Journal of Patient-Reported Outcomes最新文献

筛选
英文 中文
Cross-cultural adaptation and validation of Dysphagia Handicap Index in Bangladesh. 吞咽困难障碍指数在孟加拉国的跨文化适应与验证。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2025-01-02 DOI: 10.1186/s41687-024-00803-y
Mehrin Sultana, Md Muid Hossain Reshad, Md Shohidul Islam Mridha
{"title":"Cross-cultural adaptation and validation of Dysphagia Handicap Index in Bangladesh.","authors":"Mehrin Sultana, Md Muid Hossain Reshad, Md Shohidul Islam Mridha","doi":"10.1186/s41687-024-00803-y","DOIUrl":"10.1186/s41687-024-00803-y","url":null,"abstract":"<p><p>The Dysphagia Handicap Index (DHI) is commonly utilized for evaluating how dysphagia impacts the quality of life (QoL) of patients across physical, functional, and emotional dimensions. The primary aim of the research was to linguistically validate and culturally adapt the DHI to the Bangla version. A cross-sectional study design was chosen, with Beaton's protocol as the guiding framework for validating and adapting the DHI. It has followed a systematic process of forward translation, participation in expert discussions, and subsequent back translation to obtain a reviewed version. The Bangla version, DHI-Ban, was administered purposefully to 50 dysphagia patients in the Clinical Speech and Language Therapy (SLT) Department of the Centre for the Rehabilitation of the Paralyzed (CRP) and was also administered to 50 healthy individuals for comparison. Of the fifty, eighteen dysphagia subjects were assigned again after two weeks for the retest. The DHI-Ban demonstrated strong internal consistency (Cronbach's α = 0.89) and good test-retest reproducibility (ICC = 0.86). The Spearman test confirmed significant construct validity (p < 0.01), and the Wilcoxon test identified significant differences (p < 0.001) between patients and healthy individuals. Feedback from participants was also taken into account for acceptance and clarity. In conclusion, the adapted DHI-Ban has emerged to be a reliable patient-reported tool for assessing dysphagia in Bangla-speaking individuals. Incorporating the Bangla language framework facilitates its comprehension and effectiveness, further solidifying its reliability.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"9 1","pages":"1"},"PeriodicalIF":2.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehension of the adapted Urticaria Activity Score measure and patient guidance document: qualitative interviews with adults and adolescents with chronic spontaneous urticaria. 理解适应荨麻疹活动评分测量和患者指导文件:对慢性自发性荨麻疹成人和青少年的定性访谈。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-24 DOI: 10.1186/s41687-024-00830-9
Anne M Skalicky, Yan Wang, Olabimpe R Eseyin, Marissa Stefan, Pallavi B Rane, Julie McLaren, Marcus Maurer
{"title":"Comprehension of the adapted Urticaria Activity Score measure and patient guidance document: qualitative interviews with adults and adolescents with chronic spontaneous urticaria.","authors":"Anne M Skalicky, Yan Wang, Olabimpe R Eseyin, Marissa Stefan, Pallavi B Rane, Julie McLaren, Marcus Maurer","doi":"10.1186/s41687-024-00830-9","DOIUrl":"10.1186/s41687-024-00830-9","url":null,"abstract":"<p><strong>Objective: </strong>A key component of determining that a patient-reported outcome (PRO) measure is fit-for-purpose is to ensure that respondents understand its instructions and items. Any modification to a measure should be evaluated for relevance and understandability. The objective of the study was to assess comprehension of the adapted Urticaria Activity Score (UAS) questionnaire among adolescents aged populations with chronic spontaneous urticaria (CSU) and the modification to UAS question 2 to include patient-friendly terminology \"wheals (hives).\" A patient guidance document for completing the adapted UAS was also examined.</p><p><strong>Methods: </strong>A non-interventional, cross-sectional, qualitative study involving hybrid concept elicitation and cognitive interviews was conducted among adults and adolescents with CSU. Eligibility included clinician confirmation of CSU and experience of itch and hives for ≥ 6 weeks. Study participants were recruited from US clinical sites and online CSU patient communities. Telephone interviews were conducted using a semi-structured interview guide. Participants reviewed the UAS and provided their input on the UAS guidance document.</p><p><strong>Results: </strong>Twenty-two interviews were conducted (seven adolescents and 15 adults; mean age 34 ± 18 years, 64% female, 77% White, 77% non-Hispanic, and 59% moderate to severe CSU symptoms). All participants (n = 22/22, 100%) stated that the adapted UAS was clear and \"easy\" to understand. For the adapted UAS \"wheals (hives)\" item, several participants were unfamiliar with the term \"wheals,\" but the term \"hives\" was well understood by US participants. Most participants reported that it was \"easy\" or \"not difficult\" to count and recall the number of hives they had over the past 24 h. Participants found the adapted UAS guidance document \"helpful\" and \"easy to understand\" for determining and counting hives in a 24-hour period. Suggestions for improving the guide included adding a picture to aid in counting hives.</p><p><strong>Conclusions: </strong>Itch and hives are important symptoms of CSU. Results support the content validity of an adapted UAS as a daily measure of severity of itch and hives and provided valuable suggestions for improving its patient guidance, which can be used in future clinical trials involving adults and adolescents ≥ 12 years old with CSU to assess the severity of itch and hives.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"153"},"PeriodicalIF":2.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying meaningful aspects of health and concepts of interest for assessment in systemic lupus erythematosus: implications for digital clinical measure development. 识别系统性红斑狼疮健康的有意义方面和评估感兴趣的概念:对数字临床测量发展的影响。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-24 DOI: 10.1186/s41687-024-00832-7
Paul Kamudoni, Kate Lyden, Oliver Günther, Vikas Jaitely, Thiago Dantas Araujo, Erica Spies, Josephine Park, Erik Thomas, Joy Buie, Jennifer M Blankenship, Laurent Arnaud
{"title":"Identifying meaningful aspects of health and concepts of interest for assessment in systemic lupus erythematosus: implications for digital clinical measure development.","authors":"Paul Kamudoni, Kate Lyden, Oliver Günther, Vikas Jaitely, Thiago Dantas Araujo, Erica Spies, Josephine Park, Erik Thomas, Joy Buie, Jennifer M Blankenship, Laurent Arnaud","doi":"10.1186/s41687-024-00832-7","DOIUrl":"10.1186/s41687-024-00832-7","url":null,"abstract":"<p><strong>Objectives: </strong>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with heterogeneous clinical manifestations which significantly impacts the daily lives of patients. Herein, we aimed to (i) investigate patients' perspectives on and experience with SLE; (ii) identify meaningful aspects of health (MAHs) and concepts of interest (COIs) in SLE that could be evaluated using digital clinical measures (DCMs); and (iii) identify target DCMs for their assessment.</p><p><strong>Methods: </strong>A mixed-methods, multistep approach was deployed for (i) exploring patients' experience with SLE through a social media listening study and focused group discussions with patients; (ii) mapping patients' experiences to define MAHs and identify COIs measurable using DCMs; (iii) selecting DCMs for the target COIs; and (iv) identifying types of wearable sensors for measuring COIs in the patients.</p><p><strong>Results: </strong>Six MAHs related to physical behavior and sleep were identified: difficulty in ambulating, lack of energy, inability to perform activities of daily living, difficulty engaging in sustained walking, inability to perform leisure activities and exercise, and lack of restful sleep. Measurable COIs represented walking (fatigue and pain) and sleep (sleep and pain) characteristics. Five and six DCMs related to stepping behavior and sleep quality, respectively, were identified. Several wearable sensors are available to derive DCMs for physical behavior and sleep; however, patients showed a strong preference for a wrist-worn actigraphy sensor.</p><p><strong>Conclusion: </strong>We identified DCMs for physical behavior and sleep that are relevant and meaningful to patients with SLE, measurable in a real-world environment with wearable sensors, and have the potential to aid personalized patient care.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"154"},"PeriodicalIF":2.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic rhinosinusitis with nasal polyps (CRSwNP) symptom verbal response scales: content validity testing for use in adults with CRSwNP. 慢性鼻鼻窦炎伴鼻息肉(CRSwNP)症状言语反应量表:用于成人CRSwNP的内容效度测试
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-20 DOI: 10.1186/s41687-024-00827-4
Tom Keeley, Nina Gaw, Waseem Ahmed, Rafael Alfonso-Cristancho, Ana R Sousa, Katie Forde, Rosie Sharp, Sophie Whyman, Adam Gater
{"title":"Chronic rhinosinusitis with nasal polyps (CRSwNP) symptom verbal response scales: content validity testing for use in adults with CRSwNP.","authors":"Tom Keeley, Nina Gaw, Waseem Ahmed, Rafael Alfonso-Cristancho, Ana R Sousa, Katie Forde, Rosie Sharp, Sophie Whyman, Adam Gater","doi":"10.1186/s41687-024-00827-4","DOIUrl":"10.1186/s41687-024-00827-4","url":null,"abstract":"<p><strong>Background: </strong>PRO measures of symptoms in clinical trials have historically utilized visual and numerical scales but verbal descriptors may make it easier for patients to clearly differentiate between response options. This study assessed content validity and meaningful change in five verbal response scales (VRSs) used to assess chronic rhinosinusitis with nasal polyp (CRSwNP) symptom severity.</p><p><strong>Methodology: </strong>This qualitative, semi-structured interview study recruited adults from the US, Germany, and China with confirmed moderate-to-severe CRSwNP. Interviews included a concept elicitation section, where participants were asked about their experience of living with CRSwNP including symptoms and health-related quality-of-life impacts, and a cognitive debriefing section, where participants were debriefed and participant understanding and real-life relevance of the CRSwNP symptom VRS content were assessed. Interview transcripts were qualitatively analyzed using thematic analysis methods.</p><p><strong>Results: </strong>Among the 24 participants interviewed, the most frequently reported CRSwNP symptoms were nasal obstruction, runny nose, mucus in the throat, loss of smell and facial pain/pressure. Participants demonstrated good understanding of the CRSwNP symptom VRS instructions, items, recall period, and response options. The five CRSwNP symptom VRS items were relevant to the majority of participants' experience of CRSwNP. At the item level, a one-category within-person improvement was the level most frequently reported by participants to be a meaningful change.</p><p><strong>Conclusion: </strong>The CRSwNP symptom VRSs assess relevant and bothersome symptoms experienced by patients with moderate-to-severe CRSwNP, supporting content validity of this measure. The findings of this study provided preliminary insights into meaningful change in the VRS. Further quantitative assessment of meaningful change is needed, and psychometric evaluation of the CRSwNP symptom VRSs will be required to evaluate their appropriateness for assessment of clinical trial endpoints in patients with CRSwNP.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"152"},"PeriodicalIF":2.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing tolerability with the Functional Assessment of Cancer Therapy item GP5: psychometric evidence from LIBRETTO-531, a phase 3 trial of selpercatinib in medullary thyroid cancer. 使用癌症治疗项目GP5的功能评估评估耐受性:来自LIBRETTO-531的心理测量证据,这是一项selpercatinib治疗甲状腺髓样癌的3期试验。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-19 DOI: 10.1186/s41687-024-00823-8
Antoine Regnault, Laurine Bunod, Angely Loubert, Marcia S Brose, Lisa M Hess, Patricia Maeda, Yan Lin, Rebecca M Speck, Adrienne M Gilligan, Nalin Payakachat
{"title":"Assessing tolerability with the Functional Assessment of Cancer Therapy item GP5: psychometric evidence from LIBRETTO-531, a phase 3 trial of selpercatinib in medullary thyroid cancer.","authors":"Antoine Regnault, Laurine Bunod, Angely Loubert, Marcia S Brose, Lisa M Hess, Patricia Maeda, Yan Lin, Rebecca M Speck, Adrienne M Gilligan, Nalin Payakachat","doi":"10.1186/s41687-024-00823-8","DOIUrl":"10.1186/s41687-024-00823-8","url":null,"abstract":"<p><strong>Background: </strong>This psychometric analysis generated evidence to support the use of the Functional Assessment of Cancer Therapy item GP5 (GP5) as a measure of tolerability and confirms the appropriateness of categorizing \"high side-effect burden\" using a rating of 3 or 4 (score ranges 0-4) in patients with advanced/metastatic RET-mutant medullary thyroid cancer (MTC).</p><p><strong>Methodology: </strong>Blinded, pooled interim data from the safety population (n=290) enrolled in the phase 3 LIBRETTO-531 trial (NCT04211337) were used. Intraclass correlation coefficients (ICC) were calculated for test-retest reliability using data from cycles 1-2 post-baseline. Construct validity was evaluated by examining the correlations of GP5 ratings with (a) symptomatic adverse events (AEs; measured by the PRO-CTCAE), and (b) functioning scores of EORTC QLQ-C30. The ability to detect change over time was examined by Cochrane-Mantel-Haenszel tests for GP5 ratings and PRO-CTCAE. The relationship of \"high side-effect burden\" categories with QLQ-C30 functioning scores was examined.</p><p><strong>Results: </strong>ICCs for the GP5 ratings after cycle 1 ranged between 0.80 and 0.85, indicating good reliability. Correlations between GP5 and PRO-CTCAE items ranged from 0.18 to 0.62 and ranged from -0.37 to -0.50 for QLQ-C30 functioning scores, consistent with study assumptions. Post-baseline GP5 ratings showed significant associations with PRO-CTCAE scores (p<0.001). Participants with GP5 ratings of 3 or 4 had worse physical function than those with GP5 ratings of 0 to 2 (p<0.0001).</p><p><strong>Conclusions: </strong>This analysis generated evidence supportive of the psychometric properties of the GP5 as a fit-for-purpose measure to assess treatment tolerability in patients with advanced/metastatic MTC. The definition of \"high side-effect burden\" was associated with the clinical feature of tolerability.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"149"},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review of condition-specific preference-based measures used in young people and their valuation methods. 对年轻人使用的基于特定条件的偏好措施及其评估方法进行系统审查。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-19 DOI: 10.1186/s41687-024-00826-5
William King, Lauren Hockley, Tomos Robinson, Angela Bate, Laura Ternent
{"title":"A systematic review of condition-specific preference-based measures used in young people and their valuation methods.","authors":"William King, Lauren Hockley, Tomos Robinson, Angela Bate, Laura Ternent","doi":"10.1186/s41687-024-00826-5","DOIUrl":"10.1186/s41687-024-00826-5","url":null,"abstract":"<p><strong>Background: </strong>Condition-specific health-related quality-of-life (HRQoL) instruments can be more responsive and sensitive to specific conditions and diseases than generic HRQoL instruments. This systematic review aims to identify the condition-specific preference-based instruments that have been used with young people and identify how preference values have been obtained for these instruments. This review will inform future researchers about the methods used to elicit utilities for condition-specific HRQoL instruments.</p><p><strong>Methods: </strong>A comprehensive search strategy was used to identify condition-specific HRQoL instruments used in young people and the methods used to value these instruments. Published medical and health economic databases were searched from January 1990-March 2022. Articles were deemed eligible for inclusion if a condition-specific preference-based instrument was used in young people (age < 18). Screening, data extraction and quality assessment were conducted independently by at least two reviewers.</p><p><strong>Results: </strong>After deduplication, a total of 4273 articles were eligible for title and abstract screening. Of these, 98 articles were eligible for full-text screening. After full-text screening, 18 articles were included in the review. Valuation studies were the most prevalent study design in the review (44%), followed by mapping studies (38%) and then other designs (18%). Among the valuation studies, the choice of HRQoL instrument, preference elicitation method, anchoring method and perspective varied considerably.</p><p><strong>Conclusion: </strong>To our knowledge, this review is the first to explore what condition-specific HRQoL instruments have been used in young people. Findings from this review could inform researchers in their choice of methods for measuring and valuing HRQoL. This review illustrates that to date there does not appear to be clear consensus of how to measure and value HRQoL in young people when using condition-specific instruments. The lack of consensus could be influenced by challenges identified in prior research such as limited guidance, ethical issues, and uncertain normative decisions regarding the choice of preference elicitation method. Ordinal methods such as discrete choice experiment and best-worst scaling appear to be preferable for use in this population.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"151"},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of eptinezumab on work productivity beyond reductions in monthly migraine days: post hoc analysis of the DELIVER trial. eptinezumab对工作效率的影响超出了每月偏头痛天数的减少:DELIVER试验的事后分析。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-18 DOI: 10.1186/s41687-024-00813-w
Piero Barbanti, Susanne F Awad, Heather Rae-Espinoza, Stephane A Regnier, Xin Ying Lee, Peter J Goadsby
{"title":"Impact of eptinezumab on work productivity beyond reductions in monthly migraine days: post hoc analysis of the DELIVER trial.","authors":"Piero Barbanti, Susanne F Awad, Heather Rae-Espinoza, Stephane A Regnier, Xin Ying Lee, Peter J Goadsby","doi":"10.1186/s41687-024-00813-w","DOIUrl":"10.1186/s41687-024-00813-w","url":null,"abstract":"<p><strong>Background: </strong>Eptinezumab's impact on self-reported work productivity in adults with migraine and 2‒4 prior preventive migraine treatment failures is not fully understood.</p><p><strong>Methodology: </strong>Electronic diaries captured monthly migraine days (MMDs) reported by patients enrolled in the randomized, double-blind, placebo-controlled DELIVER trial (NCT04418765). The migraine-specific Work Productivity and Activity Impairment questionnaire, administered at baseline and each monthly visit, was a secondary outcome of DELIVER and used to model changes from baseline in self-reported monthly hours of absenteeism (decreased work attendance) and presenteeism (reduced work efficiency while at work with a migraine) in Canada, as the base case. Path analysis illustrated eptinezumab's impact on work productivity beyond MMDs.</p><p><strong>Results: </strong>As MMDs increased, monthly hours of absenteeism increased linearly while those of presenteeism increased quadratically. Best-fit models were improved after including an eptinezumab treatment effect, showing benefit over placebo after controlling for MMD frequency. Compared to placebo, patients treated with eptinezumab (pooled) had a modeled reduction from baseline of 7.2 h/month (absenteeism) (95% CI: -9.9, -4.5; P < 0.001) and 21.4 h/month (presenteeism) (95% CI: -26.3, -16.5; P < 0.001) over weeks 1‒24. Beyond MMD reductions, improvements in patient-identified most bothersome symptom (PI-MBS) and reductions in percent of severe migraine attacks contributed to eptinezumab's effect.</p><p><strong>Conclusions: </strong>Eptinezumab decreased absenteeism and presenteeism based on patient reports, with data highlighting the importance of considering the PI-MBS. The greater change from baseline than placebo in self-reported absenteeism and presenteeism was only partly explained by changes in MMDs, presenting a potential opportunity to decrease the cost of migraine in the workplace.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (Identifier: NCT04418765); EudraCT (Identifier: 2019-004497-25).</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"146"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to deterioration of patient-reported outcome endpoints in cancer clinical trials: targeted literature review and best practice recommendations. 癌症临床试验中患者报告的结局终点恶化的时间:有针对性的文献回顾和最佳实践建议。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-18 DOI: 10.1186/s41687-024-00824-7
Kim Cocks, Bellinda L King-Kallimanis, Joel Sims, Gill Worthy, Julia Stein, Lara Ayala-Nunes, Monika Achra, Zhanglin Lin Cui, Nalin Payakachat
{"title":"Time to deterioration of patient-reported outcome endpoints in cancer clinical trials: targeted literature review and best practice recommendations.","authors":"Kim Cocks, Bellinda L King-Kallimanis, Joel Sims, Gill Worthy, Julia Stein, Lara Ayala-Nunes, Monika Achra, Zhanglin Lin Cui, Nalin Payakachat","doi":"10.1186/s41687-024-00824-7","DOIUrl":"10.1186/s41687-024-00824-7","url":null,"abstract":"<p><strong>Background: </strong>Time to deterioration (TTD) endpoints are often utilized in the analysis of patient-reported outcome (PRO) data in oncology clinical trials but different endpoint definitions and analysis frameworks exist that can impact result interpretation. This review examined the analysis, reporting and heterogeneity of TTD endpoints in the literature, the impact of analysis methods on results, and provides recommendations for future trials.</p><p><strong>Methods: </strong>A targeted literature review of articles published between 2017 and 2022 was performed to collate TTD endpoints reported in oncology randomized controlled trials (RCTs). Details of endpoints and results were extracted including; deterioration definition, PRO assessment schedule, methods for handling intercurrent events, statistical analysis methods, main trial results (overall survival and/or progression-free survival) and TTD endpoint results.</p><p><strong>Results: </strong>Seventy RCTs were included covering 849 individual TTD endpoints. There were 17 primary cancer types, with lung (26%), breast (11%), and prostate (7%) cancers the most common. Most trials (71%) were for people with advanced cancer. Full definitions of TTD endpoints were often missing. There were no clear trends for a specific TTD definition within cancer types or stages. However, statistical analysis methods were consistent among trials.</p><p><strong>Conclusion: </strong>The TTD definition can vary and is ultimately driven by the research question. Points to consider for successfully implementing PRO TTD endpoints in oncology include consideration of the trial setting (e.g., early vs. advanced cancer), expected treatment effect (e.g., improvement vs. worsening), likely adverse event profile (including early vs. delayed) and PRO data collection frequency in order to improve utility of these endpoints.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"150"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review of qualitative studies examining barriers and facilitators to orthopaedic surgeon engagement with patient-reported outcome measures data. 定性研究的系统性综述,探讨矫形外科医生参与患者报告结果测量数据的障碍和促进因素。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-18 DOI: 10.1186/s41687-024-00820-x
Emma L Heath, Ian A Harris, Lorena Romero, Ilana N Ackerman
{"title":"A systematic review of qualitative studies examining barriers and facilitators to orthopaedic surgeon engagement with patient-reported outcome measures data.","authors":"Emma L Heath, Ian A Harris, Lorena Romero, Ilana N Ackerman","doi":"10.1186/s41687-024-00820-x","DOIUrl":"10.1186/s41687-024-00820-x","url":null,"abstract":"<p><strong>Background: </strong>Orthopaedic surgeon engagement with patient-reported outcome measures (PROMs) data has not been comprehensively evaluated, despite increasing uptake of orthopaedic PROMs programmes globally. The aim of this review was to systematically identify, appraise and synthesise qualitative evidence on barriers and facilitators to orthopaedic surgeons' engagement with PROMs data and their use of these data to support clinical practice.</p><p><strong>Methods: </strong>Six databases (MEDLINE, EMBASE, COCHRANE CENTRAL, PSYCINFO, CINAHL and EMCARE) were searched from January 2000-March 2024 to identify potentially eligible qualitative studies. Established systematic review methods were used for screening and data extraction, applying PRISMA guidelines. Quality assessment was undertaken using the Joanna Briggs Institute tool for qualitative research.</p><p><strong>Results: </strong>Eight studies were eligible for inclusion; of these, five studies were qualitative and three studies were mixed-method designs incorporating a qualitative component. Three studies were specific to orthopaedic surgeons and the remaining five studies comprised of mixed samples of health professionals including orthopaedic surgeons. Only one study was classified as being of high methodological quality. Key barrier themes for orthopaedic surgeons were logistical issues, difficulty interpreting and understanding PROMs, and scepticism of the value of PROMs in clinical care. Key enabler themes included improvements to PROMs infrastructure, surgeon education around the potential value, uses and interpretation of PROMs data, aggregate reporting of PROMs data and early involvement of surgeons in the planning and development of PROM systems.</p><p><strong>Conclusion: </strong>While these studies highlight some practical considerations and opportunities that can be addressed through clinician education, there is little high-quality evidence on factors that influence orthopaedic surgeon engagement with PROMs data. Robust qualitative research is needed to better inform tailored support and assist surgeons in integrating PROMs data within orthopaedic care.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"144"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a standard set of key work-related outcomes for use in practice for patients with cardiovascular disease: a modified Delphi study. 开发一套标准的关键工作相关结果,用于心血管疾病患者的实践:一项修改的德尔菲研究。
IF 2.4
Journal of Patient-Reported Outcomes Pub Date : 2024-12-18 DOI: 10.1186/s41687-024-00825-6
Marije E Hagendijk, Nina Zipfel, Jan L Hoving, Marijke Melles, Philip J van der Wees, Sylvia J van der Burg-Vermeulen
{"title":"Development of a standard set of key work-related outcomes for use in practice for patients with cardiovascular disease: a modified Delphi study.","authors":"Marije E Hagendijk, Nina Zipfel, Jan L Hoving, Marijke Melles, Philip J van der Wees, Sylvia J van der Burg-Vermeulen","doi":"10.1186/s41687-024-00825-6","DOIUrl":"10.1186/s41687-024-00825-6","url":null,"abstract":"<p><strong>Background: </strong>To facilitate the maintenance or resumption of participation in work for patients with cardiovascular disease (CVD), there is a need for high-quality work-focused healthcare. According to the concept of value-based healthcare, quality of care can be enhanced by understanding the outcomes that matter most to patients. However, a major challenge in assessing quality of work-focused healthcare in practice is the lack of consensus on which work-related outcomes should be measured.</p><p><strong>Objective: </strong>The objective of this study was to identify a standard set of key work-related outcomes for patients with CVD to be used in practice of work-focused healthcare in the Netherlands, including standardised outcome measures and associated case mix factors. This standard set is intended to assist occupational and other health professionals in delivering work-focused healthcare that meets a patient's individual needs regarding work participation, and to enhance patients' engagement in their own work-focused care process.</p><p><strong>Methods: </strong>A 2-round RAND-modified Delphi process was conducted. The process included literature searches, consecutive research team meetings, and several meetings and rounds of voting by a working group. The working group consisted of patients with CVD (n = 6) and health professionals representing different stakeholders (n = 11) involved in work-focused healthcare for this patient population in the Netherlands. Consensus was reached over four phases: (1) establishing the scope of the standard set and defining the population, (2) prioritising and defining the outcome domains, (3) selecting the outcome measures for the most important domains, including clinical data and patient-reported data, and (4) selecting and defining case mix factors.</p><p><strong>Results: </strong>A 23-item patient-reported questionnaire was developed, called the Value@WORK-Q23, including questions on nine work-related outcome domains considered most important for patients with CVD: (1) work participation, (2) physical work ability, (3) mental work ability, (4) suitable work, (5) support from the work environment, (6) flexibility of the work environment, (7) communication with the patient, (8) person-centredness, and (9) interdisciplinary communication. In addition, nine case mix variables was selected, comprising demographic-, disease-, and work factors.</p><p><strong>Conclusions: </strong>The Value@WORK-Q23 provides guidance on measuring the most important work-related outcomes for patients with CVD. Using this work-related set in practice, in addition to existing disease-specific standard sets for CVD may facilitate the provision of high-value work-focused healthcare for this patient population.</p>","PeriodicalId":36660,"journal":{"name":"Journal of Patient-Reported Outcomes","volume":"8 1","pages":"147"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信