Defence Life Science Journal最新文献_第6页

Quantification of Mental and Physiological Workload Associated with two Specialised Military Running Events on Different Terrains 两种特殊地形军事跑步项目的心理和生理负荷量化

Defence Life Science Journal Pub Date : 2022-09-13 DOI: 10.14429/dlsj.7.17841

T. Chatterjee, D. Bhattacharyya, A. Yadav, K. Arya, R. Meena, M. Pal

{"title":"Quantification of Mental and Physiological Workload Associated with two Specialised Military Running Events on Different Terrains","authors":"T. Chatterjee, D. Bhattacharyya, A. Yadav, K. Arya, R. Meena, M. Pal","doi":"10.14429/dlsj.7.17841","DOIUrl":"https://doi.org/10.14429/dlsj.7.17841","url":null,"abstract":"Intense training regimes are practiced across military facilities to develop soldiers’ mental and physical abilities to meet the demands of modern-day warfare. Two short-duration military runs through the jungle and flat natural tracks were selected to quantify their mental and physiological workloads and explore track-specific differences. Two groups of healthy Indian soldiers (n=43 and 30; similar age, height, and weight) participated in time-bound 2.4 km runs on the jungle and flat natural tracks. Physiological variables, speed, and elevation with environmental parameters like temperature and humidity were recorded throughout the exercises. Subjective responses through NASA-TLX questionnaires were collected after the exercises. Mann-Whitney ‘U’ test was applied to find out the level of significance between groups.Physiological demands of runs on the jungle and flat natural track were similar (heart rate- 178.9 and 178.4 b/min; breathing rate- 42.0 and 46.6 breaths/min respectively; body temperature- 37.6℃ for both groups). The run on the jungle track needed a lower peak acceleration of 2.5 g (2.9 g on the flat track) and a higher variation in speed (4-16 knots). Participants expressed significantly high responses after the run on the jungle track. Run on the jungle track was physically intense, required adjustments in speed and acceleration to negotiate with the natural obstacles like uneven terrain and slippery surfaces. Besides this, environmental heat and higher humidity probably led to an increase in mental workload. The run on the flat natural track needed steady physical effort, fewer mechanical adjustments, and showed lower subjective responses.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43079331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Interplay between Vitamin D and Immunity can Aid Antitubercular Treatment Vitamin D in Immunomodulation of TB 维生素D与免疫的分子相互作用有助于抗结核治疗

Defence Life Science Journal Pub Date : 2022-09-13 DOI: 10.14429/dlsj.7.17566

Priya Das, A. Banerjee, Dr Prithviraj Karak

{"title":"Molecular Interplay between Vitamin D and Immunity can Aid Antitubercular Treatment Vitamin D in Immunomodulation of TB","authors":"Priya Das, A. Banerjee, Dr Prithviraj Karak","doi":"10.14429/dlsj.7.17566","DOIUrl":"https://doi.org/10.14429/dlsj.7.17566","url":null,"abstract":"Tuberculosis (TB) causes maximum mortality and morbidity worldwide. 25 per cent of the global population harbour Mycobacterium tuberculosis (Mtb) and therefore are at risk of developing active disease. Of late, the disseminated diseases of TB are on the increase. Nearly one-third of all TB infections can be classified as extrapulmonary-TB (EPTB). TB can spread to the bone, brain, intestine, peritoneum, genitourinary system, and female genital sites leading to problems of conception. Therefore undoubtedly, TB has turned out to be a tremendous public health problem globally. The emergence of drug-resistant bacteria calls for new anti-tuberculous drugs to enhance response to antimicrobial therapy for active TB. However, discoveries of very effective anti-TB new medicines have not materialised yet. Thus, nutritional anti-TB intervention is highly important. In the pre-antibiotic era, Vitamin D was used for the treatment of TB. Its active component 1,25-dihydroxy-vitamin D3 was shown to display anti-TB activity in vitro. Vitamin D deficient humans display greater susceptibility to TB. Vitamin D deficiency induces worse disease progression in TB cases as observed in many clinical trials. The efficacy of the addition of vitamin D supplements in TB treatment has also been estimated. Thus, by now, the role of vitamin D in TB prevention and treatment is well established. Knowledge of the molecular mechanism of vitamin D is crucially vital for new anti-TB drug design. This review article discusses the recent advancement regarding the molecular mechanism of vitamin D-related anti-TB action. Further elucidation of this area may help novel anti-TB drug development.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43731230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen rich Syngas by Steam gasification of Waste Lignocellulosic Biomass 废木质纤维素生物质蒸汽气化富氢合成气

Defence Life Science Journal Pub Date : 2022-09-13 DOI: 10.14429/dlsj.7.17575

Dr Lekha Charan Meher, Milan Bora, P. Joshi, Madhu Bala

{"title":"Hydrogen rich Syngas by Steam gasification of Waste Lignocellulosic Biomass","authors":"Dr Lekha Charan Meher, Milan Bora, P. Joshi, Madhu Bala","doi":"10.14429/dlsj.7.17575","DOIUrl":"https://doi.org/10.14429/dlsj.7.17575","url":null,"abstract":"The depleting petroleum reserve, as well as increasing demand for crude oil, has attracted the research interest for alternative sources of energy. The surplus lignocellulosic biomass such as forest residues, crop residues, and weeds may be a potential source to derive biofuel by the thermochemical route. Gasification is an established technology for the utilization of biomass to obtain producer gas containing mainly H2 and CO as combustibles. The air-blown biomass gasifiers are widely installed where the resulting producer gas contains 55-60 per cent nitrogen and a lower percentage of H2 and CO with an H2/CO ratio of less than one. Gasification of lignocellulosic biomass using steam as an oxidant produces syn-gas with a lower amount of nitrogen, a higher percentage of hydrogen, and H2/CO > 2.1. Steam as an oxidant favors water gas shift reaction with the formation of hydrogen and enhances the H2/CO ratio. The ratio of steam to biomass was 1.20-1.25 so the water gas shift reaction and steam reforming of methane occur. The percentage of hydrogen in the syngas obtained by gascification of pine needles, camelina straw and Lantana biomass was 56.8, 68.7, and 72.8 per cent respectively. The present article describes the steam gasification of pine needle biomass, crop residue from Camelina sativa, and biomass from weed i.e. Lantana camara to produce syngas with a higher H2/CO ratio along with a high calorific value compared to the one with air-blown gasification.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48329700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Antioxidant and Anti quorum Sensing Activity of Aegle marmelos Picrorrhiza kurroa and Swertia chirayita 金龟子（Aegle marmelos Picrorrhiza kurroa）和香梨（Swertia chirayita）抗氧化和抗群体感应活性的测定

Defence Life Science Journal Pub Date : 2022-09-13 DOI: 10.14429/dlsj.7.17890

Pramod Ananda Kamble, M. Phadke

{"title":"Determination of Antioxidant and Anti quorum Sensing Activity of Aegle marmelos Picrorrhiza kurroa and Swertia chirayita","authors":"Pramod Ananda Kamble, M. Phadke","doi":"10.14429/dlsj.7.17890","DOIUrl":"https://doi.org/10.14429/dlsj.7.17890","url":null,"abstract":"From the ancient period, humans have been fighting pathogenic microorganisms for survivalpurposes and in this context, man has developed antibiotics as a powerful weapon to treat various infections caused by pathogens. Nevertheless, the need to discover new antimicrobial agents is increasing at an alarming rate. This is because the microorganisms have developed various mechanisms to resist the action of antibiotics. One such mechanism is the production of biofilm. Infections caused by biofilm-forming pathogenic microorganisms are very difficult to treat, even using potent antibiotics. However, in folk medicine, many plants are found to be helpful to treat certain infectious diseases. This is because of the synthesis of a variety of bioactive compounds by plants with high medicinal value. Hence, in the present study, three different plants were used viz Aegle marmelos, Picrorrhiza kurroa, and Swertia chirayita to determine their antioxidant and anti-quorum sensing activities. According to the literature, antioxidants delay the oxidation process and nullify the effect of free radicals that cause damage and accelerate aging. Quorum sensing is the chemical way of communication between biofilm-forming microorganisms. Among the alcoholic extracts, the methanolic extract of P. kurroa showed the highest DPPH radical scavenging activity of 82.11%. All the plant extracts under investigation exhibited anti-quorum sensing activity against the standard culture of Chromobacterium violaceum MTCC 2656; however, the plant extracts of A. marmelos were found to be more potent as compared to P. kurroa and S. chirayita. Plant extracts P. kurroa and S. chirayita showed almost similar anti-quorum sensing activity. This confirms the pharmaceutical importance of plant materials of interest, which might prove to be useful to treat damage caused by free radicals and biofilm-related infections, after due consideration of clinical trials for safety issues.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48930272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin 3 Rutinoside Alleviates Chromosomes Instability Induced by Lethal Dose of Gamma Radiation 槲皮素- 3芦丁苷减轻γ辐射致死剂量诱导的染色体不稳定性

Defence Life Science Journal Pub Date : 2022-09-13 DOI: 10.14429/dlsj.7.17555

S. Verma

{"title":"Quercetin 3 Rutinoside Alleviates Chromosomes Instability Induced by Lethal Dose of Gamma Radiation","authors":"S. Verma","doi":"10.14429/dlsj.7.17555","DOIUrl":"https://doi.org/10.14429/dlsj.7.17555","url":null,"abstract":"Radiation-induced genomic instability always remains a major concern for the medical society, following radiation exposure. Hence, development of a safe and effective radioprotector is of considerable interest in case of radiotherapy and radiation emergencies. Quercetin-3-Rutinoside (Q-3-R), a naturally occurring bioflavonoid, has shown promising potential against radiation injuries. The present study reports anti-genotoxic potential of Q-3-R against lethal (9Gy) dose of ionizing radiation. The mice were injected intramuscularly with Q-3-R (10mg/kg b.wt.), 1hr prior to lethal dose of radiation and dissected at 24hrs post treatment. Different kinds of chromosomal aberrations, micronuclei as well as pulverized metaphase and polyploidy were scored in bone marrow cells. Irradiated mice showed significantly (p<0.001) increased number of double minutes, fragments, dicentrics, rings, gaps and end to end association. Pulverized metaphases and polyploidy were also found to be elevated in irradiated group. Pretreatment of Q-3-R significantly countered these radiation-induced genetic variations in lethally exposed mice. Data from the present study support the anti-genotoxic potential of Q-3-R even at lethal dose of radiation. Q-3-R, possessing various pharmacological activities and being a safe supplement for treatment of other ailments, can be further explored for its radioprotective potential.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48140068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Bone Adhesives with Potential Maxillofacial Applications A Systematic Review 具有潜在颌面应用前景的外科骨粘合剂系统评价

Defence Life Science Journal Pub Date : 2022-09-13 DOI: 10.14429/dlsj.7.17966

A. Bhandari, Vanshika Jain, K. Muktawat, Rashi Bhandari, Ranjan Gupta

{"title":"Surgical Bone Adhesives with Potential Maxillofacial Applications A Systematic Review","authors":"A. Bhandari, Vanshika Jain, K. Muktawat, Rashi Bhandari, Ranjan Gupta","doi":"10.14429/dlsj.7.17966","DOIUrl":"https://doi.org/10.14429/dlsj.7.17966","url":null,"abstract":"The reduction and stabilisation of fractured bone fragments have always been a challenging task for thesurgeon. A micro-platesystem for maxillofacial fracture treatment provides excellent results. However, plates and screws are difficult toadapt to the thin bone, and small fragments often lead to the weakening of bone causing secondary fractures. Surgical bone adhesives promise as a viable alternative for issues with micro-plates, but a lotremains desired for successful usefor clinical application. The present systematic review aims to identify the bone adhesive materials available at various stages in animal or human models in the last decade and enumerate their characteristics for potential use in non-load bearing maxillofacial fractures. PubMed electronic database searched using a combination of keywords to identify English language articles between January 2011 and December 2020 yielded a total of 1204 records, of which 15 were included for final review after applying PRISMA guidelines. Cyanoacrylate was the commonly used adhesive material followed by fibrin glue and calcium phosphate-based materials. Although encouraging, results with each material still lack human randomised control trials thus presenting inconclusive evidence. Studies on these lines are suggested along with the development of newer materials to overcome the shortcomings in the currently available systems.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41469598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical and Ultrastructural Studies for Toxicity of Kaempferol Derivative Recovered from the Plant Lysimachia Ramosa 从珍珠菜中提取山奈酚衍生物毒性的生化和超微结构研究

Defence Life Science Journal Pub Date : 2022-09-13 DOI: 10.14429/dlsj.7.17322

Ashish Sarkar, B. Roy

{"title":"Biochemical and Ultrastructural Studies for Toxicity of Kaempferol Derivative Recovered from the Plant Lysimachia Ramosa","authors":"Ashish Sarkar, B. Roy","doi":"10.14429/dlsj.7.17322","DOIUrl":"https://doi.org/10.14429/dlsj.7.17322","url":null,"abstract":"Leaves of Lysimachia ramosa are used by various tribes of Meghalaya to cure intestinal helminth infections. Preliminary investigations disclosed impressive anthelmintic effects of the kaempferol derivative, an active component of the plant, however, toxic effects on its consumers, if any, are not known. Therefore, the present study has been undertaken to investigate the acute and sub-acute toxic effects of kaempferol derivative, of the plant, taking Wistar rats as a model. Following OECD 407, 250 mg, 500 mg, and 1000 mg/kg body weight doses of the active component have been selected to treat the animals for 28 days. On the 29th day, the animals have been sacrificed to assess different toxicological effects on animals. The LD50 value of the anthelmintic component was found to be more than 5000 mg/kg body weight of rats. Histological, ultrastructural, haematological, biochemical, andorgano-somatic (HSI and RSI) studies demonstrate changes in surface characteristics of various cellular organelles of different vital organs such as the liver, kidney, and intestine. Alterations were also recorded in different vital enzymes such as AST, ALT, and ALP in the phytochemical exposed rats at higher doses. The results revealed that treatment with the active component at a higher concentration may lead to toxicological effects if treatment persists for a longer period.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49421738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Physicochemical Properties, Available Nutrients of Soil and their Correlation with Incidence of Telya Disease of Pomegranate at Northern Nasik, Maharashtra 马哈拉施特拉邦纳西克北部土壤理化性质、速效养分及其与石榴特尔雅病发病的相关性分析

Defence Life Science Journal Pub Date : 2022-09-13 DOI: 10.14429/dlsj.7.17675

K. Jain, A. Marwal, K. Sharma, N. Desai

{"title":"Analysis of Physicochemical Properties, Available Nutrients of Soil and their Correlation with Incidence of Telya Disease of Pomegranate at Northern Nasik, Maharashtra","authors":"K. Jain, A. Marwal, K. Sharma, N. Desai","doi":"10.14429/dlsj.7.17675","DOIUrl":"https://doi.org/10.14429/dlsj.7.17675","url":null,"abstract":"Maharashtra government reported 10,000 crore production loss of Pomegranate every year, due to the incidence of Telya disease. The present study was aimed to analyse the physical, chemical properties, and available micro-macronutrients in the soil of pomegranate orchards infected with Telya disease. Estimation of incidence and severity of disease was done on fifty selected orchards from different villages that were MangiTungi, Daswel, Dasane, Mulher, and Sompur. Results revealed that minimum incidence (58.66%) and severity (59.89%) were recorded in Sompur village whereas maximum incidence (74.40%) and severity (68.70%) were recorded in Daswel and MangiTungi village respectively. The pH (7.5-7.9) and free lime concentration 7.4-9.4%) were exceptionally very high for all test and control samples. Deficiency of essential macronutrients N (<150-250 Kg/ha) and K (<125-200 Kg/ha) was recorded in all test samples along with additional deficiency of Zn micronutrient (<1.0-2.0 ppm). In the case of mock orchards, all the parameters were in accordance with reference values.Statistical analysis of data declared that there was a significant difference among parameters of tested groups (P>0.05) while for control fields there were no significant differences (P<0.05). Further, a positive correlation between macro-micronutrients (Na, Ca, N, P, K, Mn) and incidence of disease was recorded which concludes that an imbalance in nutrients promotes growth of pathogens and increases susceptibility of plants to pathogenic attack. Further, balancing nutrients through fertilisers or foliar spray could be an effective strategy for an integrated pest management system.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45017132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC MS Based Comparative Phytochemical Profiling of Rhodiola Imbricata Roots Collected from Different High Mountain Passes of Ladakh India and a First Report of Apocynin from Genus Rhodiola 基于GC - MS的印度拉达克不同高山山口红景天根植物化学特征比较及红景天属罗布麻苷初报

Defence Life Science Journal Pub Date : 2022-06-17 DOI: 10.14429/dlsj.7.17313

Rajni Sharma, Raj Kumar, M. Thakur, M. Patel, O. Chaurasia, S. Saxena

{"title":"GC MS Based Comparative Phytochemical Profiling of Rhodiola Imbricata Roots Collected from Different High Mountain Passes of Ladakh India and a First Report of Apocynin from Genus Rhodiola","authors":"Rajni Sharma, Raj Kumar, M. Thakur, M. Patel, O. Chaurasia, S. Saxena","doi":"10.14429/dlsj.7.17313","DOIUrl":"https://doi.org/10.14429/dlsj.7.17313","url":null,"abstract":"Rhodiola imbricata is a high value medicinal plant of trans-Himalayan mountain passes in Ladakh. This plant is a highly sought after in national and international herbal product market due to its unique phytochemical composition and resultant medicinal properties. However, compositional variation in the raw material from different geographical locations results in variation in quality as well as efficacy of the final products. The current study was designed to generate the comparative GC-MS profiles of hydro-methanolic extracts of Rhodiola imbricata root samples collected from various locations in Ladakh i.e., Chang La (17605 ft), Khardung La (18,379 ft), and Shashi La (13908 ft) mountain passes. The study highlighted variations in volatile phytochemical composition in root samples collected from different locations, especially with respect to phenols, terpenes and fatty acids. Samples from Chang La had maximum amount of phenolic compounds (96.78 per cent), followed by samples from Khardung La (77.05 per cent) while they were undetected in samples from Shashi La pass. Specifically, comparative GC-MS profiling revealed that peak area percentage of two important bioactive compounds (i.e. piceol and apocynin) varied amongst samples. In the samples collected from Chang La, the piceol covered (94 per cent) and apocynin covered (2.78 per cent) peak area whereas in samples collected from Khardung La, piceol covered (73.8 per cent) and apocynin covered (3.25 per cent) peak areas respectively, however, samples collected from Shashi La showed none of these compounds. Interestingly, in the present study, apocynin (a potent NADPH oxidase inhibitor) is being reported for the first time from Rhodoila genus. On the basis of present findings, samples collected from Chang La and Khardung La passes showed better phytochemical composition of pharmacological active phenolic compounds than Shashi La sample.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45680267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbiome and COVID 19 Role of Probiotics on Gut Lung Axis 肠道微生物组和COVID-19益生菌在胃肠轴上的作用

Defence Life Science Journal Pub Date : 2022-06-17 DOI: 10.14429/dlsj.7.17786

M. Kumari, B. Bhushan, Dolly Sharma, L. Ganju, R. Varshney, R. Meena

{"title":"Gut Microbiome and COVID 19 Role of Probiotics on Gut Lung Axis","authors":"M. Kumari, B. Bhushan, Dolly Sharma, L. Ganju, R. Varshney, R. Meena","doi":"10.14429/dlsj.7.17786","DOIUrl":"https://doi.org/10.14429/dlsj.7.17786","url":null,"abstract":"Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has caused the greatest worldwide pandemic called Coronavirus-2019 (COVID-19) disease. The SARS-CoV-2 virus primarily attacks the respiratory tract, but it also disturbs the gastrointestinal system (GIT). The presence of the angiotensin-converting enzyme-2 (ACE-2) receptor in the intestinal epithelial cells, suggest the transmission of SARS-CoV-2 viruses from lungs to gut through systemic circulation. The virus detected in fecal samples of COVID-19 patients causes several gastrointestinal maladies including vomiting, diarrhea, and pain in abdomen. The gastrointestinal symptoms are associated with alterations in gut microbial composition, an increase in inflammatory cytokines and delayed virus clearance. Several studies demonstrated a decreased abundance of beneficial microbial species and increased opportunistic pathogens in the fecal samples of COVID-19 patients. The gut and lungs, share a bi-directional relationship called the “gut-lung axis” which is modulated by imbalanced gut microbiota. Since the gut microbes are suggested to play a vital role in health and disease by maintaining homeostasis of the immune system, therefore targeting the intestinal dysbiosis with beneficial microbial species, seems plausible to eventually diminish the effects of pulmonary infections and diseases. In this review, we have summarized studies demonstrating the gut-lung axis in association with gut dysbiosis in COVID-19 patients. In addition, the review also highlights the studies showing the potential role of probiotic supplementation in the amelioration of various respiratory infections and diseases. Data demonstrate that the restoration of gut microbial communities by probiotic supplementation can enhance lung capacity to combat respiratory viral infections including SARS-CoV-2.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44383147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0