Journal of Applied Hematology最新文献

{"title":"Linezolid-induced pancytopenia and hyponatremia","authors":"Satish Kumar, N. Dhakal, Vishal Mangal, A. Menon","doi":"10.4103/joah.joah_29_21","DOIUrl":"https://doi.org/10.4103/joah.joah_29_21","url":null,"abstract":"Linezolid (LnZ) is an antibiotic that is effective against Gram-positive bacteria and vancomycin-resistant enterococcus. LnZ is notorious to cause adverse hematological effects, primarily thrombocytopenia; however, pancytopenia is an infrequent complication. Euvolemic hyponatremia is a very rare adverse effect in patients receiving LnZ for more than 2 weeks. Early identification of pancytopenia and hyponatremia due to LnZ can result in avoidance of unnecessary investigations with improved patient outcome. An 80-year-old male with no previous comorbidities was admitted with a fracture neck of the left femur. He was empirically prescribed tablet LnZ 600 mg twice daily by the orthopedics team for soft-tissue infection over the sacral area. He underwent surgery for the left femur's fracture neck and was continued on LnZ in the postoperative period. Two weeks after the surgery, he was noticed to have pancytopenia and hyponatremia. After a thorough evaluation, LnZ was suspected to be the cause of pancytopenia and euvolemic hyponatremia. After 2 weeks of withholding LnZ, his pancytopenia and hyponatremia resolved. Physicians should be aware of the rare adverse effects of LnZ and should identify the patients at risk before administrating the drug. Regular monitoring of hematological and biochemical parameters is mandatory if intended to continue the drug for a more extended period.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"57 - 59"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48440928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare clinical presentation of Hodgkin's disease","authors":"P. Parameswaran, D. Vallathol, N. Warrier, Sajna V. M. Kutty","doi":"10.4103/joah.joah_234_20","DOIUrl":"https://doi.org/10.4103/joah.joah_234_20","url":null,"abstract":"Hodgkin's disease or Hodgkin's lymphoma (HL) is a hematolymphoid neoplasm of B-cell lineage that has unique histologic, immunophenotypic, and clinical features. The occurrence of hemophagocytic lymphohistiocytosis (HLH) and neurological symptoms is rare in this disease. We present a case report of a 40-year-old woman who presented to our outpatient department with HLH and cerebellar signs. On further investigations, she was found to have classical HL. Her clinical condition improved with one cycle chemotherapy and steroids and she is on follow-up. This case indicates that a strong index of clinical suspicion is key to diagnose HLH and neurological symptoms (probably paraneoplastic) in HL. The cornerstone of management is identifying and treating the underlying cause.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"60 - 62"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49420109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematopoietic stem cell transplantation in paroxysmal nocturnal hemoglobinuria: Experience from a tertiary care center","authors":"D. Khanikar, Sandip Shah, A. Garg, Kinnari A Patel, K. Shah, A. Raj, H. Panchal, A. Patel, S. Parikh","doi":"10.4103/joah.joah_15_21","DOIUrl":"https://doi.org/10.4103/joah.joah_15_21","url":null,"abstract":"BACKGROUND: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematological disorder characterized by episodic intravascular hemolysis. Despite newer therapies such as eculizumab, hematopoietic stem cell transplantation (HSCT) remains the only curative therapy. MATERIALS AND METHODS: An observational analytical retrospective study was conducted comprising eight PNH patients who had undergone HSCT at our center. From January 2014 to December 2020, we performed HSCT in 8 PNH patients, 5 female and 3 male, with median age of 32 years (range: 15–38 years). RESULTS: Seven patients had pancytopenia, associated with marrow hypocellularity. One patient presented with a thrombotic episode. Seven had matched sibling donor (MSD) transplant and one underwent haploidentical transplant. The median time from diagnosis to transplant was 7 months (range: 1–38 months). All received reduced intensity conditioning (RIC): Flu-Bu-Cy-A TG for MSD transplants and Flu-A TG-Post Cy in haploidentical transplants. Median CD34+ stem cell dose was 5.5 × 106/kg (range 3.4–5.8 × 106/kg). All had successful engraftment. Acute graft versus host disease (GVHD) Grade I–III occurred in six patients. Chronic GVHD occurred in two patients. One patient succumbed to Grade III liver GVHD. Rest seven patients are alive till date and transfusion independent. The overall survival was 87.5% at a median of 26 months. CONCLUSIONS: HSCT is the only curative therapy for PNH. With the use of RIC, the outcomes of PNH patients can be improved. The incidence of GVHD is high with RIC regimens but can be managed with prompt immunosuppression.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"5 - 8"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46786216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow aspiration using 18g lumbar puncture needle: Correspondence","authors":"R. Mungmunpuntipantip, S. Sai Tin, V. Wiwanitkit","doi":"10.4103/joah.joah_178_21","DOIUrl":"https://doi.org/10.4103/joah.joah_178_21","url":null,"abstract":"","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"70 - 70"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48294798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency anemia in pregnancy: Subgroup analysis from Riyadh mother and baby multicenter cohort study (RAHMA)","authors":"H. Wahabi, S. Esmaeil, Hala Elmorshedy, H. Bakhsh, Aalaa Abdelrahman, A. Fayed","doi":"10.4103/joah.joah_133_21","DOIUrl":"https://doi.org/10.4103/joah.joah_133_21","url":null,"abstract":"OBJECTIVES: The objective of the study was to estimate the prevalence and risk factors of anemia among pregnant women in Riyadh and to examine its association with adverse pregnancy outcomes. METHODS: This study is a subgroup analysis from Riyadh mother and baby multicenter cohort study. Participants were grouped into four groups according to hemoglobin level: nonanemic (≥11.0 g/100 ml), mild (10–10.9 g/100 ml), moderate (7.0–9.9 g/100 ml), and severe anemia (<7.0 g/100 ml). Regression analyses were conducted to extrapolate the predicted probability (PP) for pregnancy outcomes. RESULTS: Out of 10,600 participants, 3261 (30.76%) were anemic; 1729 (16.3%), 1520 (14.3%), and 12 (0.1%) had mild, moderate, and severe anemia, respectively. The odds of anemia was higher in younger mothers (odds ratio [OR] = 0.94, confidence interval [CI]: 0.91–0.94) and in primiparous (OR = 1.01, CI: 0.90–1.14), while attendants of antenatal care and those who received iron supplements were less likely to be anemic (OR = 0.93, CI: 0.82–1.06) and (OR = 0.92, CI: 0.77–1.09), respectively. There was a significant increase in the odds of lower APGAR with the decreased hemoglobin; an increment of maternal hemoglobin by 1 g/100 ml decreased the likelihood of APGAR scores <7 by 9% (OR = 0.91, CI: 0.83–0.99). The PP showed a decrease in preterm birth (PTB) rate from 8% (CI: 6%–9%) to 6.5% (CI: 5%–8%), low birth weight (LBW) rate from 12% (CI 10%–13%) to 11% (CI: 9%–12%), stillbirth rate from 1.3% (CI: 0.7%–2.1%) to 1.1% (CI: 0.7%–1.6%), and maternal admission to intensive care unit (ICU) from 0.8% (CI: 0.2%–1.5%) to 0.2% (CI: 0.06%–0.4%), with increase of maternal hemoglobin from 7 g/100 ml to 15 g/100 ml. CONCLUSION: More than a third of the pregnant women in Riyadh had mild-to-moderate anemia. The odds of anemia increased in primipara, younger mothers, and those without antenatal care or iron supplementation. PP showed that anemia is associated with low APGAR scores, LBW, PTB stillbirth, and maternal admission to ICU.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"47 - 53"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41506158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life of adolescents with sickle cell disease on hydroxyurea: A case-control study","authors":"Hayfaa Mones, Mea`ad Hassan, Bahaa Al Hussein Ahmed","doi":"10.4103/joah.joah_7_21","DOIUrl":"https://doi.org/10.4103/joah.joah_7_21","url":null,"abstract":"BACKGROUND: Sickle cell disease (SCD) is a chronic multisystem disorder associated with acute and chronic complications that may negatively impact the quality of life (QoL). The study aimed to assess the health-related QoL (HRQoL) of patients with SCD on hydroxyurea (HU) and the factors affecting HRQoL domains. MATERIALS AND METHODS: This case-control study included 174 patients with SCD (12–18-year-old); 87 were on HU for at least 1 year and 87 were not receiving HU. It also included 174 healthy adolescents of the same age group. The HRQoL was assessed using the Short Form 36 Health Survey version 2 (SF-36v2). A multivariate linear regression analysis was performed to assess the independent effect of studied variables on HRQoL dimensions. RESULTS: Patients with SCD who were not on HU were found to have significantly lower SF-36 v2 scores (all domains) compared to those on HU and control group, P < 0.001. While patients on HU had significantly lower SF-36 v2 scores in physical functioning, role physical (RP), general health, and physical health component score only compared to the control group, P < 0.001. Multivariate linear regression analysis revealed significant associations between duration of HU therapy and RP (R2 = 0.208, P = 0.021) and mental health component score (R2 = 0.389, P = 0.047) and between hemoglobin levels with social functioning (R2 = 0.370, P = 0.023). CONCLUSIONS: HU has improved the HRQoL of SCD patients, in almost all domains, in addition to the improvement in many disease-related complications, mainly painful episodes. The positive impact of HU on HRQoL was significantly associated with the duration of therapy.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"13 - 21"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47411247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delta beta thalassemia, a rare hemoglobin variant: An experience from nodal centre in North Indian state","authors":"P. Jain, N. Marwah, N. Dalal, Richa Pawar, Meenu Gill, Susheel Kumar","doi":"10.4103/joah.joah_198_20","DOIUrl":"https://doi.org/10.4103/joah.joah_198_20","url":null,"abstract":"CONTEXT: Fetal hemoglobin (HbF) reduces to <1% few months after birth. However, it can persist beyond infancy into adult life in rare conditions such as delta-beta (δβ) thalassemia and hereditary persistence of HbF. δβ thalassemia is a relatively rare type of thalassemia due to decrease in both beta and delta globin chain production. AIMS: This study aims to assess the hematological and high-performance liquid chromatography (HPLC) findings in δβ thalassemia. SETTINGS AND DESIGN: Cross-sectional observational study. SUBJECTS AND METHODS: The study was conducted in department of Clinical Pathology, PGIMS, Rohtak. On screening of 1197 patients over a period of around 1 year, a total of 13 cases of δβ thalassemia were detected by HPLC. STATISTICAL ANALYSIS USED: Not done. RESULTS: The age of presentation ranged from 1 to 42 years with a mean age of 22.8 years. Eleven cases were diagnosed as heterozygous δβ thalassemia and two as homozygous δβ thalassemia. CONCLUSIONS: δβ thalassemia is an uncommon cause of elevated HbF. Clinical and hematological parameters should be carefully analyzed for accurate diagnosis.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"1 - 4"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46430117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Root cause analysis of a moderately large fibrinous coagulum in a thawed fresh frozen plasma bag: Discussing the lessons learnt","authors":"M. Raturi, Reshma Nambiyar, Y. Dhiman, Aditya Sahrawat","doi":"10.4103/joah.joah_164_21","DOIUrl":"https://doi.org/10.4103/joah.joah_164_21","url":null,"abstract":"","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"68 - 69"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43713106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pediatric anemia in rural population of Maharashtra, India","authors":"Debopriya Chatterjee, Swapnil More, S. Joshi","doi":"10.4103/joah.joah_50_21","DOIUrl":"https://doi.org/10.4103/joah.joah_50_21","url":null,"abstract":"INTRODUCTION: World Health Organization showed that the prevalence of anemia among children of 6–59 months was 42.6% globally in 2011 and 59% in India. Fourth National Family Health Survey, 2016, shows 58.6% of Indian children are anemic, of which 53.8% are in Maharashtra, especially among rural children. AIMS: The aim of the study was to study the morphologic and cytometric evaluation of anemia in pediatric population. MATERIAL AND METHODS: The study was conducted after obtaining approval from the ethics committee. All patients that came to outpatient department and inpatient department between 2016 and 2018, satisfying the inclusion criteria were included. Routine investigations performed were hemoglobin estimation, blood indices, and peripheral blood smear examination. RESULTS: The total number of pediatric patients that were found to be anemic was 400 (54.9%). Toddlers, aged 6 months to 6 years, were most anemic (48.0%). Moderate severity of anemia was seen most frequently (50.5%). Microcytic hypochromic anemia (67.0%), iron deficiency anemia was the most common cause seen (65.2%). CONCLUSION: The occurrence of anemia in children is essential to be constantly monitored to identify causes, formation of intervention strategies, and ensure already formed national programs are effective.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"9 - 12"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44940389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion-dependent anemia, and cytopenia secondary to parvovirus B19 infection as the first manifestation of X-linked hyper immunoglobulin M immunodeficiency syndrome in two male patients in their third decade of life","authors":"Hadel El-Haddad, Eman Khan, I. El-Hemaidi, A. Absi","doi":"10.47363/jcrr/2021(3)153","DOIUrl":"https://doi.org/10.47363/jcrr/2021(3)153","url":null,"abstract":"We describe two male patients with unique mutation of the CD40L gene, unlike the classic presentation of X-linked hyper immunoglobulin M immunodeficiency syndrome (XHIGM syndrome), both were healthy until presenting in their early twenties with a challenging symptomatic transfusion-dependent anemia, investigations confirmed XHIGM syndrome with concurrent chronic parvovirus infection.","PeriodicalId":36501,"journal":{"name":"Journal of Applied Hematology","volume":"13 1","pages":"157 - 161"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42483597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}