Current Behavioral Neuroscience Reports最新文献_第9页

Atorvastatin Blocks Advanced Glycation End Products Induced Reduction in Macrophage Cholesterol Efflux Mediated With ATP-Binding Cassette Transporters G 1. 阿托伐他汀能阻断高级糖化终产物诱导的、由 ATP 结合盒式转运体 G 1 介导的巨噬细胞胆固醇外流减少。

IF 3.1

Current Behavioral Neuroscience Reports Pub Date : 2019-08-23 Epub Date: 2019-08-02 DOI: 10.1253/circj.CJ-19-0153

Lei Xu, Yi-Ru Wang, Pei-Cheng Li, Bo Feng

{"title":"Atorvastatin Blocks Advanced Glycation End Products Induced Reduction in Macrophage Cholesterol Efflux Mediated With ATP-Binding Cassette Transporters G 1.","authors":"Lei Xu, Yi-Ru Wang, Pei-Cheng Li, Bo Feng","doi":"10.1253/circj.CJ-19-0153","DOIUrl":"10.1253/circj.CJ-19-0153","url":null,"abstract":"Background: There is accumulating evidence that the AGEs-RAGE interaction plays an important role in accelerated atherosclerosis in diabetes. Our previous study showed that the AGEs-RAGE axis can reduce the cholesterol efflux of THP-1 macrophages through suppression of the expression of ABCG1 and that statins can inhibit the expression of RAGE. However, the role of statins in recovering the cholesterol efflux of macrophages reduced by AGEs has not been assessed.Methods and results: ApoE-/-mice and THP-1 macrophages were both treated by AGEs or AGEs combined with anti-RAGE antibody (only in THP-1 cells), ALT711 and atorvastatin separately. Cholesterol efflux of THP-1 macrophages and murine peritoneal macrophages was tested by fluorescence microplate technique. RT-PCR and western blot analysis were used to measure the expression of RAGE and molecules included in cholesterol efflux. After co-incubating with atorvastatin and AGEs, reduction in lipid accumulation in THP-1 macrophages and improvement of lesions complexity occurred compared with treating by AGEs only. Atorvastatin increased cholesterol efflux and ABCG1 expression of macrophages, which were reduced by AGEs, and decreased the expression of RAGE at the same time.Conclusions: This study demonstrated that atorvastatin can recover the deleterious ABCG1-mediated cholesterol efflux induced by AGEs in THP-1 macrophages and murine peritoneal macrophages by downregulating RAGE expression. It may contribute to the protective action of atorvastatin in diabetic subjects with atherosclerosis.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 1","pages":"1954-1964"},"PeriodicalIF":3.1,"publicationDate":"2019-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89962050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antisocial and Borderline Personality Disorders in the Emergency Department: Conceptualizing and Managing “Malingered” or “Exaggerated” Symptoms 急诊科的反社会和边缘型人格障碍：“恶意”或“夸大”症状的概念化和管理

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-08-14 DOI: 10.1007/s40473-019-00183-4

V. Hong, Loreen F Pirnie, A. Shobassy

引用次数: 4

Novel Pharmacologic Strategies for Treating Behavioral Disturbances in Alzheimer’s Disease 治疗阿尔茨海默病行为障碍的新药理学策略

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-07-02 DOI: 10.1007/s40473-019-00181-6

Mathura Thiyagarajah, N. Herrmann, M. Ruthirakuhan, Abby Li, K. Lanctôt

引用次数: 1

Frustrative Non-reward and Lab-Based Paradigms for Advancing the Study of Aggression in Persons with Psychosis 挫折性非奖励和实验室范式:促进精神病患者攻击行为的研究

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-15 DOI: 10.1007/s40473-019-00173-6

Jill Del Pozzo, Christina Athineos, Taylor Zar, Lisa N. Cruz, Christopher M King

引用次数: 1

Remediation of Visual Processing Impairments in Schizophrenia: Where We Are and Where We Need to Be 精神分裂症患者视觉处理障碍的修复:我们在哪里，我们需要去哪里

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-15 DOI: 10.1007/s40473-019-00171-8

D. Demmin, Samantha I. Fradkin, S. Silverstein

引用次数: 6

Mitochondrial Dysfunction in Alzheimer’s Disease and Progress in Mitochondria-Targeted Therapeutics 阿尔茨海默病的线粒体功能障碍及线粒体靶向治疗的进展

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-08 DOI: 10.1007/s40473-019-00179-0

Padraig J. Flannery, E. Trushina

引用次数: 21

Galantamine-Memantine Combination as an Antioxidant Treatment for Schizophrenia. 加兰他明-美金刚联合抗氧化治疗精神分裂症。

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-06-01 DOI: 10.1007/s40473-019-00174-5

Maju Mathew Koola, Samir Kumar Praharaj, Anilkumar Pillai

{"title":"Galantamine-Memantine Combination as an Antioxidant Treatment for Schizophrenia.","authors":"Maju Mathew Koola, Samir Kumar Praharaj, Anilkumar Pillai","doi":"10.1007/s40473-019-00174-5","DOIUrl":"https://doi.org/10.1007/s40473-019-00174-5","url":null,"abstract":"Purpose of review: The objective of this article is to highlight the potential role of the galantamine-memantine combination as a novel antioxidant treatment for schizophrenia.Recent findings: In addition to the well-known mechanisms of action of galantamine and memantine, these medications also have antioxidant activity. Furthermore, an interplay exists between oxidative stress, inflammation (redox-inflammatory hypothesis), and kynurenine pathway metabolites. Also, there is an interaction between brain-derived neurotrophic factor and oxidative stress in schizophrenia. Oxidative stress may be associated with positive, cognitive, and negative symptoms and impairments in white matter integrity in schizophrenia. The antipsychotic-galantamine-memantine combination may provide a novel strategy in schizophrenia to treat positive, cognitive, and negative symptoms.Summary: A \"single antioxidant\" may be inadequate to counteract the complex cascade of oxidative stress. The galantamine-memantine combination as \"double antioxidants\" is promising. Hence, randomized controlled trials are warranted with the antipsychotic-galantamine-memantine combination with oxidative stress and antioxidant biomarkers in schizophrenia.","PeriodicalId":36384,"journal":{"name":"Current Behavioral Neuroscience Reports","volume":"6 2","pages":"37-50"},"PeriodicalIF":1.7,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40473-019-00174-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Frontal Alpha Asymmetry in Youth at Clinical High Risk for Psychosis 精神病临床高危青年的额叶α不对称

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-05-07 DOI: 10.1007/s40473-019-00172-7

Lisa A. Bartolomeo, Molly A. Erickson, L. Arnold, G. Strauss

引用次数: 6

Remote Monitoring for Understanding Mechanisms and Prediction in Psychiatry 远程监测对精神病学机制的理解和预测

IF 1.7

Current Behavioral Neuroscience Reports Pub Date : 2019-05-02 DOI: 10.1007/s40473-019-00176-3

G. Gillett, K. Saunders

引用次数: 10

Good Clinical Science Needs Rigorous Methodology, Enhanced Reproducibility, and Also Proper Citations 良好的临床科学需要严谨的方法论、增强的可重复性和适当的引用