Journal of Experimental Orthopaedics最新文献

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Sex differences in intra-articular treatment outcomes for knee osteoarthritis: Current evidence and research gaps: A systematic review and meta-analysis 膝关节骨性关节炎关节内治疗结果的性别差异:现有证据和研究差距:系统回顾和荟萃分析
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-23 DOI: 10.1002/jeo2.70432
Gae Fattini Fellini, Giacomo A. Fumagalli, Andrea Piano, Alessandro Bensa, Giuseppe Filardo
{"title":"Sex differences in intra-articular treatment outcomes for knee osteoarthritis: Current evidence and research gaps: A systematic review and meta-analysis","authors":"Gae Fattini Fellini,&nbsp;Giacomo A. Fumagalli,&nbsp;Andrea Piano,&nbsp;Alessandro Bensa,&nbsp;Giuseppe Filardo","doi":"10.1002/jeo2.70432","DOIUrl":"10.1002/jeo2.70432","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The aim of this systematic review and meta-analysis was to quantify and compare the evidence on sex-specific outcomes following intra-articular injections of corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP) and cell-based therapies in patients affected by knee osteoarthritis (OA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature search was conducted on PubMed, Cochrane and Web of Science in October 2024 according to PRISMA guidelines. Inclusion criteria were clinical studies of any level of evidence, a minimum of six patients, English language, no time limitations, on the use of intra-articular CS, HA, PRP and cell-based therapies for knee OA treatment. A meta-analysis was conducted for each product on the outcomes with sufficient data at short-term (&lt;3 months) and mid/long-term (≥3 months) follow-ups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 848 studies were included reporting on 99,443 patients (61.5 ± 24.7 years old, 65.8% women, 34.2% men). Out of these, only 21 articles (2.5% of the total, 2265 patients) presented sex-disaggregated data, including four studies with a CS treatment group (1.9% of CS patients), three with a HA group (0.2% of HA patients), 11 with a PRP group (5.9% of PRP patients) and eight with a cell-based therapy group (10.2% of cell-based therapies patients). The meta-analysis was performed on 15 studies (1387 patients) and did not show any statistically significant difference of VAS and WOMAC improvements at short- and mid/long-term follow-ups for any of the four injectable treatment approaches analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There is a staggering lack of sex-disaggregated data in studies evaluating the most used intra-articular injective therapies for knee OA, with only 2.5% analysing women- and men-specific outcomes for CS, HA PRP and cell-based therapies. The analysis of this limited amount of sex-disaggregated data did not show statistically significant differences between women and men for any of the investigated injectable approaches. The substantial lack of disaggregation hinders the understanding of potential sex-specific effects of these treatments and underscores the need for a shift in data reporting in this field, with more robustly designed studies incorporating sex-stratified analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level I.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five-year clinical study of a novel porcine xenograft for anterior cruciate ligament reconstruction: Positive safety and performance outcomes 一种新型猪异种移植物用于前交叉韧带重建的五年临床研究:积极的安全性和性能结果
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-23 DOI: 10.1002/jeo2.70433
Neil Hunt, Gabriel Oliver, Alberto Francés Borrego, William S. Pietrzak
{"title":"Five-year clinical study of a novel porcine xenograft for anterior cruciate ligament reconstruction: Positive safety and performance outcomes","authors":"Neil Hunt,&nbsp;Gabriel Oliver,&nbsp;Alberto Francés Borrego,&nbsp;William S. Pietrzak","doi":"10.1002/jeo2.70433","DOIUrl":"10.1002/jeo2.70433","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Many graft choices exist for anterior cruciate ligament (ACL) reconstruction including autograft, allograft and, to a lesser extent, synthetic graft, with all having significant limitations. While xenograft can circumvent many of these limitations, potential immunogenic response remains a concern. A novel decellularization process has been developed to remove the principal immunogenic epitopes from porcine digital extensor tendon to produce a nonimmunogenic, biomechanically appropriate ACL xenograft for clinical use. This study reports the first in-human series utilising this xenograft.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a 5-year study of 40 patients, mean age 31.9 years (range: 18–48), 70% male, with mean follow-up of 41.9 months (6–60 months) and 19 reaching 5 years. Radiographic and MRI analysis was performed as were a variety of clinical assessments, including arthrometric measurement of anterior tibial translation, Lachman test, Pivot Shift test, International Knee Documentation Committee (IKDC) Subjective questionnaire, and Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire. All adverse events were recorded. Clinical outcomes were compared to those reported in the literature for autograft and/or allograft.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Adverse events included six graft ruptures which were limited to young males. No evidence of an immunogenic response was noted. Clinical outcome assessments and imaging analysis were in line with those reported in the literature for autograft and/or allograft.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This first in-human study of a novel porcine ACL xenograft demonstrated that it is biomechanically and immunologically suitable for clinical use with no safety concerns evident.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145122652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic and prognostic potential of biomarkers in femoroacetabular impingement syndrome: A systematic review 生物标志物在股髋臼撞击综合征中的诊断和预后潜力:系统综述
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-22 DOI: 10.1002/jeo2.70417
Junya Yoshitani, Seper Ekhtiari, Joseph Dulleston, Ajay Malviya, Vikas Khanduja
{"title":"Diagnostic and prognostic potential of biomarkers in femoroacetabular impingement syndrome: A systematic review","authors":"Junya Yoshitani,&nbsp;Seper Ekhtiari,&nbsp;Joseph Dulleston,&nbsp;Ajay Malviya,&nbsp;Vikas Khanduja","doi":"10.1002/jeo2.70417","DOIUrl":"10.1002/jeo2.70417","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Early diagnosis of femoroacetabular impingement syndrome (FAIS) is essential. This systematic review aimed to identify biomarkers useful for diagnosing FAIS and predicting its progression to hip osteoarthritis. Our hypothesis was that there are biomarkers that are useful for the diagnosis and/or prognosis of FAIS. Our research questions were: (1) which biomarkers support diagnosis or screening of FAIS? and (2) which biomarkers predict disease progression?</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review using the PRISMA guidelines was conducted to investigate the relationship between biomarkers and FAIS. The diagnosis of FAIS was based on the criteria used in each original study, typically involving clinical symptoms and radiographic evidence of CAM or pincer morphology. The protocol for the review has been published in PROSPERO. Literature search was performed using three databases: Embase, MEDLINE and Cochrane Library. The initial search yielded 683 articles of which 16 articles were included for final analysis. Data from a total of 2134 participants were analysed. Sixty-eight unique biomarkers associated with FAIS were identified and measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Diagnostically, 19 biomarkers were identified, of which 12 could significantly detect a difference between patients with FAIS and healthy controls. Forty-two biomarkers predicting the association of FAIS with hip osteoarthritis or late FAIS were identified, of which 16 biomarkers were statistically significant. Only 4-aminobutyrate aminotransferase promoter (ABAT) and peroxisome proliferator-activated receptor gamma (PPARγ) were associated with both diagnosis and prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Biomarkers may support the diagnosis and monitoring disease progression in patients with FAIS. Twelve biomarkers may detect early changes, and 16 may predict progression to osteoarthritis. Further refinement is required to identify those most useful in clinical practice. ABAT and PPARγ may be linked to both diagnosis and progression. While primarily preclinical, these findings may improve diagnostic accuracy, reduce overtreatment and aid decisions regarding joint preservation strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Portable exoskeletons for upper limb rehabilitation: A systematic review 用于上肢康复的便携式外骨骼:系统综述
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-22 DOI: 10.1002/jeo2.70416
Arianna Carnevale, Guido Nicodemi, Matteo Giuseppe Pisani, Alberto Lalli, Francesco Scotto di Luzio, Pieter D'Hooghe, Loredana Zollo, Emiliano Schena, Umile Giuseppe Longo
{"title":"Portable exoskeletons for upper limb rehabilitation: A systematic review","authors":"Arianna Carnevale,&nbsp;Guido Nicodemi,&nbsp;Matteo Giuseppe Pisani,&nbsp;Alberto Lalli,&nbsp;Francesco Scotto di Luzio,&nbsp;Pieter D'Hooghe,&nbsp;Loredana Zollo,&nbsp;Emiliano Schena,&nbsp;Umile Giuseppe Longo","doi":"10.1002/jeo2.70416","DOIUrl":"10.1002/jeo2.70416","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This systematic review evaluates the efficacy and feasibility of portable exoskeletons for upper limb rehabilitation in patients post-stroke and with postoperative neurological complications. It focuses on motor function, range of motion (ROM), spasticity reduction and improvements in daily living activities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following PRISMA guidelines [12], PubMed, Cochrane, and Scopus databases were searched up to October 2024 using combinations of keywords and MeSH terms such as “exoskeleton devices” and “shoulder rehabilitation.” Included studies (January 2008–October 2023) assessed portable exoskeletons for upper limb function in patients with chronic stroke or postoperative neurological complications. Excluded were studies on non-portable robots, animal studies, protocols, those without quantitative outcomes, and those not involving human patients. The Joanna Briggs Institute (JBI) Critical Appraisal tool, and the Risk Of Bias 2 (ROB2) tool assessed study bias.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five selected studies included 70 patients. Evaluated exoskeletons included the Tenodesis-Induced-Grip Exoskeleton Robot (TIGER), Wilmington Robotic Exoskeleton (WREX), Hybrid Exoskeleton Upper Limb 30A (HEXO-UR30A), and Hybrid Assistive Limb (HAL). These devices demonstrated significant improvements in motor function, ROM, spasticity reduction, and kinematic parameters. High adherence and absence of severe adverse events supported feasibility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Portable exoskeletons are promising tools for upper limb rehabilitation post-stroke and after neurological surgery. They enhance motor recovery and functional outcomes. However, moderate risk of bias, small sample sizes, and limited data in orthopedic contexts—especially comparisons with conventional rehabilitation—underscore the need for further high-quality RCTs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70416","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High return to sport after rotator cuff repair in racket sport players 球拍运动员肩袖修复后的高恢复率
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-22 DOI: 10.1002/jeo2.70396
Ayham Jaber, Yazan Jaber, Christopher J. Hawryluk, Silvia Cardarelli, Gianmarco Marcello, Peter J. Millett, Giovanni Di Giacomo, Filippo Familiari
{"title":"High return to sport after rotator cuff repair in racket sport players","authors":"Ayham Jaber,&nbsp;Yazan Jaber,&nbsp;Christopher J. Hawryluk,&nbsp;Silvia Cardarelli,&nbsp;Gianmarco Marcello,&nbsp;Peter J. Millett,&nbsp;Giovanni Di Giacomo,&nbsp;Filippo Familiari","doi":"10.1002/jeo2.70396","DOIUrl":"10.1002/jeo2.70396","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To assess the return-to-sport (RTS) rates and outcomes in racket sports players after isolated supraspinatus full thickness tears, and to investigate the influence of patient-, injury-, and treatment-specific factors on these outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study reviewed 38 racket sport players (tennis and padel) who underwent primary arthroscopic RCR performed by the senior author (G.D.G.). Inclusion criteria included patients aged 16 years or older with a history of rotator cuff tear, playing racket sports at least weekly prior to injury, and a minimum two-year follow-up. Functional outcomes were assessed using the Visual Analogue Scale for pain (VAS-score) and the 12-Item Short Form Survey (SF-12). RTS was defined as returning to the same or higher level. Statistical analysis was performed to analyse categorical and continuous variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ninety percent all participants were male, with a mean age of 58 years. The majority (95%) played racket sports recreationally, with tennis being the most common sport. Most participants (80%) played on clay courts. Thirty-four participants (85%) returned to sport, with 69% returning at the same level and 10% at a higher level. The median postoperative VAS score was 0 (IQR 0–0). Patient satisfaction was high, with 97.5% of patients reporting satisfaction. No significant differences in RTS were found based on injury mechanism or symptom duration, though patients with traumatic injuries reported higher mental component summary scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Most racket sport players who undergo arthroscopic RCR for full-thickness supraspinatus tears are able to return to sport, with most returning at the same or higher level of play. Trauma-related injuries may positively influence mental recovery compared to degenerative injuries. Further prospective studies with larger cohorts and a greater focus on competitive athletes are needed to better predict patient outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limited clinical benefit of medial meniscus posterior root repair combined with high tibial osteotomy in varus knee osteoarthritis: A systematic review and meta-analysis 内侧半月板后根修复联合胫骨高位截骨治疗膝内翻性关节炎的有限临床疗效:一项系统回顾和荟萃分析
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-22 DOI: 10.1002/jeo2.70431
Gabriele Cortina, Stefano Mauro Antuofermo, Giuseppe Francesco Papalia, Raffaele Cortina, Vincenzo Condello, Simone Perelli, Joan Carles Monllau, Vincenzo Madonna
{"title":"Limited clinical benefit of medial meniscus posterior root repair combined with high tibial osteotomy in varus knee osteoarthritis: A systematic review and meta-analysis","authors":"Gabriele Cortina,&nbsp;Stefano Mauro Antuofermo,&nbsp;Giuseppe Francesco Papalia,&nbsp;Raffaele Cortina,&nbsp;Vincenzo Condello,&nbsp;Simone Perelli,&nbsp;Joan Carles Monllau,&nbsp;Vincenzo Madonna","doi":"10.1002/jeo2.70431","DOIUrl":"10.1002/jeo2.70431","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Medial meniscus posterior root tears (MMPRTs) are biomechanically comparable to total meniscectomy, leading to meniscal extrusion, increased tibiofemoral contact pressure and accelerated osteoarthritis (OA) in varus-aligned knees. While high tibial osteotomy (HTO) is effective in unloading the medial compartment, the added value of repairing the MMPRT during HTO remains debated. This systematic review and meta-analysis aimed to evaluate whether combined MMPRT repair and HTO provide superior short-term clinical and radiological outcomes compared to HTO alone.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A systematic search of PubMed, Cochrane and Scopus was performed in March 2025. Comparative studies evaluating HTO with or without concurrent MMPR repair in patients with varus knee and medial OA were included. Primary outcomes were clinical scores (International Knee Documentation Committee [IKDC], Lysholm, Knee Society Score [KSS] and Hospital for Special Surgery [HSS]), radiographic parameters (joint line convergence angle [JLCA], hip–knee–ankle [HKA] angle and joint space width), meniscal extrusion and second-look arthroscopic findings. Statistical analysis was conducted using a random-effects model with Review Manager 5.4.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Eight retrospective comparative studies (&lt;i&gt;n&lt;/i&gt; = 630 patients) met the inclusion criteria. MMPRT repair plus HTO demonstrated statistically higher IKDC scores (MD = 3.56; &lt;i&gt;p&lt;/i&gt; = 0.001) compared to HTO alone; however, there were no significant differences between groups in terms of Lysholm, KSS function and HSS scores. Radiographically, minimal improvements were noted in JLCA (MD = −0.25; &lt;i&gt;p&lt;/i&gt; = 0.006), without clear clinical implications. Meniscal extrusion did not differ significantly between groups (MD = 0.30; &lt;i&gt;p&lt;/i&gt; = 0.72). Second-look arthroscopy revealed complete root healing in 22% of cases. The risk of bias was moderate to high.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Short-term follow-up shows that combining MMPRT repair with HTO yields statistically better IKDC clinical scores. Furthermore, the actual benefit of combining MMPRT repair with HTO in routine clinical practice is questionable. Prospective studies with longer follow-up are required to clarify the long-term clinical impact of MM.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Level of Evidence&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Level III, systematic review and meta-analysis.&lt;/p&gt;\u0000 &lt;/","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound findings and clinical testing for preoperative diagnosis of long head of the biceps pathology 超声表现及临床检查对二头肌长头病变的术前诊断
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-18 DOI: 10.1002/jeo2.70430
Jacques Guery, Maxime Antoni, ReSurg, David Gallinet
{"title":"Ultrasound findings and clinical testing for preoperative diagnosis of long head of the biceps pathology","authors":"Jacques Guery,&nbsp;Maxime Antoni,&nbsp;ReSurg,&nbsp;David Gallinet","doi":"10.1002/jeo2.70430","DOIUrl":"10.1002/jeo2.70430","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To determine whether combining ultrasound (US) observations and clinical tests could substantially improve sensitivity for diagnosis of long head of the biceps tendon (LHBT) pathology compared to ultrasound alone and clinical tests alone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The authors retrospectively assessed a consecutive series of 284 patients that underwent arthroscopic rotator cuff repair for isolated supraspinatus tears. LHBT pathology was assessed preoperatively using seven US observations ((i) hypervascularisation, (ii) upper gutter signal, (iii) gutter signal, (iv) upper gutter position, (v) gutter position, (vi) upper gutter surface and (vii) gutter surface) and four clinical tests specific to shoulder injuries (Speed, Yergason, Kibler tests and bicipital groove tenderness). Binary outcomes of each assessment were combined to calculate the diagnostic accuracy using intraoperative arthroscopy as reference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study cohort comprised 246 patients aged 57.5 ± 8.8 years at index surgery. A total of 56 combinations were tested to obtain the best diagnostic algorithm for detection of LHBT pathologies. Of the 13 combinations with a sensitivity (Se) ≥ 0.85, only four had a specificity (Sp) ≥ 0.25. The ‘tenderness or bicipital gutter surface area’ combination achieved the highest sensitivity (Se, 0.93; Sp, 0.25), followed by the ‘speed or upper bicipital gutter surface area’ combination (Se, 0.87; Sp, 0.28), the ‘tenderness or upper bicipital gutter surface area’ combination (Se, 0.87; Sp, 0.33), and finally the ‘kibler or bicipital gutter surface area’ combination (Se, 0.85; Sp, 0.35).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>For the diagnosis of LHBT pathology, using a combination of ultrasound and clinical tests grants higher sensitivity compared to ultrasound or clinical tests alone. The clinical relevance of these findings is that using any combination, 85%–93% of pathologic LHBTs would be correctly diagnosed, while 65%–75% of healthy LHBTs could be misdiagnosed as pathologic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV, diagnostic accuracy study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allogenic MSCs are a safe and efficacious treatment for knee osteoarthritis: A systematic review of randomised controlled trials 同种异体间充质干细胞是一种安全有效的治疗膝关节骨关节炎的方法:随机对照试验的系统回顾
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-18 DOI: 10.1002/jeo2.70437
Randy Y. J. Loke, Zachary Chu, Jonathan Liang, Don Koh, Junwei Soong, Kong Hwee Lee, Hamid Rahmatullah Bin Abd Razak
{"title":"Allogenic MSCs are a safe and efficacious treatment for knee osteoarthritis: A systematic review of randomised controlled trials","authors":"Randy Y. J. Loke,&nbsp;Zachary Chu,&nbsp;Jonathan Liang,&nbsp;Don Koh,&nbsp;Junwei Soong,&nbsp;Kong Hwee Lee,&nbsp;Hamid Rahmatullah Bin Abd Razak","doi":"10.1002/jeo2.70437","DOIUrl":"10.1002/jeo2.70437","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Implantation of mesenchymal stem cells (MSCs) is a potential non-surgical option for cartilage repair. Currently, its clinical use largely focuses on focal cartilage defect repair and intra-articular injections in knee osteoarthritis (OA). Most studies have looked at the efficacy of MSCs from autologous sources, which can be limited by inter-patient variability of age, diseases, sites and methods of harvest. This systematic review aims to evaluate studies that focus on allogeneic MSCs implantation versus placebo in patients with knee OA to summarise the efficacy and safety of allogeneic MSCs in knee OA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search following PRISMA guidelines was performed in PubMed, Scopus and EMBASE. Original studies investigating the outcomes of allogeneic MSC implantations in patients with knee OA were included. Data on clinical outcomes, such as subjective scores such as VAS and WOMAC, radiological outcomes, such as cartilage thickness, and histological outcomes, such as ICRSII score, were extracted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven studies were included in this review. There was 30.4 points improvement in Visual Analogue Scale scores and 40.0 points of improvement in Western Ontario and McMaster Universities Osteoarthritis Index scores at 12 months. Improved cartilage thickness and decreased poor cartilage quality as measured by T2 relaxation. Measurements at the lesion site were observed in three studies as assessed by postoperative magnetic resonance imaging and this was correlated clinically. One study also showed histological improvement with overall ICRSII scores significantly improving from 32.0 ± 21.6 at baseline to 55.9 ± 23.2 at 6 months (<i>p</i> &lt; 0.05). No major complications or tumorigenesis occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Allogeneic MSC implantation in patients with knee osteoarthritis provides sustained clinical improvement and satisfactory cartilage restoration, up to 12 months follow-up. These results are supported by both imaging and histological studies. The safety profile of allogeneic MSCs is excellent, with minimal adverse events mainly limited to local reaction to injection and no long-term adverse effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level II.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The promising potential of polynucleotide injections for knee osteoarthritis: A systematic review of literature and meta-analysis of randomized control trials 多核苷酸注射治疗膝关节骨性关节炎的潜力:一项随机对照试验的系统文献综述和荟萃分析
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-15 DOI: 10.1002/jeo2.70428
Joseph Elphingstone, Michael Bowler, Pietro Conte, Giuseppe Anzillotti, Elizaveta Kon
{"title":"The promising potential of polynucleotide injections for knee osteoarthritis: A systematic review of literature and meta-analysis of randomized control trials","authors":"Joseph Elphingstone,&nbsp;Michael Bowler,&nbsp;Pietro Conte,&nbsp;Giuseppe Anzillotti,&nbsp;Elizaveta Kon","doi":"10.1002/jeo2.70428","DOIUrl":"10.1002/jeo2.70428","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The present study aims to synthesize and evaluate the evidence on the effectiveness of intra-articular polynucleotides (PNs) for knee osteoarthritis (OA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In March 2024, we searched MEDLINE, Emcare, Web of Science and Cochrane Library for studies involving PNs for knee OA in human subjects. Inclusion criteria consisted of human subjects with knee OA and the use of intra-articular PNs. Studies were excluded if they were basic science, included non-knee OA pathology, did not use PNs, were case reports, or if there was no available full-text article. The primary outcome was pain, and secondary measures were functional outcome scores and adverse events. Risk of bias was analyzed using Cochrane's Risk of Bias Tool for randomized controlled trials and ROBINS-I for non-randomized studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve studies were included for systematic review and five for meta-analysis. Two studies evaluated a combined treatment of PN and HA (PNHA) to HA but were included only for qualitative analysis. Meta-analysis demonstrated significantly better pain improvement in PN than HA at 2 months (mean difference [MD] = −1.04 [−1.63 to −0.45], <i>p</i> = 0.0006) and four months (MD = −0.84 [−1.45 to −0.24], <i>p</i> = 0.006). Functional outcomes also favoured PNs at 2 months (standardized mean difference [SMD] = 0.46 [0.17–0.74], <i>p</i> = 0.002) and 4 months (SMD = 0.25 [0.00–0.50], <i>p</i> = 0.05) over HA. Data from PNHA studies suggested better pain and functional outcomes than those from HA. Adverse events with PNs were not significantly different from those receiving HA (RR = 1.97 [0.72–5.37], <i>p</i> = 0.187).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PN injections are a safe and more effective option for treating knee OA than conventional HA. Treatments combining PN and HA also appear to be a promising therapeutic option. However, limited statistical power and potential publication bias warrant further research to enhance confidence in these findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV, systematic review of Levels II–IV studies. Level I, meta-analysis of Level I studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid and reliable alpha angle measurement using a smartphone-based artificial intelligence system for cam-type femoroacetabular impingement 基于智能手机的人工智能系统对凸轮型股髋臼撞击进行快速可靠的α角测量
IF 2.7
Journal of Experimental Orthopaedics Pub Date : 2025-09-15 DOI: 10.1002/jeo2.70418
Masayoshi Saito, Hiroyuki Ogawa, Takuya Kusakabe, Naoyuki Hirasawa, Sachiyuki Tsukada
{"title":"Rapid and reliable alpha angle measurement using a smartphone-based artificial intelligence system for cam-type femoroacetabular impingement","authors":"Masayoshi Saito,&nbsp;Hiroyuki Ogawa,&nbsp;Takuya Kusakabe,&nbsp;Naoyuki Hirasawa,&nbsp;Sachiyuki Tsukada","doi":"10.1002/jeo2.70418","DOIUrl":"10.1002/jeo2.70418","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Manual alpha angle measurement for diagnosing cam-type femoroacetabular impingement (FAI) is time-consuming and variable. We hypothesised that a smartphone-based artificial intelligence (AI) system would demonstrate a high correlation with the conventional manual method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We trained an AI model using 300 of the 45° Dunn view radiographs in a Python-based environment. The model was implemented using a smartphone application that semi-automatically extracted the femoral head from radiographs, detected at least four rim points, and calculated the femoral head centre and radius using a least-squares method. It also identified the narrowest part of the femoral neck, and allowed manual adjustment of the alpha angle deviation. The images were directly captured and transferred without time loss. We evaluated 130 hips of patients with hip pain who underwent 45° Dunn view radiography. The alpha angle was measured using both the AI system and the manual method. Pearson correlation coefficient was used to assess agreement between the two methods. Measurement time and intra- and interobserver reliability were assessed using intraclass correlation coefficients (ICC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Pearson correlation coefficient for alpha angle measurement between the two methods was 0.91, indicating a strong correlation. The average alpha angle measured by the AI system (52.7 ± 6.0°) was not significantly different from that of the conventional method (53.9 ± 6.5°, <i>p</i> = 0.12). The AI-powered system showed intra- and interobserver agreement ICCs of 0.96 and 0.93, respectively, demonstrating excellent reliability. The mean measurement time was 5.0 ± 2.4 and 46.7 ± 10.1 s for the AI-powered system and manual method, respectively, indicating significant time-saving.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The AI-powered system showed a strong correlation with the manual method and significantly reduced measurement time. This smartphone-based tool offers a rapid and reliable approach for real-time assessment of alpha angles and may help standardise the evaluation of cam-type FAI in clinical practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III, retrospective comparative study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"12 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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