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Formulation and Evaluation of Commiphora wightii Herbal Pills Treatment of Anti-Obesity 治疗肥胖症的诃子丸的配方与评估
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2024-05-23 DOI: 10.26452/ijcpms.v4i2.614
Jyoshna M, Santhi Elveena Alagala, Charishma Manyam, Raju Thoti, Jyothika Pulicherla, Madhavi Udayagiri, Swathi Krishna KV
{"title":"Formulation and Evaluation of Commiphora wightii Herbal Pills Treatment of Anti-Obesity","authors":"Jyoshna M, Santhi Elveena Alagala, Charishma Manyam, Raju Thoti, Jyothika Pulicherla, Madhavi Udayagiri, Swathi Krishna KV","doi":"10.26452/ijcpms.v4i2.614","DOIUrl":"https://doi.org/10.26452/ijcpms.v4i2.614","url":null,"abstract":"An excessive quantity of bodily fat characterizes a complex disorder called obesity. It raises the risk of developing other illnesses and medical conditions like diabetes, high blood pressure, and heart conditions. When our BMI is 30kg/m2 or greater, obesity is considered to exist. Today, more ailments are treated with traditional herbal medicines than allopathic ones. Compared to herbal medications, allopathic drugs have higher side effects. The current work aims to create and assess the herbal tablet prepared using an ethanolic extract of Commiphora wightii leaves. Wet granulation was used to manufacture the formulation. Both the pre-compression parameter and the post-compression parameter of the prepared formulation were assessed. The calculation demonstrated that the permissible pre and postcompression parameters are within bounds.Top of Form","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"10 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prospective study on assessment of risk factors, clinical characteristics and outcomes of acute pancreatitis in a tertiary care center 在一家三级医疗中心评估急性胰腺炎风险因素、临床特征和预后的前瞻性研究
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2024-02-02 DOI: 10.26452/ijcpms.v4i1.574
Radhika Chikatipalli, Asifa Banu Mohammad, Audinarayana Nelavala
{"title":"A prospective study on assessment of risk factors, clinical characteristics and outcomes of acute pancreatitis in a tertiary care center","authors":"Radhika Chikatipalli, Asifa Banu Mohammad, Audinarayana Nelavala","doi":"10.26452/ijcpms.v4i1.574","DOIUrl":"https://doi.org/10.26452/ijcpms.v4i1.574","url":null,"abstract":"This prospective study at RVS Hospital Chittoor targets acute pancreatitis, a severe pancreatic condition with significant health risks. Its goal is to improve patient care by analyzing risk factors, clinical features, and outcomes. Adult patients with acute pancreatitis will participate, providing comprehensive demographic, clinical, and lab data. The research will focus on key risk factors like alcohol use, gallstones, and prior pancreatitis episodes. Clinical aspects, including pain severity, systemic symptoms, and complications, will be documented, utilizing CT scans and MRI for accurate diagnosis and classification. The primary aims are identifying acute pancreatitis risk factors, understanding patient presentations, and monitoring complications during hospitalization. Secondary goals include evaluating the impact of risk factors on disease severity and mortality and exploring connections between specific risks and major complications like pancreatic necrosis and infections. This study is crucial for advancing understanding of acute pancreatitis, guiding healthcare professionals in early diagnosis, risk stratification, and effective management, ultimately enhancing patient outcomes in this complex medical issue.","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and Evaluation of Phenylephrine Nasal Gels 苯肾上腺素鼻凝胶的配制和评估
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2024-02-02 DOI: 10.26452/ijcpms.v4i1.573
Ameer Pasha Shaik, Sowmy Adapa
{"title":"Formulation and Evaluation of Phenylephrine Nasal Gels","authors":"Ameer Pasha Shaik, Sowmy Adapa","doi":"10.26452/ijcpms.v4i1.573","DOIUrl":"https://doi.org/10.26452/ijcpms.v4i1.573","url":null,"abstract":"The primary objective of this study is to develop and evaluate phenylephrine nasal gels, aiming for stable blood levels with lower drug doses through consistent administration, avoiding first-pass hepatic metabolism. Compatibility among the drug, polymers, and lipids was confirmed using FTIR and DSC spectra. Phenylephrine nasal gels were formulated, and their clarity assessed. The gels (ONGF1-ONGF8) had pH values of 6.1-7.2, spreadability of 18.33-21.62 g/cm/sec, and viscosity of 934.2-966.2 centipoises. Drug concentration in these formulations varied from 85.52% to 98.88%, indicating acceptable medication content. Gel strength ranged from 64% to 95%. In-vitro drug release of phenylephrine showed 77% to 95% diffusion for ONGF1. The release kinetics followed first order, zero order, Higuchi model, and Korsemeyer-Peppas equations. Kinetic values for all formulations were tabulated. ONGF1 exhibited the most efficient release, with 95% of the drug released within 7 hours, demonstrating a diffusion mechanism followed by non-Fickian transport, adhering to both zero order and Korsemeyer-Peppas models.Top of Form","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"207 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139870188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prospective study on assessment of risk factors, clinical characteristics and outcomes of acute pancreatitis in a tertiary care center 在一家三级医疗中心评估急性胰腺炎风险因素、临床特征和预后的前瞻性研究
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2024-02-02 DOI: 10.26452/ijcpms.v4i1.574
Radhika Chikatipalli, Asifa Banu Mohammad, Audinarayana Nelavala
{"title":"A prospective study on assessment of risk factors, clinical characteristics and outcomes of acute pancreatitis in a tertiary care center","authors":"Radhika Chikatipalli, Asifa Banu Mohammad, Audinarayana Nelavala","doi":"10.26452/ijcpms.v4i1.574","DOIUrl":"https://doi.org/10.26452/ijcpms.v4i1.574","url":null,"abstract":"This prospective study at RVS Hospital Chittoor targets acute pancreatitis, a severe pancreatic condition with significant health risks. Its goal is to improve patient care by analyzing risk factors, clinical features, and outcomes. Adult patients with acute pancreatitis will participate, providing comprehensive demographic, clinical, and lab data. The research will focus on key risk factors like alcohol use, gallstones, and prior pancreatitis episodes. Clinical aspects, including pain severity, systemic symptoms, and complications, will be documented, utilizing CT scans and MRI for accurate diagnosis and classification. The primary aims are identifying acute pancreatitis risk factors, understanding patient presentations, and monitoring complications during hospitalization. Secondary goals include evaluating the impact of risk factors on disease severity and mortality and exploring connections between specific risks and major complications like pancreatic necrosis and infections. This study is crucial for advancing understanding of acute pancreatitis, guiding healthcare professionals in early diagnosis, risk stratification, and effective management, ultimately enhancing patient outcomes in this complex medical issue.","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"16 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139868977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and Evaluation of Phenylephrine Nasal Gels 苯肾上腺素鼻凝胶的配制和评估
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2024-02-02 DOI: 10.26452/ijcpms.v4i1.573
Ameer Pasha Shaik, Sowmy Adapa
{"title":"Formulation and Evaluation of Phenylephrine Nasal Gels","authors":"Ameer Pasha Shaik, Sowmy Adapa","doi":"10.26452/ijcpms.v4i1.573","DOIUrl":"https://doi.org/10.26452/ijcpms.v4i1.573","url":null,"abstract":"The primary objective of this study is to develop and evaluate phenylephrine nasal gels, aiming for stable blood levels with lower drug doses through consistent administration, avoiding first-pass hepatic metabolism. Compatibility among the drug, polymers, and lipids was confirmed using FTIR and DSC spectra. Phenylephrine nasal gels were formulated, and their clarity assessed. The gels (ONGF1-ONGF8) had pH values of 6.1-7.2, spreadability of 18.33-21.62 g/cm/sec, and viscosity of 934.2-966.2 centipoises. Drug concentration in these formulations varied from 85.52% to 98.88%, indicating acceptable medication content. Gel strength ranged from 64% to 95%. In-vitro drug release of phenylephrine showed 77% to 95% diffusion for ONGF1. The release kinetics followed first order, zero order, Higuchi model, and Korsemeyer-Peppas equations. Kinetic values for all formulations were tabulated. ONGF1 exhibited the most efficient release, with 95% of the drug released within 7 hours, demonstrating a diffusion mechanism followed by non-Fickian transport, adhering to both zero order and Korsemeyer-Peppas models.Top of Form","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"138 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139810556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Prospective Study of Disease Patterns and Assessment of Drug Interactions with Prasugrel in Tertiary Care Hospital Patients 关于三级医院患者疾病模式以及普拉格雷药物相互作用评估的前瞻性研究
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2024-02-02 DOI: 10.26452/ijcpms.v4i1.575
Kishore Bandarapalle, Hemanth Yadav Mopuru, Mohammad Ishaqulla Kodadhavadi, Saran B, Sree Harsha Avvaru, Likhith C, Mujeeb Shaik
{"title":"A Prospective Study of Disease Patterns and Assessment of Drug Interactions with Prasugrel in Tertiary Care Hospital Patients","authors":"Kishore Bandarapalle, Hemanth Yadav Mopuru, Mohammad Ishaqulla Kodadhavadi, Saran B, Sree Harsha Avvaru, Likhith C, Mujeeb Shaik","doi":"10.26452/ijcpms.v4i1.575","DOIUrl":"https://doi.org/10.26452/ijcpms.v4i1.575","url":null,"abstract":"This prospective observational study evaluates the prescribing patterns and drug-drug interactions of Prasugrel in hospitalized patients at a tertiary care hospital (BBH). Conducted over six months, it involved 110 inpatients, gathering data from various sources including patient profiles, medicine charts, and lab tests. The study primarily focused on Prasugrel usage, identifying patient demographics and assessing the interactions of Prasugrel with other medications. It found that 64.02% of the patients on Prasugrel therapy were male and 36.08% female, predominantly aged between 55 to 75 years. These patients often had a history of cardiovascular and infectious diseases. The study revealed that 31.36% of patients experienced interactions with Prasugrel, with a higher incidence in males. The most common interactions were with Pantoprazole, Omeprazole, and Aspirin. These interactions were classified as severe (11.81%), moderate (55.05%), and mild (34.13%). Additionally, 17.91% of interactions were defined, 58.45% probable, and 22.62% possible. Prasugrel was mainly prescribed for heart disease, myocardial infarction, and angina. The study suggests cautious use of Pantoprazole with Prasugrel due to potential significant interactions.","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"135 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139810473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Prospective Study of Disease Patterns and Assessment of Drug Interactions with Prasugrel in Tertiary Care Hospital Patients 关于三级医院患者疾病模式以及普拉格雷药物相互作用评估的前瞻性研究
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2024-02-02 DOI: 10.26452/ijcpms.v4i1.575
Kishore Bandarapalle, Hemanth Yadav Mopuru, Mohammad Ishaqulla Kodadhavadi, Saran B, Sree Harsha Avvaru, Likhith C, Mujeeb Shaik
{"title":"A Prospective Study of Disease Patterns and Assessment of Drug Interactions with Prasugrel in Tertiary Care Hospital Patients","authors":"Kishore Bandarapalle, Hemanth Yadav Mopuru, Mohammad Ishaqulla Kodadhavadi, Saran B, Sree Harsha Avvaru, Likhith C, Mujeeb Shaik","doi":"10.26452/ijcpms.v4i1.575","DOIUrl":"https://doi.org/10.26452/ijcpms.v4i1.575","url":null,"abstract":"This prospective observational study evaluates the prescribing patterns and drug-drug interactions of Prasugrel in hospitalized patients at a tertiary care hospital (BBH). Conducted over six months, it involved 110 inpatients, gathering data from various sources including patient profiles, medicine charts, and lab tests. The study primarily focused on Prasugrel usage, identifying patient demographics and assessing the interactions of Prasugrel with other medications. It found that 64.02% of the patients on Prasugrel therapy were male and 36.08% female, predominantly aged between 55 to 75 years. These patients often had a history of cardiovascular and infectious diseases. The study revealed that 31.36% of patients experienced interactions with Prasugrel, with a higher incidence in males. The most common interactions were with Pantoprazole, Omeprazole, and Aspirin. These interactions were classified as severe (11.81%), moderate (55.05%), and mild (34.13%). Additionally, 17.91% of interactions were defined, 58.45% probable, and 22.62% possible. Prasugrel was mainly prescribed for heart disease, myocardial infarction, and angina. The study suggests cautious use of Pantoprazole with Prasugrel due to potential significant interactions.","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"158 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139870337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and evaluation of irbesartan fast disintegrating tablets by direct compression technique 采用直接压片技术制备和评估厄贝沙坦快速崩解片
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2023-11-20 DOI: 10.26452/ijcpms.v3i2.530
Archana B, Abubakar Sadiq, Anitha Mahadev, Maleka Begum
{"title":"Formulation and evaluation of irbesartan fast disintegrating tablets by direct compression technique","authors":"Archana B, Abubakar Sadiq, Anitha Mahadev, Maleka Begum","doi":"10.26452/ijcpms.v3i2.530","DOIUrl":"https://doi.org/10.26452/ijcpms.v3i2.530","url":null,"abstract":"The main objective of the present study is to develop a pharmaceutically stable, cost effective & quality improved robust formulation. The main aim of the present work is to formulate & evaluate Irbesartan fast disintegrating tablets by using pH 6.8 phosphate buffer as a dissolution medium, USP II paddle method. The superdisintegrants sodium starch glycolate, croscarmellose sodium, and crospovidone were used in the current work to generate a total of six distinct formulations employing the direct compression method. Irbesartan, an angiotensin receptor blocker, has a role in the treatment of hypertension. This review summarises recent developments in this area and looks at the role of this drug in light of studies that assessed its safety, tolerability, as well as effectiveness. The prepared batches were evaluated for disintegration and  In vitro dissolution studies. Among all the formulations, F3 was concluded to be the best formulation, because it is having the disintegration time of less than 3 mins and showed 95% dissolution within 30mins.","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"135 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139259683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on Health Promotion and Disease Prevention in Children and Adults 儿童和成人健康促进与疾病预防综述
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2023-08-25 DOI: 10.26452/ijcpms.v3i3.537
Muli Yamini, Bachu Naveena, Y. P. Chandra
{"title":"A Review on Health Promotion and Disease Prevention in Children and Adults","authors":"Muli Yamini, Bachu Naveena, Y. P. Chandra","doi":"10.26452/ijcpms.v3i3.537","DOIUrl":"https://doi.org/10.26452/ijcpms.v3i3.537","url":null,"abstract":"The risk of developing chronic diseases and other morbidities is decreased by health promotion and disease prevention. Systemic meta-analysis was used to produce review articles that were published between 2019 and 2023. The study's goal is to review the literature on illness prevention and health promotion for both adults and children. The data regarding disease prevention in children in 2019 (Diabetes Mellitus), 2020 (Obesity, Disability), 2021 In 2019, the focus was on physical activity and emotion management; in 2020, it was on reducing salt, smoking, alcohol, and increasing physical activity; in 2021, it was on reducing salt, smoking, alcohol, and increasing physical activity; in 2022, it was on positive wellbeing, resilience among individuals, and positive mental health; and in 2023, it was on lifestyle behaviours and COVID-19 preventive behaviours. In summary, this review article concludes that promoting health to both adults and children can help prevent disease by providing information on both acute and chronic conditions, which can reduce risk and prevent the disease state from worsening.","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139349152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of analysis of biomarkers or detection method of biomarkers in cancer 癌症生物标志物分析或生物标志物检测方法综述
International Journal of Clinical Pharmacokinetics and Medical Sciences Pub Date : 2023-07-28 DOI: 10.26452/ijcpms.v3i3.533
Medida Deeksha, Chejerla Sakhinamma, Y. P. Chandra
{"title":"A review of analysis of biomarkers or detection method of biomarkers in cancer","authors":"Medida Deeksha, Chejerla Sakhinamma, Y. P. Chandra","doi":"10.26452/ijcpms.v3i3.533","DOIUrl":"https://doi.org/10.26452/ijcpms.v3i3.533","url":null,"abstract":"In the last three decades, technological advancements in health services have notably enhanced the detection and treatment of diseases, including cancer. This progress is particularly evident in the research and application of cancer biomarkers for early detection and risk assessment, aiming to lower cancer fatalities. These biomarkers represent a cost-effective alternative to traditional diagnostic methods like CT scans, though they have yet to achieve the reliability needed for clinical use. This thesis explores the development, validation, and quality control of cancer biomarkers, examining market trends in genomics, proteomics, and diagnostic technologies. The potential for biomarkers to offer less invasive and more affordable diagnostic options could lead to significant healthcare savings. Highlighting this potential, the National Cancer Institute's Early Detection Research Network has initiated a project focused on enhancing cancer cell biomarker identification, driven by individual researchers' efforts. This initiative reflects the growing emphasis on prevention over treatment in the fight against cancer.","PeriodicalId":363324,"journal":{"name":"International Journal of Clinical Pharmacokinetics and Medical Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139354002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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