Eastern Journal of Medical Sciences最新文献_第4页

Influence of myocardial contractility therapy for advanced heart failure 心肌收缩治疗对晚期心力衰竭的影响

Eastern Journal of Medical Sciences Pub Date : 2022-05-02 DOI: 10.32677/ejms.v7i1.3316

Dinesh Chiriki, A. S.

{"title":"Influence of myocardial contractility therapy for advanced heart failure","authors":"Dinesh Chiriki, A. S.","doi":"10.32677/ejms.v7i1.3316","DOIUrl":"https://doi.org/10.32677/ejms.v7i1.3316","url":null,"abstract":"With more than 5 million patients’ diagnosed with heart failure (HF) and more than 1 million hospitalizations each year, HF continues to have a significant impact on health-care resources. Despite treatment, a significant number of patients continue to have progressive HF symptoms, classified as Class III or IV. The aim of this study was to compare different inotropic therapy for patients of End-Stage Heart Failure. When persistent intravenous access was used and acute hemodynamic improvement was established, the durable medical equipment (DME) benefit category reimbursed 80% of outpatient inotropic medication and supplies for HF. Acute hemodynamic improvement was defined as a 20% reduction in pulmonary capillary wedge pressure and/or a 20% increase in cardiac index, both of which were related to a decrease in dyspnea. The Centers for Medicaid and Medicare Services contracted with regional carriers to run the program. The amounts reimbursed per beneficiary for inotrope and supplies (not adjusted for differential follow-up) were essentially representative of the inotrope cost. Dobutamine, milrinone, and supplies had mean (and median) amounts of 5025 (1168), 87781 (31440), and 7284 (3131), respectively. We found that patients who received this medication had a relatively high death rate, however not as high as people who received chemotherapy. Milrinone-treated patients were compensated more for hospitalizations both before and after starting the inotrope. In addition, the milrinone group had a higher level of digoxin use in the background. Nonetheless, there is an early decrease in overall expenditures following inotrope initiation, which can be attributed to a decrease in hospitalization. Considering the lack of double-blind trials comparing inotropes to placebo or dobutamine to milrinone, decisions regarding the use of inotropes, the type of inotrope used, and the duration of treatment should take into account the impact on resources.","PeriodicalId":363370,"journal":{"name":"Eastern Journal of Medical Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127838278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 2 Diabetes Mellitus and Erectile Dysfunction: A study on risk factors and their correlation to serum testosterone level. 2型糖尿病和勃起功能障碍:危险因素及其与血清睾酮水平的相关性研究。

Eastern Journal of Medical Sciences Pub Date : 2022-05-02 DOI: 10.32677/ejms.v7i1.3364

Muhammed Jasim Abdul Jalal, Sheena John

{"title":"Type 2 Diabetes Mellitus and Erectile Dysfunction: A study on risk factors and their correlation to serum testosterone level.","authors":"Muhammed Jasim Abdul Jalal, Sheena John","doi":"10.32677/ejms.v7i1.3364","DOIUrl":"https://doi.org/10.32677/ejms.v7i1.3364","url":null,"abstract":"Background \u0000Diabetes mellitus (DM) is one of the major cause of erectile dysfunction (ED). Testosterone regulates nearly every component of ED and this subnormal testosterone concentration con tribute to ED. \u0000The objective of our work was to study the age of the patient, duration of diabetes mellitus, body mass index (BMI), glycosylated haemoglobin (hbA1c) and urinary albumin creatinine ratio (uACR) in type 2 diabetic male patients as etiology for ED and their relation to the serum testosterone level. \u0000Methodology \u0000We studied 100 male type two diabetic patients selected from the outpatient department of the Family Medicine department in Olive Healthcare. We divided our patients into two groups. Group A: 50 patients with type 2 diabetes mellitus with ED and Group B: 50 patients with type 2 diabetes mellitus without ED. We assessed their history with special focus on the age of the patient, disease duration and lab investigations. The patients answered the five item version of the International Index of Erectile Function (IIEF-5) questionnaire. \u0000Results \u0000Total serum testosterone was significantly lower in type 2 diabetic male patients with ED compared to those without ED. HbA1c, diabetes duration and uACR were independently negatively correlated with testosterone level. \u0000Conclusion \u0000The duration of diabetes, glycemic control and uACR contributed to ED in type 2 diabetics and they are independently and negatively correlated with total serum testosterone level.","PeriodicalId":363370,"journal":{"name":"Eastern Journal of Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122554898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic rupture of an intracranial dermoid cyst: A case report 外伤性颅内皮样囊肿破裂1例

Eastern Journal of Medical Sciences Pub Date : 2022-03-01 DOI: 10.32677/ejms.v6i4.3181

Uddalok Das, N. Pandit

{"title":"Traumatic rupture of an intracranial dermoid cyst: A case report","authors":"Uddalok Das, N. Pandit","doi":"10.32677/ejms.v6i4.3181","DOIUrl":"https://doi.org/10.32677/ejms.v6i4.3181","url":null,"abstract":"Intracranial dermoid cyst is a very rare primary intracranial tumor accounting for <0.5% of intracranial masses. They are usually congenital and benign. Rupture of intracranial dermoid may occur spontaneously or with trivial trauma. Most cases of rupture are spontaneous. There are very few reported cases of traumatic rupture of intracranial dermoid cysts in world medical literature. The presentation can range from headache to signs of meningeal irritation and focal neurological deficit. Computed tomography (CT) and magnetic resonance imaging (MRI) of the brain is of paramount importance for early diagnosis and prompt treatment planning which can reduce both morbidity and mortality. The following case report gives an account of a 49-year-old female who presented with complaints of headache after an episode of fall. She was examined and no neurological deficit was found. Examination of the neurological system was within normal limits. She underwent a CT and MRI of the brain and was subsequently diagnosed as traumatic rupture of dermoid cyst based on the findings. She was treated with high-dose steroids until resolution of her symptoms and then discharged with the advice of regular follow-up. This case report highlights the role of CT and MRI in early diagnosis and treatment planning of patients with ruptured dermoid cysts which leads to a decrease in mortality and morbidity and also the ability of the same to rule out other more sinister causes of headache in patients.","PeriodicalId":363370,"journal":{"name":"Eastern Journal of Medical Sciences","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121585294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Genetics of stroke in Qatar: Current situation and future opportunities 卡塔尔中风的遗传学:现状和未来的机会

Eastern Journal of Medical Sciences Pub Date : 2022-03-01 DOI: 10.32677/ejms.v6i4.3201

F. Khan

引用次数: 0

A report on chromosomal translocation types in relation to male infertility 染色体易位类型与男性不育的关系

Eastern Journal of Medical Sciences Pub Date : 2022-03-01 DOI: 10.32677/ejms.v6i4.3220

Nidhi Shah, K. Mistry, Mudra H Kansara, K. Sonali, Nirali Thakkar, Parth Shah, Sandip C. Shah, M. V. Rao

{"title":"A report on chromosomal translocation types in relation to male infertility","authors":"Nidhi Shah, K. Mistry, Mudra H Kansara, K. Sonali, Nirali Thakkar, Parth Shah, Sandip C. Shah, M. V. Rao","doi":"10.32677/ejms.v6i4.3220","DOIUrl":"https://doi.org/10.32677/ejms.v6i4.3220","url":null,"abstract":"Introduction: Male infertility (MI) in about 50% of couples is constituted due to genetic, hormonal, and epigenetic factors. Almost 10% of it is contributed to genetic anomalies. Objectives: This study was undertaken in 787 males with infertility and the impacts of the type of translocations in these cases were studied in relation to MI. Materials and Methods: Five milliliters (ml) of blood were drawn from referred cases suspected with MI and were used for cytogenetic analysis with Giemsa stain following International System for Human Cytogenetic Nomenclature. Results: Of 6142 referral cases, 787 were detected with MI (787/6142; 12.8%). Forty-four translocations (44/787; 5.6%) were detected in 787 infertile men. Other chromosomal abnormalities were 21% (167/787) in them. Among all translocations, an autosome-autosomal translocations were higher in frequency (24/787; 3.1%) than Robertsonian (15/787; 1.9%) and autogonosomal translocations (5/787; 0.6%). Few translocations seemed to be rare as our knowledge is concerned. Maharashtra had high frequency of translocations followed by Delhi union territory (UT) and Gujarat (07 each) and other states. Most of the translocations were related to infertility. Seven males had primary infertility (7/44) and six with secondary type (6/44) in this study. Conclusions: These reciprocal translocations are important in causation of infertility affecting testicular spermatogenesis. Few are rare in our study. Such cases are clinically suggested for counseling before adopting assisted reproductive technologies.","PeriodicalId":363370,"journal":{"name":"Eastern Journal of Medical Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128835350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacted leopard tooth in thyroid gland of victim in a case of leopard attack – A case report 豹攻击受害者甲状腺内嵌豹牙1例- 1例报告

Eastern Journal of Medical Sciences Pub Date : 2021-11-22 DOI: 10.32677/ejms.v6i3.3111

Uddalok Das, N. Pandit

{"title":"Impacted leopard tooth in thyroid gland of victim in a case of leopard attack – A case report","authors":"Uddalok Das, N. Pandit","doi":"10.32677/ejms.v6i3.3111","DOIUrl":"https://doi.org/10.32677/ejms.v6i3.3111","url":null,"abstract":"Attacks by wild animals on humans are not rare in India. Most of the cases are seen in rural areas and areas adjoining forest lands. The nature of the attack may be predatory or defensive. The main culprit for this is deforestation and encroachment of humans into the natural habitats of wild animals. Wild animal attacks can cause very severe injuries, including lacerations, fractures, and vascular injuries, and are often associated with high rates of mortality. Treatment depends on the type and nature of the injury. Those who survive the initial attack often succumb to infection and septicemia during the early hospital stay. Psychiatric complications are also common in survivors. We present the case of a 70-year-old man, who was attacked by a leopard. He sustained a few lacerated bite injuries to the neck and was treated at North Bengal Medical College and Hospital. A computed tomography scan of the neck revealed a tooth of the animal impacted in the thyroid gland of the patient. The patient is currently receiving treatment for deranged thyroid function, and awaiting normalization of the same, to get anesthetic fitness for surgical removal of the tooth. Treating surgeons must be well aware of the patterns of injuries and their treatment in cases of animal attack injuries. In-depth clinical and radiological investigations are of utmost importance to find out occult injuries that may become life-threatening. A standardized treatment protocol needs to be developed for the treatment of wild animal attack victims. There is a need to extend health care into the remote areas of the nation, for early treatment of such cases.","PeriodicalId":363370,"journal":{"name":"Eastern Journal of Medical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116352770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effectiveness of dequalinium chloride vaginal tablets in aerobic vaginitis: A placebo-controlled study 评价氯去qualinium阴道片治疗有氧阴道炎的有效性:一项安慰剂对照研究

Eastern Journal of Medical Sciences Pub Date : 2021-10-24 DOI: 10.32677/ejms.v6i3.3090

S. Tekgunduz, F. Saraçoğlu

{"title":"Evaluation of the effectiveness of dequalinium chloride vaginal tablets in aerobic vaginitis: A placebo-controlled study","authors":"S. Tekgunduz, F. Saraçoğlu","doi":"10.32677/ejms.v6i3.3090","DOIUrl":"https://doi.org/10.32677/ejms.v6i3.3090","url":null,"abstract":"Background: Aerobic vaginitis is a disturbance of vaginal homeostasis caused by the colonization of enteric bacteria. They are not clinically well-defined and do not have standard treatment regimes. Hence, the present study was conducted to evaluate the effectiveness of dequalinium chloride topical vaginal administration in aerobic vaginitis in a placebo-controlled manner. Materials and Methods: This study was conducted in a placebo-controlled manner to demonstrate the effectiveness of vaginal 10 mg dequalinium chloride. A total of 30 patients with different vaginal infections were included in the study. The patients included in the study were divided between the drug group and the placebo group and were treated with one vaginal tablet daily for 6 days. The total symptom score, which consists of the assessment of discharge, itching, and burning sensation, and the lactobacillus grade evaluated microscopically, was determined. Results: It was found that the effectiveness of dequalinium chloride was very high compared to placebo (92% vs. 0%). The reproduction frequency in the first visit was statistically significantly lower in the drug group compared to the placebo group (P < 0.001). Conclusion: It was found that dequalinium chloride is effective for the treatment of aerobic vaginitis. However, studies containing a larger sample group, including the long-term effects (efficacy and side effects) of the drug, should be conducted to prove our conclusion.","PeriodicalId":363370,"journal":{"name":"Eastern Journal of Medical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125401797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

C-reactive protein as a prognostic marker in coronavirus disease-2019 c反应蛋白作为冠状病毒病-2019的预后标志物

Eastern Journal of Medical Sciences Pub Date : 2021-09-18 DOI: 10.32677/ejms.v6i3.3034

Tarana Sarwat, Devendra Kumar, N. Singh, D. Kakru

{"title":"C-reactive protein as a prognostic marker in coronavirus disease-2019","authors":"Tarana Sarwat, Devendra Kumar, N. Singh, D. Kakru","doi":"10.32677/ejms.v6i3.3034","DOIUrl":"https://doi.org/10.32677/ejms.v6i3.3034","url":null,"abstract":"Background: Coronavirus disease-2019 (COVID-19) is a recently emerged viral disease, for which there’s currently no definitive treatment. It is, therefore, necessary to determine biomarkers to know the extent of disease severity so that timely action can be taken to reduce mortality. We aimed to determine the usefulness of C-reactive protein (CRP) levels in assessing COVID-19 disease severity and correlate them with mortality due to the same. Methods: Data for COVID-19 were retrospectively collected and analyzed from May 2020 to October 2020. The CRP value was correlated with disease severity using Karl Pearson’s correlation coefficient. A logistic regression model was adopted to analyze the association between mortality and related factors. Results: Out of 642 patients enrolled, 22 died while 620 recovered. Most of the non-survivors were male. Multivariate analysis showed that age, diabetes, hypertension, and CRP values were significantly associated with mortality. CRP showed a strong positive correlation with disease severity and, hence, mortality. Conclusion: In patients with COVID-19, CRP correlated with disease severity and tended to be a good predictor of adverse outcome.","PeriodicalId":363370,"journal":{"name":"Eastern Journal of Medical Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127353781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of low bone mineral density in Human Immunodeficiency Virus-infected patients and its correlation with other determinants 人类免疫缺陷病毒感染患者的低骨密度患病率及其与其他决定因素的相关性

Eastern Journal of Medical Sciences Pub Date : 2021-05-29 DOI: 10.32677/ejms.v6i2.2930

Swati M. Mahajan, R. Raina, A. Jhobta

{"title":"Prevalence of low bone mineral density in Human Immunodeficiency Virus-infected patients and its correlation with other determinants","authors":"Swati M. Mahajan, R. Raina, A. Jhobta","doi":"10.32677/ejms.v6i2.2930","DOIUrl":"https://doi.org/10.32677/ejms.v6i2.2930","url":null,"abstract":"Background: The patients infected with human immunodeficiency virus (HIV) are potentially at risk of low bone mineral density (BMD). The present study was done to find out the prevalence of low BMD in HIV-infected patients and its correlation with other factors such as gender, body mass index (BMI), CD4 count, and highly active antiretroviral therapy (HAART). Methods: This was an observational cross-sectional study conducted in a tertiary care center for 1 year period. A total of 127 HIV-infected patients were evaluated for BMD by dual-energy X-ray absorptiometry (DEXA) scans at two sites lumbosacral spine and bilateral neck femur. Correlation with other factors was also studied. Results: The diagnosis of low BMD was established in 105 (82.67%) patients. Osteoporosis (44.1%) was more common than osteopenia (38.6%) at the lumbosacral spine. The mean T score of the DEXA lumbar spine and bilateral neck femur was observed to be ?2.113 and ?1.379, respectively. Males (88.73%) had low BMD than females (75%). Approximately 94.5% of subjects having BMI <18 had low BMD in contrast to 80.8% among subjects having BMI >18. After treatment, 47 patients had CD4 count <400 and 80 > 400. Forty-three patients out of 47 (91.5%) had low BMD and 62 out of 80 (77.5%) had low BMD. Conclusion: Low BMD is prevalent in HIV-infected subjects. Low BMI, persistently low CD4 count, tenofovir containing HAART regimen showed a positive correlation with low BMD. Hence, HIV infection should be considered as a risk factor for bone disease.","PeriodicalId":363370,"journal":{"name":"Eastern Journal of Medical Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131106603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinico-pathological features of the drug reaction with eosinophilia and systemic Symptoms syndrome: A case study 嗜酸性粒细胞增多和全身症状综合征的药物反应的临床病理特征:一个病例研究

Eastern Journal of Medical Sciences Pub Date : 2021-05-29 DOI: 10.32677/ejms.v6i2.2858

S. Nagarajan, S. Harshan, Sneha Jagadeesh, S DeepakK, Yeshaswini S Pujar

引用次数: 0