{"title":"Sofosbuvir and QT interval: A new chapter in the safety profile of direct-acting antivirals","authors":"Carlos Minguito Carazo , Moisés Rodríguez Mañero","doi":"10.1016/j.rccl.2025.04.003","DOIUrl":"10.1016/j.rccl.2025.04.003","url":null,"abstract":"","PeriodicalId":36870,"journal":{"name":"REC: CardioClinics","volume":"60 3","pages":"Pages 164-166"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Belén Jiménez Azzaoui , Raúl Gascueña Rubia , Julia Gómez Diego , Carlos De Blas Ruiz , Inmaculada Fernández Rozas , Alberto Esteban-Fernández
{"title":"Características clínicas e impacto de la duración del complejo QRS en pacientes con bloqueo completo de rama izquierda","authors":"Belén Jiménez Azzaoui , Raúl Gascueña Rubia , Julia Gómez Diego , Carlos De Blas Ruiz , Inmaculada Fernández Rozas , Alberto Esteban-Fernández","doi":"10.1016/j.rccl.2024.10.006","DOIUrl":"10.1016/j.rccl.2024.10.006","url":null,"abstract":"","PeriodicalId":36870,"journal":{"name":"REC: CardioClinics","volume":"60 3","pages":"Pages 229-231"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olga Neva López-García , Daniel García-Arribas , Carmen Olmos , María José Devesa Medina , Javier Higueras Nafría , Sonia Izquierdo Rubio , Francisca Cuenca Alarcón , Maite Maroto Castellanos , Ana Fernández-Vega , Alejandro Cruz-Utrilla , Pablo Martínez-Vives , Enrique Rey
{"title":"Electrocardiographic alterations during direct-acting antiviral therapy against hepatitis C virus","authors":"Olga Neva López-García , Daniel García-Arribas , Carmen Olmos , María José Devesa Medina , Javier Higueras Nafría , Sonia Izquierdo Rubio , Francisca Cuenca Alarcón , Maite Maroto Castellanos , Ana Fernández-Vega , Alejandro Cruz-Utrilla , Pablo Martínez-Vives , Enrique Rey","doi":"10.1016/j.rccl.2025.02.004","DOIUrl":"10.1016/j.rccl.2025.02.004","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>QTc interval alterations have been described in patients receiving sofosbuvir. Our objective was to evaluate the effect of anti-hepatitis C virus drugs on the human cardiac conduction system.</div></div><div><h3>Methods</h3><div>We included all patients with hepatitis C virus infection that started treatment with direct-acting antivirals in a tertiary hospital between May 2016 and March 2017. Three electrocardiograms were performed in them: before starting treatment; during treatment; and at least 3 weeks after finished treatment. Heart rate, PR, QRS, and QTc intervals were compared between patients with and without sofosbuvir. Patients were followed for a mean time of 41.9 weeks.</div></div><div><h3>Results</h3><div>A total of 101 patients were studied, 61 received treatment with sofosbuvir and 40 without sofosbuvir. No differences were found between the 2 groups regarding heart rate, and PR intervals. There was a statistically significant enlargement of QTc in patients with sofosbuvir at the fourth week of treatment (415.3<!--> <!-->ms vs 420.8<!--> <!-->ms) that returned to baseline values once finalized (411.1<!--> <!-->ms; <em>P</em> <!-->=<!--> <!-->.029). These differences were not observed in patients without sofosbuvir.</div></div><div><h3>Conclusions</h3><div>We observed a statistically significant prolongation of the QTc interval at the fourth week of treatment in patients with sofosbuvir, which returned to baseline levels once the treatment was finished. Further prospective studies are needed to assess the clinical relevance of these findings.</div></div>","PeriodicalId":36870,"journal":{"name":"REC: CardioClinics","volume":"60 3","pages":"Pages 176-184"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rocío García-Orta , Miguel Morales García , Eduardo Moreno Escobar
{"title":"La impresión tridimensional a partir de la ecografía transtorácica en las cardiopatías congénitas","authors":"Rocío García-Orta , Miguel Morales García , Eduardo Moreno Escobar","doi":"10.1016/j.rccl.2025.01.006","DOIUrl":"10.1016/j.rccl.2025.01.006","url":null,"abstract":"","PeriodicalId":36870,"journal":{"name":"REC: CardioClinics","volume":"60 2","pages":"Pages 74-75"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}