Cell and Organ Transplantology最新文献_第8页

Are CMV and SARS-CoV-2 Infections Mutual Risk Factors in Kidney Transplant Recipients? 肾移植受者CMV和SARS-CoV-2感染是相互的危险因素吗?

Cell and Organ Transplantology Pub Date : 2022-03-16 DOI: 10.3390/transplantology3010010

J. Swist, Mateusz Krotofil, O. Mazanowska, M. Krajewska, D. Kamińska

引用次数: 1

Donation after Circulatory Death Liver Transplantation in Paediatric Recipients 小儿循环死亡肝移植受者的捐献

Cell and Organ Transplantology Pub Date : 2022-03-04 DOI: 10.3390/transplantology3010009

A. Parente, F. Tirotta, V. Ronca, A. Schlegel, P. Muiesan

引用次数: 1

Co-Infection of COVID-19 and Pneumocystosis Following Rituximab Infusion—A Case Report 利妥昔单抗输注后新冠肺炎合并肺囊虫病1例报告

Cell and Organ Transplantology Pub Date : 2022-02-24 DOI: 10.3390/transplantology3010008

Michelle Dakowitz, Justyna Korus, O. Mazanowska, M. Krajewska, D. Kamińska

引用次数: 0

Long-Term Outcomes of Kidney Transplant Recipients with Glomerulonephritides by Induction Type and Steroid Avoidance 肾移植受者肾小球肾炎诱导型和类固醇回避的长期预后

Cell and Organ Transplantology Pub Date : 2022-02-11 DOI: 10.3390/transplantology3010007

Prasanth Ravipati, S. Jackson, G. Tumer, P. Nachman, S. Riad

{"title":"Long-Term Outcomes of Kidney Transplant Recipients with Glomerulonephritides by Induction Type and Steroid Avoidance","authors":"Prasanth Ravipati, S. Jackson, G. Tumer, P. Nachman, S. Riad","doi":"10.3390/transplantology3010007","DOIUrl":"https://doi.org/10.3390/transplantology3010007","url":null,"abstract":"Kidney transplant programs have different approaches to induction immunosuppression, and conflicting data exist on the role of steroid maintenance in recipients with glomerulonephritis (GN). GN patients are unique because of a higher risk for immune system exhaustion due to prior exposure to immunosuppressants to treat their GN; this raises questions regarding the optimal immunosuppression needed for transplant success and reduction of complications. We sought to assess the effect of induction type and steroid maintenance on the recipient and kidney graft survival in those with IgA nephropathy (IgAN), systemic lupus erythematosus related GN (SLE), small-vessel vasculitis (SVV), and anti-glomerular basement membrane disease (anti-GBM). We analyzed the Scientific Registry of Transplant Recipients (SRTR) database for adult, primary kidney recipients with the above glomerulonephritides through September 2019. Kaplan–Meier curves were generated to examine kidney graft and recipient survival. We used multivariable Cox proportional hazard models to investigate the impact of induction type and steroid maintenance in each group separately. Our study included 9176 IgAN, 5355 SLE, 1189 SVV, and 660 anti-GBM recipients. Neither induction type nor steroid maintenance therapy influenced recipient or death-censored graft survival in this cohort of recipients. Our findings provide an opportunity for recipients with a history of one of the studied glomerulonephritides to receive a more tailored immunosuppression regimen, considering their previous exposure to immunosuppressants.","PeriodicalId":36461,"journal":{"name":"Cell and Organ Transplantology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82623397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HSCT with Mismatched Unrelated Donors (MMUD): A Comparison of Different Platforms for GvHD Prophylaxis 不匹配非亲属供体(MMUD)的HSCT: GvHD预防不同平台的比较

Cell and Organ Transplantology Pub Date : 2022-02-08 DOI: 10.3390/transplantology3010006

Massimo Berger, Marta Barone, F. Carnevale-Schianca, M. De Gobbi, P. Nicoli, D. Caravelli, D. Cilloni, L. Paruzzo, M. Spadea, K. Mareschi, M. Aglietta, F. Fagioli

{"title":"HSCT with Mismatched Unrelated Donors (MMUD): A Comparison of Different Platforms for GvHD Prophylaxis","authors":"Massimo Berger, Marta Barone, F. Carnevale-Schianca, M. De Gobbi, P. Nicoli, D. Caravelli, D. Cilloni, L. Paruzzo, M. Spadea, K. Mareschi, M. Aglietta, F. Fagioli","doi":"10.3390/transplantology3010006","DOIUrl":"https://doi.org/10.3390/transplantology3010006","url":null,"abstract":"HSCT from an unrelated HLA-mismatched donor (MMUD) is one of the alternatives where an HLA-matched donor is not found. The aim of this study was to compare GvHD prophylaxis with anti-thymocyte globulin (ATG) vs. post-transplant cyclophosphamide (PT-Cy). Thirty-nine adult patients were uniformly treated with rabbit ATG-Cy-A-MTX and peripheral blood stem cell (PBSC) and 40 adult patients with PT-Cy-MMF-tacrolimus and PBSC. This retrospective study was registered at ClinicalTrials.gov NCT04598789. Three-year overall survival was 42% vs. 64% for ATG and PT-Cy (p < 0.0005), three-year treatment-related mortality (TRM) was 36% vs. 8% (p = 0.0033) and the three-year relapse incidence (RI) was 15% vs. 28% (p = NS), respectively. The incidences of day-100 GvHD graded II–IV and III–IV were 39% vs. 7% (p = 0.0006) and 11% vs. 0% (p = 0.04), respectively, whereas the three-year cGvHD incidences were 48% vs. 13% (p = 0.0005), respectively. We were able to show how PT-Cy can reduce the incidence of GvHDs and TRM in adults, but relapse remains an issue.","PeriodicalId":36461,"journal":{"name":"Cell and Organ Transplantology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85936854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment to Reviewers of Transplantology in 2021 向2021年《移植学》审稿人致谢

Cell and Organ Transplantology Pub Date : 2022-02-07 DOI: 10.3390/transplantology3010005

引用次数: 0

SARS-CoV-2 in Kidney Transplant Recipients: A Systematic Review 肾移植受者的SARS-CoV-2:系统综述

Cell and Organ Transplantology Pub Date : 2022-01-20 DOI: 10.3390/transplantology3010004

Naveen Kumar, R. Rana, D. Rana, Anurag Gupta, M. Sachdeva

{"title":"SARS-CoV-2 in Kidney Transplant Recipients: A Systematic Review","authors":"Naveen Kumar, R. Rana, D. Rana, Anurag Gupta, M. Sachdeva","doi":"10.3390/transplantology3010004","DOIUrl":"https://doi.org/10.3390/transplantology3010004","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global healthcare crisis. Kidney transplant (KTx) patients and the patients with chronic kidney disease are two of the most vulnerable populations to the risks of coronavirus disease 2019 (COVID-19). A systematic literature search on PubMed and Web of Science was conducted. We analyzed published case reports, case series and articles on COVID-19’s clinical presentation, management, outcomes and vaccination among kidney transplant recipients. A total of 33 studies were included in the study, which included 1676 KTx recipients and 108 waiting list patients infected with COVID-19. These studies reported the clinical presentation, management and immunosuppressive adjustment among the KTx recipients. The remaining studies focused on other aspects, such as vaccination and transplantation, during the COVID-19 pandemic. Mortality due to COVID-19 was observed to be the highest for KTx recipients, followed by patients on hemodialysis, and lowest in the general population. There is no definitive treatment of COVID-19 yet, and managing transplant patients is enigmatic of this: the treatment is based on symptom management. There is an urgent need for guidelines on managing kidney transplant recipients and immunosuppressive adjustments for the course of COVID-19 treatment.","PeriodicalId":36461,"journal":{"name":"Cell and Organ Transplantology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72681345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Innate Immunity Response to BK Virus Infection in Polyomavirus-Associated Nephropathy in Kidney Transplant Recipients 肾移植受者多瘤病毒相关性肾病患者对BK病毒感染的先天免疫应答

Cell and Organ Transplantology Pub Date : 2022-01-06 DOI: 10.3390/transplantology3010003

W. Chancharoenthana, A. Leelahavanichkul

{"title":"Innate Immunity Response to BK Virus Infection in Polyomavirus-Associated Nephropathy in Kidney Transplant Recipients","authors":"W. Chancharoenthana, A. Leelahavanichkul","doi":"10.3390/transplantology3010003","DOIUrl":"https://doi.org/10.3390/transplantology3010003","url":null,"abstract":"BK polyomavirus (BKV) mainly causes infection in uroepithelial and renal tubular epithelial cells of either immunocompetent or immunocompromised hosts. Despite asymptomatic or mild clinical features in immunocompetent hosts with BK infection, serious complications are frequently found in immunocompromised patients, especially patients with kidney transplantation. Accordingly, BKV-associated nephropathy (BKVN) demonstrates a wide range of clinical manifestations, including ureteric stenosis and hemorrhagic cystitis. In addition, BKV re-infection in post-kidney transplantation is also a main cause of kidney allograft dysfunction and graft loss. Since the direct anti-BKV is unavailable, immune response against BKV infection is the main mechanism for organism control and might be a novel strategy to treat or suppress BKV. As such, the innate immunity, consisting of immune cells and soluble molecules, does not only suppress BKV but also enhances the subsequent adaptive immunity to eradicate the virus. Furthermore, the re-activation of BKV in BKVN of kidney-transplanted recipients seems to be related to the status of innate immunity. Therefore, this review aims to collate the most recent knowledge of innate immune response against BKV and the association between the innate immunity status of kidney-transplanted recipients and BKV re-activation.","PeriodicalId":36461,"journal":{"name":"Cell and Organ Transplantology","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80554330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Development of a Porcine Slaughterhouse Kidney Perfusion Model 猪屠宰场肾灌注模型的建立

Cell and Organ Transplantology Pub Date : 2021-12-28 DOI: 10.3390/transplantology3010002

L. Venema, H. Leuvenink

{"title":"Development of a Porcine Slaughterhouse Kidney Perfusion Model","authors":"L. Venema, H. Leuvenink","doi":"10.3390/transplantology3010002","DOIUrl":"https://doi.org/10.3390/transplantology3010002","url":null,"abstract":"Machine perfusion techniques are becoming standard care in the clinical donation and transplantation setting. However, more research is needed to understand the mechanisms of the protective effects of machine perfusion. For preservation related experiments, porcine kidneys are acceptable alternatives to human kidneys, because of their size and similar physiology. In this experiment, the use of slaughterhouse kidneys was evaluated with normothermic kidney perfusion (NKP), thereby avoiding the use of laboratory animals. Porcine kidneys were derived from two local abattoirs. To induce different degrees of injury, different warm ischemic times and preservation techniques were used. After preservation, kidneys were reperfused for 4 h with two different NKP solutions to test renal function and damage. The effect of the preservation technique or a short warm ischemic time was clearly seen in functional markers, such as creatinine clearance and fractional sodium excretion levels, as well as in the generic damage marker lactate dehydrogenase (LDH). Porcine slaughterhouse kidneys are a useful alternative to laboratory animals for transplantation- and preservation-related research questions. To maintain kidney function during NKP, a short warm ischemic time or hypothermic machine perfusion during the preservation phase are mandatory.","PeriodicalId":36461,"journal":{"name":"Cell and Organ Transplantology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84209817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Living Donor Kidney Transplantation for a Recipient after 41 Years of Hemodialysis 血液透析41年后的活体肾移植

Cell and Organ Transplantology Pub Date : 2021-12-27 DOI: 10.3390/transplantology3010001

Kosuke Tanaka, Y. Hidaka, Shigeyoshi Yamanaga, Kohei Kinoshita, Akari Kaba, M. Toyoda, H. Yokomizo

{"title":"Living Donor Kidney Transplantation for a Recipient after 41 Years of Hemodialysis","authors":"Kosuke Tanaka, Y. Hidaka, Shigeyoshi Yamanaga, Kohei Kinoshita, Akari Kaba, M. Toyoda, H. Yokomizo","doi":"10.3390/transplantology3010001","DOIUrl":"https://doi.org/10.3390/transplantology3010001","url":null,"abstract":"Due to atrophic bladder, patients undergoing long-term dialysis experience vesicoureteral reflux and complicated urinary tract infections after kidney transplantation. A 58-year-old woman underwent living donor kidney transplantation after 41 years of dialysis. She had no contraindications, with good cardiac function and minimal artery calcification despite the long history of hemodialysis. Immunosuppression was initiated with tacrolimus, mycophenolate mofetil, prednisolone, and basiliximab. Ureteroneocystostomy with an antireflux technique was carefully conducted as her bladder volume was 15 mL. The postoperative clinical course was uneventful with immediate graft function. The bladder volume gradually increased to 81 mL at discharge, 3 weeks postoperatively. The patient was initially depressed due to frequent urination early post-transplant but recovered soon after as the bladder volume gradually increased to 400 mL. The patient has not yet reported a urinary tract infection episode. This case highlights living donor kidney transplantation-induced recovery of bladder function with careful ureteroneocystostomy, despite the long dialysis history.","PeriodicalId":36461,"journal":{"name":"Cell and Organ Transplantology","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77322678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1