Neuroscience Insights最新文献_第3页

Amygdala fMRI-A Critical Appraisal of the Extant Literature. 杏仁核 fMRI--对现有文献的批判性评估。

IF 2.9

Neuroscience Insights Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241270591

Tim Varkevisser, Elbert Geuze, Jack van Honk

{"title":"Amygdala fMRI-A Critical Appraisal of the Extant Literature.","authors":"Tim Varkevisser, Elbert Geuze, Jack van Honk","doi":"10.1177/26331055241270591","DOIUrl":"10.1177/26331055241270591","url":null,"abstract":"Even before the advent of fMRI, the amygdala occupied a central space in the affective neurosciences. Yet this amygdala-centred view on emotion processing gained even wider acceptance after the inception of fMRI in the early 1990s, a landmark that triggered a goldrush of fMRI studies targeting the amygdala in vivo. Initially, this amygdala fMRI research was mostly confined to task-activation studies measuring the magnitude of the amygdala's response to emotional stimuli. Later, interest began to shift more towards the study of the amygdala's resting-state functional connectivity and task-based psychophysiological interactions. Later still, the test-retest reliability of amygdala fMRI came under closer scrutiny, while at the same time, amygdala-based real-time fMRI neurofeedback gained widespread popularity. Each of these major subdomains of amygdala fMRI research has left its marks on the field of affective neuroscience at large. The purpose of this review is to provide a critical assessment of this literature. By integrating the insights garnered by these research branches, we aim to answer the question: What part (if any) can amygdala fMRI still play within the current landscape of affective neuroscience? Our findings show that serious questions can be raised with regard to both the reliability and validity of amygdala fMRI. These conclusions force us to cast doubt on the continued viability of amygdala fMRI as a core pilar of the affective neurosciences.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241270591"},"PeriodicalIF":2.9,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative Association of Cognitive Performance With Blood Serum Neurotoxicity and Its Modulation by Human Herpes Virus 5 (HHV5) Seropositivity in Healthy Women. 健康女性认知能力与血清神经毒性的负相关以及人类疱疹病毒 5 (HHV5) 血清阳性对其的调节作用

IF 3.6

Neuroscience Insights Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241258436

Lisa M James, Effie-Photini Tsilibary, Erik J Wanberg, Apostolos P Georgopoulos

{"title":"Negative Association of Cognitive Performance With Blood Serum Neurotoxicity and Its Modulation by Human Herpes Virus 5 (HHV5) Seropositivity in Healthy Women.","authors":"Lisa M James, Effie-Photini Tsilibary, Erik J Wanberg, Apostolos P Georgopoulos","doi":"10.1177/26331055241258436","DOIUrl":"10.1177/26331055241258436","url":null,"abstract":"Identification of early influences on cognitive decline is of paramount importance in order to stem the impacts of decrements in cognitive functioning and to potentially intervene. Thus, here we focused on 132 healthy adult women (age range 26-98 years) to (a) determine whether factors circulating in serum may exert neurotoxic effects in vitro, (b) evaluate associations between serum neurotoxicity and cognitive performance, and (c) assess the influence of human herpes virus (HHV) seroprevalence and other factors on apoptosis and cognitive performance. The results documented that the addition of serum from healthy adult women to neural cell cultures resulted in apoptosis, indicating the presence of circulating neurotoxic factors in the serum. Furthermore, apoptosis increased with age, and was associated with decreased cognitive performance. Stepwise regression evaluating the influence of 6 HHVs on apoptosis and cognitive function revealed that only HHV5 (cytomegalovirus; CMV) seropositivity was significantly associated with apoptosis and cognitive decline, controlling for age. These findings document neurotoxic effects of serum from healthy women across the adult lifespan and suggest a unique detrimental influence associated with CMV seropositivity.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241258436"},"PeriodicalIF":3.6,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Mesocortical System Encodes the Strength of Subsequent Force Generation. 中皮层系统编码后续力量产生的强度

IF 3.6

Neuroscience Insights Pub Date : 2024-05-30 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241256948

Sho K Sugawara, Yukio Nishimura

{"title":"The Mesocortical System Encodes the Strength of Subsequent Force Generation.","authors":"Sho K Sugawara, Yukio Nishimura","doi":"10.1177/26331055241256948","DOIUrl":"10.1177/26331055241256948","url":null,"abstract":"Our minds impact motor outputs. Such mind-motor interactions are critical for understanding motor control mechanisms and optimizing motor performance. In particular, incentive motivation strongly enhances motor performance. Dopaminergic neurons located in the ventral midbrain (VM) are believed to be the center of incentive motivation. Direct projections from the VM to the primary motor cortex constitute a mesocortical pathway. However, the functional role of this pathway in humans remains unclear. Recently, we demonstrated the functional role of the mesocortical pathway in human motor control in the context of incentive motivation by using functional magnetic resonance imaging (fMRI). Incentive motivation remarkably improved not only reaction times but also the peak grip force in subsequent grip responses. Although the reaction time has been used as a proxy for incentive motivation mediated by dopaminergic midbrain activity, the premovement activity of the mesocortical pathway is involved in controlling the force strength rather than the initiation of subsequent force generation. In this commentary, we review our recent findings and discuss remaining questions regarding the functional role of the mesocortical pathway in mind-motor interactions.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241256948"},"PeriodicalIF":3.6,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria-Associated MicroRNAs and Parkinson's Disease. 线粒体相关微RNA与帕金森病

IF 3.6

Neuroscience Insights Pub Date : 2024-05-24 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241254846

Gayatri Reddy Aaluri, Yashmit Choudhary, Subodh Kumar

{"title":"Mitochondria-Associated MicroRNAs and Parkinson's Disease.","authors":"Gayatri Reddy Aaluri, Yashmit Choudhary, Subodh Kumar","doi":"10.1177/26331055241254846","DOIUrl":"10.1177/26331055241254846","url":null,"abstract":"Parkinson's Disease (PD) occurs as a result of the progressive loss of dopaminergic neurons within the substantia nigra causing motor and non-motor symptoms and has become more prevalent within the last several decades. With mitochondria being essential to cellular survival, mitochondrial dysfunction contributes to the disease progression by increasing neuron loss through (1) insufficient ATP production and (2) reactive oxygen species generation. MicroRNAs (miRNAs) are small molecules located throughout cells that regulate gene expression, particularly mitochondrial function. Through their own dysregulation, miRNAs offset the delicate balance of mitochondrial function by altering or dysregulating the expression of proteins, increasing neuroinflammation, increasing retention of toxic substances, limiting the removal of reactive oxygen species, and preventing mitophagy. Improper mitochondrial function places cells at increased risk of apoptosis, a major concern in individuals with PD due to their reduced number of dopaminergic neurons. This article has identified the 17 most promising mitochondrial associated miRNAs within PD: hsa-miR-4639-5p, miR-376a, miR-205, miR-421, miR-34b/c, miR-150, miR-7, miR-132, miR-17-5p, miR-20a, miR-93, miR-106, miR-181, miR-193b, miR-128, miR-181a, and miR-124-3p. These miRNAs alter mitochondrial function and synaptic energy by impeding normal gene expression when up or downregulated. However, there is limited research regarding mitochondria-localized miRNAs that are typically seen in other diseases. Mitochondria-localized miRNA may have a greater impact on mitochondrial dysfunction due to their proximity. Further research is needed to determine the location of these miRNAs and to better understand their regulatory capabilities on mitochondrial and synaptic function within PD.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241254846"},"PeriodicalIF":3.6,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Reactive Astrocytes in Vascular Dementia: Investigation of Neuronal-Astrocyte-Vascular Interactions. 针对血管性痴呆症中的反应性星形胶质细胞：神经元-星形胶质细胞-血管相互作用研究

IF 2.9

Neuroscience Insights Pub Date : 2024-05-22 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241255332

Pradoldej Sompol

{"title":"Targeting Reactive Astrocytes in Vascular Dementia: Investigation of Neuronal-Astrocyte-Vascular Interactions.","authors":"Pradoldej Sompol","doi":"10.1177/26331055241255332","DOIUrl":"10.1177/26331055241255332","url":null,"abstract":"Historically known as neuronal support cells, astrocytes are now widely studied for their close structural and functional interactions with multiple neural cell types and cerebral vessels where they maintain an ideal environment for optimized brain function. Under pathological conditions, astrocytes become reactive and lose key protective functions. In this commentary, we discuss our recent work in The Journal of Neuroscience (Sompol et al., 2023) that showed Ca2+ dysregulation in reactive astrocytes, as well as hyperactivation of the Ca2+-dependent protein phosphatase calcineurin (CN) and the Nuclear Factor of Activated T Cells (NFATs), in a diet-induced hyperhomocystienemia (HHcy) mouse model of Vascular Contributions to Cognitive Impairment and Dementia (VCID). Intravital multiphoton imaging coupled with whisker stimulation was used to explore astrocyte Ca2+ signaling and neurovascular function under active phase, fully awake conditions. Interestingly, evoked Ca2+ transients in individual astrocytes were greater, even though intercorrelated Ca2+ signaling across networks of astrocytes was impaired in HHcy mice. Blockade of astrocytic CN/NFAT reduced signs of astrocyte reactivity, normalized cerebrovascular function, and improved hippocampal synaptic strength and hippocampal dependent cognition in HHcy mice, revealing a previously unrecognized deficit regarding neuron-astrocyte-vascular interactions. These findings strongly support the use of astrocyte targeting strategies to mitigate pathophysiological changes associated with VCID and other Alzheimer's-related dementias.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241255332"},"PeriodicalIF":2.9,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Connection: Cholesterol, Calcium Signaling, and Neurodegeneration. 解开联系：胆固醇、钙信号和神经退行性变。

IF 3.6

Neuroscience Insights Pub Date : 2024-05-11 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241252772

Maria Casas, Eamonn J Dickson

{"title":"Unraveling the Connection: Cholesterol, Calcium Signaling, and Neurodegeneration.","authors":"Maria Casas, Eamonn J Dickson","doi":"10.1177/26331055241252772","DOIUrl":"10.1177/26331055241252772","url":null,"abstract":"Cholesterol and calcium play crucial roles as integral structural components and functional signaling entities within the central nervous system. Disruption in cholesterol homeostasis has been linked to Alzheimer's, Parkinson's, and Huntington's Disease while alterations in calcium signaling is hypothesized to be a key substrate for neurodegeneration across many disorders. Despite the importance of regulated cholesterol and calcium homeostasis for brain health there has been an absence of research investigating the interdependence of these signaling molecules and how they can tune each other's abundance at membranes to influence membrane identity. Here, we discuss the role of cholesterol in shaping calcium dynamics in a neurodegenerative disorder that arises due to mutations in the lysosomal cholesterol transporter, Niemann Pick Type C1 (NPC1). We discuss the molecular mechanisms through which altered lysosomal cholesterol transport influences calcium signaling pathways through remodeling of ion channel distribution at organelle-organelle membrane contacts leading to neurodegeneration. This scientific inquiry not only sheds light on NPC disease but also holds implications for comprehending other cholesterol-associated neurodegenerative disorders.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241252772"},"PeriodicalIF":3.6,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11088808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting Psychiatric Disease Characteristics in Post-Mortem- and Biological Research. 在尸检和生物学研究中报告精神疾病特征。

IF 3.6

Neuroscience Insights Pub Date : 2024-05-11 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241252632

Karel Scheepstra, Mark Mizee, Dennis Wever, Cheng-Chih Hsiao, Lin Zhang, Dick Swaab, Jörg Hamann, Inge Huitinga

{"title":"Reporting Psychiatric Disease Characteristics in Post-Mortem- and Biological Research.","authors":"Karel Scheepstra, Mark Mizee, Dennis Wever, Cheng-Chih Hsiao, Lin Zhang, Dick Swaab, Jörg Hamann, Inge Huitinga","doi":"10.1177/26331055241252632","DOIUrl":"10.1177/26331055241252632","url":null,"abstract":"Inflammation is a prominent hypothesis in the neurobiology of depression. In our transcriptomic profiling study of microglia in chronic major depressive disorder (MDD), we revealed a distinct disease-associated microglia (DAM) transcriptomic profile exclusively found in cortical gray matter, that we have designated DepDAM. These DepDAM revealed an immune-suppressed state, with a possible upstream mechanism for microglial suppression, by upregulation of CD200 and CD47 (\"don't eat me signals\") located on synapses. We extensively report on disease characteristics, such as cause of death, reason for euthanasia, and psychiatric state when deceased. When excluding MDD donors in a euthymic state, the trend of lower CD45 membrane expression on white matter microglia became significant, and the difference in gray matter microglia became larger. For Western blot analysis of CD47 and CD200, both means of the definitely depressed donor groups (MDD-D) increased. This underscores the utmost importance of reporting on patient and episode characteristics, such as severity, episode traits, (type of) suicidality, mode of decease, and state of illness at death in post-mortem- and biological psychiatric research. For psychiatric post-mortem research, we suggest using well-characterized donors (eg, after \"psychological autopsy\") selected by an experienced clinician.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241252632"},"PeriodicalIF":3.6,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11088795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Severity and Risk Factors for Ischemic Stroke in Patients With Hyperlipidemia. 高脂血症患者缺血性脑卒中严重程度和风险因素的性别差异。

IF 3.6

Neuroscience Insights Pub Date : 2024-05-03 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241246745

Emmanuel Imeh-Nathaniel, Samuel Imeh-Nathaniel, Adebobola Imeh-Nathaniel, Oreoluwa Coker-Ayo, Nikhil Kulkarni, Thomas I Nathaniel

{"title":"Sex Differences in Severity and Risk Factors for Ischemic Stroke in Patients With Hyperlipidemia.","authors":"Emmanuel Imeh-Nathaniel, Samuel Imeh-Nathaniel, Adebobola Imeh-Nathaniel, Oreoluwa Coker-Ayo, Nikhil Kulkarni, Thomas I Nathaniel","doi":"10.1177/26331055241246745","DOIUrl":"https://doi.org/10.1177/26331055241246745","url":null,"abstract":"Objective: This study aims to determine sex differences in poststroke hypertriglyceridemia (serum triglyceride levels ⩾ 200 mg/dl) and high stroke severity in ischemic stroke patients.Method: Our study analyzed data from 392 males and 373 females with hypertriglyceridemia. Stroke severity on admission was measured using the National Institute of Health Stroke Scale (NIHSS) with a value ⩽7 indicating a more favorable post-stroke prognosis while a score of >7 indicates poorer post-stroke outcomes. Logistic regression models adjusted for demographic and risk factors. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for each clinical risk factor were used to predict the increasing odds of an association of a specific clinical baseline risk factor with the male or female AIS with hypertriglyceridemia.Results: In the adjusted analysis, male patients with hypertriglyceridemia, diastolic blood pressure (OR = 1.100, 95% CI, 1.034-1.171, P = .002), and Ischemic stroke mortality (OR = 6.474, 95% CI, 3.262-12.847, P < .001) were significantly associated with increased stroke severity. In female patients with hypertriglyceridemia, age (OR = 0.920, 95% CI, 0.866-0.978, P = .008) was associated with reduced stroke severity, while ischemic stroke mortality score (OR = 37.477, 95% CI, 9.636-145.756, P < .001) was associated with increased stroke severity.Conclusion: Increased ischemic stroke mortality risk score was associated with increased severity in both male and female AIS patients with hypertriglyceridemia. Our findings provide information about sex differences in specific risk factors that can be managed to improve the care of male and female ischemic stroke patients with hypertriglyceridemia.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241246745"},"PeriodicalIF":3.6,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11069268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticospinal Modulation of Precision Movements. 皮层脊髓对精确运动的调控

IF 3.6

Neuroscience Insights Pub Date : 2024-04-27 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241249497

Francesca Marino, Yunuen Moreno-López, Edmund Hollis

引用次数: 0

Collateral Damage: Neurological Correlates of Non-Fatal Overdose in the Era of Fentanyl-Xylazine. 附带损害：芬太尼-恶嗪时代非致命性用药过量的神经学相关性。

IF 2.9

Neuroscience Insights Pub Date : 2024-04-24 eCollection Date: 2024-01-01 DOI: 10.1177/26331055241247156

Dustin R Todaro, Nora D Volkow, Daniel D Langleben, Zhenhao Shi, Corinde E Wiers

{"title":"Collateral Damage: Neurological Correlates of Non-Fatal Overdose in the Era of Fentanyl-Xylazine.","authors":"Dustin R Todaro, Nora D Volkow, Daniel D Langleben, Zhenhao Shi, Corinde E Wiers","doi":"10.1177/26331055241247156","DOIUrl":"10.1177/26331055241247156","url":null,"abstract":"Non-fatal opioid overdoses are associated with significant morbidity. Hypoxic brain injury caused by opioid-induced respiratory depression is a key mechanism of such morbidity. For example, reports describe an amnestic syndrome in opioid users associated with acute injury to the hippocampus, a brain region that is highly susceptible to hypoxic injury. In our recent study we investigated the effects of non-fatal opioid overdose on the hippocampal volume in a well-characterized sample of opioid use disorder (OUD) patients with a history of overdose (OD) compared to those with no prior overdose (NOD). Using structural magnetic resonance imaging (MRI) and voxel-based morphometry, we observed lower hippocampal volume in patients with a history OD than in the NOD group. These findings support an association between non-fatal opioid overdose and hippocampal injury, which we hypothesize contributes to recently reported cases of OUD related amnestic syndrome. Here we review our study findings and the potential pathophysiological mechanisms underlying the acute and delayed hippocampal injury in nonfatal opioid overdose. We also discuss the implications for the risk of overdose and brain injury with the increased prevalence of fentanyl and xylazine contamination of the illicit opioid supply. Lastly, we highlight considerations for clinical management of the underappreciated neurological injury and cognitive dysfunction in OUD patients.","PeriodicalId":36527,"journal":{"name":"Neuroscience Insights","volume":"19 ","pages":"26331055241247156"},"PeriodicalIF":2.9,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11409300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0