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Advances in Optical Imaging and Photon Migration最新文献

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Optical Coherence Tomography of Embryonic Morphology During Cellular Differentiation 细胞分化过程中胚胎形态的光学相干断层扫描
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1996.cit231
S. Boppart, G. Tearney, B. Bouma, J. Fujimoto, M. Brezinski
{"title":"Optical Coherence Tomography of Embryonic Morphology During Cellular Differentiation","authors":"S. Boppart, G. Tearney, B. Bouma, J. Fujimoto, M. Brezinski","doi":"10.1364/aoipm.1996.cit231","DOIUrl":"https://doi.org/10.1364/aoipm.1996.cit231","url":null,"abstract":"Improved imaging of morphological changes has the potential of offering new insight into the complex process of embryonic development. Optical coherence tomography (OCT), is a new imaging technique for performing in vivo cross-sectional imaging of architectural morphology by measuring backscattered infrared light. This study investigates the application of OCT for imaging developing structure in Xenopus laevis (African frog) and Brachydanio rerio (zebra fish), two developmental biology animal models. Images are compared to corresponding histological preparations. Cross sectional imaging can be performed and structural morphology identified at greater imaging depths than possible with confocal and light microscopy. Repeated OCT imaging may be performed in vivo in order to track structural changes throughout development. Imaging in vivo microscopic embryonic morphology with OCT is a fundamental biological research application for the study of genetic disease.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"70 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129895894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Spatial Variations in the Time and Frequency Dependence of Imaging Operators for Diffusion Tomography 扩散层析成像算子的时间和频率依赖性的空间变化评价
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.apmpdwi.99
H. Graber, J. Chang, R. Barbour, R. Aronson
{"title":"Evaluation of Spatial Variations in the Time and Frequency Dependence of Imaging Operators for Diffusion Tomography","authors":"H. Graber, J. Chang, R. Barbour, R. Aronson","doi":"10.1364/aoipm.1994.apmpdwi.99","DOIUrl":"https://doi.org/10.1364/aoipm.1994.apmpdwi.99","url":null,"abstract":"Employing the framework of a perturbation model for optical diffusion tomography, the sensitivity and selectivity attainable from optical time- and frequency-domain, including phased array, measurements, are compared and contrasted. Monte Carlo simulations were used to calculate impulse-response functions in the interior of several homogeneous media. From the results, the impact on detected light due to small localized changes in absorption cross-section were computed. A feature unique to the frequency domain is the ability to qualitatively modify the depth profile of the weight amplitude by employing several sources in a phased array. In the case of single-source transmission measurements, a time-resolved measurement with a short integration time leads to enhanced ability to resolve deep-lying structures, by increasing the weight in deep regions relative to those near the surface. In contrast, as the source modulation frequency is increased in a frequency-domain measurement, the weight amplitude drops off most rapidly in regions farthest from the boundaries, and more slowly in more superficial regions. The significance of these findings for perturbation-based image recovery schemes is discussed.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120952365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time Gated Imaging Through Scattering Materials with Nonlinear Optical Raman Interactions 非线性光学拉曼相互作用散射材料的时间门控成像
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.trbsdi.129
J. Reintjes, M. Duncan, M. Bashkansky, J. A. Moon, R. Mahon, L. Tankersley, J. Prewitt
{"title":"Time Gated Imaging Through Scattering Materials with Nonlinear Optical Raman Interactions","authors":"J. Reintjes, M. Duncan, M. Bashkansky, J. A. Moon, R. Mahon, L. Tankersley, J. Prewitt","doi":"10.1364/aoipm.1994.trbsdi.129","DOIUrl":"https://doi.org/10.1364/aoipm.1994.trbsdi.129","url":null,"abstract":"We have developed several time-gated imaging techniques that allow the viewing of objects through dense scattering material. These techniques are based on nonlinear optical Raman interactions and include pulse gating using stimulated Raman amplification and correlation gating using both coherent anti-Stokes Raman scattering and stimulated Raman scattering. In the ballistic imaging regime, images with resolution better than 125 μm have been obtained after scattering attenuations of up to e−33. We have performed theoretical studies to determine image resolution in the diffuse and quasi-diffuse scattering regimes. In the fully diffuse regime the spatial resolution is found to be approximately one-fifth of the length of the scatterer. We have verified this result experimentally. We have also used the above techniques to perform range-gated imaging of objects embedded in scattering and non-scattering material.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115760983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical Vortices in Random Wavefields 随机波场中的光涡旋
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.wpl.20
I. Freund
{"title":"Optical Vortices in Random Wavefields","authors":"I. Freund","doi":"10.1364/aoipm.1994.wpl.20","DOIUrl":"https://doi.org/10.1364/aoipm.1994.wpl.20","url":null,"abstract":"Vortices (topological phase singularities), which may be either positive or negative\u0000 in sign, are found in many different types of optical fields. On every zero crossing of the real or\u0000 imaginary part of the wavefield, adjacent vortices must be of opposite sign. This\u0000 new \"sign principle\", which is unaffected by boundaries, leads to the surprising results that for a\u0000 given set of zero crossings: (i) fixing the sign of any given vortex automatically\u0000 fixes the signs of all other vortices in the wavefield, (ii) the sign of the\u0000 first vortex created during the evolution of a wavefield determines the signs of\u0000 all subsequent vortices, and (iii) the sign of this first vortex places additional\u0000 strong constraints on the future development of the wavefunction. The sign\u0000 principle also constrains how contours of equal phase thread through the wavefield from one vortex\u0000 to another.\u0000 Amplitude topological (AT) singularities are defined (for the first time) in terms\u0000 of the gradient of the field amplitude. Such singularities correspond to stationary points of the\u0000 amplitude and are located at the intersections of the zero crossings of the x- and y-partial\u0000 derivatives of the amplitude. Amplitude maxima and minima are positive AT\u0000 singularities and saddle points are negative AT singularities. The sign principle\u0000 implies that adjacent AT singularities on any given zero crossing must be of\u0000 opposite sign, that in an unbounded wavefield the total number of maxima and minima must equal the\u0000 number of saddle points, that in free space stationary points of the amplitude must\u0000 first appear as positive-negative AT singularity twins, and that there must exist strong\u0000 correlations between neighboring maxima, minima and saddle points.\u0000 The numerous, far reaching implications of the sign principle have been verified using a computer\u0000 simulation that generates a random Gaussian wavefield.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132479062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Independent Intensity-Modulation and Phase-Modulation Microscope Images Using Phase-Conjugate Illumination 使用相位共轭照明的独立强度调制和相位调制显微镜图像
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.apmpdwi.116
P. S. Brody, C. Garvin, L. Shentu, Arthur W. Gillman
{"title":"Independent Intensity-Modulation and Phase-Modulation Microscope Images Using Phase-Conjugate Illumination","authors":"P. S. Brody, C. Garvin, L. Shentu, Arthur W. Gillman","doi":"10.1364/aoipm.1994.apmpdwi.116","DOIUrl":"https://doi.org/10.1364/aoipm.1994.apmpdwi.116","url":null,"abstract":"The laser holographic microscope (LHM) uses phase-conjugate illumination from a photorefractive hologram to transilluminate subjects. We use the LHM to generate both intensity- and phase-modulation images. In this paper we also show that the distorting effects of an aberrating medium, for intensity-modulation images, can be reduced using the LHM.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131390428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical Description of Snake Photons 蛇形光子的解析描述
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1996.pmst69
A. Borovoi
{"title":"Analytical Description of Snake Photons","authors":"A. Borovoi","doi":"10.1364/aoipm.1996.pmst69","DOIUrl":"https://doi.org/10.1364/aoipm.1996.pmst69","url":null,"abstract":"The snake photons are shown to obey the parabolic instead of the more general Maxwell As a result, the snake photons are described by the well-known small-angle approximation of the radiative transfer having a rather simple analytical solutions. Some applications of the solutions for retrieving the parameters of highly scattering media (density inhomogeneities, particle size distributions, etc.) are discussed.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131325372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Near-Infrared Medical Imaging: Improved Approximations for the Forward and Inverse Problems 近红外医学成像:正反问题的改进逼近
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1996.ria307
J. Virmont, G. Ledanois
{"title":"Near-Infrared Medical Imaging: Improved Approximations for the Forward and Inverse Problems","authors":"J. Virmont, G. Ledanois","doi":"10.1364/aoipm.1996.ria307","DOIUrl":"https://doi.org/10.1364/aoipm.1996.ria307","url":null,"abstract":"We consider imaging of objects hidden in a scattering and absorbing medium, thick enough for the diffusion approximation to be valid, e.g. mammography or brain activity studies. We propose approximate models improving over Born to calculate the image: the electrostatic approximation if the object is small, plus a renormalization transform if it is larger. Using an exact solution of the ‘sphere in slab’ problem for comparison, and a Bayesian simplified inverse code, we demonstrate that these approximations improve the reconstruction.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114184168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical Imaging for Medical Diagnostics Using Femtosecond White Light 利用飞秒白光进行医学诊断光学成像
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.trbsdi.126
R. Berg, S. Andersson-Engels, C. Klinteberg, S. Svanberg, O. Jarlman
{"title":"Optical Imaging for Medical Diagnostics Using Femtosecond White Light","authors":"R. Berg, S. Andersson-Engels, C. Klinteberg, S. Svanberg, O. Jarlman","doi":"10.1364/aoipm.1994.trbsdi.126","DOIUrl":"https://doi.org/10.1364/aoipm.1994.trbsdi.126","url":null,"abstract":"Femtosecond white light has been used for simultaneous multi-spectral time-resolved tissue-phantom transillumination. Contrast enhancement has been studied using differential absorbers located inside the tissue phantoms. Measurements on female breast in vitro are also presented.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121688447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Contrast Enhancement by Edge Effect Corrections in Frequency-domain Optical Mammography 频域光学乳房x光造影中边缘效应校正的对比度增强
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1996.mt160
S. Fantini, M. Franceschini, G. Gaida, H. Jess, H. Erdl, W. Mantulin, E. Gratton, K. T. Moesta, P. Schlag, M. Kaschke
{"title":"Contrast Enhancement by Edge Effect Corrections in Frequency-domain Optical Mammography","authors":"S. Fantini, M. Franceschini, G. Gaida, H. Jess, H. Erdl, W. Mantulin, E. Gratton, K. T. Moesta, P. Schlag, M. Kaschke","doi":"10.1364/aoipm.1996.mt160","DOIUrl":"https://doi.org/10.1364/aoipm.1996.mt160","url":null,"abstract":"The planar tandem scan of light source and optical detector in a transmission geometry produces 2-D projection images of the human breast. This approach to near-infrared optical mammography suffers from the strong influence of edge effects: breast thickness variability, lateral photon losses, and variability in the optical coupling with breast tissue. Taking advantage of the information content of frequency-domain data, we have developed an algorithm for the correction of edge effects which is based on data at a single wavelength. We compare the images yielded by this single-wavelength algorithm with those provided by the ratio of the ac amplitudes at two wavelengths. The edge correction is excellent in both cases. However, the tumor detectability in the optical mammogram of a human breast affected by cancer is significantly better in the single-wavelength edge corrected image. We attribute this result to the similar effect caused by the tumor on the ac signal at the two wavelengths employed in this study (685 and 825 nm).","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130107291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Imaging through Highly Scattering Media with a Novel Upconverting Time Gate 基于新型上变频时间门的高散射介质成像
Advances in Optical Imaging and Photon Migration Pub Date : 1900-01-01 DOI: 10.1364/aoipm.1994.trbsdi.139
G. Faris, M. Banks
{"title":"Imaging through Highly Scattering Media with a Novel Upconverting Time Gate","authors":"G. Faris, M. Banks","doi":"10.1364/aoipm.1994.trbsdi.139","DOIUrl":"https://doi.org/10.1364/aoipm.1994.trbsdi.139","url":null,"abstract":"We demonstrate a new upconverting time-gate suitable for two-dimensional imaging at wavelengths longer than 1 μm where scatter is typically reduced. Image amplification is obtained when using a difference frequency upconverting time gate.","PeriodicalId":368664,"journal":{"name":"Advances in Optical Imaging and Photon Migration","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128765414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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