Current Behavioral Neuroscience Reports最新文献_第10页

Frustrative Non-reward and Lab-Based Paradigms for Advancing the Study of Aggression in Persons with Psychosis 挫折性非奖励和实验室范式:促进精神病患者攻击行为的研究

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-15 DOI: 10.1007/s40473-019-00173-6

Jill Del Pozzo, Christina Athineos, Taylor Zar, Lisa N. Cruz, Christopher M King

引用次数: 1

Remediation of Visual Processing Impairments in Schizophrenia: Where We Are and Where We Need to Be 精神分裂症患者视觉处理障碍的修复:我们在哪里，我们需要去哪里

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-15 DOI: 10.1007/s40473-019-00171-8

D. Demmin, Samantha I. Fradkin, S. Silverstein

引用次数: 6

Mitochondrial Dysfunction in Alzheimer’s Disease and Progress in Mitochondria-Targeted Therapeutics 阿尔茨海默病的线粒体功能障碍及线粒体靶向治疗的进展

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-08 DOI: 10.1007/s40473-019-00179-0

Padraig J. Flannery, E. Trushina

引用次数: 21

Galantamine-Memantine Combination as an Antioxidant Treatment for Schizophrenia. 加兰他明-美金刚联合抗氧化治疗精神分裂症。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-01 DOI: 10.1007/s40473-019-00174-5

Maju Mathew Koola, Samir Kumar Praharaj, Anilkumar Pillai

{"title":"Galantamine-Memantine Combination as an Antioxidant Treatment for Schizophrenia.","authors":"Maju Mathew Koola, Samir Kumar Praharaj, Anilkumar Pillai","doi":"10.1007/s40473-019-00174-5","DOIUrl":"https://doi.org/10.1007/s40473-019-00174-5","url":null,"abstract":"Purpose of review: The objective of this article is to highlight the potential role of the galantamine-memantine combination as a novel antioxidant treatment for schizophrenia.Recent findings: In addition to the well-known mechanisms of action of galantamine and memantine, these medications also have antioxidant activity. Furthermore, an interplay exists between oxidative stress, inflammation (redox-inflammatory hypothesis), and kynurenine pathway metabolites. Also, there is an interaction between brain-derived neurotrophic factor and oxidative stress in schizophrenia. Oxidative stress may be associated with positive, cognitive, and negative symptoms and impairments in white matter integrity in schizophrenia. The antipsychotic-galantamine-memantine combination may provide a novel strategy in schizophrenia to treat positive, cognitive, and negative symptoms.Summary: A \"single antioxidant\" may be inadequate to counteract the complex cascade of oxidative stress. The galantamine-memantine combination as \"double antioxidants\" is promising. Hence, randomized controlled trials are warranted with the antipsychotic-galantamine-memantine combination with oxidative stress and antioxidant biomarkers in schizophrenia.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 2","pages":"37-50"},"PeriodicalIF":1.7,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00174-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

FRONTAL ALPHA ASYMMETRY IN YOUTH AT CLINICAL HIGH-RISK FOR PSYCHOSIS. 青少年临床精神病高危人群的额叶α不对称。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-01 Epub Date: 2019-05-07

Lisa A Bartolomeo, Molly A Erickson, Lauren E Arnold, Gregory P Strauss

{"title":"FRONTAL ALPHA ASYMMETRY IN YOUTH AT CLINICAL HIGH-RISK FOR PSYCHOSIS.","authors":"Lisa A Bartolomeo, Molly A Erickson, Lauren E Arnold, Gregory P Strauss","doi":"","DOIUrl":"","url":null,"abstract":"Purpose of the review: Negative symptoms are highly predictive of whether individuals at clinical high-risk (CHR) develop a psychotic disorder. However, little is known about pathophysiological mechanisms underlying negative symptoms during this period. The current study examined neurophysiological mechanisms underlying negative symptoms in CHR individuals using electroencephalography frontal alpha asymmetry power, a biomarker of approach and avoidance motivation.Recent findings: People with schizophrenia display abnormal patterns of frontal alpha asymmetry indicative of reduced approach motivation. However, It is unknown whether similar abnormalities occur in CHR youth that predict negative symptoms.Summary: Results indicated that CHR and healthy controls did not differ in frontal alpha asymmetry scores. However, in CHR youth, frontal alpha asymmetry was inversely correlated with the motivation and pleasure dimension of negative symptoms, which was accounted for by mood symptoms. Findings suggest that depression contributes to reduced approach motivation in CHR youth that manifests clinically as negative symptoms.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":" ","pages":"21-26"},"PeriodicalIF":1.7,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922025/pdf/nihms-1528825.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37475216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontal Alpha Asymmetry in Youth at Clinical High Risk for Psychosis 精神病临床高危青年的额叶α不对称

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-05-07 DOI: 10.1007/s40473-019-00172-7

Lisa A. Bartolomeo, Molly A. Erickson, L. Arnold, G. Strauss

引用次数: 6

Remote Monitoring for Understanding Mechanisms and Prediction in Psychiatry 远程监测对精神病学机制的理解和预测

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-05-02 DOI: 10.1007/s40473-019-00176-3

G. Gillett, K. Saunders

引用次数: 10

Good Clinical Science Needs Rigorous Methodology, Enhanced Reproducibility, and Also Proper Citations 良好的临床科学需要严谨的方法论、增强的可重复性和适当的引用

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-04-30 DOI: 10.1007/s40473-019-00175-4

K. Luedtke, A. May

引用次数: 0

Current understanding of the neurobiology of opioid use disorder: An overview. 目前对阿片类药物使用障碍的神经生物学理解:综述。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-03-15 Epub Date: 2019-01-17 DOI: 10.1007/s40473-019-0170-4

Hestia Moningka, Sarah Lichenstein, Sarah W Yip

{"title":"Current understanding of the neurobiology of opioid use disorder: An overview.","authors":"Hestia Moningka, Sarah Lichenstein, Sarah W Yip","doi":"10.1007/s40473-019-0170-4","DOIUrl":"10.1007/s40473-019-0170-4","url":null,"abstract":"Purpose of review: This review provides an overview of the neurobiological mechanisms underlying opioid use disorder (OUD) drawing from genetic, functional and structural magnetic resonance imaging (MRI) research.Recent findings: Preliminary evidence suggests an association between OUD and specific variants of the DRD2, δ-opioid receptor 1 (OPRD1) and μ-opioid receptor 1 (OPRM1) genes. Additionally, MRI research indicates functional and structural alterations in striatal and corticolimbic brain regions and pathways underlying reward, emotion/stress and cognitive control processes among individuals with OUD.Summary: Individual differences in genetic and functional and structural brain-based features are correlated with differences in OUD severity and treatment outcomes, and therefore may potentially one day be used to inform OUD treatment selection. However, given the heterogeneous findings reported, further longitudinal research across different stages of opioid addiction is needed to yield a convergent characterization of OUD and improve treatment and prevention.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 1","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-0170-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39386638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Biological responses to acute stress and suicide: A review and opportunities for methodological innovation. 急性应激和自杀的生物学反应:方法创新的回顾和机会。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-01-01 Epub Date: 2019-08-21 DOI: 10.1007/s40473-019-00185-2

Adam Bryant Miller, Tory A Eisenlohr-Moul

{"title":"Biological responses to acute stress and suicide: A review and opportunities for methodological innovation.","authors":"Adam Bryant Miller, Tory A Eisenlohr-Moul","doi":"10.1007/s40473-019-00185-2","DOIUrl":"https://doi.org/10.1007/s40473-019-00185-2","url":null,"abstract":"Purpose of review: While rates of other medical illnesses have declined over the past several decades, rates of suicide have increased, particularly among adolescents. Prior research on biological underpinnings of suicide risk has remained limited. In this review, we describe a recent model conceptualizing suicide as a failure of biological responses to acute stress. According to this model, youth who fail to mount an adaptive stress response following exposure to a stressor are at acute risk for suicide.Recent findings: Although much more research is needed, early evidence suggests that abnormal biological responses to acute stress, such as altered autonomic nervous system activity and altered hypothalamic-pituitary-adrenal axis function, may underlie risk for suicide, particularly during the transition to adolescence.Summary: Overall, initial evidence supports a link between biological responses to acute stress and suicide risk. However, future work that incorporates makers of other biological and environmental systems will sharpen our understanding of who is at suicide risk and when this risk is highest.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 ","pages":"141-150"},"PeriodicalIF":1.7,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00185-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38635082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4