Current Behavioral Neuroscience Reports最新文献_第10页

Current understanding of the neurobiology of opioid use disorder: An overview. 目前对阿片类药物使用障碍的神经生物学理解:综述。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-03-15 Epub Date: 2019-01-17 DOI: 10.1007/s40473-019-0170-4

Hestia Moningka, Sarah Lichenstein, Sarah W Yip

{"title":"Current understanding of the neurobiology of opioid use disorder: An overview.","authors":"Hestia Moningka, Sarah Lichenstein, Sarah W Yip","doi":"10.1007/s40473-019-0170-4","DOIUrl":"10.1007/s40473-019-0170-4","url":null,"abstract":"Purpose of review: This review provides an overview of the neurobiological mechanisms underlying opioid use disorder (OUD) drawing from genetic, functional and structural magnetic resonance imaging (MRI) research.Recent findings: Preliminary evidence suggests an association between OUD and specific variants of the DRD2, δ-opioid receptor 1 (OPRD1) and μ-opioid receptor 1 (OPRM1) genes. Additionally, MRI research indicates functional and structural alterations in striatal and corticolimbic brain regions and pathways underlying reward, emotion/stress and cognitive control processes among individuals with OUD.Summary: Individual differences in genetic and functional and structural brain-based features are correlated with differences in OUD severity and treatment outcomes, and therefore may potentially one day be used to inform OUD treatment selection. However, given the heterogeneous findings reported, further longitudinal research across different stages of opioid addiction is needed to yield a convergent characterization of OUD and improve treatment and prevention.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 1","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-0170-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39386638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Biological responses to acute stress and suicide: A review and opportunities for methodological innovation. 急性应激和自杀的生物学反应:方法创新的回顾和机会。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-01-01 Epub Date: 2019-08-21 DOI: 10.1007/s40473-019-00185-2

Adam Bryant Miller, Tory A Eisenlohr-Moul

{"title":"Biological responses to acute stress and suicide: A review and opportunities for methodological innovation.","authors":"Adam Bryant Miller, Tory A Eisenlohr-Moul","doi":"10.1007/s40473-019-00185-2","DOIUrl":"https://doi.org/10.1007/s40473-019-00185-2","url":null,"abstract":"Purpose of review: While rates of other medical illnesses have declined over the past several decades, rates of suicide have increased, particularly among adolescents. Prior research on biological underpinnings of suicide risk has remained limited. In this review, we describe a recent model conceptualizing suicide as a failure of biological responses to acute stress. According to this model, youth who fail to mount an adaptive stress response following exposure to a stressor are at acute risk for suicide.Recent findings: Although much more research is needed, early evidence suggests that abnormal biological responses to acute stress, such as altered autonomic nervous system activity and altered hypothalamic-pituitary-adrenal axis function, may underlie risk for suicide, particularly during the transition to adolescence.Summary: Overall, initial evidence supports a link between biological responses to acute stress and suicide risk. However, future work that incorporates makers of other biological and environmental systems will sharpen our understanding of who is at suicide risk and when this risk is highest.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 ","pages":"141-150"},"PeriodicalIF":1.7,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00185-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38635082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Linking late life depression and Alzheimer's disease: mechanisms and resilience. 晚年抑郁症与阿尔茨海默病之间的联系：机制与恢复力。

IF 2.1

Current Behavioral Neuroscience Reports Pub Date : 2019-01-01 Epub Date: 2019-07-25 DOI: 10.1007/s40473-019-00180-7

Sara L Weisenbach, Joseph Kim, Dustin Hammers, Kelly Konopacki, Vincent Koppelmans

{"title":"Linking late life depression and Alzheimer's disease: mechanisms and resilience.","authors":"Sara L Weisenbach, Joseph Kim, Dustin Hammers, Kelly Konopacki, Vincent Koppelmans","doi":"10.1007/s40473-019-00180-7","DOIUrl":"10.1007/s40473-019-00180-7","url":null,"abstract":"Purpose of review: This review summarizes recent literature linking Alzheimer's disease (AD) and late life depression (LLD). It describes shared neurobiological features associated with both conditions, as well as factors that may increase resilience to onset and severity of cognitive decline and AD. Finally, we pose a number of future research directions toward improving detection, management, and treatment of both conditions.Recent findings: Epidemiological studies have consistently shown a significant relationship between LLD and AD, with support for depression as a prodromal feature of AD, a risk factor for AD, and observation of some shared risk factors underlying both disease processes. Three major neurobiological features shared by LLD and AD include neurodegeneration, disruption to cerebrovascular functioning, and increased levels of neuroinflammation. There are also potentially modifiable factors that can increase resilience to AD and LLD, including social support, physical and cognitive engagement, and cognitive reserve.Summary: We propose that, in the context of depression, neurobiological events, such as neurodegeneration, cerebrovascular disease, and neuroinflammation result in a brain that is more vulnerable to the consequences of the pathophysiological features of AD, lowering the threshold for the onset of the behavioral presentation of AD (i.e., cognitive decline and dementia). We discuss factors that can increase resilience to AD and LLD, including social support, physical and cognitive engagement, and cognitive reserve. We conclude with a discussion of future research directions.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 3","pages":"103-112"},"PeriodicalIF":2.1,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597973/pdf/nihms-1535733.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38555805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabis Use: Neurobiological, Behavioral, and Sex/Gender Considerations. 大麻的使用：神经生物学、行为学和性别/性别因素。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2018-12-01 Epub Date: 2018-11-10

Anahita Bassir Nia, Claire Mann, Harsimar Kaur, Mohini Ranganathan

引用次数: 0

Neurobiological Considerations for Tobacco Use Disorder. 烟草使用障碍的神经生物学因素。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2018-12-01 Epub Date: 2018-10-30 DOI: 10.1007/s40473-018-0168-3

Megha Chawla, Kathleen A Garrison

{"title":"Neurobiological Considerations for Tobacco Use Disorder.","authors":"Megha Chawla, Kathleen A Garrison","doi":"10.1007/s40473-018-0168-3","DOIUrl":"10.1007/s40473-018-0168-3","url":null,"abstract":"Purpose of review: Neurobiological studies of tobacco/nicotine use examining genetic, molecular, functional, and behavioral correlates have improved our understanding of nicotine/tobacco dependence and have informed treatment. Recent work extending previously established findings and reporting novel methodologies and discoveries in preclinical and human studies are reviewed.Recent findings: Recent work in preclinical models has focused on the differential roles of nicotinic receptor subtypes and nicotine's effects on neural systems beyond cortico-striatal dopaminergic pathways, and utilizing advanced methodologies such as pharmacogenetics, optogenetics and rodent fMRI to identify targets for treatment. Likewise, human neuroimaging studies have identified molecular and functional dynamic shifts associated with tobacco/nicotine use that further inform treatment.Summary: Nicotine/tobacco use is associated with widespread neural adaptations that are persistent and function to maintain addiction. The continued identification of genetic, molecular, neural, and behavioral endophenotypes related to nicotine/tobacco use, dependence, and addiction will facilitate the development and delivery of personalized treatment.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"5 4","pages":"238-248"},"PeriodicalIF":1.7,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-018-0168-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37258375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Concept of Food Addiction: a Review of the Current Evidence 食物成瘾的概念：对现有证据的回顾

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2018-11-17 DOI: 10.1007/s40473-018-0169-2

K. Naish, J. Mackillop, I. Balodis

引用次数: 11

Cannabis Use: Neurobiological, Behavioral, and Sex/Gender Considerations 大麻的使用：神经生物学、行为学和性别/性别因素

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2018-11-10 DOI: 10.1007/s40473-018-0167-4

Anahita Bassir Nia, Claire L. Mann, H. Kaur, M. Ranganathan

引用次数: 30

Do Obese Bacteria Make us “Want them”? Intestinal Microbiota, Mesocorticolimbic Circuit and Non-Homeostatic Feeding 肥胖细菌会让我们“想要它们”吗?肠道微生物群，中皮质边缘回路和非稳态进食

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2018-11-03 DOI: 10.1007/s40473-018-0161-x

Jocelyn Urrutia-Piñones, Javiera Illanes-González, Alejandra López-Aguilera, M. Julio-Pieper, J. Bravo

引用次数: 3

Review of Neurobiological Influences on Externalizing and Internalizing Pathways to Alcohol Use Disorder 酒精使用障碍外化和内化途径的神经生物学影响综述

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2018-10-29 DOI: 10.1007/s40473-018-0166-5

Jillian E. Hardee, L. Cope, M. Martz, M. Heitzeg

引用次数: 12

Behavioral Neuroscience of Buying-Shopping Disorder: a Review 购物障碍的行为神经科学研究综述

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2018-10-26 DOI: 10.1007/s40473-018-0165-6

M. Kyrios, Patrick Trotzke, L. Lawrence, D. Fassnacht, K. Ali, Nora M. Laskowski, A. Müller

引用次数: 34