ACS Pharmacology and Translational Science最新文献

{"title":"","authors":"Veronica M. Hong, Avaneesh Rade, Amulya Bhaskara, Tarik Ehsan, See Hyun Tack, Muhammad Saad Yousuf, Stephen F. Martin, Theodore J. Price and Benedict Kolber*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Nausheen Alam*, Safia Abdul Quddoos, Humera Khatoon, Tuba Siddiqui and Sadia Suri Kashif, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.4c00618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Savio Monteiro dos Santos, Joni Tetsuo Sakai, Bruno Alexandre Quadros Gomes, Lisa Maria Mendes de Almeida Souza, Roseane Guimarães Ferreira, Kaio Murilo Monteiro Espíndola, Ana Flávia Oliveira Pampolha, Kelly Davis, Pamela Suelen da S. Seabra, Larissa de N. da Paz Lopes, Fabricia de Jesus Paiva da Fonseca Sizo, Agnaldo da Silva Carneiro, Michael D. Coleman and Marta Chagas Monteiro*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/ptv008i007_1957821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Thomas M. Morin, Nick Allan, Jacob M. Hooker, Wendy Bernhard, Kris Barreto, Kimberly A. Jett, Jorge Luis Costa Carvalho, Konstantine Sarafis, C. Ronald Geyer, Yuanhao Wei, Lida Zhu, Fugang Li, Kenza Enright* and Ken Irving, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorine-18 ImmunoPET Imaging of Antibody Brain Kinetics and Amyloid-Beta Pathology","authors":"Eva Schlein,&nbsp;Sara Lopes van den Broek,&nbsp;Tiffany Dallas,&nbsp;Ken G. Andersson,&nbsp;Stina Syvänen,&nbsp;Jonas Eriksson and Dag Sehlin*,&nbsp;","doi":"10.1021/acsptsci.5c00359","DOIUrl":"https://doi.org/10.1021/acsptsci.5c00359","url":null,"abstract":"<p >Bispecific antibodies utilizing the transferrin receptor (TfR) for transport into the brain are being developed for both therapeutic and diagnostic targeting of the amyloid-β (Aβ) protein that deposits in the Alzheimer’s disease (AD) brain. In contrast to traditional antibodies, TfR-binding bispecific antibodies display rapid and efficient brain uptake. However, due to differences in pharmacokinetic properties, it has been challenging to directly compare mono- and bispecific antibody brain uptake in vivo. Here, we have studied the Aβ antibody Bapineuzumab (Bapi) and its bispecific variant Bapi-Fab8D3, which contains a fragment of the TfR-binding antibody 8D3, enabling receptor-mediated transcytosis into the brain. Both antibodies were engineered to reduce binding to the neonatal Fc receptor (FcRn), thereby increasing their clearance from the blood. The antibodies were radiolabeled with fluorine-18 (¹⁸F) and administered to wildtype (WT) mice, which were PET scanned in an alternating manner to visualize antibody brain pharmacokinetics over a period of 9 h, followed by ex vivo analyses. Next, the bispecific antibody [¹⁸F]F-Bapi-Fab8D3^FcRn– was used for PET imaging to quantify Aβ pathology in AD mouse model <i>App</i>^{<i>NL-G-F</i>} mice at 12 h after antibody administration. [¹⁸F]F-Bapi ^FcRn– and [¹⁸F]F-Bapi-Fab8D3^FcRn– had identical blood concentration curves in the WT mice. PET data quantification demonstrated that while the brain concentration of [¹⁸F]F-Bapi^FcRn– declined, that of [¹⁸F]F-Bapi-Fab8D3^FcRn– increased throughout the 9 h time period, indicative of its active transport into the brain. PET imaging discriminated <i>App</i>^{<i>NL-G-F</i>} from WT mice at 12 h after [¹⁸F]F-Bapi-Fab8D3^FcRn– administration, suggesting that this novel antibody-based tracer may be used for the same-day PET imaging of Aβ.</p>","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 8","pages":"2804–2813"},"PeriodicalIF":3.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00359","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144806188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Minjian Huang,&nbsp;Jiaqi Li,&nbsp;Jing Li,&nbsp;Ben Hu,&nbsp;Ran Liu,&nbsp;Lianghao Huang,&nbsp;Caiqian Wang,&nbsp;Rong Hua,&nbsp;Chuanjian Wu,&nbsp;Zhuli Li,&nbsp;Zherui Zhang,&nbsp;Yanan Zhang,&nbsp;Yingjun Wu,&nbsp;Qiuyan Zhang,&nbsp;Yong Wang,&nbsp;Jing Liu,&nbsp;Zixin Deng,&nbsp;Wei Wang,&nbsp;Wei Hou,&nbsp;Ling Zhao,&nbsp;Yucheng Xia,&nbsp;Xiaolian Zhang,&nbsp;Longfei Wang*,&nbsp;Bo Zhang* and Tiangang Liu*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Anja Federa,&nbsp;Hemma Schueffl,&nbsp;Iris K. Minichmayr,&nbsp;Alexander Kastner,&nbsp;Julia Kronberger,&nbsp;Thomas L. Mindt,&nbsp;Petra Heffeter and Christian R. Kowol*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Michal Jurášek,&nbsp;Eduarda Dráberová,&nbsp;Jiří Řehulka,&nbsp;Soňa Gurská,&nbsp;Aleksandra Ivanova,&nbsp;Pavel Polishchuk,&nbsp;Kateřina Ječmeňová,&nbsp;Jan Fähnrich,&nbsp;Anna Marešová,&nbsp;Jan Tauchen,&nbsp;Atilio Reyes Romero,&nbsp;Alexander Dömling,&nbsp;Marián Hajdúch,&nbsp;Pavel B. Drašar,&nbsp;Pavel Dráber* and Petr Džubák*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.4c00730","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Yinlong Li,&nbsp;Kenneth Dahl,&nbsp;Charles S. Elmore,&nbsp;Johan Sandell,&nbsp;Akihiro Takano,&nbsp;Christer Halldin,&nbsp;Lars Farde,&nbsp;Charlotte Ahlgren,&nbsp;Alison Cochrane,&nbsp;Jian Rong,&nbsp;Jiahui Chen,&nbsp;Chunyu Zhao,&nbsp;Xin Zhou,&nbsp;Jimmy S. Patel,&nbsp;Zhendong Song,&nbsp;Ahmad Chaudhary,&nbsp;Yabiao Gao,&nbsp;Zhenkun Sun,&nbsp;Zachary Zhang,&nbsp;Siyan Feng,&nbsp;Achi Haider,&nbsp;Steven H. Liang* and Magnus Schou*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}