Liver Research最新文献

{"title":"Plasma microRNA-15a/16-1-based machine learning for early detection of hepatitis B virus-related hepatocellular carcinoma","authors":"Huan Wei ,&nbsp;Songhao Luo ,&nbsp;Yanhua Bi ,&nbsp;Chunhong Liao ,&nbsp;Yifan Lian ,&nbsp;Jiajun Zhang ,&nbsp;Yuehua Huang","doi":"10.1016/j.livres.2024.05.003","DOIUrl":"10.1016/j.livres.2024.05.003","url":null,"abstract":"<div><h3>Background and aims</h3><p>Hepatocellular carcinoma (HCC), which is prevalent worldwide and has a high mortality rate, needs to be effectively diagnosed. We aimed to evaluate the significance of plasma microRNA-15a/16-1 (miR-15a/16) as a biomarker of hepatitis B virus-related HCC (HBV-HCC) using the machine learning model. This study was the first large-scale investigation of these two miRNAs in HCC plasma samples.</p></div><div><h3>Methods</h3><p>Using quantitative polymerase chain reaction, we measured the plasma miR-15a/16 levels in a total of 766 participants, including 74 healthy controls, 335 with chronic hepatitis B (CHB), 47 with compensated liver cirrhosis, and 310 with HBV-HCC. The diagnostic performance of miR-15a/16 was examined using a machine learning model and compared with that of alpha-fetoprotein (AFP). Lastly, to validate the diagnostic efficiency of miR-15a/16, we performed pseudotemporal sorting of the samples to simulate progression from CHB to HCC.</p></div><div><h3>Results</h3><p>Plasma miR-15a/16 was significantly decreased in HCC than in all control groups (<em>P</em> &lt; 0.05 for all). In the training cohort, the area under the receiver operating characteristic curve (AUC), sensitivity, and average precision (AP) for the detection of HCC were higher for miR-15a (AUC = 0.80, 67.3%, AP = 0.80) and miR-16 (AUC = 0.83, 79.0%, AP = 0.83) than for AFP (AUC = 0.74, 61.7%, AP = 0.72). Combining miR-15a/16 with AFP increased the AUC to 0.86 (sensitivity 85.9%) and the AP to 0.85 and was significantly superior to the other markers in this study (<em>P</em> &lt; 0.05 for all), as further demonstrated by the detection error tradeoff curves. Moreover, miR-15a/16 impressively showed potent diagnostic power in early-stage, small-tumor, and AFP-negative HCC. A validation cohort confirmed these results. Lastly, the simulated follow-up of patients further validated the diagnostic efficiency of miR-15a/16.</p></div><div><h3>Conclusions</h3><p>We developed and validated a plasma miR-15a/16-based machine learning model, which exhibited better diagnostic performance for the early diagnosis of HCC compared to that of AFP.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 2","pages":"Pages 105-117"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000187/pdfft?md5=1f363a82844e27afef2899a66bb34c27&pid=1-s2.0-S2542568424000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early plasma exchange and continuous renal replacement therapy improve puerperal prognosis in hepatitis B virus-related acute-on-chronic liver failure in pregnancy","authors":"Lijuan Li,&nbsp;Mingming Fan,&nbsp;Mi Zhou,&nbsp;Pinglan Lu,&nbsp;Jianrong Liu,&nbsp;Huimin Yi,&nbsp;Xuxia Wei","doi":"10.1016/j.livres.2024.06.003","DOIUrl":"10.1016/j.livres.2024.06.003","url":null,"abstract":"<div><h3>Background and aim</h3><p>Hepatitis B virus (HBV)-related gestational acute-on-chronic liver failure (ACLF) is a severe condition with limited treatment options. This study aimed to evaluate the efficacy and ideal timing of plasma exchange and continuous renal replacement therapy (CRRT) in managing pregnant women with HBV-related ACLF.</p></div><div><h3>Methods</h3><p>This study retrospectively analyzed 51 eligible patients with HBV-related gestational ACLF between 2009 and 2020. Patients admitted to the study were divided into a conventional treatment group and a new treatment group according to whether they received the new management protocol, which included more aggressive plasma exchange (PE) and CRRT strategies. All 19 pregnant women with hepatic encephalopathy (HE) were divided into an early treatment group and a non-early treatment group according to whether PE therapy was initiated within three days. Our study had two primary objectives. Firstly, we aimed to evaluate the impact of PE and CRRT on puerperal survival. Secondly, we sought to assess the effects of early PE and CRRT regimens on puerperal survival in women with HE.</p></div><div><h3>Results</h3><p>The levels of total bilirubin on the second day postpartum (D3), the third day postpartum (D4), and the fifth day postpartum (D6) were significantly lower in the new treatment group compared to the conventional treatment group (<em>P</em> = 0.02, 0.01, and 0.02, respectively). The ALT of D3 was significantly elevated in the new treatment group compared to the conventional treatment group (<em>P</em> = 0.02). The incidence of HE overall increased from prenatal to postpartum D4, peaked on D4, and then gradually decreased from the fourth day postpartum (D5) （<em>P</em> = 0.027）. The first week after delivery revealed a significant difference in survival rate between the two groups, the conventional treatment group had statistically higher mortality rates compared to the new treatment group (<em>P</em> = 0.002). Similarly, the entire puerperal period mortality rate of the conventional treatment group was statistically higher than the new treatment group (<em>P</em> = 0.002). Moreover, among all patients with HE, the non-early treatment group showed significantly higher puerperal mortality rates compared to the early treatment group (<em>P</em> = 0.006).</p></div><div><h3>Conclusions</h3><p>Early PE and CRRT conducted within three days post-childbirth, enhance puerperal prognosis for HBV-related gestational ACLF.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 2","pages":"Pages 118-126"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000229/pdfft?md5=7ea33d0a0647910d804af90293985ebd&pid=1-s2.0-S2542568424000229-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese expert consensus on refined diagnosis, treatment, and management of advanced primary liver cancer (2023 edition)","authors":"Xiufeng Liu ,&nbsp;Feng Xia ,&nbsp;Yue Chen ,&nbsp;Huichuan Sun ,&nbsp;Zhengqiang Yang ,&nbsp;Bo Chen ,&nbsp;Ming Zhao ,&nbsp;Xinyu Bi ,&nbsp;Tao Peng ,&nbsp;Aizier Ainiwaer ,&nbsp;Zhiwen Luo ,&nbsp;Fusheng Wang ,&nbsp;Yinying Lu ,&nbsp;National Clinical Research Center for Infectious Diseases,&nbsp;Society of Hepatology, Beijing Medical Association,&nbsp;Translational Medicine Branch,&nbsp;China Association of Gerontology and Geriatrics","doi":"10.1016/j.livres.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.livres.2024.05.001","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC), commonly known as primary liver cancer, is a major cause of malignant tumors and cancer-related deaths in China, accounting for approximately 85% of all cancer cases in the country. Several guidelines have been used to diagnose and treat liver cancer. However, these guidelines provide a broad definition for classifying advanced liver cancer, with an emphasis on a singular approach, without considering treatment options for individual patients. Therefore, it is necessary to establish a comprehensive and practical expert consensus, specifically for China, to enhance the diagnosis and treatment of HCC using the Delphi method. The classification criteria were refined for Chinese patients with HCC, and the corresponding optimal treatment regimen recommendations were developed. These recommendations took into account various factors, including tumor characteristics, vascular tumor thrombus grade, distant metastasis, liver function status, portal hypertension, and the hepatitis B virus replication status of patients with primary HCC, along with treatment prognosis. The findings and recommendations provide detailed, scientific, and reasonable individualized diagnosis and treatment strategies for clinicians.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 2","pages":"Pages 61-71"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000163/pdfft?md5=65238cf8a759d85a68fa46f409b307fd&pid=1-s2.0-S2542568424000163-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative AI: A transformative force in advancing research and care in metabolic dysfunction-associated fatty liver disease","authors":"Partha Pratim Ray","doi":"10.1016/j.livres.2024.05.002","DOIUrl":"10.1016/j.livres.2024.05.002","url":null,"abstract":"","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 2","pages":"Pages 127-129"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000175/pdfft?md5=72cb71a33ad53ab396453fd192d25bf7&pid=1-s2.0-S2542568424000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141136377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of immune cell interactions in alcohol-associated liver diseases","authors":"Xianda Wang ,&nbsp;Juan Wang ,&nbsp;Haodong Peng ,&nbsp;Li Zuo ,&nbsp;Hua Wang","doi":"10.1016/j.livres.2024.06.002","DOIUrl":"10.1016/j.livres.2024.06.002","url":null,"abstract":"<div><p>Research on inflammatory response, liver injury, and immune regulation has demonstrated that the intricate interactions among immune cells constitute a critical regulatory network. Alcohol consumption alters the liver microenvironment, triggering inflammation and immune responses. Elucidating the inhibitory, cooperative, and synergistic effects among lymphocytes and myeloid cells may reveal the core mechanisms of alcohol-associated liver disease (ALD) pathogenesis and identify promising therapeutic targets. This review seeks to elucidate the intricate and multifaceted interactions among immune cells, encompassing both direct cellular interactions and the secretion of various effector molecules. It is essential to underscore that these interactions have broader and more complex roles in ALD than the activities of individual immune cell types. These interactions play a crucial role in mutually regulating one another, thereby preserving the homeostasis of the inflammatory and immune response in the liver environment. Targeting these immune cell interactions is anticipated to offer a novel approach to the prevention and treatment of ALD.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 2","pages":"Pages 72-82"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000217/pdfft?md5=d0bfb0849b65a5d05ca91b0d3640b151&pid=1-s2.0-S2542568424000217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141398510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variants in the 6p21.3 region influence hepatitis B virus clearance and chronic hepatitis B risk in the Han Chinese population","authors":"Jiancheng Huang ,&nbsp;Mingkuan Su ,&nbsp;Fanhui Kong ,&nbsp;Hongbin Chen ,&nbsp;Shuiqing Wu ,&nbsp;Jianfeng Guo ,&nbsp;Haiying Wu","doi":"10.1016/j.livres.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.livres.2024.02.001","url":null,"abstract":"<div><h3>Background and aim</h3><p>A genome-wide association study has indicated the association of numerous genes in the 6p21.3 region with chronic hepatitis B virus (HBV) infection. In this study, we screened 12 representative single-nucleotide polymorphisms (SNPs) from the 6p21.3 region and investigated their association with the risk of chronic hepatitis B (CHB) to better understand the molecular etiology underlying CHB risk in the Han Chinese population.</p></div><div><h3>Methods</h3><p>Between March 2021 and November 2022, we included 183 patients with CHB (case group) and 196 with natural HBV clearance (control group). Allele typing of the selected SNPs was performed using snapshot technology. The correlation between the 12 chosen SNPs and the risk of chronic HBV infection was examined using binary logistic regression analysis. Interacting genes of the variants were identified, and expression quantitative trait loci (eQTL) were analyzed using the 3DSNP database.</p></div><div><h3>Results</h3><p>We validated 12 previously reported CHB susceptibility sites, including rs1419881 of transcription factor 19 (<em>TCF19</em>), rs3130542 and rs2853953 of human leukocyte antigen (<em>HLA</em>)<em>-C</em>, rs652888 of euchromatic histone-lysine-methyltransferase 2 (<em>EHMT2</em>), rs2856718, rs9276370, rs7756516, and rs7453920 of <em>HLA-DQ</em>, rs378352 of <em>HLA-DOA</em>, and rs3077, rs9277535, and rs9366816 of <em>HLA-DP</em>. Logistic regression analyses revealed that polymorphisms such as rs9276370, rs7756516, rs7453920, rs3077, rs9277535, and rs9366816 were positively correlated with natural HBV clearance in the dominant model. Conversely, rs3130542 and rs378352 were identified as risk factors for CHB. Haplotype analysis revealed that rs9276370, rs7756516, and rs7453920 in <em>HLA-DQ</em> were TTG and GCA haplotypes. Although the TTG haplotype was positively correlated with a higher risk of CHB, the GCA haplotype significantly influenced the natural clearance of HBV. Bioinformatics analysis demonstrated that rs378352, rs3077, and rs9366816 were located within enhancer states; rs3077 and rs9366816 overlapped with nine transcription factor-binding sites, whereas rs378352 altered five sequence motifs. Furthermore, eQTL analysis demonstrated the functional tendencies of eight statistically significant SNPs (rs3130542, rs9276370, rs7756516, rs7453920, rs378352, rs3077, rs9277535, and rs9366816).</p></div><div><h3>Conclusions</h3><p>Genetic variations within the 6p21.3 region were associated with chronic HBV infection in the Han Chinese population in southern China. Furthermore, the GCA haplotype including rs9276370, rs7756516, and rs7453920 of <em>HLA-DQ</em> contributed significantly to natural HBV clearance, implying that multiple SNPs exert a cumulative allelic effect on HBV infection.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 1","pages":"Pages 54-60"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000035/pdfft?md5=c552965074bc3e0d17f6b385b80c27c0&pid=1-s2.0-S2542568424000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the portal system in liver regeneration: From molecular mechanisms to clinical management","authors":"Hanzhi Xu ,&nbsp;Xun Qiu ,&nbsp;Zhoucheng Wang ,&nbsp;Kai Wang ,&nbsp;Yawen Tan ,&nbsp;Fengqiang Gao ,&nbsp;Marcos Vinicius Perini ,&nbsp;Xiao Xu","doi":"10.1016/j.livres.2024.01.002","DOIUrl":"10.1016/j.livres.2024.01.002","url":null,"abstract":"<div><p>The liver has a strong regenerative capacity that ensures patient recovery after hepatectomy and liver transplantation. The portal system plays a crucial role in the dual blood supply to the liver, making it a significant factor in hepatic function. Several surgical strategies, such as portal vein ligation, associating liver partition and portal vein ligation for staged hepatectomy, and dual vein embolization, have highlighted the portal system's importance in liver regeneration. Following hepatectomy or liver transplantation, the hemodynamic properties of the portal system change dramatically, triggering regeneration via shear stress and the induction of hypoxia. However, excessive portal hyperperfusion can harm the liver and negatively affect patient outcomes. Furthermore, as the importance of the gut–liver axis has gradually been revealed, the effect of metabolites and cytokines from gut microbes carried by portal blood on liver regeneration has been acknowledged. From these perspectives, this review outlines the molecular mechanisms of the portal system's role in liver regeneration and summarizes therapeutic strategies based on the portal system intervention to promote liver regeneration.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 1","pages":"Pages 1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000023/pdfft?md5=622f9be0188cb2c7281e914cd7c00c48&pid=1-s2.0-S2542568424000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139633506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral hepatitis E: Clinical manifestations, treatment, and prevention","authors":"Qiumin Luo ,&nbsp;Jia Chen ,&nbsp;Yeqiong Zhang ,&nbsp;Wenxiong Xu ,&nbsp;Ying Liu ,&nbsp;Chan Xie ,&nbsp;Liang Peng","doi":"10.1016/j.livres.2024.01.001","DOIUrl":"10.1016/j.livres.2024.01.001","url":null,"abstract":"<div><p>Hepatitis E is a globally distributed infection that varies in seroprevalence between developed and developing regions. In the less developed regions of Asia and Africa, a high seropositivity rate has been reported for hepatitis E virus (HEV) antibodies. Although acute hepatitis E is often self-limited and has a favorable prognosis, some populations experience severe manifestations, which may progress to liver failure. Moreover, some immunocompromised patients are at risk of developing chronic HEV infection and cirrhosis. Proactive screening, reducing misdiagnosis, improving patient management, timely antiviral therapy for severe and chronic cases, and vaccination of high-risk groups are important measures to reduce the morbidity of hepatitis E. This review focused on the clinical presentation, management, and prevention of hepatitis E.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 1","pages":"Pages 11-21"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000011/pdfft?md5=a81de35d4a3a39aa3f885f8dcf39374d&pid=1-s2.0-S2542568424000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting nuclear receptors for NASH/MASH: From bench to bedside","authors":"Rohit A. Sinha","doi":"10.1016/j.livres.2024.03.002","DOIUrl":"10.1016/j.livres.2024.03.002","url":null,"abstract":"<div><p>The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent hepatic complications in the natural progression of what is now termed metabolic dysfunction-associated steatotic liver diseases (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD). With no pharmacological treatment currently available for MASH/NASH, the race is on to develop drugs targeting multiple facets of hepatic metabolism, inflammation, and pro-fibrotic events, which are major drivers of MASH. Nuclear receptors (NRs) regulate genomic transcription upon binding to lipophilic ligands and govern multiple aspects of liver metabolism and inflammation. Ligands of NRs may include hormones, lipids, bile acids, and synthetic ligands, which upon binding to NRs regulate the transcriptional activities of target genes. NR ligands are presently the most promising drug candidates expected to receive approval from the United States Food and Drug Administration as a pharmacological treatment for MASH. This review aims to cover the current understanding of NRs, including nuclear hormone receptors, non-steroid hormone receptors, circadian NRs, and orphan NRs, which are currently undergoing clinical trials for MASH treatment, along with NRs that have shown promising results in preclinical studies.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 1","pages":"Pages 34-45"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000060/pdfft?md5=29b254d4b61a06006290c45ed5b8e30c&pid=1-s2.0-S2542568424000060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity and exercise in liver cancer","authors":"Haiyan Chen ,&nbsp;Huimin Zhou ,&nbsp;Bo Wu ,&nbsp;Hanxiao Lu ,&nbsp;Jie Zhang ,&nbsp;Yan Zhang ,&nbsp;Yuanlong Gu ,&nbsp;Guangwen Zhou ,&nbsp;Jie Xiang ,&nbsp;Jun Yang","doi":"10.1016/j.livres.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.livres.2024.03.001","url":null,"abstract":"<div><p>Sarcopenia and physical deconditioning are common complications in patients with liver cancer, which are frequently caused by insufficient physical activity and poor nutritional status, resulting in physical frailty and a significant impact on the patient’s physical fitness. Notably, sarcopenia, frailty, and poor cardiopulmonary endurance have all been linked to higher mortality rates among patients with liver cancer. Exercise intervention significantly improves various health parameters in liver cancer patients, including metabolic syndrome, muscle wasting, cardiorespiratory endurance, health-related quality of life, and reduction in hepatic venous pressure gradient. However, the link between physical exercise and liver cancer is commonly overlooked. In this article, we will examine the impact of exercise on liver cancer and present the most recent evidence on the best types of exercise for various stages of liver cancer. This article also summarizes and discusses the molecular mechanisms that control metabolism and systemic immune function in tumors. In brief, physical exercise should be considered an important intervention in the prevention and treatment of liver cancer and its complications.</p></div>","PeriodicalId":36741,"journal":{"name":"Liver Research","volume":"8 1","pages":"Pages 22-33"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542568424000059/pdfft?md5=78998b626ea43c8886f4937301389c06&pid=1-s2.0-S2542568424000059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140296802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}