Journal of Applied Hematology最新文献

{"title":"Primary Plasma Cell Leukemia Presenting Mainly with Negative CD38 Expression at Diagnosis: A Case Report with Literature Review","authors":"Abdullah S. Al Saleh, Asma Aloufi, Lubna Alzadjali, A. Alhejazi, M. Almahayni","doi":"10.4103/joah.joah_82_22","DOIUrl":"https://doi.org/10.4103/joah.joah_82_22","url":null,"abstract":"","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and prevalence of acute stroke and its clinical implications and outcomes in patients with sickle cell disease: A systematic review","authors":"Aakanksha Pitliya, Kanishka Khatri, AnjanaChowdary Elapolu, Rabia Ahmed, Neeraj Kancherla, RamyaReddy Jonnala, AbdulgafarDare Ibrahim, Harshini Muppidi, Amir Ashiq, Anmol Pitliya","doi":"10.4103/joah.joah_48_23","DOIUrl":"https://doi.org/10.4103/joah.joah_48_23","url":null,"abstract":"This systematic review aims to determine the incidence and prevalence of acute stroke in patients with sickle cell disease (SCD) and explore its clinical implications and outcomes. A comprehensive search was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines to identify relevant studies published between 2013 and 2023. Databases including PubMed, Google Scholar, ResearchGate, ScienceDirect, and Wiley Online Library are searched. Inclusion criteria are applied to select studies involving human subjects, written in English, and reporting the association between acute stroke and confirmed cases of SCD. Study quality assessment and data extraction are performed by two independent reviewers using study-specific tools. A total of 9 studies met the inclusion criteria including 7 cohort studies, and two meta-analyses are included in the systematic review with a total of 24,480 participants. The prevalence of stroke in SCD patients varied across studies, ranging from 1.24% to 27.3%. The incidence rates of stroke showed significant variability, ranging from 0.31% to 31%. Long-term disabilities, recurrence, and reduced quality of life characterized the clinical outcomes of stroke in SCD patients. Mortality rates varied among studies, emphasizing the need for early detection and comprehensive care. The review provides valuable insights for health-care professionals, researchers, and policymakers involved in SCD care, emphasizing the importance of early detection, intervention, and comprehensive management to improve patient outcomes. Further research is needed to address knowledge gaps and understand the underlying mechanisms of stroke in SCD.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Haploidentical Hematopoietic Stem Cell Transplantation with a Donor and Recipient Infected with SARS-CoV-2 Infection","authors":"G. Ali, M. Altareb, N. Chaudhri, F. Alfraih","doi":"10.4103/joah.joah_10_21","DOIUrl":"https://doi.org/10.4103/joah.joah_10_21","url":null,"abstract":"The current coronavirus disease 2019 (COVID 19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV 2), has impacted many facets of hematopoietic cell transplantation (HCT) in both developed and developing countries. The full impact of the COVID 19 pandemic, caused by the SARS CoV 2, on the field of hematopoietic cell transplantation (HCT) is unknown. Here, we report a rare case of a 21-year-old male patient known to have chronic myeloid leukemia (CML) with progression to T-cell lymphoblastic lymphoma as extramedullary blast crisis of CML. The patient was treated by pediatric chemotherapy regimen then. He underwent haploidentical stem cell transplantation. Posttransplantation, on day +7, he developed SARS-CoV-2 after receiving stem cell graft from a donor who was diagnosed with SARS-CoV-2 on the day of stem cells harvesting. The case elaborates complications and outcome of a patient receiving stem cell transplant from a donor with SARS-CoV-2 infection.Copyright © 2023 Journal of Applied Hematology Published by Wolters Kluwer - Medknow.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70810380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High D-Dimer level at first incident cancer-associated venous thromboembolism is a predictor for recurrence: A retrospective cohort study","authors":"FahadA S. Al-Eidan, ShadenA Alotaibi, HindM Almajid, Taghreed Alnahedh, Abdel Galil Abdel Gadir","doi":"10.4103/joah.joah_107_22","DOIUrl":"https://doi.org/10.4103/joah.joah_107_22","url":null,"abstract":"","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70810664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal Hemoglobin Inducer Activity of Moringa oleifera, Curcuma aueruginosa Roxb., and Artocarpus altilis Based on the Gamma Globin Expression","authors":"ItaMargaretha Nainggolan, NisaWidya Amanda, Irmanida Batubara, U. Saepuloh, H. Darusman","doi":"10.4103/joah.joah_74_22","DOIUrl":"https://doi.org/10.4103/joah.joah_74_22","url":null,"abstract":"","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 Pandemic on Treatment Decisions of Patients Treated by Hematologists in Saudi Arabia","authors":"A. Barefah, Salem Bahashwan, Hatem M Alahwal, Abdullah T. Almohammadi, O. Radhwi, Shahida Khan","doi":"10.4103/joah.joah_85_22","DOIUrl":"https://doi.org/10.4103/joah.joah_85_22","url":null,"abstract":"BACKGROUND: As on March 12, 2020, the WHO declared COVID-19 as a global pandemic. Its rapid spread has posed major challenges to the management of health-care systems. Patients with hematological disorders, being immunocompromised in more ways than one, face a lot of challenges. Most of these patients require frequent visits to health-care facilities for transfusion support, infusions, surveillance, and follow-ups, which increase the risk of exposure and hence infection with severe acute respiratory syndrome coronavirus 2. AIM: We assessed the impact of the pandemic on the decisions of hematologists in Saudi Arabia. Method(s): An online survey was done through questionnaires, to understand the decisions and course of clinical treatments taken. 45 hematologist answered 20-questions structured questionnaires through online link. RESULT(S): The majority of hematologist have used virtual clinics in managing patients and have delayed or canceled well visits. Although some hematologist delayed treatment in stable patients like autologous stem cell transplantation for myeloma patients, the majority did not delay induction or consolidation therapies for patients with leukemia with curative intent plans. CONCLUSION(S): The crisis brought along with it challenges and opportunities to improve patient care through research and clinical practice. Telemedicine was sought for supporting outpatients. Malignancies were taken care of, with due precautions. Observations of decisions of hematologists resulted in the patients still being closely followed up and urgent treatments being attended to. The hematologists expressed satisfaction with the use of telemedicine. Online consultations and monitoring of patients could probably be taken as an alternative resource in such situations.Copyright © 2023 Journal of Applied Hematology Published by Wolters Kluwer - Medknow.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70812159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blastic Plasmacytoid Dendritic Cell Neoplasm: A 10-year Bibliometric Study","authors":"Frank Mayta-Tovalino, C. Quispe-Vicuña, M. Cabanillas-Lazo, John Barja-Ore, Cesar Mauricio-Vilchez, M. Guerrero, Arnaldo Munive-Degregori","doi":"10.4103/joah.joah_81_22","DOIUrl":"https://doi.org/10.4103/joah.joah_81_22","url":null,"abstract":"","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70811978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of lymphoma among adult patients in the eastern province of Saudi Arabia – A single-center study","authors":"RehabYusuf Al-Ansari, NasserMohammed Aljarah, GhufranMoaid Alofi, FaisalAhmed Abu Shaigah, FaisalHani Al-Qahtany, ArulananthamZechariah Jebakumar, SaadMohammed Alsubaie, SaadMohammed Al-Almaie, ArifaJamaluddin Qureshi","doi":"10.4103/joah.joah_50_23","DOIUrl":"https://doi.org/10.4103/joah.joah_50_23","url":null,"abstract":"BACKGROUND: Lymphoma is a cancer of the lymphatic system with two main types, namely Hodgkin lymphoma (HL) and non-HL (NHL). Within these, there are many subtypes. Based on data from the National Cancer Institute, NHL accounts for 4.2% whereas HL accounts for 0.5% of all cancers in the United States. The treatment strategy depends on the type and the stage of the lymphoma. In this study, we are studying the incidence rate of lymphoma in a military-nononcology center for better understanding and recording of the condition.METHODS: We conducted an observational, analytical, retrospective study in a tertiary care hospital on 56 patients admitted to the hospital between January 2016 and the end of December 2021, with lymphadenopathy or body mass, who were diagnosed with lymphoma. The modality of diagnosis was tissue histopathology. All data including demographics, details of lymphoma lesions, and laboratory and histopathology results were obtained from health informatics or manual records.RESULTS: In this study, we found that 67.9% of the cases were male, with a significantly higher rate among Saudi patients in comparison to non-Saudi (94.6% and 5.3%, respectively). Among Saudi cases, we found that a significantly higher percentage of lymphoma cases were originally from the Eastern and the Southern provinces (47.1% and 35.8%, respectively), and 46.5% of them were living in Dammam at the time of diagnosis. The percentage of NHL was significantly higher than Hodgkin type (80.3% and 19.6%, respectively). The majority of the cases belonged to B-cell NHL (73.2%). Moreover, the incidence rate increased from 2016 to 2021 with an accumulative rate of 25.14 / 100,000 person-years.CONCLUSION: Our data indicate that the incidence rate of lymphoma increased in the last 5 years at a tertiary care center. We found evidence for associations between the original province and the rate of the lymphoma. Moreover, the rate of B-cell NHL was significantly higher with superior mortality rate in comparison to other types of lymphoma in our cohort, which supported previous studies in the Kingdom of Saudi Arabia. There was no increase in incidence of lymphoma in our study cohort of military personnel, and it matches the incidence data of other local studies. Further national studies and initiation of lymphoma registry may add a value for future researches.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The home care delivery program in hemophilia: A descriptive italian multicentric study on patients, caregivers, and clinicians' points of view","authors":"Annamaria Porreca, OrazioDi Gregorio, Francesca Brambillasca, AngeloClaudio Molinari","doi":"10.4103/joah.joah_45_23","DOIUrl":"https://doi.org/10.4103/joah.joah_45_23","url":null,"abstract":"BACKGROUND: For patients affected by haemophilia, Patient Support Programs (PSPs) may be a support tool to assist patients and physicians in optimising treatment and improving disease management. PSP on the Pharmacokinetics (PK) service in Italy aims to support haemophilia A or B patients.MATERIALS AND METHODS: This report analyses data of patients and physicians who benefited from the PK program from October 2018 to October 2022. Data was collected by a web-based questionnaire and by telephone calls. We provide a descriptive report on the benefits of participation in the PK program for patients with haemophilia and medical professionals involved in their care.RESULTS: In total, 69.6% of the respondent patients stated they were very satisfied with the Program, and 97.7% said they would benefit from the service again. Among the interviewed physicians, 60% felt satisfied with the Program and thought it was helpful.CONCLUSION: Patient satisfaction remained consistently high, with sustained improvements in all aspects of life. Medical professionals also reported positive outcomes in their patient interactions and satisfaction with the Program. PSPs have empowered patients to manage their pathology, increasing their satisfaction with treatments and quality of life.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigational workout for the diagnosis of paroxysmal nocturnal hemoglobinuria","authors":"ManalAwadh Almutairi, OmarAbdulaziz Alnujeidi, NadaAbdulaziz Aldhuwaihi","doi":"10.4103/joah.joah_67_22","DOIUrl":"https://doi.org/10.4103/joah.joah_67_22","url":null,"abstract":"Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired rare disease that affects both males and females characterized by the triad of intravascular hemolytic anemia, thrombosis, and bone marrow failure. Flow cytometry is the gold standard for the final diagnosis. This is a PNH case of a 42-year-old Indonesian woman who presented to the emergency department with sustained generalized fatigability, pallor, and jaundice with a history of multiple recurrent previous events managed by blood transfusions. The diagnosis was reached by laboratory studies that revealed hemolytic anemia and erythroid hyperplasia, which was confirmed by a clonal deficiency of CD59 red blood cells (RBCs) using flow cytometry. She was prescribed eculizumab. Hemolytic anemia and jaundice in patients with PNH can be caused by RBCs hemolysis due to the absence of CD55 and CD59 proteins caused by a genetic defect (PIG-A) on the X chromosome. That is why flow cytometry must be made for each patient suspected of having PNH.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135750306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}