in repaired versus reconstructed anterior cruciate ligaments: A case–control study","authors":"Edoardo Monaco,&nbsp;Alessandro Annibaldi,&nbsp;Adnan Saithna,&nbsp;Fabio Marzilli,&nbsp;Alessandro Carrozzo,&nbsp;Vincenzo Visco,&nbsp;Andrea Ferretti,&nbsp;Danilo Ranieri","doi":"10.1002/jeo2.70364","DOIUrl":"https://doi.org/10.1002/jeo2.70364","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The aim of this study was to compare gene expression and cell biology in biopsy specimens from repaired and reconstructed anterior cruciate ligaments</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A biopsy of the repaired and reconstructed anterior cruciate ligaments was performed. Gene expression analysis of alpha smooth muscle alpha actin via immunofluorescence and gene expression analysis of Collagen I, Collagen III, Collagen I–III ratio, and p16 via reverse transcription polymerase chain reaction was performed. In addition, cell motility and migration were quantitatively assessed. Data analysis was performed using analysis of variance (ANOVA) and Tukey's multiple comparison tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-five biopsies, 15 from repaired anterior cruciate ligaments and 10 from reconstructed anterior cruciate ligaments were obtained. Gene expression analysis showed a higher expression of Collagen I in the reconstruction group (<i>p</i> = 0.0027) while the expression of alpha smooth muscle actine, was significantly greater for the repair group (<i>p</i> = 0.001). Quantitative analysis demonstrated significantly higher cell motility in the cells from repaired ligament compared to cells cultured from grafts (43 vs. 54% residual open area from scratch, <i>p</i> = 0.0001 at 24 h; 10 vs. 17% residual open area from scratch, <i>p</i> = 0.001 at 48 h).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Molecular analysis of repaired and reconstructed anterior cruciate ligaments demonstrates significant differences with respect to collagen quality, α-SMA, and p16. dPCs cultured from biopsies tissue showed a greater cellular activation and migration capacity in the repaired ligament. The clinical importance of these findings is a confirmation that repaired anterior cruciate ligament tissue exhibits a cellular behaviour consistent with excellent biological healing potential.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III, case–control study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet rich plasma compared to viscosupplementation in the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomised controlled trials with 6 month and 12 month follow-up","authors":"Kian Bagheri,&nbsp;Adithya Shekhar,&nbsp;Eric Kwok,&nbsp;Danton Dungy,&nbsp;Susan L. Stewart,&nbsp;Amir A. Jamali","doi":"10.1002/jeo2.70335","DOIUrl":"https://doi.org/10.1002/jeo2.70335","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Platelet rich plasma (PRP) and hyaluronic acid (HA) have been utilised in the last few decades as a conservative treatment for knee osteoarthritis (OA). We sought to evaluate the patient reported outcomes at specific intermediate term endpoints comparing PRP to HA through a systematic review and meta-analysis of randomised controlled trials (RCTs). We also sought to determine the effect of platelet concentration on the relative outcomes between PRP and HA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Embase, PubMed, Scopus and Cochrane databases were searched for terms related to PRP and osteoarthritis. RCTs comparing PRP and HA in the treatment of knee OA were selected. A total of 26 trials with 1650 knees were included. The two treatments were compared based on the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS) at specific time points of baseline, 6 months, and 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PRP had a significant benefit over HA based on the WOMAC at 6 months and at 12 months. It also had a significant benefit over HA on the VAS at 6 months and at 12 months. When limiting the analysis to 6 month follow-up and separating the studies by platelet count, PRP had a statistically significant benefit over HA for platelet counts corresponding to ‘greater than baseline to 1,250,000 platelets/μL’ for the WOMAC score and platelet counts corresponding to ‘between 750,000 and 1,250,000 platelets/μL’ for the VAS score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>When taken as a whole, PRP demonstrates a significantly superior clinical result compared to HA at 6 months and 12 months. These findings must be considered in light of the numerous preparation protocols and PRP classifications detailed in this report for the included studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level 1, systematic review of Level-1 randomised controlled studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hamstring autograft, bone-patellar-tendon-bone autograft and synthetic graft in primary anterior cruciate ligament reconstruction: A meta-analysis of comparative studies","authors":"Michele Mercurio,&nbsp;Erminia Cofano,&nbsp;Orlando Cosentino,&nbsp;Katia Corona,&nbsp;Fabrizio Mocini,&nbsp;Umberto Rossi,&nbsp;Olimpio Galasso,&nbsp;Giorgio Gasparini,&nbsp;Simone Cerciello","doi":"10.1002/jeo2.70326","DOIUrl":"https://doi.org/10.1002/jeo2.70326","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Anterior cruciate ligament reconstruction (ACLR) yields favourable results, but failure and reinjury rates are still a concern. Graft choice is a modifiable risk factor for surgeons to avoid failure. The topic of optimal graft selection remains a subject of ongoing debate. Graft choices include autografts, allografts and synthetic grafts. The purpose of this meta-analysis was to compare functional outcomes and complications between autografts, hamstring (HT) tendon and bone-patellar-tendon-bone, and synthetic graft in primary ACLR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The PubMed, MEDLINE, Scopus and Cochrane Central databases were used for the research, and nine studies were included. The first author, journal name, year of publication, patient demographics, type of surgery, type of graft used for ACLR, time from injury to surgery, and follow-up period were recorded. The data extracted for quantitative analysis included Lysholm activity scale score, Tegner activity scale score, International Knee Documentation Committee (IKDC) score, laxity measured with the KT-1000 knee arthrometer (KT-1000), number of complications, re-rupture, and re-intervention rates. Random and fixed effect models were used for the meta-analysis of pooled mean differences (MDs) and odds ratios (ORs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 734 patients were identified, 377 of whom underwent ACLR with autograft and 326 with synthetic graft. The mean age was 28.7 ± 20.3 and 31.6 ± 9.3 years for the ACLR with autograft and ACLR with synthetic graft groups. The mean follow-up durations were 82.3 ± 38 and 81.4 ± 39.2 months. Comparable postoperative Lysholm knee score (<i>p</i> = 0.06), Tegner activity scale score (<i>p</i> = 0.64) and IKDC score (<i>p</i> = 0.15) were found between groups. Significantly greater knee laxity was found in the autograft group (2.6 ± 1.4 and 1.5 ± 1.4 mm; MD = 1.22, 95% confidence interval [CI]: 0.96, 1.48; <i>p</i> &lt; 0.001). Comparable overall complications (<i>p</i> = 0.70), re-rupture (<i>p</i> = 0.81) and re-intervention (<i>p</i> = 0.85) rates were found between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Compared to ACLR with HT autograft, the ACLR with synthetic graft showed statistically but not clinically important decreased knee laxity. Comparable functional outcomes, complication and re-rupture rates were found between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level I, meta-analysis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of total knee arthroplasty on functional outcomes and mental health: A prospective study","authors":"Bassem Haddad,&nbsp;Tasneem N. Alhosanie,&nbsp;Noor Yousef,&nbsp;Ali Kanaan,&nbsp;Leen A. Mazahreh,&nbsp;Khuzama Mohammad,&nbsp;Aya Al-Zurgan,&nbsp;Leen Al-Zghoul,&nbsp;Tala M. Mesmar,&nbsp;Fahad Alabhoul,&nbsp;Abdel Rahman Abuawad,&nbsp;Feras Abuhajleh,&nbsp;Mohammad Hamdan","doi":"10.1002/jeo2.70314","DOIUrl":"https://doi.org/10.1002/jeo2.70314","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Knee osteoarthritis (OA) is a leading cause of disability and chronic pain; total knee arthroplasty (TKA) is the effective treatment in the end stages of knee OA after failure of conservative management. This study has focused on the effects of primary TKA on knee function, levels of depression, and anxiety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study population is a cohort of 100 patients who underwent primary TKA in a tertiary center in Jordan. Oxford Knee Score (OKS), Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 score assessments were performed preoperatively and three months postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed a dramatic improvement in knee function, with the mean OKS increasing from 17.9 preoperatively to 38.4 postoperatively (<i>p</i> &lt; 0.001). Moreover, the percentage of patients who reported no or mild depression increased from 62% to 91%, and those who reported minimal or mild anxiety also increased from 76% to 95%. A multivariate linear regression showed that age, osteoporosis, and smoking were independently associated with the anxiety and depression score changes. These represent not only pain improvement but also a dual benefit in the field of mental health following TKA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Primary TKA showed significant improvement in patients' depression and anxiety, along with the improvement of their knee functional scores. Discussing psychological factors with patients preoperatively might be important along with the functional outcome in making the surgical decision.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level II, prospective cohort study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}