Endocrinology, Diabetes and Metabolism最新文献

{"title":"Association Analysis of Insulin Resistance Metabolic Score (METS-IR) and Gestational Diabetes Mellitus: Based on National Health and Nutrition Examination Survey Database From 2007 to 2018","authors":"Hou Wenxuan,&nbsp;Xu Lingyun,&nbsp;Tang Yujie,&nbsp;Zhang Ting,&nbsp;Han Zhen,&nbsp;Luo Xiao,&nbsp;Yang Zhao","doi":"10.1002/edm2.70062","DOIUrl":"https://doi.org/10.1002/edm2.70062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study focused on the association of the Insulin resistance metabolic score (METS-IR) with the risk of gestational diabetes mellitus (GDM) using data from the National Health and Nutrition Examination Survey (NHANES).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from 6 cycles of NHANES (2007–2018) were analysed. Weighted logistic regression models were constructed to explore the relationship between METS-IR and GDM. Stratified and subgroup analyses with adjustment for confounding factors were carried out to explore the association between METS-IR and GDM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 5189 samples were analysed. Based on the weighted logistic regression model, Ln(METS-IR) was positively associated with GDM with full adjustment (OR = 1.94, 95% CI 1.08–3.46, <i>p</i> &lt; 0.005). After transferring Ln(METS-IR) into a categorical variable by quartiles, the positive connection between Ln(METS-IR) and GDM was still observed in the higher Ln(METS-IR) group compared to the lowest Ln(METS-IR) interval (OR of 1.86, 1.76 for participants in the Q3(3.73, 3.93) and Q4(3.93, 4.83) quartile, respectively, <i>p</i> &lt; 0.05). The threshold effect model showed that when Ln(METS-IR) ≤ 4, the positive correlation between Ln(METS-IR) and GDM was more significant (β = 2.69, 95% CI 1.55–4.67, <i>p</i> = 0.0004). The area under the ROC curves of Ln(METS-IR) for GDM was 0.603, suggesting Ln(METS-IR) a more systematic predictor for GDM. Specifically, the OR and 95% CIs of GDM for women above high school in the Q2, Q3, and Q4 quartiles were 2.05 (1.04, 4.02), 3.41 (1.72, 6.78) and 2.78 (1.55, 4.99), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>METS-IR in women elevates the likelihood of GDM occurrence. METS-IR serves as a comprehensive alternative to HOMA-IR rather than HbA1c and non-based insulin level to predict GDM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Endoscopic Sutured Gastroplasty on Diabetes Mellitus Type 2—A Systematic Review","authors":"Fenna M. M. Beeren,&nbsp;Mitchell J. R. Harker,&nbsp;Arianne C. van Bon,&nbsp;Marcel J. M. Groenen,&nbsp;Peter D. Siersema","doi":"10.1002/edm2.70057","DOIUrl":"https://doi.org/10.1002/edm2.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Endoscopic sutured gastroplasty (ESG) is one of the currently available endoscopic techniques that mimics bariatric surgery. Although the efficacy of ESG on weight loss has repeatedly been demonstrated, its effect on diabetes mellitus type 2 (T2DM) related outcomes is not yet fully clear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic review summarising the efficacy of ESG on T2DM. Therefore, PubMed, Embase and Cochrane library were searched for studies evaluating the effect of ESG on T2DM. Both prospective and retrospective studies, published in the English language, were included. Two reviewers independently screened all studies. The primary objectives were T2DM remission rate, decrease in glucose-lowering medication and decrease in HbA1c.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 16 studies including 760 patients with (pre)diabetes were included. Overall, T2DM-related outcomes after ESG improved in 303 of 599 patients (50.6%) (including tapering dose of insulin and/or improvement of HbA1c/fasting glucose). Remission rates of T2DM were reported in 6/11 studies and seen in 89 of 155 (57.0%) patients after 6–36 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This systematic review on the efficacy of ESG on T2DM suggests that ESG is able to improve diabetes-related outcomes in approximately half of treated patients, with T2DM remission rates in more than half of them.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh","authors":"Abu Taher,&nbsp;Aporajita Das Trisha,&nbsp;Shamim Ahmed,&nbsp;Jannat Begum,&nbsp;Falguni Sinha,&nbsp;Nusrat Zaman Sarna,&nbsp;Nurshad Ali","doi":"10.1002/edm2.70063","DOIUrl":"https://doi.org/10.1002/edm2.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>While some reports exist on the relationship between serum uric acid (SUA) and dyslipidemia in adults, there is limited information available regarding young adults. This study aimed to evaluate the relationship between SUA and dyslipidemia, as well as its components, among young adults in Bangladesh.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study consisted of 458 participants (281 male and 177 female) aged between 18 and 30 years. The levels of SUA, fasting blood glucose and lipid profile (TG, TC, HDL-C and LDL-C) were measured using standard colorimetric methods. Bivariate logistic regression modelling was used to examine the relationship between SUA and dyslipidemia and its components.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall prevalence of hyperuricemia was 24% with 27.6% in males and 18.6% in females. Males had a higher mean SUA level (6.6 ± 1.5 mg/dL) than females (5.3 ± 1.2 mg/dL) (<i>p</i> &lt; 0.001). The prevalence of dyslipidemia was 74.2% with 83.2% in male and 59.8% in female subjects. The prevalence of hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C was 30.1%, 26.2%, 28.8% and 64.8%, respectively. There was an increasing trend in the level and prevalence of elevated lipid profile markers across the SUA quartiles (<i>p</i> &lt; 0.001). SUA level showed a positive correlation with TG, TC and LDL-C and a negative correlation with HDL (<i>p</i> &lt; 0.001). In regression analysis, a significant association was found between SUA and dyslipidemia in all participants as well as in the male–female groups separately (at least <i>p</i> &lt; 0.05). Furthermore, a significant association (<i>p</i> &lt; 0.001) was found between SUA and individual lipid components in the regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This study identified a significant association between SUA and dyslipidemia in young adults in Bangladesh. Further research is needed to explore the mechanisms behind this association.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Pioglitazone Add-On in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin and Dapagliflozin: A Systematic Review and Meta-Analysis of Randomised Controlled Trials","authors":"Ubaid Khan,&nbsp;Zuhair Majeed,&nbsp;Muhammad Haris Khan,&nbsp;Ahmed Bostamy Elsnhory,&nbsp;Ahmed Mazen Amin,&nbsp;Anum Nawaz,&nbsp;Ahmed Raza,&nbsp;Hafiz Muhammad Waqas Siddque,&nbsp;Mustafa Turkmani,&nbsp;Mohamed Abuelazm","doi":"10.1002/edm2.70061","DOIUrl":"https://doi.org/10.1002/edm2.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Type 2 diabetes mellitus (T2DM) accounts for over 90% of diabetes cases worldwide. Pioglitazone, a thiazolidinedione, enhances insulin sensitivity by activating PPAR-γ. Evidence on its efficacy and safety as an add-on to metformin and SGLT2 inhibitors in inadequately controlled T2DM is limited. This systematic review and meta-analysis evaluates pioglitazone's role as a third-line therapy for improving glycaemic control in addition to metformin and Dapagliflozin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>We conducted comprehensive searches across PubMed, CENTRAL, WOS, Scopus and EMBASE until December 2024. Pooled data were reported using risk ratio (RR) for dichotomous outcomes and mean difference (MD) for continuous outcomes, along with a 95% confidence interval (CI). This systematic review and meta-analysis is registered with PROSPERO ID: CRD42024612005.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included three RCTs with 885 patients. Pioglitazone add-on therapy significantly reduced HbA1c levels (MD: −0.41; 95% CI: −0.54 to −0.27, <i>p</i> = &lt; 0.00001, <i>I</i>² = 0%), fasting blood glucose (MD: −11.91; 95% CI: −16.34 to −7.48, <i>p</i> = &lt; 0.00001, <i>I</i>² = 0%), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (MD: −0.65; 95% CI: −1.05 to −0.25, <i>p</i> = 0.001, <i>I</i>² = 4.89%), increased the rate of achieving HbA1c &lt; 7% (RR: 2.09; 95% CI: 1.66 to 2.64, <i>p</i> = &lt; 0.00001, <i>I</i>² = 0%), and HbA1c &lt; 6.5% (RR: 2.19; 95% CI: 1.36 to 3.53, <i>p</i> = 0.001, <i>I</i>² = 0%). However, there was no difference regarding Homeostasis model assessment of β-cell function (HOMA-β) between the two groups (MD: 2.73; 95% CI: −5.24 to 10.70, <i>p</i> = 0.5, <i>I</i>² = 27.53%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pioglitazone add-on therapy significantly improved glycaemic control by reducing HbA1c, fasting blood glucose and HOMA-IR while increasing the likelihood of achieving HbA1c targets. However, no significant difference was observed in HOMA-β between groups. These findings suggest the potential benefit of pioglitazone in enhancing glycaemic outcomes in diabetes management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Physical Activity and Dietary Changes on Management of Type 2 Diabetes Mellitus Patients: A Case–Control Study in Bangladesh","authors":"Hasan Mahmud Hadi,&nbsp;Md. Monir Hossain Shimul,&nbsp;Md. Sakhawath Hossain,&nbsp;Afroza Sultana,&nbsp;Md. Kamrul Hossain,&nbsp;Salamat Khandker,&nbsp;Salim Khan","doi":"10.1002/edm2.70051","DOIUrl":"https://doi.org/10.1002/edm2.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Type 2 diabetes mellitus (T2DM) is a growing public health issue in Bangladesh, projected to affect 13.7 million individuals by 2045. Physical inactivity and poor dietary habits increase the risk of complications. This study examined the effects of physical activity and lifestyle modifications on T2DM management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A case–control study was conducted at Manikganj District Diabetic Hospital with 334 T2DM patients (aged 45–60 years). The case group (<i>n</i> = 167) followed structured physical activity and dietary modifications, while the control group (<i>n</i> = 167) did not. Data on socio-demographics, lifestyle and glycaemic markers—fasting plasma glucose (FPG), postprandial plasma glucose (PPG) and HbA1c—were collected at baseline, 3 months and 6 months. Chi-square tests and ordinal logistic regression models assessed associations between lifestyle factors and glycaemic outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The control group had significantly higher plasma glucose levels, associated with gender (<i>p</i> &lt; 0.001), treatment type (<i>p</i> = 0.004), medical adherence (<i>p</i> = 0.009), food habits (<i>p</i> = 0.007) and BMI (<i>p</i> = 0.005). The case group showed a significant FPG reduction from 10.035 mmol/L to 6.261 mmol/L (<i>p</i> &lt; 0.001), with similar trends for PPG and HbA1c. Males had 1.8 times higher odds of elevated FPG, while poor adherence increased this risk 2.5-fold.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Lifestyle modifications significantly improve glycaemic control in T2DM patients. Strengthening adherence to medical advice and integrating structured interventions into routine care could enhance diabetes management in Bangladesh.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Dependent Effects of Muscle Resting Calcium on Fasting Blood Glucose: Implications for Prediabetes Risk","authors":"Eshwar R. Tammineni,&nbsp;Lourdes Figueroa,&nbsp;Michael Fill,&nbsp;Sheila Riazi,&nbsp;Carlo Manno","doi":"10.1002/edm2.70052","DOIUrl":"https://doi.org/10.1002/edm2.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Skeletal muscle is the primary site for insulin-mediated glucose uptake and is critical in maintaining whole-body glucose homeostasis. Muscle cells from malignant hyperthermia-susceptible (MHS) individuals exhibit elevated resting cytosolic calcium concentration ([Ca²⁺]_cyto), and MHS subjects have a higher incidence of hyperglycaemia. This study investigates the association between elevated resting [Ca²⁺]_cyto and fasting blood sugar (FBS) levels while accounting for subject demographics and clinical variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We measured resting [Ca²⁺]_cyto in myotubes derived from muscle biopsies of control and MHS subjects. We analysed the impact of [Ca²⁺]_cyto on FBS levels based on age, sex, and MH status through correlation and comparative analyses. Data were stratified by FBS, [Ca²⁺]_cyto, and age, and heat map and 3D mesh plot analyses were performed to assess the risk of prediabetes in subjects with varying [Ca²⁺]_cyto and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2013 and 2024, muscle biopsies from 152 subjects (90 MHS, 62 controls) were used to establish primary myotube culture. MHS myotubes exhibited significantly higher resting [Ca²⁺]_cyto than controls and [Ca²⁺]_cyto positively correlated with fasting blood sugar (FBS) in MHS subjects (<i>r</i> = 0.227; <i>p</i> = 0.031) and across the entire cohort (<i>r</i> = 0.176; <i>p</i> = 0.034). This correlation was high in prediabetic individuals (<i>r</i> = 0.43; <i>p</i> = 0.005) but absent in those with normal FBS. Subjects over 40 years with [Ca²⁺]_cyto &gt; 150 nM showed a higher risk of prediabetes. While aging is a significant risk factor for type 2 diabetes, increased age did not impact FBS levels in individuals with [Ca²⁺]_cyto below 150 nM. However, in those with [Ca²⁺]_cyto exceeding 150 nM, increasing age significantly influenced FBS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Elevated resting [Ca²⁺]_cyto in skeletal muscle amplifies the risk of hyperglycemia and may contribute to the onset of type 2 diabetes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Individuals With Type 2 Diabetes Metabolically Inflexible? A Systematic Review and Meta-Analysis","authors":"Maria Hansen,&nbsp;Kristine Kjær Lange,&nbsp;Martin Bjørn Stausholm,&nbsp;Flemming Dela","doi":"10.1002/edm2.70044","DOIUrl":"https://doi.org/10.1002/edm2.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Type 2 diabetes (T2D) is characterised by insulin resistance and possibly by impaired metabolic flexibility, the latter referring to the body's ability to switch between fuel sources. This review systematically examines metabolic flexibility, measured by changes in the respiratory exchange ratio (ΔRER) during hyperinsulinaemic clamps, across lean, overweight/obese, and T2D populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive search of PubMed identified 65 studies meeting the inclusion criteria, with 35 using a ~40 mU/m²/min insulin infusion rate for accurate comparisons. These studies included 985 participants: 256 lean, 497 overweight/obese, and 232 T2D individuals. The differences in ΔRER between the three groups were meta-analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Basal RER values did not significantly differ across groups, but insulin-stimulated ΔRER was higher in lean individuals compared to overweight/obese and T2D groups (ΔRER values 0.10, 0.07 and 0.07, respectively; <i>p</i> = 0.037) indicating greater metabolic flexibility in the lean group. However, high statistical heterogeneity in the ΔRER within-group results (<i>I</i>² values: 92.3%–94.5%) suggests considerable variability among studies. A meta-regression analysis accounting for age, sex, and BMI indicated that only BMI was significantly associated with ΔRER. Factors contributing to the remaining heterogeneity likely include differences in participant characteristics (e.g., glycaemic control) and study design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The review highlights the need for standardised data presentation in metabolic studies. Overall, metabolic flexibility appears more influenced by overweight status than T2D per se, challenging the notion of a distinct metabolic inflexibility threshold for T2D.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Relationship Between Serum Uric Acid and Cardiovascular Disease: A Cross-Sectional Study in Bangladesh","authors":"Nurshad Ali,&nbsp;Nayan Chandra Mohanto,&nbsp;Ali Newaj,&nbsp;Jannat Begum,&nbsp;Farjana Islam","doi":"10.1002/edm2.70055","DOIUrl":"https://doi.org/10.1002/edm2.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Serum uric acid (SUA) has been suggested to be associated with obesity, dyslipidaemia, diabetes, and hypertension. However, whether uric acid is independently associated with the risk of myocardial infarction (MI), a major type of cardiovascular disease (CVD), remains debatable, especially across different populations. This study aims to examine the relationship between SUA levels and MI in an adult population group in Bangladesh.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 392 participants: 188 with a history of MI in the CVD group and 204 healthy individuals without CVD in the control group. Anthropometric, blood pressure, SUA, and other biochemical parameters were measured. A multivariate regression model was used to assess the relationship between elevated SUA levels and the risk of CVD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean level of SUA was significantly higher in the CVD group (7.6 ± 4.5 mg/dL) compared to the non-CVD group (5.3 ± 1.8 mg/dL) (<i>p</i> &lt; 0.001). The prevalence of hyperuricemia was also observed to be higher in the CVD group (46.3%) compared to the non-CVD group (18.2%) (<i>p</i> &lt; 0.001). A significant difference was observed in the levels of blood glucose and lipid profile between the CVD and non-CVD groups (<i>p</i> &lt; 0.001 for all cases). No significant differences were observed in the mean level of SUA or the prevalence of hyperuricemia between the gender groups. When SUA was divided into four quartiles, a significant difference was observed for systolic blood pressure across the quartile groups. After adjusting for potential confounders in the regression models, SUA was found to have a significant association with CVD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Elevated levels of SUA were associated with increased odds of CVD among the study participants. Managing SUA levels and implementing intervention strategies could be effective in preventing and controlling cardiovascular events.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycaemia and Its Risk Factors Among Adults Living With HIV on Follow-Up at the Hawassa City Administration, Southern Ethiopia: A Cross-Sectional Study","authors":"Agete Tadewos Hirigo,&nbsp;Daniel Yilma,&nbsp;Ayalew Astatkie,&nbsp;Zelalem Debebe","doi":"10.1002/edm2.70054","DOIUrl":"https://doi.org/10.1002/edm2.70054","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ethiopia implemented the universal test and treat in 2017 and later adopted dolutegravir-based regimens for people living with HIV (PLWH). However, the impact of these changes on glucose metabolism in Ethiopia remains unclear, highlighting the need for further investigation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted in southern Ethiopia from 5 January 2023 to 30 May 2024. We included 443 adult PLWH using systematic random sampling. American Diabetes Association criteria was used to define hyperglycaemia. To identify factors associated with hyperglycaemia, binary logistic regression was used with adjusted odds ratio (AOR) and 95% confidence interval (CI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall prevalence of hyperglycaemia was 24.4% (16.7% prediabetes and 7.7% diabetes mellitus [DM]). Of the participants with DM, 82.3% were newly diagnosed. Significant predictors of hyperglycaemia were age &gt; 50 years (AOR 2.1; 95% CI 1.1–3.9), alcohol intake (AOR 2.1; 95% CI 1.02–4.2), obesity (AOR 3.2; 95% CI 1.3–7.9), high waist–hip ratio (AOR 2.6; 95% CI 1.4–5.05) and LDL-cholesterol (AOR 2.2; 95% CI 1.02–4.6). While significant predictors of DM were alcohol intake (AOR 3.0; 95% CI 1.1–8.4), co-morbidity (AOR 2.6; 95% CI 1.1–6.05), high waist circumference (AOR 7.5; 95% CI 1.3–43.3), high waist–hip ratio (AOR 4.1; 95% CI 1.02–16.2) and high triglycerides (AOR 3.2; 95% CI 1.3–7.7). Dolutegravir-based regimen was not associated with hyperglycaemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hyperglycaemia prevalence among adult PLWH on antiretroviral therapy in southern Ethiopia is rising, with most diabetes cases newly identified. This emphasises the critical need for routine screening to enable early detection, prevention and management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of GLP-1 Receptor Agonists on Paediatric Population in a Real World Setting","authors":"A. G. Barajas,&nbsp;Charles A. Gagnon-Vargas,&nbsp;Jessica A. Schmitt","doi":"10.1002/edm2.70053","DOIUrl":"https://doi.org/10.1002/edm2.70053","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Incidence of type 2 diabetes mellitus (T2DM) and obesity is increasing in children. We aimed to observe the metabolic health effects of glucagon-like peptide 1 (GLP-1) receptor agonists in paediatric patients with T2DM in a real-world setting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective chart review of patients aged 0 to 18 years with T2DM who were started on a GLP-1 receptor agonist between August 2019 and August 2023 and followed for up to 24 months was included in this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>321 patients were included in the analysis. After 12 months of treatment with a GLP-1 receptor agonist, haemoglobin A1c (HbA1c) was reduced by −1.04% ± 2.3% (<i>p</i> &lt; 0.001). At 24 months, HbA1c was similar to baseline (8.3% ± 2.5% vs. 7.9% ± 2.5%, <i>p</i> = 0.24). There was a significant (<i>p</i> &lt; 0.05) decrease in the use of metformin, basal insulin, and bolus insulin at one year which was sustained at the two-year follow-up for metformin (<i>p</i> = 0.002). Overall, there was no significant change in BMI nor other metabolic parameters while undergoing treatment with a GLP-1 receptor agonist.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Paediatric patients with T2DM using GLP-1 receptor agonists experienced a significant decrease in HbA1c after 12 months of use, which was not sustained at 24 months. However, patients had a reduction in insulin and metformin use at 12 months. No significant impact was appreciated on BMI or other metabolic variables.</p>\u0000 </section>\u0000 </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":"8 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}