International Journal of Cardiology: Hypertension最新文献

{"title":"Telemedicine can revolutionize the treatment of chronic disease","authors":"Jeffrey A. Corbett , Janice M. Opladen , John D. Bisognano","doi":"10.1016/j.ijchy.2020.100051","DOIUrl":"10.1016/j.ijchy.2020.100051","url":null,"abstract":"","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"7 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38733231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential benefits and harms of various arterial hypertension guidelines","authors":"Maria Dorobantu, Nicoleta-Monica Popa-Fotea","doi":"10.1016/j.ijchy.2020.100047","DOIUrl":"10.1016/j.ijchy.2020.100047","url":null,"abstract":"","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"7 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38821492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hypertension and controlled hypertension among United States adults: Evidence from NHANES 2017-18 survey","authors":"Juwel Rana ,&nbsp;John Oldroyd ,&nbsp;Md. Momin Islam ,&nbsp;Carla E. Tarazona-Meza ,&nbsp;Rakibul M. Islam","doi":"10.1016/j.ijchy.2020.100061","DOIUrl":"10.1016/j.ijchy.2020.100061","url":null,"abstract":"<div><h3>Background</h3><p>This study aims to compare the prevalence of hypertension (HTN) and controlled hypertension (CHTN) in US adults and determine the absolute difference in the prevalence of HTN and CHTN between the JNC7 and ACC/AHA 2017 guidelines.</p></div><div><h3>Methods</h3><p>Data for this study were derived from the most recent cycle of the National Health and Nutrition Examination Survey (NHANES) 2017–2018. After excluding participants with missing systolic blood pressure (BP) or diastolic BP and aged &lt;18 years, 4730 participants were included in the final analyses. BP was defined as the average of the first three measurements. The prevalence of HTN and CHTN, including absolute differences of these prevalences, were estimated using both JNC7 and ACC/AHA 2017 guidelines.</p></div><div><h3>Results</h3><p>The overall weighted prevalence of HTN was 31.7% (95% CI: 28.7–34.8) based on JNC7, while the corresponding prevalence was 45.6% (95% CI: 43.0–48.3) when new guideline of ACC/AHA was used. Of the people who had HTN according to the JNC7 and ACC/AHA 2017 guidelines, 48.2% (95% CI: 44.4–52.0) and 21.0% (95% CI: 18.1–24.2) had a controlled blood pressure level, respectively. When blood pressure was assessed using both guidelines, the greatest absolute increase in rates of HTN and CHTN was 17.4% and 30.0% in people aged 40–59 years, respectively.</p></div><div><h3>Conclusion</h3><p>Given the high burden of disease due to complications arising from untreated HTN, as well as the higher costs of untreated disease, new guidelines have important public health implications to early detection of patients at risk and prevent complications across different populations.</p></div>","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"7 ","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38824639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10-Year community prevalence and trends of severe asymptomatic hypertension among patients with hypertension in the USA: 2007–2016","authors":"Muchi Ditah Chobufo ,&nbsp;Ebad Ur Rahman ,&nbsp;Fatima Farah ,&nbsp;Mohamed Suliman ,&nbsp;Kanaan Mansoor ,&nbsp;Adee Elhamdani ,&nbsp;Mehiar El-Hamdani ,&nbsp;Sudarshan Balla","doi":"10.1016/j.ijchy.2020.100066","DOIUrl":"10.1016/j.ijchy.2020.100066","url":null,"abstract":"<div><h3>Background</h3><p>Severe asymptomatic hypertension (SAH) is associated with significant health cost, morbidity and mortality.</p></div><div><h3>Aim</h3><p>Establish the nationwide prevalence, trends and associated sociodemographic characteristics of SAH among patients with hypertension in the USA.</p></div><div><h3>Methods</h3><p>We utilized the National Health and Nutrition Examination data collected over five survey cycles (2007–2016). Included were participants aged 20–80 years with self-reported diagnosis of hypertension. SAH was defined as having a mean systolic blood pressure (SBP) ≥180 mmHg and/or mean diastolic blood pressure (DBP) ≥120 mmHg at the time of examination. The Chi square test was used to compare prevalence across different categories. Associations between sociodemographic variables and SAH were assessed using multivariate binary logistic regression.</p></div><div><h3>Results</h3><p>The prevalence of SAH among patients with hypertension is 2.15% (95% CI 1.80–2.56), mainly explained by isolated mean SBP≥180 mmHg (86% of all cases), with no statistically significant change between 2007: 2.66% (95% CI 2.10–3.36) and 2016:2.61% [95% CI 1.73–3.94), p-trend = 0.17. Increasing age (OR 1.07, 95% CI 1.04–1.09), NH Blacks (OR 2.20, 95% CI 1.37–3.54), BMI&lt; 25 (OR 2.52, 95% CI 1.48–4.28), lack of health insurance OR 4.92% (95% CI 2.53–9.54) and never married individuals (OR = 2.59%, 95% CI 1.20–5.60) were more likely to have SAH, comparatively. There was no significant association between duration of hypertension and SAH.</p></div><div><h3>Conclusion</h3><p>The prevalence of SAH in the USA is 2.15% and has been stable over the past decade. Our study underscores the importance of identifying barriers to screening and treatment of hypertension which is a major treatable risk factor for cardiovascular disease.</p></div>","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"7 ","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38824644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body weight variability is not associated with changes in risk factors for cardiometabolic disease","authors":"Jake Turicchi ,&nbsp;Ruairi O'Driscoll ,&nbsp;Graham Horgan ,&nbsp;Cristiana Duarte ,&nbsp;Inês Santos ,&nbsp;Jorge Encantado ,&nbsp;Antonio L. Palmeira ,&nbsp;Sofus C. Larsen ,&nbsp;Jack K. Olsen ,&nbsp;Berit L. Heitmann ,&nbsp;R. James Stubbs","doi":"10.1016/j.ijchy.2020.100045","DOIUrl":"10.1016/j.ijchy.2020.100045","url":null,"abstract":"<div><h3>Context</h3><p>Weight loss is known to improve health, however the influence of variability in body weight around the overall trajectory on these outcomes is unknown. Few studies have measured body weight frequently enough to accurately estimate the variability component.</p></div><div><h3>Objective</h3><p>To investigate the association of 12-month weight variability and concurrent weight change with changes in health markers and body composition.</p></div><div><h3>Methods</h3><p>This study was a secondary analysis of the NoHoW trial, a 2 × 2 factorial randomised controlled trial promoting evidence-based behaviour change for weight loss maintenance. Outcome measurements related to cardiometabolic health and body composition were taken at 0, 6 and 12 months. Participants were provided with Wi-Fi connected smart scales (Fitbit Aria 2) and asked to self-weigh regularly over this period. Associations of weight variability and weight change with change in outcomes were investigated using multiple linear regression with multiple levels of adjustment in 955 participants.</p></div><div><h3>Results</h3><p>Twelve models were generated for each health marker. Associations between weight variability and changes in health markers were inconsistent between models and showed no evidence of a consistent relationship, with all effects explaining &lt;1% of the outcome, and most 0%. Weight loss was consistently associated with improvements in health and body composition, with the greatest effects seen in percent body fat (R² = 10.4–11.1%) followed by changes in diastolic (4.2–4.7%) and systolic (3–4%) blood pressure.</p></div><div><h3>Conclusion</h3><p>Over 12-months, weight variability was not consistently associated with any measure of cardiometabolic health or body composition, however weight loss consistently improved all outcomes.</p></div><div><h3>Trial registration number</h3><p>ISRCTN88405328.</p></div>","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"6 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38821493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and control rates of hypertension in the USA: 2017–2018","authors":"Muchi Ditah Chobufo ,&nbsp;Vijay Gayam ,&nbsp;Jean Soluny ,&nbsp;Ebad U. Rahman ,&nbsp;Sostanie Enoru ,&nbsp;Joyce Bei Foryoung ,&nbsp;Valirie N. Agbor ,&nbsp;Alix Dufresne ,&nbsp;Tonga Nfor","doi":"10.1016/j.ijchy.2020.100044","DOIUrl":"10.1016/j.ijchy.2020.100044","url":null,"abstract":"<div><h3>Background</h3><p>Recent review of hypertension guidelines requires fresh updates of prevalence and control rates. Though retrospective analysis provided burden estimates, control rates were grossly misleading. We set out to update the prevalence and control rates of hypertension in the USA using contemporary NHANES data.</p></div><div><h3>Methods</h3><p>Persons with mean systolic blood pressure (mSBP) ≥130 mmHg or mean diastolic blood pressure (mDBP) ≥80 mmHg or self-reported current use of antihypertensive medications were classified as hypertensives. Hypertensives on medications with mSBP &lt;130 mmHg and mDBP &lt;80 mmHg were classified as having well-controlled hypertension. Subgroup comparisons of hypertension prevalence were computed using Chi-square test. Predictors of hypertension and well-controlled BP were assessed using multivariable logistic regressions. Two tailed p-values &lt;0.05 were considered statistically significant.</p></div><div><h3>Results</h3><p>The prevalence of hypertension in the USA in 2017–2018 was 49.64% (95% CI 46.67–52.61) corresponding to 115(95% CI 104–128) million persons. NH Blacks: 58.53% (95% CI 55.39–61.60); Men: 54.46% (95% CI 51.01–57.87); older persons and obese individuals: 61.03% (95% CI 57.31–64.63) as well as persons with diabetes and CKD, comparatively. The overall rate of well-controlled hypertension was 39.64% (95% CI 36.20–42.81). Persons with at least a college degree: OR 2.20(95% CI 1.02–5.04, p=0.049) and persons with incomes ≥3 times the poverty threshold; OR 1.88(95% CI 1.1.8–2.99, p=0.011) had higher rates of well-controlled hypertension when compared to lowest categories.</p></div><div><h3>Conclusion</h3><p>One in every two persons ≥20 years in the USA has hypertension with only 39.64% on medications having well-controlled hypertension. Significant discrepancies exist in the burden and control rates in different subpopulation categories. Targeted interventions could help improve the prevalence and hypertension control rates in the USA.</p></div>","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"6 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38821491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Position statement of the Interamerican Society of Cardiology (IASC) on the current guidelines for the prevention, diagnosis and treatment of arterial hypertension 2017–2020","authors":"Fernando Wyss ,&nbsp;Antonio Coca ,&nbsp;Patricio Lopez-Jaramillo ,&nbsp;Carlos Ponte-Negretti","doi":"10.1016/j.ijchy.2020.100041","DOIUrl":"10.1016/j.ijchy.2020.100041","url":null,"abstract":"<div><h3>Objectives</h3><p>As an Inter-American Society we are convinced of the need to standardize the steps in which we diagnose, evaluate, treat and control hypertension, establishing guidelines and rules that should be adopted in all countries of Latin America, aimed at standardizing management and control of CV risk in order to achieve a substantial decrease in CV events.</p></div><div><h3>Methods</h3><p>In the last four years important international guidelines for the diagnosis, management, treatment and control of arterial hypertension have been published. In America, mostly in mid- and low-income countries, hypertension is a major problem of public health, being the most important cardiovascular risk factor due to its great population impact. Therefore, it is crucial to dedicate all the possible efforts to increase substantially the number of hypertensive patients diagnosed in a given area, and to improve the percentage of controlled patients. This is a major necessity in order to reduce the morbidity and mortality for CVD in the Latin American region, although no guidelines takes the Latin American populations into account, and much less standardizes their diagnosis and management.</p></div><div><h3>Conclusions</h3><p>The Inter-American Society of Cardiology suggest the use of the blood pressure classification of the Latin American Society of Hypertension (LASH) and recommends the use of the SCORE System to stratify the global CV risk because this system has the capability to adapt the global risk by means of a correcting factor based on the ethnicity of the different native populations in America.</p></div>","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"6 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10290237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of feedback on cardiovascular risk factors on optimization of primary prevention: The PharmLines initiative","authors":"M. Yldau van der Ende ,&nbsp;Ingmar E. Waardenburg ,&nbsp;E. Lipsic ,&nbsp;Jens H.J. Bos ,&nbsp;Eelko Hak ,&nbsp;H. Snieder ,&nbsp;Pim van der Harst","doi":"10.1016/j.ijchy.2020.100042","DOIUrl":"10.1016/j.ijchy.2020.100042","url":null,"abstract":"<div><h3>Background</h3><p>It is unknown whether population based single assessment of cardiovascular disease (CVD) risk and feedback to individuals and general practitioners results in initiation of preventive cardiovascular pharmacotherapy in those at risk.</p></div><div><h3>Methods</h3><p>The population based cohort study Lifelines was linked to the IADB.nl pharmacy database to assess information on the initiation of preventive medication (<em>N</em> = 48,770). At the baseline visit, information on cardiovascular risk factors was collected and reported to the participants and their general practitioners. An interrupted-time-series-analysis was plotted, in which the start year of blood pressure and lipid lowering medication was displayed in years before or after the baseline visit. Subsequently, predictors of the initiation of pharmacotherapy were determined and possible reduction in cardiovascular events that could be achieved by optimal treatment of individuals at risk.</p></div><div><h3>Results</h3><p>Before the Lifelines baseline visit, 34% (out of 1,527, 95% Confidence interval (CI) 32%–36%) and 30% (out of 1,991, 95%CI 28%–32%) of the individuals at risk had a blood pressure or lipid lowering drug prescription, respectively. In those at risk, the use of blood pressure lowering medication, increased substantially during the year of the baseline visit. Treating individuals at increased risk (≥5% 10-year risk) with lipid or blood pressure lowering medication (<em>N</em> = 8515 and <em>N</em> = 6899) would have prevented 162 and 183 CVD events, respectively, in the upcoming five years.</p></div><div><h3>Conclusion</h3><p>Primary prevention of CVD in the general population appears suboptimal. Feedback of cardiovascular risk factors resulted in a substantial increase of blood pressure lowering medication and extrapolated health benefits.</p></div>","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"6 ","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38821558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-employment and cardiovascular risk in the US general population","authors":"Chayakrit Krittanawong ,&nbsp;Anirudh Kumar ,&nbsp;Zhen Wang ,&nbsp;Usman Baber ,&nbsp;Deepak L. Bhatt","doi":"10.1016/j.ijchy.2020.100035","DOIUrl":"10.1016/j.ijchy.2020.100035","url":null,"abstract":"<div><h3>Background</h3><p>Studies on self-employment and cardiovascular risk are very limited. We examined the relationship between self-employment and cardiovascular risk among the general population in the United States from 1999 to 2016.</p></div><div><h3>Methods</h3><p>Using the National Health and Nutrition Examination Survey (NHANES), we identified all patients with hypertension (HTN), hyperlipidemia (HLD), diabetes mellitus (DM), stroke, heart failure (HF), and coronary artery disease (CAD) between 1999 and 2016. Type of job was defined based on the participant's response to the survey question as “an employee of a private company, business, or individual for wages, salary, or commission” or “self-employed in own business, professional practice or farm”. Multivariable logistic regression analyses were performed to adjust for confounders.</p></div><div><h3>Results</h3><p>Of 30,103 patients, 2835 (9.4%) were self-employed in their own business, professional practice, or farm and 27,268 (90.6%) were employed by a private company, business, or government. After adjusting for age, race, sex, BMI, marital status, educational level, health insurance status, smoking status, sleep duration and lipid profiles, self-employed individuals had a higher prevalence of HTN (OR: 1.12; 95% confidence interval [CI] 1.05–1.20), HLD (OR: 1.10; 95% CI 1.07–1.31), stroke (OR: 1.45; 95% CI 1.27–1.67), HF (OR: 1.17; 95% CI 1.03–1.32), and CAD (OR: 1.26; 95% CI 1.13–1.35) (all P v&lt; 0.05).</p></div><div><h3>Conclusions</h3><p>Self-employment may be associated with greater cardiovascular risk in the US general population. Further prospective studies are urgently needed to establish the optimal preventive strategy to reduce cardiovascular risk in self-employed individuals.</p></div>","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"6 ","pages":"Article 100035"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38820353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial stiffening is a crucial factor for left ventricular diastolic dysfunction in a community-based normotensive population","authors":"Maeda Mika ,&nbsp;Hideaki Kanzaki ,&nbsp;Takuya Hasegawa ,&nbsp;Hiroki Fukuda ,&nbsp;Makoto Amaki ,&nbsp;Jiyoong Kim ,&nbsp;Masanori Asakura ,&nbsp;Hiroshi Asanuma ,&nbsp;Motonobu Nishimura ,&nbsp;Masafumi Kitakaze","doi":"10.1016/j.ijchy.2020.100038","DOIUrl":"10.1016/j.ijchy.2020.100038","url":null,"abstract":"<div><h3>Background</h3><p>Left ventricular (LV) diastolic dysfunction is an important underlying hemodynamic mechanism for heart failure. Hypertension reportedly increases aortic stiffness with histological changes in the aorta assessed using aortic pulse wave velocity (PWV) that is associated with LV diastolic dysfunction. The role of hypertension <em>per se</em> in the relationship between aortic stiffness and LV diastolic dysfunction has not been clarified; therefore, we investigated whether this relation works for normotensive subjects.</p></div><div><h3>Methods</h3><p>Of the 502 subjects who underwent both echocardiography and PWV measurement in a medical check-up conducted in Arita, Japan, we enrolled 262 consecutive normotensive subjects (age 52 ± 13 years). LV diastolic dysfunction was defined as abnormal relaxation and pseudonormal or restrictive patterns determined with both transmitral flow velocity and mitral annular velocity. Aortic stiffness was assessed via non-invasive brachial-ankle PWV measurement.</p></div><div><h3>Results</h3><p>LV diastolic dysfunction was detected in 67 of the 262 (26%) normotensive subjects, and PWV was higher in subjects with LV diastolic dysfunction (15.4 ± 3.6 vs. 13.0 ± 2.7 m/s, <em>p</em> &lt; 0.01). Multivariate logistic regression analyses revealed that PWV was independently associated with LV diastolic dysfunction (<em>p</em> = 0.02) after the adjustment for age; body mass index; blood pressure; eGFR; blood levels of BNP, glucose, and HDL cholesterol; LV mass index; and LA dimension.</p></div><div><h3>Conclusions</h3><p>Both aortic stiffness and LV diastolic function are mutually related even in normotensive subjects, independent of the potential confounding factors. The increase in aortic stiffness may be a risk factor for LV diastolic dysfunction, irrespective of blood pressure.</p></div>","PeriodicalId":36839,"journal":{"name":"International Journal of Cardiology: Hypertension","volume":"6 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijchy.2020.100038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38821555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}