Journal of Applied Hematology最新文献_第3页

Immune erythrocyte alloantibodies among pregnant women attending an antenatal clinic in a tertiary health facility, Benin City, Nigeria 在尼日利亚贝宁市一家三级保健机构产前诊所就诊的孕妇的免疫红细胞同种抗体

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_94_22

A. Adewoyin, O. Adeyemi, A. Ande, O. Awodu

引用次数: 0

Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor 凝血参数和炎症生物标志物在2019冠状病毒病患者中的作用:一项揭开神秘面纱的努力

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_41_23

BN Kumarguru, Sindhu Sreegiri, D Swathi, AS Ramaswamy, CA Arathi

{"title":"Role of coagulation parameters and inflammatory biomarkers in coronavirus disease 2019 patients: A demystifying endeavor","authors":"BN Kumarguru, Sindhu Sreegiri, D Swathi, AS Ramaswamy, CA Arathi","doi":"10.4103/joah.joah_41_23","DOIUrl":"https://doi.org/10.4103/joah.joah_41_23","url":null,"abstract":"BACKGROUND: Coronavirus disease 2019 (COVID-19) globally known as COVID-19 is a heterogeneous disease caused by the severe acute respiratory syndrome coronavirus 2. COVID-19 patients having severe disease and are critically ill are more prone to have abnormal coagulation prolife. It may lead to thromboinflammation in severe conditions.AIM: The aim is to evaluate the utility of coagulation parameters and inflammatory biomarkers in COVID-19 patients in the study conducted for 6 months duration.MATERIALS AND METHODS: It was a retrospective observational study conducted from April 2021 to September 2021 in a rural tertiary care referral Institute. Available data of the baseline values of coagulation parameters (platelet count [PLC], prothrombin time [PT], international normalized ratio [INR], partial thromboplastin time [PTT] and D-dimer) and inflammatory markers (C-reactive protein [CRP], serum lactate dehydrogenase [LDH], and serum ferritin) were evaluated with respect to the clinical severity of the disease and also the survival status of COVID-19 patients.RESULTS: One hundred and fifty-five cases of COVID-19-positive patients were analyzed. PT, INR, PTT, D-dimer, CRP, LDH, and ferritin had higher mean in severe cases than the nonsevere cases. PLC had higher mean in the severe cases than the nonsevere cases. PT, INR, PTT, D-dimer, CRP, LDH and ferritin had higher mean in nonsurvivors than the survivors. PLC had lower mean in nonsurvivors than the survivors.CONCLUSION: Baseline values of PT, INR, PTT, D-dimer, LDH, and ferritin may be considered reliable indicators of severity of COVID-19 disease. Baseline values of D-dimer, LDH, and ferritin may be considered a reliable indicator of survival of patients suffering from COVID-19 infection.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spurious thrombocytosis in beta thalassemia intermedia – Even autoanalyzers do get perplexed! -地中海贫血中间介质中的假血小板增多-即使是自体分析仪也会感到困惑!

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_49_23

Nidha Gaffoor, Archana Shetty

引用次数: 0

Hematological scoring system and its correlation with blood culture, C-reactive protein, and micro-erythrocyte sedimentation rate in early diagnosis of neonatal sepsis 血液学评分系统及其与血培养、c反应蛋白、微红细胞沉降率的相关性在新生儿败血症早期诊断中的意义

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_39_23

MohammadJaseem Hassan, Nawal Amir, Murad Ahmad, Kafil Akhtar

{"title":"Hematological scoring system and its correlation with blood culture, C-reactive protein, and micro-erythrocyte sedimentation rate in early diagnosis of neonatal sepsis","authors":"MohammadJaseem Hassan, Nawal Amir, Murad Ahmad, Kafil Akhtar","doi":"10.4103/joah.joah_39_23","DOIUrl":"https://doi.org/10.4103/joah.joah_39_23","url":null,"abstract":"BACKGROUND: Neonatal sepsis is a major health problem in our country. The cause for most of the deaths is not a failure to treat the infection, instead, it is the failure to treat it on time. Sepsis is usually identified by a gold-standard blood culture test. However, there is a need for a simple and cost-effective diagnostic tool with quick results.MATERIALS AND METHODS: A total of 70 neonates with clinical suspicion of sepsis were included in our study. The hematological parameters such as total leukocyte count(TLC), absolute neutrophil count (ANC), platelet count, immature neutrophil count, immature to total neutrophil ratio (I:T), immature to mature neutrophil ratio (I:M), toxic granules, and cytoplasmic vacuolation in neutrophil were correlated with C-reactive protein (CRP), blood culture and micro-erythrocyte sedimentation rate (micro-ESR). The performance of these hematological parameters was evaluated with the help of hematological scoring system (HSS).RESULTS: Among the hematological parameters, TLC has high sensitivity (77.8%) and specificity (72.1%), ANC has the least sensitivity (44.4%) but the highest specificity (96.7%), platelet count has high sensitivity (88.9%) but low specificity (44.3%), I:T and I:M ratio have the highest sensitivity (88.9% both), specificity (71.1% and 88.5%, respectively) and negative predictive value (91.3% and 92.8% respectively). ANC and I:M ratios have the highest positive predictive value (89.3% and 82.5%, respectively) in predicting the early diagnosis of neonatal sepsis.CONCLUSION: HSS along with CRP and micro-ESR can be used as a screening tool in neonates with clinical suspicion of sepsis as they are simple to perform, and can be done even in rural parts of the country.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"283 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135750661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimal residual disease analysis in multiple myeloma: A single-center experience 多发性骨髓瘤最小残留疾病分析:单中心经验

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_69_22

A. Rath, Tribikram Panda, J. Dass, T. Seth, M. Mahapatra, S. Tyagi

引用次数: 0

Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report 间变性淋巴瘤激酶阳性大b细胞淋巴瘤模拟浆细胞肿瘤:罕见病例报告

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_40_23

Kaustav Ghosh, Chirasree Sanyal, PrakasKumar Mandal

引用次数: 0

An online educational module to improve general internal medicine trainees' knowledge and comfort in managing acute complications of sickle cell disease 一个在线教育模块，以提高一般内科培训生的知识和舒适度管理镰状细胞病的急性并发症

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_18_22

Richard Ward, Sita Bhella, Mansoor Radwi

{"title":"An online educational module to improve general internal medicine trainees' knowledge and comfort in managing acute complications of sickle cell disease","authors":"Richard Ward, Sita Bhella, Mansoor Radwi","doi":"10.4103/joah.joah_18_22","DOIUrl":"https://doi.org/10.4103/joah.joah_18_22","url":null,"abstract":"BACKGROUND: Sickle cell disease (SCD) is a genetic disorder characterized by hemolytic anemia and vaso-occlusive episodes. Many adults with SCD require hospitalization for the management of acute manifestations. There appears to be a gap in the level of knowledge that general internal medicine (GIM) trainees possess regarding the treatment and management of SCD.METHODS: We created an online module that helps medical residents improve their knowledge about SCD. Participants were exposed to different scenarios related to SCD. A pre-and posttests were administered to detect improvement in knowledge and comfort when managing SCD and its acute complications.RESULTS: Thirty consecutive GIM residents participated. Of these, 20 completed the demographic survey, 17 completed the pretest, and 10 completed the posttest and usability survey. The median time to complete the module was 68 min. Fifty percent of participants were 1st-year postgraduation from medical school. Forty-five percent stated that they were uncomfortable managing patients with SCD 80% had cared for at least 1–5 patients with SCD. All reported having no SCD lectures in residency. The median pretest score was 12/20 (range, 8–15) and posttest score was 20.5/25 (range, 13–24).CONCLUSIONS: Residents agreed that the module was useful, helps understanding about SCD and its complication, and aids with clinical duties. This module demonstrated to be an effective educational tool that can support resident education during their internal medicine. Further strategies will be needed to improve the delivery of online modules to keep residents engaged with the module and attaint full benefit from these activities.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135750629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated level of plasma micro RNA-210 in beta thalassemia patients and its relation to hemoglobin F level and disease severity 地中海贫血患者血浆微量RNA-210水平及其与血红蛋白F水平和疾病严重程度的关系

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_42_23

OlaA Balbaa, HomamM Sharshera, ShereenM El Maghraby, ShaimaaA Aglan, IreneL Mikhael

{"title":"Estimated level of plasma micro RNA-210 in beta thalassemia patients and its relation to hemoglobin F level and disease severity","authors":"OlaA Balbaa, HomamM Sharshera, ShereenM El Maghraby, ShaimaaA Aglan, IreneL Mikhael","doi":"10.4103/joah.joah_42_23","DOIUrl":"https://doi.org/10.4103/joah.joah_42_23","url":null,"abstract":"BACKGROUND: Beta-thalassemia is an autosomal recessive hereditary blood disorder occurs due to absent or diminished β-globin chains synthesis. The transformation from fetal to adult in globin synthesis is controlled by different mechanisms; one of those is BCL11A which is downregulated by microRNA-210 (miRNA-210). Therefore, this would lead to reactivation of fetal hemoglobin (HbF) production that improves anemia and reduces the needs for transfusion.OBJECTIVE: To study miRNA-210 in the plasma of beta thalassemia patients and its relation to HbF level and disease severity.SUBJECTS AND METHODS: The study was carried out on 50 individuals divided into three groups. Group A included 30 thalassemia major patients, Group B included 10 thalassemia intermedia patients, and Group C is 10 healthy volunteers as control. All individuals underwent to history taking, physical examination, and laboratory investigations, complete blood count, serum ferritin, hemoglobin electrophoresis, and measurement of miRNA-210 expression levels in plasma of peripheral blood samples by quantitative real-time polymerase chain reaction.RESULTS: Examination of miRNA-210 plasma level among different groups revealed no statistically significant association between control and thalassemia group or its subgroups (Major and intermedia) (P = 0.224, P = 0.116, and P = 0.734, respectively). Moreover, miRNA-210 was slightly higher in responders than nonresponders to hydroxyurea but did not reach significant level.CONCLUSION: miRNA-210 levels were not associated with increase in HbF levels in thalassemia patients.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A lymphoproliferative disorder playing hide and seek 一种淋巴增生性疾病在玩捉迷藏

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_91_22

Nicolas Athanase, E. Frébet

引用次数: 0

Journal of Applied Hematology Pub Date : 2023-01-01 DOI: 10.4103/joah.joah_92_22

Nicolas Athanase, E. Frébet

引用次数: 1