Translational Medicine of Aging最新文献_第5页

The regulation of healthspan and lifespan by dietary amino acids 膳食氨基酸对健康寿命的调节作用

Translational Medicine of Aging Pub Date : 2021-01-01 DOI: 10.1016/j.tma.2021.05.001

Reji Babygirija , Dudley W. Lamming

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引用次数: 15

The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate 以硫酸铜为例，探讨金属硫蛋白在幼龄和老年动物对有毒化合物的抗性形成层次机制中的作用

Translational Medicine of Aging Pub Date : 2021-01-01 DOI: 10.1016/j.tma.2021.11.001

Anatoly I. Bozhkov , Vadim I. Sidorov , Omar K. Alboqai , Rustam A. Akzhyhitov , Natalia I. Kurguzova , Anatoly B. Malyshev , Mohammad Ali Yousef Albegai , Taras Yu. Gromovoi

{"title":"The role of metallothioneins in the formation of hierarchical mechanisms of resistance to toxic compounds in young and old animals on the example of copper sulfate","authors":"Anatoly I. Bozhkov , Vadim I. Sidorov , Omar K. Alboqai , Rustam A. Akzhyhitov , Natalia I. Kurguzova , Anatoly B. Malyshev , Mohammad Ali Yousef Albegai , Taras Yu. Gromovoi","doi":"10.1016/j.tma.2021.11.001","DOIUrl":"10.1016/j.tma.2021.11.001","url":null,"abstract":"<div><p>We used classical methods of biochemistry, chromolithography, atomic adsorption spectrometry for the determination of copper ions and MALDI-TOF mass spectrometry for the determination of metallothioneins. We have found sequential administration of small doses of copper sulfate provided the formation of resistance to subsequent lethal doses of copper sulfate. Age-dependent differences in the adaptive response match with the difference in the metallothioneins content in liver cells. In this case of adaptation formation, there was not only an increase in metallothioneins, but also a change in the intracellular distribution of copper ions. We revealed that a multiple increase in copper ions in mitochondria and endoplasmic reticulum of liver cells was accompanied by a slight decrease in the activity of antioxidant enzymes included in their composition. It has been suggested that metallothioneins are involved not only in the accumulation and retention of copper ions, but also in active inter-protein swap. Age-dependent differences in resistance, adaptability and long-term effects of copper ions are due to differences in the metabolic systems of copper metabolism before the toxic doses administration of copper sulfate, i.e. difference in initial states.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"5 ","pages":"Pages 62-74"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468501121000067/pdfft?md5=24dba3bf5c45a3eb795339b024e7372e&pid=1-s2.0-S2468501121000067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41911479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The microbiome: an emerging key player in aging and longevity. 微生物群:在衰老和长寿中一个新兴的关键角色。

Translational Medicine of Aging Pub Date : 2020-01-01 Epub Date: 2020-07-21

Minhoo Kim, Bérénice A Benayoun

{"title":"The microbiome: an emerging key player in aging and longevity.","authors":"Minhoo Kim, Bérénice A Benayoun","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Revolutionary advancements of high-throughput sequencing and metagenomic tools have provided new insights to microbiome function, including a bidirectional relationship between the microbiome and host aging. The intestinal tract is the largest surface in the human body that directly interacts with foreign antigens - it is covered with extremely complex and diverse community of microorganisms, known as the gut microbiome. In a healthy gut, microbial communities maintain a homeostatic metabolism and reside within the host in a state of immune tolerance. Abnormal shifts in the gut microbiome, however, have been implicated in the pathogenesis of age-related chronic diseases, including obesity, cardiovascular diseases and neurodegenerative diseases. The gut microbiome is emerging as a key factor in the aging process. In this review, we describe studies of humans and model organisms that suggest a direct causal role of the gut microbiome on host aging. Additionally, we also discuss sex-dimorphism in the gut microbiome and its possible roles in age-related sex-dimorphic phenotypes. We also provide an overview of widely used microbiome analysis methods and tools which could be used to explore the impact of microbiome remodeling on aging.</p>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"4 ","pages":"103-116"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437988/pdf/nihms-1613770.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38295522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The eroding chromatin landscape of aging stem cells 老化干细胞的染色质侵蚀景观

Translational Medicine of Aging Pub Date : 2020-01-01 DOI: 10.1016/j.tma.2020.08.002

Changyou Shi , Lin Wang , Payel Sen

引用次数: 8

High-throughput chromatin screens to identify targets of senescence and aging 高通量染色质筛选，以确定衰老和衰老的目标

Translational Medicine of Aging Pub Date : 2020-01-01 DOI: 10.1016/j.tma.2020.06.002

Payel Sen

引用次数: 1

Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases 秀丽隐杆线虫作为研究衰老相关神经退行性疾病的模型系统

Translational Medicine of Aging Pub Date : 2020-01-01 DOI: 10.1016/j.tma.2020.05.001

Kate M. Van Pelt , Matthias C. Truttmann

{"title":"Caenorhabditis elegans as a model system for studying aging-associated neurodegenerative diseases","authors":"Kate M. Van Pelt , Matthias C. Truttmann","doi":"10.1016/j.tma.2020.05.001","DOIUrl":"10.1016/j.tma.2020.05.001","url":null,"abstract":"<div><p>Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated disorders characterized by the disruption of cellular proteostasis machinery and the misfolding of distinct protein species to form toxic aggregates in neurons. The increasing prevalence of NDs represents a growing healthcare burden worldwide, a concern compounded by the fact that few, if any, treatments exist to target the underlying cause of these diseases. Consequently, the application of a high-throughput, physiologically relevant model system to studies dissecting the molecular mechanisms governing ND pathology is crucial for identifying novel avenues for the development of targeted therapeutics. The nematode <em>Caenorhabditis elegans</em> (<em>C. elegans</em>) has emerged as a powerful tool for the study of disease mechanisms due to its ease of genetic manipulation and swift cultivation, while providing a whole-animal system amendable to numerous molecular and biochemical techniques. To date, numerous <em>C. elegans</em> models have been generated for a variety of NDs, allowing for the large-scale <em>in vivo</em> study of protein-conformation disorders. Furthermore, the comparatively low barriers to entry in the development of transgenic worm models have facilitated the modeling of rare or “orphan” NDs, thereby providing unparalleled insight into the shared mechanisms underlying these pathologies. In this review, we summarize findings from a comprehensive collection of <em>C. elegans</em> neurodegenerative disease models of varying prevalence to emphasize shared mechanisms of proteotoxicity, and highlight the utility of these models in elucidating the molecular basis of ND pathologies.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"4 ","pages":"Pages 60-72"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2020.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39259843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

The microbiome: An emerging key player in aging and longevity 微生物群:在衰老和长寿中一个新兴的关键角色

Translational Medicine of Aging Pub Date : 2020-01-01 DOI: 10.1016/j.tma.2020.07.004

Minhoo Kim , Bérénice A. Benayoun

{"title":"The microbiome: An emerging key player in aging and longevity","authors":"Minhoo Kim , Bérénice A. Benayoun","doi":"10.1016/j.tma.2020.07.004","DOIUrl":"10.1016/j.tma.2020.07.004","url":null,"abstract":"<div><p>Revolutionary advancements of high-throughput sequencing and metagenomic tools have provided new insights to microbiome function, including a bidirectional relationship between the microbiome and host aging. The intestinal tract is the largest surface in the human body that directly interacts with foreign antigens – it is covered with extremely complex and diverse community of microorganisms, known as the gut microbiome. In a healthy gut, microbial communities maintain a homeostatic metabolism and reside within the host in a state of immune tolerance. Abnormal shifts in the gut microbiome, however, have been implicated in the pathogenesis of age-related chronic diseases, including obesity, cardiovascular diseases and neurodegenerative diseases. The gut microbiome is emerging as a key factor in the aging process. In this review, we describe studies of humans and model organisms that suggest a direct causal role of the gut microbiome on host aging. Additionally, we discuss sex-dimorphism in the gut microbiome and its possible roles in age-related sex-dimorphic phenotypes. We also provide an overview of widely used microbiome analysis methods and tools which could be used to explore the impact of microbiome remodeling on aging.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"4 ","pages":"Pages 103-116"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2020.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial RTB101与老年人免疫功能:一项不成功临床试验的解释

Translational Medicine of Aging Pub Date : 2020-01-01 DOI: 10.1016/j.tma.2020.01.002

Matt Kaeberlein

{"title":"RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial","authors":"Matt Kaeberlein","doi":"10.1016/j.tma.2020.01.002","DOIUrl":"10.1016/j.tma.2020.01.002","url":null,"abstract":"<div><p>The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly. The company reported that the first stage of the PROTECTOR1 trial did not meet its primary endpoint for reducing clinically symptomatic respiratory illness in healthy older adults. Although RTB101 has been described as an inhibitor of the mechanistic target of rapamycin (mTOR), the PROTECTOR1 trial was not a test of the geroscience hypothesis. Unlike the geroprotective compound rapamycin, RTB101 has not been found to increase lifespan or delay age-related functional or molecular phenotypes in pre-clinical animal models. RTB101 was first developed as an inhibitor of phosphoinositide-3-kinase (PI3K) with secondary inhibitory effects on mTOR. It’s ATP-competitive mechanism of action is distinct from the allosteric inhibition by rapamycin and does not specifically target mTOR complex 1 over mTOR complex 2. Clinical development of rapamycin and other specific mTOR complex 1 inhibitors to target age-related indications continues to be robust, and there is growing momentum for translational geroscience, with numerous clinical trials planned or ongoing in this area.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"4 ","pages":"Pages 32-34"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2020.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55175728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae 酿酒酵母菌繁殖衰老定量生物学研究进展

Translational Medicine of Aging Pub Date : 2020-01-01 DOI: 10.1016/j.tma.2019.09.002

Richard O'Laughlin , Meng Jin , Yang Li , Lorraine Pillus , Lev S. Tsimring , Jeff Hasty , Nan Hao

{"title":"Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae","authors":"Richard O'Laughlin , Meng Jin , Yang Li , Lorraine Pillus , Lev S. Tsimring , Jeff Hasty , Nan Hao","doi":"10.1016/j.tma.2019.09.002","DOIUrl":"https://doi.org/10.1016/j.tma.2019.09.002","url":null,"abstract":"<div><p>Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb to the deteriorating effects of aging, so too comes a host of age-related ailments such as neurodegenerative disorders, cardiovascular disease and cancer. Therefore, elucidation of the molecular networks that drive aging is of paramount importance to human health. Progress toward this goal has been aided by studies from simple model organisms such as <em>Saccharomyces cerevisiae</em>. While work in budding yeast has already revealed much about the basic biology of aging as well as a number of evolutionarily conserved pathways involved in this process, recent technological advances are poised to greatly expand our knowledge of aging in this simple eukaryote. Here, we review the latest developments in microfluidics, single-cell analysis and high-throughput technologies for studying single-cell replicative aging in <em>S. cerevisiae</em>. We detail the challenges each of these methods addresses as well as the unique insights into aging that each has provided. We conclude with a discussion of potential future applications of these techniques as well as the importance of single-cell dynamics and quantitative biology approaches for understanding cell aging.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"4 ","pages":"Pages 151-160"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2019.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91706029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Maintaining a scientific community while social distancing 在保持社会距离的同时保持科学共同体

Translational Medicine of Aging Pub Date : 2020-01-01 DOI: 10.1016/j.tma.2020.05.002

Dudley W. Lamming , Christy S. Carter

{"title":"Maintaining a scientific community while social distancing","authors":"Dudley W. Lamming , Christy S. Carter","doi":"10.1016/j.tma.2020.05.002","DOIUrl":"10.1016/j.tma.2020.05.002","url":null,"abstract":"<div><p>The “Aging Science Talks: Science for the Community” daily online seminar series was established in reaction to the cancellation of a myriad of regional, national, and international meetings focused on the biology of aging due to the COVID-19 pandemic. The inability to attend scientific meetings has far-reaching implications for our field, as we lose the ability to 1) disseminate both published and non-published data through talks and posters; 2) network and establish new collaborations to produce innovative science in the aging field; and 3) continue the career development of early career researchers (ECRs). Through these virtual seminars, we hope to offset the negative effects of these canceled meetings. We established the program rapidly using a “lean” approach, making use of existing technologies broadly available at academic institutions. Here, we provide an initial description of how this program was developed and implemented. We discuss advantages and limitations of this approach, including “real-time” participation and the creation of an on/off-line community of inquiry (CoI). In the future, we hope to formally evaluate the success of this program in building engagement, creating a community, and enhancing the development of ECRs, and to capture metrics associated with the continued progress of science. Our approach to building a CoI may be applied across multiple scientific disciplines during this time of uncertainty, and may offer a valuable example of how to continue to advance science during pandemics or similar events.</p></div>","PeriodicalId":36555,"journal":{"name":"Translational Medicine of Aging","volume":"4 ","pages":"Pages 55-59"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tma.2020.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38295736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9