Journal of Experimental Orthopaedics最新文献

{"title":"Tibial spino–meniscal clearance: A reproducible MRI-derived measurement associated with hypermobile lateral meniscus","authors":"Camilo Helito,&nbsp;Francisco Endara Urresta,&nbsp;Carlos Peñaherrera-Carrillo,&nbsp;Alejandro Barros Castro","doi":"10.1002/jeo2.70660","DOIUrl":"10.1002/jeo2.70660","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To evaluate whether tibial spino–meniscal clearance (TSMC), a magnetic resonance imaging (MRI)-derived imaging measurement, is associated with arthroscopically confirmed hypermobile lateral meniscus (HML), and to assess the reproducibility of this measurement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A combined retrospective–prospective diagnostic accuracy study was conducted including 164 patients who underwent knee MRI followed by arthroscopy within six months. TSMC was measured on sagittal MRI as the shortest distance between the apex of the lateral tibial spine and the inner margin of the posterior horn of the lateral meniscus. Three blinded observers independently performed measurements to assess intra- and interobserver reliability using intraclass correlation coefficients (ICCs). Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis, and multivariable logistic regression was used to examine the association between TSMC and HML.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean TSMC values were lower in patients with arthroscopically confirmed HML compared with controls. The measurement demonstrated excellent intra- and interobserver reliability. ROC analysis showed good discriminatory performance for identifying HML, and TSMC remained independently associated with hypermobility after adjustment for demographic and anatomical variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TSMC is a reproducible MRI-derived imaging measurement associated with HML. While these findings suggest that TSMC may assist in preoperative suspicion of lateral meniscal instability, further external validation is required before routine clinical application.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substantial variability and inconsistent quality of publicly available rehabilitation protocols after quadriceps tendon anterior cruciate ligament reconstruction: A cross-sectional analysis of academic orthopaedic surgery programmes","authors":"David Slawaska-Eng,&nbsp;Caitlin Svendsen,&nbsp;Emily Zhang,&nbsp;Kanika Tibriwal,&nbsp;Dan Cohen,&nbsp;Lauren Gyemi,&nbsp;Sachin Tapasvi,&nbsp;Matthieu Ollivier,&nbsp;Darren de Sa","doi":"10.1002/jeo2.70653","DOIUrl":"10.1002/jeo2.70653","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Quadriceps tendon (QT) autograft is increasingly used for anterior cruciate ligament reconstruction (ACLR), yet rehabilitation guidelines remain extrapolated from patellar tendon (PT) or hamstring tendon (HT) protocols. This cross‑sectional study evaluated publicly available postoperative rehabilitation protocols from academic orthopaedic programmes to describe their content, assess variability and identify key trends.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Accredited orthopaedic residency programmes were identified through the Electronic Residency Application Service (ERAS) and Canadian Resident Matching Service (CaRMS). A three-step systematic web-based search was conducted to identify publicly available QT-ACLR rehabilitation protocols. Protocols were included if specific to QT autografts and excluded if addressing concomitant meniscal repairs. Two independent reviewers extracted data on rehabilitation components and timelines. The proportion of protocols including each component and the median initiation time were calculated.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Of 219 programmes screened, 16 eligible protocols were identified. Nine were QT-specific and seven were general ACLR protocols. Key trends included: (1) use of a hinged brace locked in extension for 2–4 weeks (86.7%); (2) initiation of icing, cryotherapy and patellar mobilizations immediately postoperatively (68.8%); (3) neuromuscular electrical stimulation use within the first 4 weeks (56.2%); (4) target of full extension by 2–4 weeks and flexion by 3–4 months (100%); (5) strengthening, balance and proprioceptive training beginning between 1–3 months (93.8%–100%) and (6) return‑to‑sport (RTS) testing between 5 and 9 months, using time-based and/or criterion-based recommendations (100%). Substantial variability existed in exercise prescriptions, adjunctive therapy use and RTS criteria.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Publicly available QT-ACLR rehabilitation protocols from academic programmes emphasize early weight-bearing, range of motion restoration and progressive strengthening but reveal considerable variability in timing, adjunctive therapies and RTS guidelines. Many protocols mirror those for PT and HT autografts rather than being tailored to QT-specific considerations. Standardized, evidence-based rehabilitation guidelines that address graft-specific risks, psychological readiness and telehealth delivery are needed to optimize outcomes following QT-ACLR.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12903539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and radiological results of allogenous bone graft versus synthetic calcium-phosphate graft in opening wedge high tibial osteotomy","authors":"Yoosef Mehrabi,&nbsp;Salar Baghbani,&nbsp;Seyyed Reza Sharifzadeh,&nbsp;Davood Feizi,&nbsp;Saeed Hesaraki,&nbsp;Saeed Bakhshi,&nbsp;Mohammad Movahedinia,&nbsp;Mostafa Shahrezaee","doi":"10.1002/jeo2.70592","DOIUrl":"10.1002/jeo2.70592","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Purpose&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To compare the clinical and radiographic data after opening wedge high tibial osteotomy (OWHTO) using an allogenous bone graft versus a tricalcium phosphate (TCP) graft.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This prospective clinical study enroled 42 patients (84 knees) between September 2022 and March 2023, undergoing bilateral OWHTO for genu varum. Patients' knees were randomized intraoperatively into two groups: those receiving an allograft or TCP graft to fill the osteotomy defect. Preoperative assessments included pain severity via the visual analogue scale (VAS) and joint function using the Western Ontario and McMaster University Osteoarthritis Index (WOMAC). The osteotomy was corrected using the Minami–Miniaci method, and stabilization was achieved with a fixed-angle locking plate. Pain, complications and radiographic outcomes were monitored post-operatively, with bone union assessed via the Hemert criteria.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this cohort of 42 patients (59.5% male, mean age 36.6 ± 5.0 years), all non-smokers, the mean follow-up was 2.1 years. Pre- and post-operative comparison using WOMAC (pre-op = 16.1 ± 8.4; post-op = allograft: 11.3 ± 4.7, &lt;i&gt;p&lt;/i&gt; = 0.00; TCP = 9.3 ± 4.8, &lt;i&gt;p&lt;/i&gt; = 0.00) and VAS scores (pre-op = 2.8 ± 0.9; post-op = allograft: 2.2 ± 0.8, &lt;i&gt;p&lt;/i&gt; = 0.00; TCP = 1.8 ± 1.2, &lt;i&gt;p&lt;/i&gt; = 0.00) revealed statistically and clinically significant outcomes. In WOMAC components meaningful pain (pre-op = 4.4 ± 1.7; post-op = allograft: 2.9 ± 1.3, &lt;i&gt;p&lt;/i&gt; = 0.00; TCP = 2.4 ± 1.4, &lt;i&gt;p&lt;/i&gt; = 0.00), stiffness (pre-op = 1.7 ± 1.2; TCP = 1.3 ± 1.1, &lt;i&gt;p&lt;/i&gt; = 0.01) and physical function (pre-op = 9.9 ± 7.1; post-op = allograft: 7.7 ± 3.9, &lt;i&gt;p&lt;/i&gt; = 0.00; TCP = 6.4 ± 4.0, &lt;i&gt;p&lt;/i&gt; = 0.00) improvements at 12 months in both grafts, except stiffness in allograft group (pre-op = 1.7 ± 1.2 post-op = allograft: 1.6 ± 1.2, &lt;i&gt;p&lt;/i&gt; = 0.08). However, post-operative analysis revealed that the TCP graft showed statistically significant superiority in WOMAC and VAS scores (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), except pain component of WOMAC (TCP = 2.4 ± 1.4, allograft = 2.9 ± 1.3, &lt;i&gt;p&lt;/i&gt; = 0.305). Bone consolidation occurred in 54.8% of cases. No intraoperative complications, infections or loss of correction were reported during follow-up.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients undergoing OWHTO with TCP granules experienced better outcomes and less pain, compared to those receiving allogeneic bone grafts.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12891808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of endoscopic transcapsular iliopsoas tenotomy for snapping hip syndrome: Minimum 10-year follow-up","authors":"Mattia Loppini,&nbsp;Marco Minelli,&nbsp;Katia Chiappetta,&nbsp;Francesco La Camera,&nbsp;Guido Grappiolo,&nbsp;Federico Della Rocca","doi":"10.1002/jeo2.70543","DOIUrl":"10.1002/jeo2.70543","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aims to evaluate the clinical outcomes of patients who underwent endoscopic transcapsular iliopsoas tenotomy for painful snapping hip syndrome at minimum of ten years follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a monocentric retrospective study on a consecutive series of patients undergoing endoscopic transcapsular iliopsoas tenotomy procedure for painful snapping hip syndrome between January 2012 and June 2015. Included patients were clinically evaluated at a minimum of ten years of follow-up. Perioperative, early or late complications and adverse events were recorded. Modified Harris Hip Score (mHHS) and Hip Disability and Osteoarthritis Outcome Score (HOOS) were calculated preoperatively, at 1 year, and after 10 years postoperatively. Hip flexion strength was assessed preoperatively and at 1 month, 6 months, 1 year and after 10 years postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty patients were included in the study. No patient was lost to follow-up at a minimum of 10 years. Mean follow-up was 10.6 years. No perioperative complications were reported. No serious or minor adverse events were recorded. None of the patients required revision hip arthroscopy or was scheduled for total hip arthroplasty at the last follow-up. Three patients (15%) exhibited hip flexion weakness on clinical examination and in these patients MRI revealed iliopsoas muscle atrophy. Three patients (15%) reported persistent snapping during hip flexion-extension. No sensory deficits were observed. Both mHHS and HOOS were significantly improved (<i>p</i> &lt; 0.001) at the last follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Endoscopic transcapsular iliopsoas tenotomy is a safe and effective procedure for snapping hip syndrome at long-term follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee extensor strength normalised to body weight is associated with patient-reported outcomes at 12 months after open-wedge high tibial osteotomy","authors":"Yuya Ueda,&nbsp;Takehiko Matsushita,&nbsp;Yohei Shibata,&nbsp;Ryo Goto,&nbsp;Daisuke Miura,&nbsp;Kumiko Ono,&nbsp;Akihiro Kida,&nbsp;Kyohei Nishida,&nbsp;Kanto Nagai,&nbsp;Yuichi Hoshino,&nbsp;Tomoyuki Matsumoto,&nbsp;Yoshitada Sakai,&nbsp;Ryosuke Kuroda","doi":"10.1002/jeo2.70625","DOIUrl":"10.1002/jeo2.70625","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Knee extensor strength is a critical factor in patients with knee osteoarthritis. However, no studies have investigated whether knee extensor strength directly affects patient-reported outcomes after open-wedge high tibial osteotomy (OWHTO). The purpose of this study was to investigate the association between knee extensor strength and patient-reported outcomes after OWHTO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent OWHTO between 2016 and 2023 with knee function test results 12 months after surgery were included in this study. Isokinetic knee extensor strength was measured on the involved and uninvolved limb and normalised to body weight (KES/BW). Patient-reported outcomes were assessed using the International Knee Documentation Committee (IKDC) subjective scores. Pearson correlation analysis and multivariable linear regression analysis were used to determine whether KES/BW on the involved limb was related to the IKDC subjective score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-eight knees from 52 patients who received OWHTO were evaluated. Pearson correlation analysis showed that KES/BW on the involved limb was significantly associated with the IKDC subjective score in OWHTO (<i>r</i> = 0.52, <i>p</i> &lt; 0.001). Multivariable linear regression analysis indicated that KES/BW on the involved limb was independently associated with the IKDC subjective score at 12 months after OWHTO (<i>β</i> = 0.40, <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>KES/BW on the involved limb was independently associated with the IKDC subjective score at 12 months after OWHTO. This metric should be considered to achieve better patient-reported outcomes after OWHTO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A practical guide to the implementation of AI in orthopaedic research part 8: Resource management checklist for AI-driven research projects in orthopaedics","authors":"Umile Giuseppe Longo,&nbsp;Benedetta Bandini,&nbsp;Maristella Saccomanno,&nbsp;Pieter D'Hooghe,&nbsp;Bálint Zsidai,&nbsp;Jacob F. Oeding,&nbsp;Felix Conrad Oettl,&nbsp;Kristian Samuelsson,&nbsp;Alessandro De Sire,&nbsp;Robert Feldt,&nbsp;Yinan Yu,&nbsp;ESSKA Artificial Intelligence Working Group","doi":"10.1002/jeo2.70623","DOIUrl":"10.1002/jeo2.70623","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Artificial intelligence (AI) is transforming a multitude of medical fields, including orthopaedic surgery. AI-driven approaches such as machine learning, deep learning, natural language processing and large language models are being increasingly employed across various aspects of orthopaedic practice, offering innovative solutions for diagnostics, patient care and surgical training. To successfully execute an AI-driven orthopaedic project, the initial step involves defining the aim and rationale of the project. The study must be designed to answer a clinically relevant topic in a way that influences the behavior of the health professional and leads to better patient outcomes. Once this planning phase is complete, selecting the most appropriate AI model becomes crucial, as models differ in applications, costs and required staff expertise. After model selection, successful AI implementation demands ongoing monitoring and adaptation to ensure optimal performance and reliability. Achieving the best and most ethical outcomes requires interdisciplinary collaboration, combining clinical expertise with technological proficiency. Ultimately, a comprehensive approach to AI integration can lead to transformative advancements in orthopaedic surgery and medical research, paving the way for improved patient care and innovative treatment solutions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Not applicable.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12859751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothyroidism is associated with higher healthcare utilisation and higher need for blood transfusion after primary total knee arthroplasty (TKA) in patients with osteoarthritis: A National Inpatient Sample analysis","authors":"Sumanth R. Chandrupatla,&nbsp;Kranti C. Rumalla,&nbsp;Jasvinder A. Singh","doi":"10.1002/jeo2.70413","DOIUrl":"10.1002/jeo2.70413","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To examine the association of hypothyroidism with primary total knee arthroplasty (TKA) outcomes in adults with primary underlying diagnosis of osteoarthritis (OA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We identified a prospective cohort of patients in the 2016–2020 national inpatient sample (NIS) that received primary TKA with an underlying diagnosis of OA, identified using International Classification of Diseases, Tenth Revision, Common Modification (ICD-10-CM) and Procedure Coding System (ICD-10-PCS) codes in the primary procedure and diagnosis positions, respectively. We performed multivariable-adjusted regression analyses for healthcare utilisation (length of hospital stay, hospital charges and discharge destination) and clinical outcomes (blood transfusion; prosthetic fracture, dislocation or infection; inpatient mortality), adjusted for age, sex, race, income, comorbidity, insurance payer, elective surgery, hospital bed size, census region and teaching status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2016 and 2020, we identified 2,922,075 adults who underwent primary TKA with an underlying diagnosis of OA, of whom 447,875 (16%) had hypothyroidism. For the primary TKA OA cohort, the average age was 66.8 years, 61.4% were female, and 81.3% were White. In the primary TKA OA cohort, hypothyroidism was associated with significantly higher multivariable adjusted odds ratio (aOR) for length of hospital stay above the median, 1.06 (95% confidence interval [CI]: 1.05–1.08, <i>p</i> &lt; 0.001); total hospital charges above the median, aOR 1.07 (95% CI: 1.04–1.09, <i>p</i> &lt; 0.001); non-routine discharge, aOR 1.07 (95% CI: 1.05–1.09, <i>p</i> &lt; 0.001); and the need for blood transfusion, aOR 1.15 (95% CI: 1.08–1.23, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hypothyroidism was associated with increased healthcare utilisation and need for blood transfusion after primary TKA for OA. Future studies should investigate whether preoperative optimisation of hypothyroidism can positively improve primary TKA outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level II, prospective cohort study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12856714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-antibiotic bone cement (gentamicin + vancomycin) in preventing and treating infections during revision knee arthroplasty in high-risk patients","authors":"Shengdong Yang,&nbsp;Nicolas Cance,&nbsp;Cécile Batailler,&nbsp;Tristan Ferry,&nbsp;Pierre Longlune,&nbsp;Luca Andriollo,&nbsp;Hannes Vermue,&nbsp;Sébastien Lustig","doi":"10.1002/jeo2.70638","DOIUrl":"10.1002/jeo2.70638","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aimed to evaluate the treatment and preventive effects, as well as the safety, of dual-antibiotic bone cement (DABC; gentamicin + vancomycin) in revision total knee arthroplasty (RTKA) in high-risk patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective observational study included patients who underwent RTKA for septic or aseptic indications with intraoperative application of DABC (Copal G + V, Heraeus-Medical GmbH) at our centre between December 2015 and December 2022. Patients were followed for a minimum of 2 years. Postoperative infection rates were documented, and preoperative patient risk was calculated using the periprosthetic joint infection (PJI) risk calculator. Microbiological profiles and antibiotic resistance patterns of postoperative infections were analysed, and all complications were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 85 patients were included. The overall postoperative infection rate after DABC use was 17.6% (15/85), 95% confidence interval (CI) [11.0%, 27.1%], while the mean preoperative PJI risk percentage was 54.19 ± 16.58%. When stratified by revision indication, infection rates were 21.2% (14/66), 95% CI [13.1%, 32.5%] in septic revisions and 5.3% (1/19), 95% CI [0.9%, 24.6%] in aseptic revisions, with corresponding preoperative PJI risk values of 54.34 ± 16.95% and 53.65 ± 15.62%. Among the 15 patients who developed postoperative infections, the most common organisms were <i>Staphylococcus aureus</i> (<i>n</i> = 5) and <i>Staphylococcus epidermidis</i> (<i>n</i> = 5). Kidney complications occurred in 5.9% (5/85), 95% CI [0.8%, 11.0%], and wound complications in 21.2% (18/85), 95% CI [12.3%, 30.0%]. Implant removal or component exchange was required in 7.1% (6/85), 95% CI [1.5%, 12.6%].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DABC (G + V) demonstrated favourable infection control in septic RTKA and effective infection prevention in aseptic RTKA, with a low complication rate and good overall safety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level III.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12841594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and functional outcomes of arthroscopic autologous collagen-induced chondrogenesis (ACIC) for osteochondral lesions of the talus: A retrospective case series","authors":"Simone Daniel Gatti,&nbsp;Pierre-Henri Vermorel,&nbsp;Jordi Vega,&nbsp;Jorge Batista,&nbsp;Matteo Guelfi","doi":"10.1002/jeo2.70642","DOIUrl":"https://doi.org/10.1002/jeo2.70642","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The aim of this retrospective study was to assess the clinical outcomes for osteochondral lesions of the talus (OLT) treated with all arthroscopic autologous collagen-induced chondrogenesis (ACIC) technique using an injectable collagen scaffold combined with microfractures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between 2020 and 2023, 21 patients with Hepple Grade II–IV OLTs underwent arthroscopic ACIC technique using an injectable collagen scaffold combined with microfractures. Concomitant intra-articular pathologies identified during arthroscopy were addressed simultaneously. Clinical outcomes, including Visual Analogue Scale (VAS), Foot Functional Index (FFI) and Foot and Ankle Ability Measure–Sports subscale (FAAM-SS), were assessed preoperatively and at the latest follow-up. Patient expectations, complications and return-to-activity times were also recorded at final follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean follow-up was 37.4 ± 20.7 (range, 13–68) months. The mean defect size was 76.6 ± 33.6 mm² (range, 35–135 mm²). All clinical scores significantly improved compared with preoperative values (<i>p</i> &lt; 0.05): VAS improved from 3.17 ± 1.82 (95% confidence interval [CI]: 2.34–4.00) to 0.27 ± 0.48 (95% CI 0.05–0.49), FFI from 40.90 ± 25.42 (95% CI: 29.33–52.47) to 4.02 ± 3.86 (95% CI: 2.26–5.78) and FAAM-SS from 37.81 ± 28.51 (95% CI: 24.83–50.79) to 86.11 ± 13.75 (95% CI: 79.85–92.37). All patients reported that their expectations were met or exceeded regarding pain relief, functional recovery and return to daily activities. Associated intra-articular pathologies were identified in all patients; in 17 patients (80.9%), a concomitant lateral ligament injury was observed and treated with arthroscopic repair. No major complications or revision surgeries occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Arthroscopic ACIC with an injectable atelocollagen scaffold was feasible and safe in this series of Hepple II–IV OLT, yielding improvements in patient‑reported outcomes at a mean 37.4‑month follow‑up. Due to design limitations and frequent concomitant ligament stabilization, these findings should be considered hypothesis‑generating rather than definitive evidence of cartilage regeneration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level IV, retrospective case series.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://esskajournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jeo2.70642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management with ketorolac or corticosteroids for subacromial impingement syndrome: Results from a randomised controlled trial","authors":"Omid Salkhori MD,&nbsp;Mahdi Sahebi MD, MPH,&nbsp;Mohammad Reza Guity MD,&nbsp;Saman Ghiasi Nezhad MD,&nbsp;Nima Bagheri MD","doi":"10.1002/jeo2.70648","DOIUrl":"10.1002/jeo2.70648","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Subacromial impingement syndrome (SAIS) causes shoulder pain and limitations. While corticosteroid injections are common, concerns about side effects lead to exploring alternatives like ketorolac. This trial compared the short-term effectiveness of subacromial ketorolac versus corticosteroids in SAIS patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This double-blind, randomised controlled trial enrolled 120 patients with clinically diagnosed SAIS. Participants were randomly assigned to receive a single ultrasound-guided subacromial injection of either ketorolac (30 mg) or methylprednisolone acetate (40 mg). The primary outcome was change in active shoulder forward flexion at 3 months. Secondary outcomes included other shoulder range-of-motion measures, shoulder abduction strength, the simple shoulder test (SST) and the Oxford shoulder score (OSS). Between-group comparisons were performed using baseline-adjusted analyses of covariance, with a noninferiority margin of −10° prespecified for the primary outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 118 patients completed the 3-month follow-up and were included in the final analysis (two dropouts). Both groups demonstrated statistically significant improvements from baseline in shoulder range of motion, strength and patient-reported outcomes (<i>p</i> &lt; 0.001). The adjusted mean difference in forward flexion between the ketorolac and corticosteroid groups was 0.07° (95% CI, −4.40° to 4.26°), meeting the prespecified criterion for noninferiority. No clinically meaningful between-group differences were observed for secondary outcomes. No injection-related adverse events were reported during follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Subacromial ketorolac injection produced short-term improvements comparable to those of corticosteroid injection in patients with SAIS. Ketorolac was non-inferior to corticosteroids for shoulder forward flexion at 3 months. Longer-term studies are needed to confirm these findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Level I.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36909,"journal":{"name":"Journal of Experimental Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146067618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}