Iranian Journal of Veterinary Science and Technology最新文献_第9页

Lipid-based nanoparticles as novel drug delivery systems for antimicrobial agents 基于脂质纳米颗粒的新型抗菌剂给药系统

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-03-01 DOI: 10.22067/VETERINARY.V2I10.75569

A. Rassouli, Alwan Al-Qushawi

{"title":"Lipid-based nanoparticles as novel drug delivery systems for antimicrobial agents","authors":"A. Rassouli, Alwan Al-Qushawi","doi":"10.22067/VETERINARY.V2I10.75569","DOIUrl":"https://doi.org/10.22067/VETERINARY.V2I10.75569","url":null,"abstract":"Despite the development of novel drugs and technologies in combating the infectious diseases, they remain as a global health challenge. The use of conventional antimicrobial drugs are always associated with problems such as antimicrobial resistance, adverse effects, and inefficient drug delivery. In this regard, the unique physiochemical properties of the nanoparticles have led to increase in the researches on nanoparticles and their application as promising antimicrobial products. Lipid nanoparticles (LNPs) are new carrier systems developed as an alternative to traditional nanoparticle vehicles. The solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLCs), lipid-drug conjugates (LDCs), Lipid-core nanocapsules (LNCs) and lipid-polymer nanoparticles (LPNs) are carriers with a lipid matrix showing advantages for different applications due to the use of biodegradable, and biocompatible lipids. LNPs have exclusive properties owing to their ultra-small size and high surface area, thereby, they are able to increase drug targeting, treatment efficiency and reduce the toxicity of antimicrobial drugs. LNPs are often used as sustained release systems, and they also used for improving drug bioavailability. It has been found that the composition and structure of LNPs are two critical factors that may influence their pharmaceutical performance in different body organs. This review focuses on the development of LNP systems for antimicrobial drugs delivery and gives an overview on the modern LNP- based therapeutic strategies against the infections. The mechanism of action and advantages of these nanoparticles as antibacterial, antifungal, antiviral and anti-parasitic agents are highlighted in this review.","PeriodicalId":36826,"journal":{"name":"Iranian Journal of Veterinary Science and Technology","volume":"10 1","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47197624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of sensory and motor blocking action of lidocaine and lidocaine-tramadol following brachial plexus block in sheep 利多卡因与利多卡因-曲马多对羊臂丛神经阻滞后感觉和运动阻滞作用的比较

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-03-01 DOI: 10.22067/VETERINARY.V2I10.73791

H. I. Rastabi, H. Naddaf, A. Nikvand, M. Kamyabnia

{"title":"Comparison of sensory and motor blocking action of lidocaine and lidocaine-tramadol following brachial plexus block in sheep","authors":"H. I. Rastabi, H. Naddaf, A. Nikvand, M. Kamyabnia","doi":"10.22067/VETERINARY.V2I10.73791","DOIUrl":"https://doi.org/10.22067/VETERINARY.V2I10.73791","url":null,"abstract":"The aim of the present study was to evaluate the effect of adding tramadol to lidocaine for brachial plexus block in sheep. Six healthy, adult ewes weighing 41.7 ± 3.82 kg were used. Using an electrical stimulator, brachial plexus block was performed with lidocaine (4 mg/kg) (LID), lidocaine (4 mg/kg)-tramadol (2 mg/kg) (LTL), and lidocaine (4 mg/kg)-tramadol (4 mg/kg) (LTH). All sheep received the three treatments with one-week interval. The final volume of administered solutions was adjusted to 0.3 mL/kg. Time to the onset and duration of anesthesia as well as changes in heart rate, respiratory rate, and rectal temperature were determined. Time to the onset of sensory blockade and motor blockade was not significantly different among groups. The duration of sensory blockade and motor blockade were significantly longer in LTH (128.3 ± 9.7 and 151.5 ± 21.5 min, respectively) compared with those of LID (88.6 ± 6.5 and 110.5 ± 21 min, respectively) and LTL (51.6 ± 11.8 and 89.6 ± 22.7 min, respectively). Although the onset of sensory blockade was longer than that of motor blockade in the three treatments, the difference was only significant in LTL. No significant differences were observed in heart rate, respiratory rate and rectal temperature among and within treatments. It was concluded that addition of tramadol (4 mg/kg) to lidocaine, without altering the onset, can provide more prolonged anesthesia than that of lidocaine in brachial plexus block in sheep.","PeriodicalId":36826,"journal":{"name":"Iranian Journal of Veterinary Science and Technology","volume":"10 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45083455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Review on the Medicinal Values of Ginger for Human and Animal Ailments 生姜对人畜疾病的药用价值综述

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-02-23 DOI: 10.4172/2157-7579.1000519

Wondale Mekuriya, Berhanu Mekibib

引用次数: 18

An Approach to Rumen pH and Temperature Dynamics during the Bullfight and its Settings 斗牛过程中瘤胃pH和温度的变化及其设置

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-02-16 DOI: 10.4172/2157-7579.1000515

Juan García, D. Bartolomé, R. Posado, Zúñiga Ja, M. Montañés, R. Bodas

引用次数: 0

Effect of Physical Processing of Pea (Pisum sativum) on Nitrogen Fractionation and Intestinal Protein Digestion 豌豆物理加工对氮分解和肠道蛋白质消化的影响

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-02-12 DOI: 10.4172/2157-7579.1000514

A. Naeiny, M. D. Mesgaran, A. Vakili, H. Ebrahimi

{"title":"Effect of Physical Processing of Pea (Pisum sativum) on Nitrogen Fractionation and Intestinal Protein Digestion","authors":"A. Naeiny, M. D. Mesgaran, A. Vakili, H. Ebrahimi","doi":"10.4172/2157-7579.1000514","DOIUrl":"https://doi.org/10.4172/2157-7579.1000514","url":null,"abstract":"The aim of this study was to investigate the effect of different methods of physical processing of pea (Pisum sativum) on ruminal and intestinal digestion and protein fractionation using in vitro techniques. Raw pea unprocessed contain 95.8 dry matter, 22.9 crude protein, 35.4 NDF, 6.5 ADF, 6 crude fat and 1.2 minerals % per DM. Physical processing of raw peas was done using four methods 1: Soaking the peas in water, 2: Autoclaved pea for different times, 3: Microwaving of peas for 0, 2, 4, 6 and 8 minutes at 1000 watts and 4: Roasting peas for 30 minutes in a thermal tunnel. Among the various processing methods in this experiment, microwaved peas for 4 to 8 minutes and roasting caused to a reduction in NPN, rapidly degraded true protein (B1), and an increase in True protein with an intermediate degradation rate (B2) and true protein (TP). Comparing the effect of processing on digestibility of pea protein in the rumen and intestinal showed that roasting for 30 minutes at 100°C not only increased rumen degradable protein (RDP), but also increased the digestibility of protein in the small intestine.","PeriodicalId":36826,"journal":{"name":"Iranian Journal of Veterinary Science and Technology","volume":"47 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79887868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Subclinical Hypocalcemia in Dairy Cows: Pathophysiology, Consequences and Monitoring 奶牛亚临床低钙血症:病理生理学、后果和监测

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-01-20 DOI: 10.22067/VETERINARY.V9I2.69198

حسام الدین سیفی, ساموئل کیا

{"title":"Subclinical Hypocalcemia in Dairy Cows: Pathophysiology, Consequences and Monitoring","authors":"حسام الدین سیفی, ساموئل کیا","doi":"10.22067/VETERINARY.V9I2.69198","DOIUrl":"https://doi.org/10.22067/VETERINARY.V9I2.69198","url":null,"abstract":"Milk fever and subclinical hypocalcemia are the most important macro-mineral metabolic disorders that affect transition dairy cows. Many studies have shown that cows with subclinical hypocalcemia are also prone to many diseases and disorders. The drain of Calcium (Ca) during early lactation represents a significant increase in Ca demand over that for late fetal growth and physiological maintenance. The requirements of the mammary gland for Ca often exceeds the ability of the cow to replenish the plasma Ca pools. Blood Ca concentrations remarkably decline in dairy cows around calving, with the lowest concentrations occurring about 12 to 24 hours after calving. To maintain Ca homeostasis after calving, at the start of lactation, Ca compensating mechanisms are activated. \u0000These mechanisms involve a coordinated effort among the hormones 1,25-dihydroxyvitamin D3, parathyroid hormone (PTH), and calcitonin. Hypocalcemia is associated with an increased risk of several important health conditions such as mastitis, retained placenta, metritis, abomasum displacement and immune insufficiency, particularly in transition period. The incidence of subclinical hypocalcemia approaches 40-50% in multiparous cows after calving in dairy herds. In spite of developments in preventive approaches, tremendous economical impact of hypocalcemia on health, production and fertility of dairy cows is a major concern for dairy herd owners. The paramount advances in dairy health have been the paradigm shift from treatment of clinical illness to disease prevention and redefining disease more broadly, to include subclinical conditions. Herd-based tests are now available for use in routine herd monitoring and for investigating dairy herds with metabolic subclinical problems. This review provides the criteria for hypocalcemia monitoring and interpretation of the results in dairy herds.","PeriodicalId":36826,"journal":{"name":"Iranian Journal of Veterinary Science and Technology","volume":"9 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2018-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44443153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Immune response characteristics of Capri pox virus vaccines following emergency vaccination of cattle against lumpy skin disease virus 卡普里痘病毒疫苗在牛紧急接种块状皮肤病病毒后的免疫反应特性

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-01-20 DOI: 10.22067/VETERINARY.V9I2.65381

H. Varshovi, R. Norian, A. Azadmehr, N. A. Ahangaran

{"title":"Immune response characteristics of Capri pox virus vaccines following emergency vaccination of cattle against lumpy skin disease virus","authors":"H. Varshovi, R. Norian, A. Azadmehr, N. A. Ahangaran","doi":"10.22067/VETERINARY.V9I2.65381","DOIUrl":"https://doi.org/10.22067/VETERINARY.V9I2.65381","url":null,"abstract":"In this research immune response characteristics of two available heterologous vaccines including Gorgan goat pox virus (GPV) and Romanian sheep pox virus (SPV) vaccines against lumpy skin disease have been examined, by using the monitoring of humoral and cell-mediated immune responses in vaccinated calves in the field. The evaluation of humoral immune response showed that the neutralizing antibody titers in both vaccinated groups started at day 7 post-vaccination, then reached to the protective level at day 21 post-vaccination and persisted till 35 day post-vaccination. The neutralizing antibody titers in GPV-vaccinated calves (GVC) the ratio was higher than SPV-vaccinated calves (RVC), and on days 21 and 35 post-vaccination were significantly different (p <0.05). Also, in vitro evaluation of cellular immune responses showed that the lymphocyte proliferation index and IFN-γ and IL-4 pro \u0000duction levels in both vaccinated groups began to increase at day 7 post-vaccination until reached to its peak at day 21 post-vaccination and decreased in the period thereafter. So that, in GVC this ratio was higher than that in RVC and was significant at day 21 post-vaccination (p < 0.05). The findings show that the live attenuated GPV vaccine due to induction of high level of antibody titer and higher lymphocyte proliferation and IFN-γ and IL-4 production has a good immunogenic response, so it is considered a suitable vaccine to control lumpy skin disease.","PeriodicalId":36826,"journal":{"name":"Iranian Journal of Veterinary Science and Technology","volume":"9 1","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2018-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49387970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

A survey on Feline Leukemia virus infection in cats of Ahvaz district, Iran: Seroprevalence and risk factors 伊朗阿瓦兹地区猫白血病病毒感染的调查：血清流行率和危险因素

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-01-20 DOI: 10.22067/VETERINARY.V9I2.63968

Faezeh Zarmehi Shahrebabak, M. P. Borujeni, B. Mosallanejad, M. S. A. Shapouri

引用次数: 0

Histopathological changes in experimental infestation of Paederus fuscipes in rats 灰隐翅虫实验性感染大鼠的组织病理学变化

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-01-20 DOI: 10.22067/veterinary.v9i2.64024

M. Tavassoli, A. Tehrani, Javad Mahdavi Ghajari

{"title":"Histopathological changes in experimental infestation of Paederus fuscipes in rats","authors":"M. Tavassoli, A. Tehrani, Javad Mahdavi Ghajari","doi":"10.22067/veterinary.v9i2.64024","DOIUrl":"https://doi.org/10.22067/veterinary.v9i2.64024","url":null,"abstract":"The genus Paederus consists of approximately 621 species associated with outbreaks of dermatitis. Our aim was to determine gross and microscopic changes induced by Paederus fuscipes. Adult P. fuscipes beetles were collected from infested house and then sent to laboratory. In the first group beetles were placed on the shaved parts over the shoulders of each rat. In the second group smashed insect materials were rubbed over the ear of examined animals. Gross changes after 12 hr were noticed as erythematous papules and in 72 hr the red elevated area became bigger and swollen. Microscopic examination revealed edema and mild infiltration of inflammatory cells (lymphocytes and eosinophils) after 12 hr, cell swelling and vacuolar degeneration in basal and squamous cells after 24 hr, but by 72 hr the epidermal cells were necrotic with intense accumulation of fluid and vesicles formation. Gross and microscopic changes were compared between rats exposed with squeezed beetle materials and rats exposed to live beetles. The typical gross changes were maculopapuls on the skin that histologically showed dermal edema and infiltration of lymphocytes and eosinophils.","PeriodicalId":36826,"journal":{"name":"Iranian Journal of Veterinary Science and Technology","volume":"9 1","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2018-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42292741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection and identification of avian adenovirus in broiler chickens suspected of inclusion body hepatitis in Khuzestan, Iran during 2015-2016 2015-2016年伊朗胡齐斯坦地区疑似包涵体肝炎肉鸡中禽腺病毒的检测与鉴定

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-01-20 DOI: 10.22067/VETERINARY.V9I2.66216

Parisa Ghafari, Z. Boroomand, A. Rezaie, M. Mayahi, S. Eftekharian

{"title":"Detection and identification of avian adenovirus in broiler chickens suspected of inclusion body hepatitis in Khuzestan, Iran during 2015-2016","authors":"Parisa Ghafari, Z. Boroomand, A. Rezaie, M. Mayahi, S. Eftekharian","doi":"10.22067/VETERINARY.V9I2.66216","DOIUrl":"https://doi.org/10.22067/VETERINARY.V9I2.66216","url":null,"abstract":"Avian adenoviruses (AAV) are known as a very diverse group of pathogens causing a variety of clinical symptoms or being totally asymptomatic in poultry flocks. The aim of this study was the molecular detection of avian adenoviruses in broiler flocks suspected of the IBH and respiratory syndrome in the southwest of Iran. For this intent, the liver and lung samples with macroscopic lesions were collected from 30 different poultry flocks (poultry of slaughterhouse and flock mortalities). Subsequently, DNA was extracted from samples and examined using PCR. The L1 (Loop1) region of the hexon gene was amplified. PCR products were sequenced to reveal the identity of the avian adenoviruses. The data resulted from the nucleo \u0000tide sequencing were analyzed using programs and services provided by National Center for Biotechnology Information (NCBI). The results showed that the pools of liver samples from a 25 days old flock were positive in the PCR test. Based on the sequence data, adenoviruses belonged to the D genotype of avian adenoviruses. In phylogenetic analysis, FADV isolates were closely related to the FADV-11 isolates of Iran, China, Canada and Australia with nucleotide homology up to 99%. This is the first study on molecular detection and analyzing the nucleotide sequence of hexon gene fragment of FADV in broiler farms in Southwest Iran.","PeriodicalId":36826,"journal":{"name":"Iranian Journal of Veterinary Science and Technology","volume":"9 1","pages":"41-45"},"PeriodicalIF":0.0,"publicationDate":"2018-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46947136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4