FRONTAL ALPHA ASYMMETRY IN YOUTH AT CLINICAL HIGH-RISK FOR PSYCHOSIS.

IF 2.1 Q3 NEUROSCIENCES
Current Behavioral Neuroscience Reports Pub Date : 2019-06-01 Epub Date: 2019-05-07
Lisa A Bartolomeo, Molly A Erickson, Lauren E Arnold, Gregory P Strauss
{"title":"FRONTAL ALPHA ASYMMETRY IN YOUTH AT CLINICAL HIGH-RISK FOR PSYCHOSIS.","authors":"Lisa A Bartolomeo,&nbsp;Molly A Erickson,&nbsp;Lauren E Arnold,&nbsp;Gregory P Strauss","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of the review: </strong>Negative symptoms are highly predictive of whether individuals at clinical high-risk (CHR) develop a psychotic disorder. However, little is known about pathophysiological mechanisms underlying negative symptoms during this period. The current study examined neurophysiological mechanisms underlying negative symptoms in CHR individuals using electroencephalography frontal alpha asymmetry power, a biomarker of approach and avoidance motivation.</p><p><strong>Recent findings: </strong>People with schizophrenia display abnormal patterns of frontal alpha asymmetry indicative of reduced approach motivation. However, It is unknown whether similar abnormalities occur in CHR youth that predict negative symptoms.</p><p><strong>Summary: </strong>Results indicated that CHR and healthy controls did not differ in frontal alpha asymmetry scores. However, in CHR youth, frontal alpha asymmetry was inversely correlated with the motivation and pleasure dimension of negative symptoms, which was accounted for by mood symptoms. Findings suggest that depression contributes to reduced approach motivation in CHR youth that manifests clinically as negative symptoms.</p>","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":" ","pages":"21-26"},"PeriodicalIF":2.1000,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922025/pdf/nihms-1528825.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Behavioral Neuroscience Reports","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/5/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose of the review: Negative symptoms are highly predictive of whether individuals at clinical high-risk (CHR) develop a psychotic disorder. However, little is known about pathophysiological mechanisms underlying negative symptoms during this period. The current study examined neurophysiological mechanisms underlying negative symptoms in CHR individuals using electroencephalography frontal alpha asymmetry power, a biomarker of approach and avoidance motivation.

Recent findings: People with schizophrenia display abnormal patterns of frontal alpha asymmetry indicative of reduced approach motivation. However, It is unknown whether similar abnormalities occur in CHR youth that predict negative symptoms.

Summary: Results indicated that CHR and healthy controls did not differ in frontal alpha asymmetry scores. However, in CHR youth, frontal alpha asymmetry was inversely correlated with the motivation and pleasure dimension of negative symptoms, which was accounted for by mood symptoms. Findings suggest that depression contributes to reduced approach motivation in CHR youth that manifests clinically as negative symptoms.

青少年临床精神病高危人群的额叶α不对称。
本综述的目的:阴性症状可高度预测临床高危(CHR)个体是否发展为精神障碍。然而,对这一时期阴性症状的病理生理机制知之甚少。目前的研究使用脑电图额叶α不对称功率(一种接近和回避动机的生物标志物)来检查CHR患者阴性症状的神经生理机制。最近的研究发现:精神分裂症患者表现出额叶α不对称的异常模式,表明接近动机减少。然而,尚不清楚CHR青年是否发生类似的异常,预示阴性症状。结果表明CHR和健康对照组在额叶α不对称评分上没有差异。然而,在CHR青年中,额叶α不对称与消极症状的动机和愉悦维度呈负相关,这是由情绪症状解释的。研究结果表明,抑郁症有助于降低CHR青年的接近动机,临床表现为阴性症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Current Behavioral Neuroscience Reports
Current Behavioral Neuroscience Reports Medicine-Public Health, Environmental and Occupational Health
CiteScore
3.60
自引率
0.00%
发文量
11
期刊介绍: Under the leadership of Emil Coccaro, Current Behavioral Neuroscience Reports will provide an in-depth review of topics covering personality and impulse control disorders, psychosis, mood and anxiety disorders, genetics and neuroscience, geropsychiatry and cognitive disorders of late life, child and developmental psychiatry, addictions, and neuromodulation.We accomplish this aim by inviting international authorities to contribute review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists.  By providing clear, insightful balanced contributions, the journal intends to serve those involved in the field of behavioral neuroscience.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信