Technical Innovations and Patient Support in Radiation Oncology最新文献

{"title":"Comparative evaluation of two dose-volume histogram prediction tools for treatment planning: Treatment planning quality and dose verification accuracy","authors":"Shoma Nakano ,&nbsp;Motoharu Sasaki ,&nbsp;Yuji Nakaguchi ,&nbsp;Takeshi Kamomae ,&nbsp;Kanako Sakuragawa ,&nbsp;Yuto Yamaji ,&nbsp;Hitoshi Ikushima","doi":"10.1016/j.tipsro.2024.100297","DOIUrl":"10.1016/j.tipsro.2024.100297","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to compare treatment plans created using RapidPlan and PlanIQ for twelve patients with prostate cancer, focusing on dose uniformity, dose reduction to organs at risk (OARs), plan complexity, and dose verification accuracy. The goal is to identify the tool that demonstrates superior performance in achieving uniform target dose distribution and reducing OAR dose, while ensuring accurate dose verification.</div></div><div><h3>Methods</h3><div>Dose uniformity in the planning target volume, excluding the rectum, and dose reduction in the OARs (the rectum and bladder) were assessed. The validation included point-dose measurements with an ionization chamber dosimeter and gamma analysis of dose distributions. Monitor units were calculated to evaluate plan complexity.</div></div><div><h3>Results</h3><div>PlanIQ provided superior dose uniformity, with improvements in the dose homogeneity index compared with RapidPlan. RapidPlan was more effective in reducing OAR doses, particularly in the rectum, with significant reductions at various dose levels. Dose verification showed no significant differences between the two tools. However, PlanIQ showed a smaller mean difference between the calculated and measured doses and a slightly better dose distribution match with less variability than RapidPlan.</div></div><div><h3>Conclusions</h3><div>RapidPlan was more effective at reducing OAR doses, whereas PlanIQ achieved better dose uniformity and lower plan complexity. Both tools performed similarly in terms of dose verification accuracy, with PlanIQ showing a slight advantage in dose-distribution matching. The choice of planning tool depends on the primary treatment goal, whether it is to reduce the OAR doses or improve the target dose uniformity.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100297"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating the hidden cost: A systematic review of cognitive late effects regarding cancer-related fatigue in treated paediatric brain tumors","authors":"Ingrid Vethe Hernes ,&nbsp;Amalie Jansdatter ,&nbsp;Anita Nordsteien ,&nbsp;Mathilde Haraldsen Normann","doi":"10.1016/j.tipsro.2024.100291","DOIUrl":"10.1016/j.tipsro.2024.100291","url":null,"abstract":"<div><h3>Objective</h3><div>Globally, in 2022, 30,871 children were diagnosed with CNS-tumors. Many have been treated with radiotherapy, and a significant number suffer from chronic late effects, including fatigue. This study aims to investigate previous research on the impact of cancer-related fatigue for neurocognitive function that can be related to radiotherapy in patients who have undergone primary brain radiotherapy before the age of 18.</div></div><div><h3>Methods</h3><div>Conducted under PRISMA-S framework, this systematic review searched MEDLINE ALL (Ovid), EMBASE (Ovid), CINAHL (EBSCO), and PsycINFO (Ovid) for relevant studies. Criteria for inclusion were children under 18 who underwent radiotherapy for primary brain cancer, focusing on late cognitive side effects, published 2000–2023.</div></div><div><h3>Results</h3><div>From 4,067 records, 10 studies were included, examining Proton Radiation Therapy (n = 4), X-ray Radiation Therapy (n = 3), and their comparisons (n = 3). The studies used various cognitive tests, and late effects that emerged were neurocognitive functions and disorders, intellectual functioning, specific cognitive functions and daily life, social functioning, and performance. These themes can be encompassed by cancer-related fatigue.</div></div><div><h3>Conclusions</h3><div>The findings underscore critical need for more in-depth research to understand the health perception variations among children post-primary brain radiotherapy. Furthermore, detailed insights of treatment specifics, disease progression, target volume sizes, and doses to surrounding organs at risk are imperative.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Clinical workflow considerations for treating soft-tissue sarcoma on a 1.5-T MR-Linac","authors":"Gye Won Choi,&nbsp;Gary A. Eastwick,&nbsp;Leonard H. Kim","doi":"10.1016/j.tipsro.2024.100296","DOIUrl":"10.1016/j.tipsro.2024.100296","url":null,"abstract":"<div><div>We present specific issues that arose when using a 1.5-Tesla MR-Linac to treat a series of 4 soft-tissue sarcoma (STS) patients. These issues arose from the combination of typical STS attributes (long, off-axis target) and MR-Linac design-specific limitations on field size and patient positioning. Despite the availability of on-line plan adaptation, STS patients were more efficiently treated after workflow changes to improve patient selection and immobilization. Other issues arising from off-axis STS target locations: geometric distortion of MR images and patient-specific QA, are discussed.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100296"},"PeriodicalIF":0.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced practice radiation therapist led vaginal vault brachytherapy: An evaluation of efficiency and effectiveness of service delivery","authors":"Rhona Goodwin","doi":"10.1016/j.tipsro.2024.100289","DOIUrl":"10.1016/j.tipsro.2024.100289","url":null,"abstract":"<div><h3>Aims</h3><div>An advanced practice radiation therapist (APRT) role in vaginal vault brachytherapy (VBT) was first introduced in 2015. The aim of this manuscript was to clarify how the introduction of an APRT can improve efficiencies within service delivery while maintaining non inferior clinical outcomes of recurrence.</div></div><div><h3>Materials and methods</h3><div>This was a single-centred retrospective comparative service evaluation of stage 1 endometrial cancer patients treated with postoperative high dose rate VBT alone. Sixty patients in total were included in the evaluation. They were divided into two equal groups of ‘before’ and ‘after’ based on the introduction of the APRT-led role and changes made to treatment processes. Quantitative analysis of waiting times from surgery to adjuvant VBT (weeks), duration of day one treatment procedure (minutes), rate of isolated vaginal recurrence and loco regional recurrence (vaginal and pelvic) were compared between the groups.</div></div><div><h3>Results</h3><div>The mean time from surgery to treatment between the ‘before’ and ‘after’ groups was 13.1 and 9.1 weeks respectively. The mean time for day one treatment procedure was 91 min in the ‘before’ group and 59 min in the ‘after’ group. Vaginal free recurrence (VFR) was 100 % for both groups..</div></div><div><h3>Conclusion</h3><div>An APRT led vaginal vault service, with learnt role extension, allows for a more efficient and effective service delivery.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"32 ","pages":"Article 100289"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Tho oncology (Việt Nam) hospital radiotherapy department: A Snapshot of current and future practice","authors":"Tran Thanh Phong,&nbsp;Vo Van Kha,&nbsp;Le Thi Den","doi":"10.1016/j.tipsro.2024.100292","DOIUrl":"10.1016/j.tipsro.2024.100292","url":null,"abstract":"<div><div>Can Tho City Oncology Hospital was established on September 28, 2007, by the People’s Committee of Can Tho City. The Can Tho City Oncology Hospital has been in operation for 17 years and has over time become a reliable place for the provision of oncological patient services and treatment for Can Tho citizens and the Mekong Delta area. The Hospital includes approximately 400 patient beds, 9 clinical departments, 5 paraclinical departments (radiology, pathology etc), and 8 functional rooms (customer care epartment, admissions, discharge office, finance and accounting division,). The Radiotherapy Department is a busy and important part of the Hospital and plays an important role in cancer patient treatment.</div><div>Introducing the current situation, challenges and future plans for the Radiotherapy Department in Can Tho Oncology Hospital, Việt Nam.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"32 ","pages":"Article 100292"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benchmarking and performance evaluation of a novel deformable image registration software for radiotherapy CT images","authors":"Shorug S. Alshammari ,&nbsp;Sridhar Yaddanapudi ,&nbsp;Blaž Kušnik ,&nbsp;Rok Ivančič ,&nbsp;Kristjan Anderle ,&nbsp;Jonathan G. Li ,&nbsp;Keith M. Furutani ,&nbsp;Chris J. Beltran ,&nbsp;Bo Lu","doi":"10.1016/j.tipsro.2024.100295","DOIUrl":"10.1016/j.tipsro.2024.100295","url":null,"abstract":"<div><h3>Purpose</h3><div>We evaluated and benchmarked a novel deformable image registration (DIR) software functionality (DirOne, Cosylab d.d., Ljubljana, Slovenia) by comparing it to two commercial systems, MIM and VelocityAI, following AAPM task group 132 (TG-132) guidelines.</div></div><div><h3>Methods</h3><div>Three publicly available datasets were used for evaluation. The first dataset includes primary and deformed phantom images for a male pelvis. The second, from DIR-Lab, contains ten sets of 4D CT thoracic scans. The third dataset, from the DIR Evaluation Project (DIREP), includes ten head and neck CTs. VelocityAI and MIM served as benchmarks to assess DirOne’s performance. Target registration error (TRE), dice similarity coefficient (DSC), and mean distance to agreement (MDA) were the evaluation metrics.</div></div><div><h3>Results</h3><div>For TRE, the average results for DirOne, MIM, and VelocityAI were 3.3 ± 3.1 mm, 2.7 ± 3.7 mm, and 3.4 ± 2.4 mm, respectively. For DSC, DirOne achieved 0.96 ± 0.02, MIM 0.98 ± 0.02, and VelocityAI 0.98 ± 0.01 across the first and second datasets. In the DIREP dataset, DirOne achieved 0.73 ± 0.34 for MDA and 0.91 ± 0.03 for DSC; MIM achieved 0.54 ± 0.36 and 0.93 ± 0.02, and VelocityAI 0.93 ± 0.38 and 0.90 ± 0.03.</div></div><div><h3>Conclusion</h3><div>The novel DIR software demonstrated clinically acceptable accuracy compared to other commercial systems, supporting its potential use in radiotherapy treatment planning applications such as automatic image segmentation, 4D segmentation propagation, and dose warping.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"32 ","pages":"Article 100295"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of predicted and actual dermatitis generated from computed tomography images and dose distribution maps","authors":"Yasuhide Miyabe ,&nbsp;Saori Oshiro ,&nbsp;Hiroto Seki ,&nbsp;Yusuke Muroi ,&nbsp;Eriko Kawashima ,&nbsp;Megumi Hosoda ,&nbsp;Kento Ohashi ,&nbsp;Hiromu Yamanaka ,&nbsp;Mingliang Shao ,&nbsp;Hiromi Sugawara ,&nbsp;Jyunetsu Mizoe ,&nbsp;Ritsuko Komaki","doi":"10.1016/j.tipsro.2024.100294","DOIUrl":"10.1016/j.tipsro.2024.100294","url":null,"abstract":"<div><div>Anticipating the onset, location and severity of radiation dermatitis before radiotherapy can aid in dermatological care. This study developed a method for creation of a prediction diagram for dermatitis and conducted a comparative verification between the prediction diagram and actual patient condition. The prediction diagram involved converting skin doses into 2 Gy fractionated equivalent doses using α/β of 10.0, defining regions of interest (ROIs) from 20-50 Gy at 10 Gy intervals. Overlaps between these ROIs at each dose level and the skin (external) was sequentially color-coded as blue, yellow, red, and purple. The study included four patients: two underwent head and neck treatment and two received neck and chest treatment. This approach involved a visual assessment comparing the prediction diagram with skin photographs captured at the end of treatment. Nurses marked skin sites corresponding to grades 1 and 2 on photographs, assessing their correlation with the predicted range. Visual assessment results were largely positive, although one patient exhibited slightly lower scores. Results revealed a correlation between grade 1 skin reactions and the 20 Gy regions. Grade 2 reactions were observed in regions near 30 and 40 Gy. Although discrepancies between prediction diagram and actual skin symptoms were observed in patients, a broad agreement was evident. The prediction diagram cannot accurately predict radiation dermatitis, as it does not account for skin symptoms unrelated to the dose. However, the diagram is significant as it provides physicians, nurses, and patients with concise and visually comprehensible information regarding the location of dermatitis.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"32 ","pages":"Article 100294"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a modern radiotherapy department in a rural hospital in Cameroon: The Mbingo experience","authors":"Ntumsi Akundoh Tontu ,&nbsp;William W.Y. Cheung ,&nbsp;Marcus Jones ,&nbsp;Linda Grossheim ,&nbsp;Dennis Palmer ,&nbsp;Earnest Chukwudi N. Okonkwo ,&nbsp;Eric Moore ,&nbsp;Keith Streatfield ,&nbsp;Laurie Elit","doi":"10.1016/j.tipsro.2024.100293","DOIUrl":"10.1016/j.tipsro.2024.100293","url":null,"abstract":"<div><div>Although radiotherapy is critical for cancer cure and palliation, access to such expensive and sophisticated technology is very limited in low- and middle-income countries (LMIC). Cancer incidence in Africa is currently 1.5 million case per year, thus urgent and innovative solutions are required to build necessary infrastructure needed to address this global health challenge. We describe our approach and challenges as a faith based non-government organization in setting up a modern radiotherapy department in a rural hospital in Cameroon to mitigate this unmet need. We highlite our engagement with international bodies and individuals for fund raising and volunteerism, local radiotherapy workforce development and training (radiation oncology, dosimetrists, radiation therapist and medical physicists) and the expertise required for construction of the bunker and installation of the Linac machine.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"32 ","pages":"Article 100293"},"PeriodicalIF":0.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical application of in vivo dosimetry for gynaecological brachytherapy: A scoping review","authors":"Amani A. Chowdhury ,&nbsp;Steve Bolton ,&nbsp;Gerry Lowe ,&nbsp;Eliana Vasquez Osorio ,&nbsp;William Hamblyn ,&nbsp;Peter J Hoskin","doi":"10.1016/j.tipsro.2024.100290","DOIUrl":"10.1016/j.tipsro.2024.100290","url":null,"abstract":"<div><div>Brachytherapy is a key treatment for gynaecological malignancies, delivering high doses to the tumour volume whilst sparing nearby normal tissues due to its steep dose gradient. Accuracy is imperative as small shifts can lead to clinically significant under- or over-dosing of the target volume or organs at risk (OARs), respectively. Independent verification of dose delivered during brachytherapy is not routinely performed but it is important to identify gross errors and define action thresholds to guide inter-fraction treatment decisions. In vivo dosimetry (IVD) is one strategy for improving accuracy and identifying potential errors. Despite promising phantom work, clinical application of IVD is lacking. A literature search was performed using Medline and EMBASE without date limits and based on the PICO framework to evaluate the clinical application of IVD in gynaecological brachytherapy. After screening of titles and abstracts, full text papers were reviewed and 28 studies were identified. Several dosimeters were utilised and measurements were typically taken from the rectum, bladder, vagina and within interstitial catheters. Significant differences between calculated and measured dose were attributed to geometric shifts. The studies reviewed demonstrated the feasibility of IVD in brachytherapy for dose verification but further work is required before IVD can be used to optimise treatment. The purpose of this scoping review is to investigate the clinical application of IVD in gynaecological brachytherapy, understand its challenges and identify the steps required to facilitate integration into everyday clinical practice.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100290"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The status quo of global geriatric radiation oncology education: A scoping review","authors":"Lucinda Morris ,&nbsp;Sandra Turner ,&nbsp;Jane L. Phillips ,&nbsp;Anamika Parmar ,&nbsp;Meera Agar","doi":"10.1016/j.tipsro.2024.100288","DOIUrl":"10.1016/j.tipsro.2024.100288","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify potential gaps in geriatric radiation oncology (RO) education worldwide, as measured by geriatric oncology (GO) content within postgraduate RO training program (TP) curricula across 8 focus countries.</div></div><div><h3>Methods and materials</h3><div>The need for improved education around GO is internationally recognized and is a key strategic priority of the International Society of Geriatric Oncology (SIOG).</div><div>Two reviewers undertook a systematic scoping review from March to September 2023. Focus countries were selected using predefined selection criteria based on national radiation therapy (RT) service provision, RT access and post-graduate specialty training standards. This review is in accordance with evidence-based curriculum design methodology and represents the initial phase i.e., problem identification and needs assessment.</div></div><div><h3>Results</h3><div>Overall RO TP and curriculum elements varied by jurisdiction. Common elements included length of training, summative assessments and prerequisite requirements. Considerable variability exists across TPs around identified learning outcomes, content, TP organization, training networks and accreditation.</div><div>Across 6 TPs, only 2 had any documented GO curriculum content. Of these, only one contained geriatric RO content scoring moderate to high based on accepted quality benchmarks. Outside official RO TPs, there is considerable GO online education content, including face to face courses, peer-reviewed articles, learning materials and resources relevant to RO postgraduate training worldwide. However accessibility to these learning interventions may be region specific and content is not standardized.</div></div><div><h3>Conclusions</h3><div>As expected, this systematic scoping review has identified significant gaps in GO education within RO TPs worldwide. These findings represent an essential step in the development of evidence-based recommendations for updating standards for GO training within RO training programs and establishing a globally accepted, standardized benchmarks for minimal geriatric RO education. In turn, this will ensure future radiation oncologists are able to deliver a high standard of care to and improve outcomes for older people with cancer.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"32 ","pages":"Article 100288"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}