Non-coding RNAs in alcohol-associated liver disease

Q2 Medicine

Liver Research Pub Date : 2025-06-01 DOI:10.1016/j.livres.2025.04.007

Ge Zeng , Hui Gao , Yanchao Jiang , Nazmul Huda , Themis Thoudam , Zhihong Yang , Jing Ma , Jian Sun , Suthat Liangpunsakul

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Abstract

Non-coding RNAs (ncRNAs), encompassing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as critical regulators of gene expression and cellular function. In alcohol-associated liver disease (ALD), chronic alcohol consumption disrupts the expression and function of ncRNAs in the liver and circulation, contributing to the disease's pathogenesis and progression. Dysregulated ncRNAs influence key pathways involved in hepatocyte injury, lipid metabolism, inflammation, and hepatic stellate cell (HSC) activation, thereby exacerbating steatosis, inflammation, and fibrosis. Furthermore, extracellular vesicles play a pivotal role in mediating ncRNA-driven intercellular communication, amplifying liver damage and fibrosis. This review provides a comprehensive overview of the multifaceted roles of ncRNAs in ALD, with a focus on their mechanistic contributions to disease development and progression. Additionally, we discuss the potential of ncRNAs as diagnostic biomarkers and therapeutic targets, emphasizing their translational relevance in addressing the burden of ALD.

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非编码rna在酒精相关肝病中的作用

非编码rna (ncRNAs)，包括微rna （miRNAs）、长链非编码rna （lncRNAs）和环状rna (circRNAs)，已经成为基因表达和细胞功能的关键调节因子。在酒精相关性肝病（ALD）中，慢性饮酒会破坏肝脏和循环中ncrna的表达和功能，从而导致疾病的发病和进展。失调的ncrna影响肝细胞损伤、脂质代谢、炎症和肝星状细胞（HSC）活化的关键途径，从而加剧脂肪变性、炎症和纤维化。此外，细胞外囊泡在介导ncrna驱动的细胞间通讯、放大肝损伤和纤维化中发挥关键作用。这篇综述全面概述了ncrna在ALD中的多方面作用，重点是它们对疾病发生和进展的机制贡献。此外，我们讨论了ncrna作为诊断生物标志物和治疗靶点的潜力，强调了它们在解决ALD负担方面的翻译相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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