BANTAO Journal最新文献

{"title":"Factors that Influence Graft Function at 1-Year Posttransplantation and Correlation with Baseline Donated Kidney Function Measured with Radioisotopes","authors":"Irena Rambabova- Bushljetik, Jelka Masin Spasovska, G. Selim, Olivera Stojceva Taneva, O. Stankov, S. Stavridis, S. Saidi, M. Penev, S. Dohcev, T. Balkanov, G. Spasovski","doi":"10.1515/bj-2016-0006","DOIUrl":"https://doi.org/10.1515/bj-2016-0006","url":null,"abstract":"Abstract Introduction. Assessment of renal function is a crucial component of donor evaluation. The higher measured donor GFR is independently associated with a better allograft outcomes in living donor kidney transplantation (LDKT). Monitoring graft function and estimation of GFR is a recommended method for patients’ follow-up in posttransplantation period. The aim of our study was to investigate the correlation of directly measured GFR of donated kidney with estimated GFR through creatininebased formulas and to detect impact factors on the graft function at 12 months posttransplantation. Methods. Fifty LDKT patients (related and nonrelated donors) with stable renal function in a period of 12 months after transplantation were included in our study. The mean recipient age was 30.7±9.6 years, and donor age 55.45±9.41 years. The mean directly measured donated kidney GFR was 47.61±5.72 ml/min. Graft function was estimated at 3, 6 and 12 months by 3 formulas: Cockcroft- Gault (C-G), MDRD 6 variables and Nankivell. Direct correlation of estimated with measured radiolabeled 99mTc DTPA GFR was performed. Various impact factors such as donor age, dialysis vintage and different calcineurin inhibitors as a part of immunosupression were evaluated. Results. Estimated GFR at 12 months with MDRD, Cockroft Gault, and Nankivell formulas was 72.65±22.6, 94.25±36.42, and 81.78±17.89 ml/min, respectively. The highest estimated GFR was obtained with C-G formula at all three time points. The estimated allograft GFR did not correlate with directly measured GFR of donated kidney. Donor age well correlated with the graft function at 12 months. Allografts from standard criteria donors-SCD (<60 years) had better function than allografts form expanded criteria donors-ECD (>60 years). The highest GFR was estimated with C-G equation (106.08±39.26 ml/min), while GFR estimated with Nankivell was 86.86±15.30 ml/min, and with MDRD 79.67±20.28 ml/min, presenting patients in stage 2 of chronic kidney disease. Duration of hemodialysis treatment under 24 months showed better graft function estimated by C-G at 12 months (102.23±38.86 ml/min), compared to that above 24 months of HD (77.84±18.11 ml/ min). Different type of calcineurin inhibitors did not influence on the graft function at any time point. Conclusion. Creatinine-based formulas for estimation of the graft function did not correlate with directly measured function of the donated kidney with radiolabeled isotopes, nor between each other. Hence, the monitoring of the graft function should be done by a single formula in the posttransplantation period. Expectedly, a better graft function was observed in young donors (standard criteria) and in patients with shorter hemodialysis treatment.","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"377 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132603321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bardet Biedel Syndrome: a Rare Cause of Chronic Kidney Disease","authors":"T. D. Yıldırım, Mehmet Can Uğur, U. Soyaltin, H. Akar","doi":"10.1515/bj-2016-0009","DOIUrl":"https://doi.org/10.1515/bj-2016-0009","url":null,"abstract":"Abstract Bardet Biedl syndrome (BBS) is characterized by obesity, retinitis pigmentosa, hypogonadism, mental retardation and polydactyly. Additionally, renal, cardiac and neurological manifestations may be seen. We report a case of BBS with chronic kidney disease (CKD) at the age of 43.","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"188 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127742129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA in kidney disease","authors":"I. Prkačin, G. Cavrić, N. Bašić-Jukić","doi":"10.1515/bj-2016-0002","DOIUrl":"https://doi.org/10.1515/bj-2016-0002","url":null,"abstract":"Abstract Clinical and laboratory findings of kidney disease in an adult may find an explanation in kidney functional and/or structural abnormalities that already existed during infancy and childhood, but that may have been missed or underdiagnosed. All the cardiovascular abnormalities that occur in adults with chronic kidney disease are also present in children with chronic kidney disease. Complications in childhood chronic kidney disease will have consequences well beyond pediatric age and influence outcomes of affected young adults with disease. Kidney dysfunction appears early in the course of kidney disease and has been observed in children and adults with chronic kidney disease, condition characterised with kidney fibrosis. Transforming growth factor beta is recognized as a major mediator of kidney fibrosis. New evidence illustrates the relationship between transforming growth factor beta signaling and microRNAs expression during kidney diseases development. MicroRNAs play important roles in kidney development and kidney diseases; they are naturally occurring, 22-nucleotide, noncoding RNAs that mediate posttranscriptional gene regulation. Dysregulation of miRNA expression is an indicator of several diseases including chronic kidney disease. Targeting microRNAs should be a therapeutic potential to ameliorate the disease related to fibrosis. The discovery that circulating miRNAs are detectable in serum and plasma, and that their expression varies as a result of disease, presents great potential to be used as biomarkers in kidney disease prevention and diagnosis.","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123910737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Extremely High Level of Creatinine in Non-dialysed Female Patient","authors":"M. Vučković, I. Prkačin, G. Cavrić, M. Zeljko","doi":"10.1515/bj-2016-0013","DOIUrl":"https://doi.org/10.1515/bj-2016-0013","url":null,"abstract":"There are only a few published studies confirming the ability of either urea or creatinine to induce adverse biochemical and physiological effects and there is not a defined level of serum creatinine that is lethal itself. Given the fact that by consulting the literature we did not find the highest level of creatinine in a surviving patient published in Croatia, we want to present the highest recorded level in our practice and probably in Croatia. A sixty-two year old woman presented to the Merkur Clinical Hospital Emergency Department in Zagreb with the serum creatinine 2316 μmol/L (26.2 mg/dl) and a one week history of uremic symptoms. Her previous medical history was negative; she has not been taking any medications. Renal failure in this patient occurred due to bilateral hydronephrosis developed as the result of advanced cervical malignancy and was accompanied by severe microcytic anemia (hemoglobin 35 g/l, hematocrit 0.120, MCV 71.4 fL), compensated metabolic acidosis (arterial pH 7.230) and hyperkalemia (serum potassium 6.4 mmol/l). An acute hemodialysis was made on the day of admission. About one month later at the time of the discharge the serum creatinine was 490 μmol/L. During hospitalization the patient was conscious, oriented and cardiorespiratory compensated. Creatinine is the endogenous marker most commonly used to measure kidney function [1]. The proximal tubules secrete creatinine, which accounts for 10-20% of the excreted load [2]. The normal reference range for serum creatinine is 0.7 to 1.3 mg/dL (62-115 umol/L) for men and 0.6 to 1.1 mg/dL (53-97 umol/L) for women [3]. Progressive obstructive uropathy may lead to uremia, electrolyte imbalances and persistent urinary tract infections, if obstruction is not bypassed [4], as we report in this case. Although it is a marker of uremic toxicity, the actual effect of creatinine on homeostasis in humans is unresolved [3]. One of the most disabling features of kidney failure is encephalopathy that is caused by the accumulation of uremic toxins [5]. The patient we report on presented the highest creatinine level (2316 μmol/L) we experienced in our twenty-eight years long practice and presented with symptoms of uremia including nausea, vomiting, fatigue and slowed cognitive functions. Searching through literature and available data we could not find written evidence on the highest creatinine level in practice in Croatia in non-dialysed patients. A literature search indicates that the surviving uremic male patient (BMI 28) with creatinine 53 mg/dl (4685.2μmol/L) reported by A.C. Storm et al. in Open Journal of Nephrology (2013) could be the highest creatinine in the literature [3]. A renal failure and increased creatinine level in the patient we reported occurred due to bilateral hydronephrosis that had been developed due to advanced stage of cervical carcinoma. The finding of ureteral obstruction due to malignancy carries a poor prognosis with a resulting median survival of 3 to 7 months,","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121216507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BANTAO Association - from Foundation to Present and Future Perspectives","authors":"N. Dimkovic, M. Arıcı, D. Goumenos, N. Jukić, L. Djukanović, M. Polenaković, G. Spasovski","doi":"10.1515/BJ-2015-0012","DOIUrl":"https://doi.org/10.1515/BJ-2015-0012","url":null,"abstract":"1 Clinical Department for Renal Diseases, Zvezdara University Medical Center, Belgrade, Serbia, 2 Unit of Nephrology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey, 3 Department of Nephrology and Renal Transplantation, University Hospital of Patras, Greece, 4 School of Medicine University of Zagreb, University Hospital Centre Zagreb, Zagreb, Croatia 5 Macedonian Academy of Sciences and Arts; 3 University Department of Nephrology, University \"Ss Cyril and Methodius\" Medical Faculty, Skopje, Republic of Macedonia","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127187772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Cleft Detected by Transthoracic Echocardiography in a Patient with Autosomal Dominant Polycystic Kidney Disease","authors":"G. Gok, I. Ilhan, Ibrahim Beydili, T. Guvenc, A. Kaya, K. Mağden","doi":"10.1515/bj-2015-0018","DOIUrl":"https://doi.org/10.1515/bj-2015-0018","url":null,"abstract":"Abstract Recently, the presence of left ventricular clefts has been identified frequently with the advancement of cardiac imaging modalities such as cardiac magnetic resonance imaging and computed tomography. Here we report a rare case of left ventricular cleft that was incidentally diagnosed with the ECG changes that imitated the presence of LMCA stenosis and diagnosed by transthoracic echocardiography in a patient with autosomal dominant polycytic kidney disease.","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130907628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcified Double J Stent after Sequential Liver and Renal Transplantation Associated to Primary Oxalosis: Case Report","authors":"A. Si̇nangi̇l, V. Çelik, S. Barlas, F. Altunrende, E. B. Akin, T. Ecder","doi":"10.1515/bj-2015-0022","DOIUrl":"https://doi.org/10.1515/bj-2015-0022","url":null,"abstract":"Abstract Hyperoxaluria type I (HPI) is a metabolic disorder secondary to liver alanine glyoxylate aminotransferase deficiency. Renal failure occurs due to the excessive production and precipitation of oxalate in the kidney. Combined liver-renal transplantation is the correct treatment for this condition when end-stage renal failure occurs since in renal transplantation alone the risk of recurrence of the same pathology in the transplanted kidney would be high. We determined the calcification surrounding the double J stent inserted to the transplant ureter in a short time in a 22-year-old patient who underwent sequential liver and renal transplantation with the diagnoses of oxalosis. In the literature we have not found papers on calcification of double J stent following combined or sequential transplantation. Although after the sequential transplantation the calcification, nephrocalcinosis, and renal stones were practically not of great concern, these patients should be followed up more carefully in terms of stent calcification during the early post-transplant period.","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117305163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Renal Injury: Similarities and Differences Between Glomerular Diseases and Transplantation","authors":"S. Marinaki, J. Boletis","doi":"10.1515/bj-2015-0013","DOIUrl":"https://doi.org/10.1515/bj-2015-0013","url":null,"abstract":"Abstract Glomerular diseases and renal transplantation are the main fields in nephrology in which the immune system plays a prevalent role. They have for long been considered as independent conditions due to the prominent role of autoimmunity in glomerular diseases and of alloimmunity in renal transplantation. Moreover, histologic features differ between glomerular diseases and transplantation: in glomerular diseases, histologic damage involves primarily the glomeruli and secondarily the tubulointerstitium and small vessels, whereas in transplantation, allograft injury comprises primarily the tubulointerstitium and vessels and to a lesser degree the glomeruli. However, recent research has shown that the pathogenetic mechanisms in both conditions share common pathways and that there is cross-reaction between innate and adaptive immunity as well as between auto- and alloimmunity [1].","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123585252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Amyloidosis Presenting with Nephrotic Syndrome and Atypical Intrahepatic Cholestasis: Report of 2 Cases","authors":"U. İlgen, Z. Çelebi, G. Kaygusuz, S. Kutlay, G. Nergizoğlu, K. Ateş","doi":"10.1515/bj-2015-0020","DOIUrl":"https://doi.org/10.1515/bj-2015-0020","url":null,"abstract":"Abstract Liver is one of the most commonly involved organs in both primary and secondary systemic amyloidoses, but hepatic amyloidosis, manifested as mild to moderate enlargement, is usually not symptomatic nor it is clinically problematic. Rarely, massive hepatomegaly, severe cholestatic hepatitis or liver failure may be encountered in patients with systemic amyloidosis. Two cases with lambda light-chain amyloidosis presenting with nephrotic syndrome and atypical intrahepatic cholestasis are discussed with clinical features, laboratory and kidney, liver and bone marrow biopsy findings in view of the relevant literature.","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131112005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Acute Peritonitis after Gynecological Procedure in a Peritoneal Dialysis Patient","authors":"D. Klarić","doi":"10.1515/bj-2015-0010","DOIUrl":"https://doi.org/10.1515/bj-2015-0010","url":null,"abstract":"Abstract Although the majority of peritonitis cases in peritoneal (PD) dialysis patients are caused by gram-positive cocci, streptococcus agalactiae, a gram-positive group B β haemoliticus streptococcus, may rarely be found in this group of patients. We present a case of acute peritonitis caused by streptococcus agalactiae with bacteriemia and septic shock occurring after a curettage indicated because of gynecologic bleeding. The patient did not receive antimicrobial prophylaxis since the gynecologist considered this case as a \"routine\" procedure without the need to administer antibiotics. Our case demonstrate that small procedures may cause great problems and therefore one should always give priority to individual approach regardless of the protocol for \"routine\" surgery, especially if there are no indications for the emergency procedure","PeriodicalId":365549,"journal":{"name":"BANTAO Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125525749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}