{"title":"Forensic Investigation of Rare Complications of Endoscopic Sinus Surgery: Two Case Reports.","authors":"Semyon S Plis, Olesya V Veselkina","doi":"10.1177/19253621241286142","DOIUrl":"10.1177/19253621241286142","url":null,"abstract":"<p><p>This article describes two cases of rare surgical complications during functional endoscopic sinus surgery (FESS) and the resulting forensic investigations. The first case involved damage to the skull base and intracerebral artery, leading to a fatal cerebrovascular event, while the second case involved destruction of the medial orbital wall. The clinical and pathological findings are described in detail for each case. In Russia, in cases of disputes regarding medical malpractice, a commission-based expert examination is appointed by the civil court, criminal court, or investigator. This commission includes, in addition to a forensic pathologist, a practicing physician specializing in the field related to the case under consideration. Single-expert examinations for such cases are not provided; the investigation is always conducted jointly by a forensic pathologist and a clinician. It is important to investigate whether the mistake was due to preventable causes or deviations from accepted standards. This can only be done through the joint work of clinicians and forensic pathologists. These two cases are important because they demonstrate how different forensic conclusions can be for patients who undergo the same operation and experience similar severe complications. Despite the similarities, the forensic and legal outcomes were entirely different due to different reasons for the mistakes.</p>","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":" ","pages":"19253621241286142"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas Scibetta, Barbara A. Sampson, Yingying Tang, Bruce D. Gelb
{"title":"Sudden Death in Pediatric Patient With Dilated Cardiomyopathy Due to Founder Variant in NKX2-5: Case Report","authors":"Nicholas Scibetta, Barbara A. Sampson, Yingying Tang, Bruce D. Gelb","doi":"10.1177/19253621241264857","DOIUrl":"https://doi.org/10.1177/19253621241264857","url":null,"abstract":"Background: The NKX2-5 gene encodes a transcription factor that plays a role in atrioventricular nodal and myocardial development. Pathogenic variants of NKX2-5 are associated with congenital heart disease and sudden cardiac death. The missense variant in this case is one of the more common ones in Northern Europe and has high penetrance in familial cases. To our knowledge, this is the youngest person who died due to this variant. Case summary: This was a healthy, asymptomatic 14-year-old male with well-managed mild congenital dilated cardiomyopathy who died unexpectedly in his home. Postmortem examination revealed the NKX2-5 pathogenic missense variant, p.Phe145Leu, as the only explicable cause of death. Discussion: We propose that immediate family members of those who die suddenly due to NKX2-5 disease undergo genetic counseling and longitudinal screening to include this gene, as pathogenic variants in the NKX2-5 gene may manifest in a time-dependent manner.","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":"86 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141818556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gandhak-Potash Blast: Mechanism of Explosion and its Legal Consideration in India","authors":"Devendra Jadav","doi":"10.1177/19253621241259706","DOIUrl":"https://doi.org/10.1177/19253621241259706","url":null,"abstract":"","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":"67 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141348195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fatal Hemoperitoneum Secondary to a Spontaneous Splenic Vein Rupture","authors":"Luther Fleury, Carolina McEnnan","doi":"10.1177/19253621241259827","DOIUrl":"https://doi.org/10.1177/19253621241259827","url":null,"abstract":"Spontaneous hemoperitoneum is rare and is often labeled as idiopathic because the source of bleeding is never found. We report the case of a 35-year-old male who died of a splenic vein rupture. The decedent was a chronic alcoholic with a reported history of cirrhosis and medication noncompliance. Internal examination revealed pale visceral organs, marked hemoperitoneum, a fibrotic/nodular liver, esophageal varices, and a ruptured splenic vein. Pertinent microscopic findings include liver parenchyma with bridging fibrous septa, nodules of regenerating hepatocytes, and the presence of Mallory-Denk bodies. The immediate cause of death was determined to be splenic vein rupture with the underlying cause of death being chronic alcoholism. This case is reported to emphasize the importance of correlating past medical history with thorough vascular dissection in cases of spontaneous hemoperitoneum. In a patient with fatal hemoperitoneum and risk factors for splenic vein pathology (ie, cirrhosis, portal vein hypertension), a high suspicion should be kept for splenic vein rupture.","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":"53 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141349321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph A Prahlow, Prentiss Jones, Kristi Bailey, Abigail Grande, Asmaa Obead, Christine Pink, Elizabeth Douglas, Brandy Shattuck, Amanda Fisher-Hubbard, Theodore Brown, Joyce L deJong
{"title":"SARS-CoV-2 (COVID-19) Experience at an Academic Medical Examiner's Office.","authors":"Joseph A Prahlow, Prentiss Jones, Kristi Bailey, Abigail Grande, Asmaa Obead, Christine Pink, Elizabeth Douglas, Brandy Shattuck, Amanda Fisher-Hubbard, Theodore Brown, Joyce L deJong","doi":"10.1177/19253621231224532","DOIUrl":"10.1177/19253621231224532","url":null,"abstract":"<p><strong>Introduction: </strong>The coronavirus disease of 2019 (COVID-19) pandemic has resulted in a great deal of morbidity and mortality worldwide. Since most deaths related to COVID-19 are currently considered natural, and they tend to occur following a clinically recognized illness, many medical examiner/coroner offices within the United States do not take jurisdiction over the majority of COVID-19 deaths.</p><p><strong>Methods: </strong>In this review, we present the experience of a medium-sized medical examiner's office affiliated with an academic medical school institution, over the first 15 months of the COVID-19 pandemic.</p><p><strong>Results: </strong>Compared to a 15-month period that immediately preceded the pandemic, our office experienced a significant increase in the total number of reported deaths, scene investigations, full autopsies, natural deaths, accidents, homicides, and drug-related deaths, but a decrease in the number of suicides. Overall, our office performed 5 autopsies during the study period where COVID-19 was considered the primary cause of death, 4 cases where COVID-19 was considered a contributory cause of death, and 28 cases where COVID-19 testing was positive, but COVID-19 was not contributory to death.</p><p><strong>Discussion: </strong>The COVID-19 pandemic was accompanied by a sizeable increase in work volume within our academic medical examiner's office. Although this increased workload was not related to a large number of COVID-19-related deaths investigated by the office, there were numerous areas of increased workload that were likely secondarily related to the conditions associated with the pandemic.</p>","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":"14 3","pages":"87-107"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gandhak Potash Blast: An Actual Sitting Over the Powder Keg-A Case Report.","authors":"Rahul Kaushik, Luv Sharma, Jitender Kumar Jakhar, Piyush Jain, Priti Singh","doi":"10.1177/19253621231218028","DOIUrl":"10.1177/19253621231218028","url":null,"abstract":"<p><p>An explosive is a container that is filled with material that will explode when it is thrown or dropped, or when a device inside it makes it explode. Many materials can be used in making up of a bomb individually or when mixed with some other chemical. The type of explosive that gets misused most commonly are those used in manufacturing and other commercial applications due to their easy accessibility to public. Improper handling and inattentive behavior toward the explosives can lead to disastrous circumstances. Here we report such a case in which a 30-year-old male took rocks of potassium sulphate (called Gandhak Potash in the local vernacular language) and struck them with a metallic pestle, which triggered an explosion. The distal phalanges of both hands were found traumatically amputated. Stippling effect due to unburnt powdered explosive substance were present over the head, face, chest, and anteromedial aspect of legs. He died within few hours after the blast. Different type of mechanical injuries and injuries to the internal organs can be sustained over the body due to effects of explosion as we've seen in our case, that is, abrasion, contusion, lacerations, fractures, burn injury and such pattern of injury, and specific injuries sustained due to pressure effect like blast lung along with circumstantial evidence helps in deciding the manner of death.</p>","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":" ","pages":"19253621231218028"},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffrey J. Feng, Joyce L. deJong, Elizabeth A. Douglas, Amanda O. Fisher-Hubbard, J. Prahlow
{"title":"Lethal Complications of Meningiomas: A Case Series","authors":"Jeffrey J. Feng, Joyce L. deJong, Elizabeth A. Douglas, Amanda O. Fisher-Hubbard, J. Prahlow","doi":"10.1177/19253621241228625","DOIUrl":"https://doi.org/10.1177/19253621241228625","url":null,"abstract":"Meningiomas are the most prevalent type of primary intracranial tumor in adults, comprising nearly one-third of all intracranial tumors. They are typically benign, slow-growing, and asymptomatic but may cause neurological symptoms as they expand due to mass effect. Classification is determined by World Health Organization (WHO) grades 1 to 3 following pathological examination corresponding to benign, atypical, and anaplastic (malignant), respectively, reflecting their rate of growth and risk of recurrence. The vast majority are WHO grade 1 and their slow growth permits timely presentation for elective resection; however, meningiomas in vulnerable locations and coexisting morbidities can result in sudden death. We present a series of four adult patients with meningiomas which resulted in death, including a case of fatal seizure, midline hemorrhagic meningioma, postresection meningitis, and compression of the cerebellum. Retrospective review of the authors’ cases was conducted. Available pathology, medical, and autopsy records including gross images were reviewed in each case. The inclusion criteria were adult patients (>18 years old) and that the cause of death had to include meningioma. The four patients included a 61-year-old male, an 84-year-old female, a 62-year-old male, and a 37-year-old female. Qualitative; autopsy reports describing cause of death and pathology report findings including gross and microscopic analysis. Meningiomas are often benign in nature but can rarely result in death. Size and location of the tumor and risk factors are contributory. Autopsy examination can be instrumental in identifying the cause and mechanism of deaths associated with meningiomas.","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":"204 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffrey J. Feng, Joyce L. deJong, Elizabeth A. Douglas, Amanda O. Fisher-Hubbard, J. Prahlow
{"title":"Lethal Complications of Meningiomas: A Case Series","authors":"Jeffrey J. Feng, Joyce L. deJong, Elizabeth A. Douglas, Amanda O. Fisher-Hubbard, J. Prahlow","doi":"10.1177/19253621241228625","DOIUrl":"https://doi.org/10.1177/19253621241228625","url":null,"abstract":"Meningiomas are the most prevalent type of primary intracranial tumor in adults, comprising nearly one-third of all intracranial tumors. They are typically benign, slow-growing, and asymptomatic but may cause neurological symptoms as they expand due to mass effect. Classification is determined by World Health Organization (WHO) grades 1 to 3 following pathological examination corresponding to benign, atypical, and anaplastic (malignant), respectively, reflecting their rate of growth and risk of recurrence. The vast majority are WHO grade 1 and their slow growth permits timely presentation for elective resection; however, meningiomas in vulnerable locations and coexisting morbidities can result in sudden death. We present a series of four adult patients with meningiomas which resulted in death, including a case of fatal seizure, midline hemorrhagic meningioma, postresection meningitis, and compression of the cerebellum. Retrospective review of the authors’ cases was conducted. Available pathology, medical, and autopsy records including gross images were reviewed in each case. The inclusion criteria were adult patients (>18 years old) and that the cause of death had to include meningioma. The four patients included a 61-year-old male, an 84-year-old female, a 62-year-old male, and a 37-year-old female. Qualitative; autopsy reports describing cause of death and pathology report findings including gross and microscopic analysis. Meningiomas are often benign in nature but can rarely result in death. Size and location of the tumor and risk factors are contributory. Autopsy examination can be instrumental in identifying the cause and mechanism of deaths associated with meningiomas.","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential Dextromethorphan-Induced Serotonin Syndrome Leading to Homicide and Suicide.","authors":"Matthew M Pavelka, Roland Kohr","doi":"10.1177/19253621231224531","DOIUrl":"10.1177/19253621231224531","url":null,"abstract":"<p><p>Limited case reports have been published regarding serotonin syndrome due to the combined effects of supratherapeutic levels of dextromethorphan and selective serotonin reuptake inhibitor. We report a case of an adolescent with postmortem findings suggestive of a diagnosis of serotonin syndrome-induced psychosis associated with a double homicide and suicide. Postmortem toxicology of the suicide victim was remarkable for elevated serotonergic metabolites of fluoxetine and dextromethorphan in a 14-year-old male.</p>","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":"14 1","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10947710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chalachew Tiruneh, Daniel Teshome, Teshome Geberemeskel, Mohammed Derso, Mogesie Necho, Yossef Teshome, Abebaw Molla
{"title":"Prediction of Body Height Using Hand Length and Hand Breadth in Pharmacy and Nursing Students at Misrake Ghion College, Northeast Ethiopia: An Anthropometry Study.","authors":"Chalachew Tiruneh, Daniel Teshome, Teshome Geberemeskel, Mohammed Derso, Mogesie Necho, Yossef Teshome, Abebaw Molla","doi":"10.1177/19253621231225259","DOIUrl":"10.1177/19253621231225259","url":null,"abstract":"<p><strong>Objectives: </strong>To predict body height using hand length and hand breadth in pharmacy and nursing students at Misrake Ghion College, Northeast Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional prospective study was conducted from October 15 to January 20, 2021. The study was carried out on 316 students (160 males and 156 females). The study participants were from the Amhara ethnic groups, with the age range of 18 to 25 years. Body height, hand length, and hand breath were measured and analyzed using SPSS version 23. The strength of association was evaluated using correlation analysis. The significance level was set at <i>p</i> < 0.05. A paired sample <i>t</i> test was performed. Regression equations were derived using simple and multiple linear regression analysis.</p><p><strong>Results: </strong>Hand length and hand breadth had a positive significant correlation with body height in both male and females. In both males and females, left hand length had a strong significant correlation (males <i>r</i> = 0.768, females <i>r</i> = 0.670), followed by right hand length (males <i>r</i> = 0.711, females <i>r</i> = 0.626). Regarding hand length, right hand breadth (males <i>r</i> = 0.671, female <i>r</i> = 0.438) and left hand length (males <i>r</i> = 0.504, females <i>r</i> = 0.525). There was a significant bilateral difference in hand length and hand breadth on its right and left sides (<i>p</i> < 0.05). Simple and multiple regression equations were formulated for each sex.</p><p><strong>Conclusion: </strong>In both males and females, body height can be estimated from hand length and breadth using simple or multiple regression equations.</p>","PeriodicalId":36813,"journal":{"name":"Academic Forensic Pathology","volume":"14 1","pages":"10-20"},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10947709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}