Journal of Pediatrics: X最新文献

{"title":"Skeletal Calcium Overload in Addition to Nephrocalcinosis in Severe Hypercalcemia","authors":"Michael Torchinsky MD, FAAP, Eric Bugaieski MD","doi":"10.1016/j.ympdx.2020.100025","DOIUrl":"10.1016/j.ympdx.2020.100025","url":null,"abstract":"","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"3 ","pages":"Article 100025"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2020.100025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9716818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the Number of Injections per Visit on the Likelihood of Human Papillomavirus Immunization","authors":"Steve G. Robison MPH","doi":"10.1016/j.ympdx.2020.100024","DOIUrl":"10.1016/j.ympdx.2020.100024","url":null,"abstract":"<div><h3>Objective</h3><p>To test whether adolescents, who are injection limited, that is, receiving only a limited number of immunization injections per visit, are less likely to complete the human papillomavirus (HPV) immunization series.</p></div><div><h3>Study design</h3><p>For Oregon adolescents age 13-17 years, HPV series completion rates were assessed based on never receiving &gt;1 injection per visit from age ≥9 years. Among a study subset born and resident in Oregon through adolescence, HPV series rates were assessed based on never receiving &gt;1 or 2 injections per visit from age ≥4 years. Cox proportional hazards regression was used to assess delays owing to limiting injections, controlling for sex and rural location.</p></div><div><h3>Results</h3><p>Among 241 453 study adolescents, 16.3% had only single-injection visits from age ≥9 years. Their HPV completion rate was 7.7% as compared with 61.7% for those with no limitations of number of injections. Among study adolescents born in Oregon, 10.2% never received &gt;1 or 2 injections per visit from age ≥4 and were less than half as likely to complete the HPV series (28.4% vs 59.1%).</p></div><div><h3>Conclusions</h3><p>Limiting the number of injections per visit is associated with decreased completion of HPV immunization. As larger cohorts of young children with early injection-limiting characteristics age into adolescence, progress on HPV immunization rates may be challenged.</p></div>","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"3 ","pages":"Article 100024"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2020.100024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Sudden Death in a Population-Based Study of Infants and Children","authors":"Kristin M. Burns MD ,&nbsp;Carri Cottengim MA ,&nbsp;Heather Dykstra MPA ,&nbsp;Meghan Faulkner MA ,&nbsp;Alexa B. Erck Lambert MPH ,&nbsp;Heather MacLeod MS CGC ,&nbsp;Alissa Novak BSc ,&nbsp;Sharyn E. Parks PhD, MPH ,&nbsp;Mark W. Russell MD ,&nbsp;Carrie K. Shapiro-Mendoza PhD, MPH ,&nbsp;Esther Shaw MSIS ,&nbsp;Niu Tian MD, PhD ,&nbsp;Vicky Whittemore PhD ,&nbsp;Jonathan R. Kaltman MD ,&nbsp;Sudden Death in the Young Case Registry","doi":"10.1016/j.ympdx.2020.100023","DOIUrl":"10.1016/j.ympdx.2020.100023","url":null,"abstract":"<div><h3>Objective</h3><p>To describe epidemiologic data from the Sudden Death in the Young (SDY) Case Registry. Understanding the scope of SDY may optimize prevention efforts.</p></div><div><h3>Study design</h3><p>We analyzed sudden, unexpected deaths of infants (&lt;365 days) and children (1-17 years) from a population-based registry of 8 states/jurisdictions in 2015 and 9 in 2016. Natural deaths and injury deaths from drowning, motor vehicle accident drivers, and infant suffocation were included; other injury deaths, homicide, suicide, intentional overdose, and terminal illness were excluded. Cases were categorized using a standardized algorithm. Descriptive statistics were used to characterize deaths, and mortality rates were calculated.</p></div><div><h3>Results</h3><p>Of 1319 cases identified, 92% had an autopsy. We removed incomplete cases<em>,</em> leaving 1132 analyzable deaths (889 infants, 243 children). The SDY rate for infants was 120/100 000 live births and for children was 1.9/100 000 children. <em>Explained Cardiac</em> rates were greater for infants (2.7/100 000 live births) than children (0.3/100 000 children). The pediatric <em>Sudden Unexpected Death in Epilepsy</em> (<em>SUDEP</em>) mortality rate was 0.2/100 000 live births and children. Blacks comprised 42% of infant and 43% of child deaths but only 23% of the population. In all ages, myocarditis/endocarditis was the most common <em>Explained Cardiac</em> cause; respiratory illness was the most common <em>Explained Other</em> cause. SDY occurred during activity in 13% of childhood cases.</p></div><div><h3>Conclusions</h3><p>Prevention strategies include optimizing identification and treatment of respiratory and cardiac diseases.</p></div>","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"2 ","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2020.100023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38218710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Losing Sleep: Considering Caregivers of Children with Rare Epilepsy Syndromes","authors":"Gita Gupta MD,&nbsp;Renée A. Shellhaas MD, MS","doi":"10.1016/j.ympdx.2020.100022","DOIUrl":"10.1016/j.ympdx.2020.100022","url":null,"abstract":"","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"2 ","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2020.100022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9716280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2590-0420(20)30013-6","DOIUrl":"https://doi.org/10.1016/S2590-0420(20)30013-6","url":null,"abstract":"","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"2 ","pages":"Article 100032"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2590-0420(20)30013-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71763966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Caregiver Sleep Quality Related to Children with Rare Epilepsy Syndromes","authors":"Dale C. Hesdorffer PhD ,&nbsp;Barbara L. Kroner PhD ,&nbsp;Jing Shen PhD ,&nbsp;Kathleen Farrell MB, BCh, BAO ,&nbsp;Steve Roberds PhD ,&nbsp;Brandy Fureman PhD","doi":"10.1016/j.ympdx.2020.100021","DOIUrl":"10.1016/j.ympdx.2020.100021","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the impact of pediatric sleep disturbances and night-time seizure monitoring of children with rare epilepsy syndromes on the sleep quality and mental health of caregivers.</p></div><div><h3>Study design</h3><p>A cross-sectional study was conducted using caregiver entered data from the Rare Epilepsy Network on pediatric sleep disturbances and Patient Reported Outcomes Measurement Information System measures for caregiver fatigue, sleep disturbance, sleep-related impairment, depression, anxiety, companionship, and cognition. Logistic regression was used to examine associations between risk factors and caregiver sleep quality.</p></div><div><h3>Results</h3><p>Non-Hispanic white mothers comprised 83% of the 742 respondents in this study. After adjusting for covariates, difficulty falling asleep, excessive daytime sleepiness, frequent night-time awakenings, and very restless sleep in children were associated with fatigue (aOR 95% CI, 1.5-2.2), sleep-related disturbance (aOR 95% CI, 1.7-2.6) and sleep impairment (aOR 95% CI, 1.5-2.4) in caregivers. Caregiver anxiety (aOR 95% CI, 3.6-6.0) and depression (aOR 95% CI, 2.8-6.0) were also highly associated with their fatigue and sleep quality, whereas companionship (aOR 95% CI, 0.3-0.4) and higher caregiver cognition (aOR 95% CI, 0.1-0.2) were protective. In addition, sharing a room or bed or using methods that require listening for seizures were significantly related to sleep disturbance and fatigue in the caregivers.</p></div><div><h3>Conclusions</h3><p>In rare epilepsies, pediatric sleep disturbances and night-time seizure monitoring are significantly associated with caregiver fatigue and poor sleep quality. In addition to the intense caregiving needs of children with rare epilepsies, fatigue and poor sleep quality in caregivers may contribute to or result from mental health problems.</p></div>","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"2 ","pages":"Article 100021"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2020.100021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9716276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Early Literacy Promotion on Child Language Development and Home Reading Environment: A Randomized Controlled Trial","authors":"James P. Guevara MD, MPH ,&nbsp;Danielle Erkoboni MD ,&nbsp;Marsha Gerdes PhD ,&nbsp;Sherry Winston MS ,&nbsp;Danielle Sands MPH ,&nbsp;Kirsten Rogers BS ,&nbsp;Trude Haecker MD ,&nbsp;Manuel E. Jimenez MD, MSHP ,&nbsp;Alan L. Mendelsohn MD","doi":"10.1016/j.ympdx.2020.100020","DOIUrl":"10.1016/j.ympdx.2020.100020","url":null,"abstract":"<div><h3>Objective</h3><p>To determine if early literacy promotion, which consisted of board books and reading promotion beginning with newborns, is more effective than standard literacy promotion beginning at 6 months.</p></div><div><h3>Study design</h3><p>Hybrid type 1 randomized controlled implementation trial of Medicaid-eligible newborns. Prior to 6 months of age, early literacy promotion participants received board books and reading promotion at well visits plus weekly text messages on reading, while standard literacy promotion participants only received weekly text messages on safety. Both groups received board books and reading promotion at well visits after 6 months as part of Reach Out and Read. Measures included proportion who received board books to assess implementation and StimQ Read Subscale (SQRS) scores and Preschool Language Scale-Fifth Edition (PLS-5) scores at 6 and 24 months to assess outcomes. Differences in measures were assessed using intention-to-treat analysis.</p></div><div><h3>Results</h3><p>Of 120 newborns enrolled, most were African American, resided with a single parent, or had a parent with ≤high school education. Overall 82% of early literacy promotion participants received books/counseling at well visits &lt;6 months old. Children in the early literacy promotion arm had greater SQRS scores (11.0 vs 9.4, <em>P</em> = .006) but similar PLS-5 scores at 6 months, but there were no differences in SQRS or PLS-5 scores between groups at 24 months.</p></div><div><h3>Conclusions</h3><p>Implementation of a literacy promotion program early in infancy was associated with richer home reading environments at 6 months but did not improve language development. Although an early literacy program was feasible, additional study may be needed to assess other potential benefits.</p></div><div><h3>Trial registration</h3><p><span>Clinicaltrials.gov</span><svg><path></path></svg>: <span>NCT02713659</span><svg><path></path></svg>.</p></div>","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"2 ","pages":"Article 100020"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2020.100020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9660458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Cardiovascular Function after Antenatal Sildenafil for Severe, Early-Onset Intrauterine Growth Restriction: A Substudy of the STRIDER-NZAus Randomized Placebo-Controlled Trial","authors":"Sarah L. Harris PhD ,&nbsp;Chris McKinlay PhD ,&nbsp;Katie Groom PhD ,&nbsp;Friederike Beker FRACP ,&nbsp;Anuradha Kochar FRACP ,&nbsp;Andrew Gill FRACP","doi":"10.1016/j.ympdx.2019.100009","DOIUrl":"10.1016/j.ympdx.2019.100009","url":null,"abstract":"<div><p>We evaluated the effect of antenatal sildenafil on neonatal cardiovascular function in a subgroup of 27 infants of mothers participating in the STRIDER-NZAus randomized controlled trial. In this small study, we found no association between antenatal sildenafil and neonatal cardiac dysfunction including no pulmonary hypertension in exposed or unexposed infants.</p></div>","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"1 ","pages":"Article 100009"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2019.100009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swollen Digits: An Unusual Manifestation of Childhood Acute Lymphoblastic Leukemia","authors":"Sidharth Totadri MD, DM,&nbsp;Akshay Kumar Saxena MD,&nbsp;Amita Trehan MD","doi":"10.1016/j.ympdx.2019.100002","DOIUrl":"10.1016/j.ympdx.2019.100002","url":null,"abstract":"","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"1 ","pages":"Article 100002"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2019.100002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9662475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Counts in Healthy South African Infants: Implications for Enrollment and Adverse Event Grading in Clinical Trials in an African Setting","authors":"Anthonet Koen MBBCh ,&nbsp;Lisa Jose MBBCh ,&nbsp;Shabir A. Madhi PhD ,&nbsp;Alan Fix MD ,&nbsp;Stanley Cryz PhD ,&nbsp;Michelle J. Groome PhD","doi":"10.1016/j.ympdx.2019.100005","DOIUrl":"10.1016/j.ympdx.2019.100005","url":null,"abstract":"<div><p>Absolute neutrophil counts are used to assess eligibility and safety during clinical trials but the toxicity grading scale used can affect enrollment and reporting of adverse events. During a trial investigating a parenteral rotavirus vaccine in South Africa, we excluded otherwise healthy infants without HIV infection from participation owing to neutropenia.</p></div><div><h3>Trial registration</h3><p><span>ClinicalTrials.gov</span><svg><path></path></svg>: <span>NCT02109484</span><svg><path></path></svg>.</p></div>","PeriodicalId":36706,"journal":{"name":"Journal of Pediatrics: X","volume":"1 ","pages":"Article 100005"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ympdx.2019.100005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9699216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}