Technical Innovations and Patient Support in Radiation Oncology最新文献

{"title":"Patient experience preparing for prostate cancer radiotherapy","authors":"S.E. Alexander ,&nbsp;J. Selous-Hodges ,&nbsp;A. Araujo ,&nbsp;L. Booth ,&nbsp;L. Delacroix ,&nbsp;E. Garrad ,&nbsp;A. Gordon ,&nbsp;C. Graham ,&nbsp;A. Guerra ,&nbsp;C. Gulyaeva ,&nbsp;C. Ockwell ,&nbsp;S. Shire ,&nbsp;U. Oelfke ,&nbsp;H.A. McNair ,&nbsp;A.C. Tree","doi":"10.1016/j.tipsro.2025.100306","DOIUrl":"10.1016/j.tipsro.2025.100306","url":null,"abstract":"<div><h3>Introduction</h3><div>Bladder and rectal preparation regimes for prostate cancer (PCa) radiotherapy (RT) can heighten anxiety before and during RT. Patient’s perception of RT preparation is under-represented in the literature. To address this gap, patient’s experience of preparation with respect to understanding, comfort, anxiety, effectiveness and impact on daily life was examined.</div></div><div><h3>Materials and methods</h3><div>A novel patient preparation survey was created and validated, it contained 12 original questions related to general, bladder and rectal preparation. Plus, the Patient Health Questionnaire 4 (PHQ4) and question 15 of the Expanded Prostate Cancer Index Composite (EPIC).</div><div>Eligible patients were individuals referred for prostate or prostate bed +/− pelvic lymph node RT from March-May 2024. Surveys were issued immediately after the patient’s planning scan, those completing the survey at this timepoint were asked to repeat it in their first and final weeks of RT.</div></div><div><h3>Results</h3><div>The survey was completed by 103/125 eligible patients at their planning scan, 47/103 in the first and 52/103 in the final week of RT. Perception of preparation was largely positive. For general and bladder preparation positive question response rate ranged from 55 to 98 % and negative from 0 to 26 %. Rectal preparation response rate was 59–100 % positive and 0–35 % negative. Difficulty maintaining a full bladder and using enemas was greatest at the end of RT.</div><div>No significant difference in experience was found for participants using or not using enemas for preparation. Anxiety and depression (PHQ4) affected 12–13 % of respondents, and significantly more patients reported bowel toxicity (EPIC), in the last week of RT compared to earlier timepoints.</div></div><div><h3>Conclusion</h3><div>The authors conclude that the preparation needs of their patients are well met. However, a considerable number did find preparation difficult, disruptive and ineffective, more so at the end of treatment. Further qualitative analysis of patient’s experience is needed to better understand why individuals experience varies.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100306"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training for tomorrow: Establishing a worldwide curriculum in online adaptive radiation therapy","authors":"Meegan Shepherd ,&nbsp;Elizabeth Joyce ,&nbsp;Bethany Williams ,&nbsp;Siobhan Graham ,&nbsp;Winnie Li ,&nbsp;Jeremy Booth ,&nbsp;Helen A. McNair","doi":"10.1016/j.tipsro.2025.100304","DOIUrl":"10.1016/j.tipsro.2025.100304","url":null,"abstract":"<div><div>This commentary discusses the implementation of online adaptive radiation therapy (oART) in cancer treatment within the context of current challenges faced by radiation therapy professionals. oART enables modifications to treatment plans based on daily imaging, enhancing target accuracy while minimising harm to surrounding organs. Despite its potential to improve patient outcomes, the application of oART is hindered by notable barriers, particularly in human resources. A global shortage of skilled radiation professionals such as radiation therapists or therapeutic radiographers (RTTs), medical physicists and radiation oncologists, along with training challenges in online adaptive techniques, hinders oART implementation and sustainability. Moreover, geographical disparities limit access to advanced training programs, leaving RTTs and their patients in underserved regions at a disadvantage. There is growing global evidence that RTTs are being successfully trained to lead adaptive fractions in both cone-beam computed tomography and magnetic resonance imaging guided oART. This commentary proposes the notion of standards for a global training curriculum to address barriers and expand RTT capabilities in delivering oART. By leveraging artificial intelligence and fostering interdisciplinary collaboration, the radiation therapy field can enhance efficiency and accuracy in oART. Successful training models from leading institutions illustrate the importance of hands-on experience and ongoing mentorship. A coordinated effort among stakeholders is essential to establish a comprehensive global training framework, ultimately improving patient access to oART and elevating standards of care worldwide.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100304"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pan-Canadian assessment of image guided adaptive radiation therapy and the role of the radiation therapist","authors":"Amanda Moreira ,&nbsp;Tara Rosewall ,&nbsp;Yat Tsang ,&nbsp;Patricia Lindsay ,&nbsp;Peter Chung ,&nbsp;Winnie Li","doi":"10.1016/j.tipsro.2025.100303","DOIUrl":"10.1016/j.tipsro.2025.100303","url":null,"abstract":"<div><h3>Purpose</h3><div>Adaptive radiation therapy (ART) is a close-looped process where anatomic changes observed during treatment are identified, leading to plan modification prior to treatment delivery. The aim of this study was to explore the status of ART across Canada and review the impact of adaptive technologies on the roles and responsibilities of Radiation Therapists (RTTs).</div></div><div><h3>Materials and Methods</h3><div>Study information and a link to a 30-question survey was sent via email to the RTT manager of all cancer centres across Canada (n = 48). The survey questions included centre demographics, presence of offline and/or online ART activities as standard of care, corresponding roles and responsibilities of the multidisciplinary team, and training activities. The survey was administered electronically and closed after a 3-week accrual period. Responses were analyzed using descriptive statistics.</div></div><div><h3>Results</h3><div>Thirty-two out of 48 centres responded across all ten provinces (67 % response rate). Twenty-five centres (78 %) currently perform ART, all of which practiced offline ART while 5 practiced online ART. Most common responses for lack of ART were ‘technical limitations’ and ‘lack of resources’. RTTs are responsible for 50 % (offline) versus 58 % (online) ART respectively, with the most notable change being the addition of target delineation to their daily practice.</div></div><div><h3>Conclusions</h3><div>The status of ART varies across Canada. Offline ART is commonly practiced, but online ART remains an infrequent process due to technical limitations and lack of resources. As centres move towards implementing online ART, the role of the RTT will need to be redefined with corresponding upskilling to support the emergent treatment paradigm.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100303"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geometric and dosimetric evaluation of CTV contour adaptations by radiation therapists for adaptive prostate radiotherapy on a 0.35 T MR-Linac","authors":"Boaz Kalkhoven ,&nbsp;Marjolein N. Hilberts ,&nbsp;Melissa A.L. Verdonk ,&nbsp;An-Sofie E. Verrijssen ,&nbsp;Peter-Paul G. van der Toorn ,&nbsp;Tom C.G. Budiharto ,&nbsp;Patricia F.C. Bronius ,&nbsp;Diana Geerts ,&nbsp;Coen W. Hurkmans ,&nbsp;Shyama U. Tetar ,&nbsp;Rob H.N. Tijssen","doi":"10.1016/j.tipsro.2025.100302","DOIUrl":"10.1016/j.tipsro.2025.100302","url":null,"abstract":"<div><h3>Background &amp; purpose</h3><div>Magnetic resonance guided adaptive radiotherapy (MRgART) enables hypofractionated prostate radiotherapy by daily contour adaptation. The MRgART workflow, however, is labour intensive and in many institutes still requires the presence of the radiation oncologist (RO). Transferring the online contour adaptation task to the radiation therapist (RTT) will release the clinician from attending each treatment fraction making MRgRT more efficient and cost effective. In this study we investigate the viability of RTT-led prostate MRgART on a low-field MR-linac, by assessing the interobserver variations of RTT- and RO-generated CTV contour adaptations as well as the resulting dosimetric effects.</div></div><div><h3>Materials &amp; methods</h3><div>Four RTTs and four ROs performed CTV contour adaptations on first fraction data in ten patients. Delineations were compared against a gold standard contour using target volume, Dice similarity coefficient (DSC), and 95th percentile Hausdorff distance. In addition, a dosimetric evaluation was performed on all first fractions by performing plan adaptations based on all RTT contour adaptation and comparing these to the clinically delivered plan. Finally, a full-treatment simulation was performed in four patients to investigate the dosimetric effects of the RTTs’ contour adaptations throughout an entire treatment.</div></div><div><h3>Results</h3><div>RTTs with no experience in prostate delineation prior to this study spent more time on CTV contour adaptations. The geometric and dosimetric analyses, however, showed no statistically significant differences between both groups.</div></div><div><h3>Conclusions</h3><div>This study confirmed that RTTs perform similarly to ROs in carrying out online contour adaptations. These results indicate the feasibility of initiating a transition in contour adaptation tasks from ROs to RTTs.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100302"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation therapists’ perspectives on artificial intelligence: Insights from a single institution on Improving effectiveness and educational supports","authors":"Caroline Marr ,&nbsp;Yat Tsang","doi":"10.1016/j.tipsro.2025.100300","DOIUrl":"10.1016/j.tipsro.2025.100300","url":null,"abstract":"<div><h3>Introduction</h3><div>In recent years, artificial intelligence (AI) technology has played an evolving role in radiation science, influencing the clinical practice of radiation therapists. This study aimed to explore the knowledge, attitude, clinical applications, and learning needs from the perspective of radiation therapists.</div></div><div><h3>Materials and Methods</h3><div>This study used a cross-sectional online survey with a population of radiation therapists from a single institution. The survey was developed iteratively and was based on past literature. The questions were constructed to measure perception using four themes: knowledge of AI, perceived utilization, job impact, clinical applications, learning needs, and educational support. The data was analyzed using descriptive statistics according to the key themes.</div></div><div><h3>Results</h3><div>Between 22nd December 2023 and 17th January 2024, 74 radiation therapists completed the survey. The majority (55.4 %) were 44 years or older (Baby Boomers and Generation X). Additionally, 37.8 % rated their knowledge of AI as none or limited, but 93.2 % expressed interest in learning more about AI. Many (79.7 %) perceived AI not to be fully used in radiation therapy but has increased its effectiveness in image registration, reconstruction, and contouring. With the increasing use of AI in healthcare, 96.0 % feel that AI may affect their role, and 82.4 % believe it may impact their job satisfaction. Educational supports indicated to be the most advantageous for their job were online modules (36.5 %) and in-person workshops (35.1 %).</div></div><div><h3>Conclusion</h3><div>Exploring the perspectives of radiation therapists has shown a strong interest in learning about AI and its role in radiation therapy. This information can help in understanding how to develop tailored strategies to mitigate potential barriers,<!--> <!-->leading to the successful implementation of AI in clinical radiation therapy practice.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100300"},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating knowledge-based planning and noncoplanar oblique VMAT arcs: A study of dose to the heart and immune cells in thoracic radiotherapy","authors":"Brennan Diedrich,&nbsp;Justin Roper,&nbsp;Benjamin Hopkins,&nbsp;Sibo Tian,&nbsp;Shadab Momin,&nbsp;Eduard Schreibmann,&nbsp;Aparna H. Kesarwala,&nbsp;Kirk Luca","doi":"10.1016/j.tipsro.2025.100301","DOIUrl":"10.1016/j.tipsro.2025.100301","url":null,"abstract":"<div><h3>Background</h3><div>Recent patient studies have linked higher immune cell doses with worse quality of life and survival. For thoracic radiotherapy, heart dose is a major contributor to the effective dose to immune cells (EDIC).</div></div><div><h3>Purpose</h3><div>This study investigates heart and immune cell doses for plans optimized using a cardiac-sparing knowledge-based planning (KBP) model and the impact of carefully crafted beam geometry.</div></div><div><h3>Methods</h3><div>Sixteen stage III NSCLC patients previously treated to 60 Gy in 30 fractions using coplanar VMAT arcs were replanned using a cardiac-sparing KBP model with either the clinical field arrangement or noncoplanar oblique arcs that prioritize heart sparing. The cardiac-sparing KBP model consisted of fifteen substructures, all of which were used during optimization. All plans were normalized to 95% PTV coverage at 60 Gy. Statistical significance was assessed for EDIC (Jin Model), along with mean doses to the heart, lungs, body, and both the mean dose and D0.03 cc values for cardiac substructures, using the Wilcoxon signed-rank test.</div></div><div><h3>Results</h3><div>Compared to the clinically treated plans with the same beam geometry, cardiac-sparing KBP reduced mean heart dose from 8.50 Gy to 4.09 Gy and EDIC from 4.27 Gy to 3.81 Gy (p &lt; 0.001). For the novel arcs, the mean heart dose was reduced to 3.70 Gy, significantly lower than KBP with clinical beam geometry (p = 0.001). EDIC, however, was equivalent. No statistically meaningful differences were observed for the remaining organs at risk, and all plans met institutional planning goals.</div></div><div><h3>Conclusion</h3><div>Cardiac-sparing RapidPlan is a valuable tool for reducing heart dose and lowering EDIC in NSCLC patients. Additional heart sparing is possible by strategically crafting noncoplanar oblique beams to minimize heart dose.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100301"},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global professional issues in radiation therapy: Collaboration, adaptation and innovation","authors":"Yolanda Surjan ,&nbsp;Sandra Ndarukwa","doi":"10.1016/j.tipsro.2024.100298","DOIUrl":"10.1016/j.tipsro.2024.100298","url":null,"abstract":"","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100298"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton beam therapy image-guided radiotherapy training for RTTs – Experience from a single institution","authors":"Jannath Shirin Kottakunnan ,&nbsp;Samaneh Shoraka ,&nbsp;Amy Dodd ,&nbsp;Maria Kilkenny ,&nbsp;Sarah Petty ,&nbsp;Kathryn Osborn ,&nbsp;Amanda Webster","doi":"10.1016/j.tipsro.2024.100299","DOIUrl":"10.1016/j.tipsro.2024.100299","url":null,"abstract":"<div><div>This study investigates whether an Image-Guided Radiation Therapy (IGRT) workbook and Cone Beam Computed Tomography (CBCT) case studies enhances Radiation Therapists’ (RTTs) confidence analysing Proton Beam Therapy (PBT) CBCTs. An 11-participant questionnaire-based study was conducted to assess pre- and post-training confidence. Prior to training, RTTs exhibited higher confidence in photon CBCT decision-making over proton CBCT, highlighting the need for PBT-specific IGRT training, irrespective of prior photon experience. After completing the PBT IGRT workbook and case studies, RTTs experienced increased confidence in analysing PBT CBCTs. The workbook was particularly beneficial for junior RTTs, while experienced staff desired clearer guidance and real-life scenarios. The results show the IGRT workbook and CBCT case studies enhance RTTs’ confidence in PBT CBCT analysis. PBT departments should consider these results for RTT led IGRT. Future work could involve adjusting training to account for participants’ prior IGRT experience and conducting larger-scale studies to validate our results.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100299"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of two dose-volume histogram prediction tools for treatment planning: Treatment planning quality and dose verification accuracy","authors":"Shoma Nakano ,&nbsp;Motoharu Sasaki ,&nbsp;Yuji Nakaguchi ,&nbsp;Takeshi Kamomae ,&nbsp;Kanako Sakuragawa ,&nbsp;Yuto Yamaji ,&nbsp;Hitoshi Ikushima","doi":"10.1016/j.tipsro.2024.100297","DOIUrl":"10.1016/j.tipsro.2024.100297","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to compare treatment plans created using RapidPlan and PlanIQ for twelve patients with prostate cancer, focusing on dose uniformity, dose reduction to organs at risk (OARs), plan complexity, and dose verification accuracy. The goal is to identify the tool that demonstrates superior performance in achieving uniform target dose distribution and reducing OAR dose, while ensuring accurate dose verification.</div></div><div><h3>Methods</h3><div>Dose uniformity in the planning target volume, excluding the rectum, and dose reduction in the OARs (the rectum and bladder) were assessed. The validation included point-dose measurements with an ionization chamber dosimeter and gamma analysis of dose distributions. Monitor units were calculated to evaluate plan complexity.</div></div><div><h3>Results</h3><div>PlanIQ provided superior dose uniformity, with improvements in the dose homogeneity index compared with RapidPlan. RapidPlan was more effective in reducing OAR doses, particularly in the rectum, with significant reductions at various dose levels. Dose verification showed no significant differences between the two tools. However, PlanIQ showed a smaller mean difference between the calculated and measured doses and a slightly better dose distribution match with less variability than RapidPlan.</div></div><div><h3>Conclusions</h3><div>RapidPlan was more effective at reducing OAR doses, whereas PlanIQ achieved better dose uniformity and lower plan complexity. Both tools performed similarly in terms of dose verification accuracy, with PlanIQ showing a slight advantage in dose-distribution matching. The choice of planning tool depends on the primary treatment goal, whether it is to reduce the OAR doses or improve the target dose uniformity.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100297"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating the hidden cost: A systematic review of cognitive late effects regarding cancer-related fatigue in treated paediatric brain tumors","authors":"Ingrid Vethe Hernes ,&nbsp;Amalie Jansdatter ,&nbsp;Anita Nordsteien ,&nbsp;Mathilde Haraldsen Normann","doi":"10.1016/j.tipsro.2024.100291","DOIUrl":"10.1016/j.tipsro.2024.100291","url":null,"abstract":"<div><h3>Objective</h3><div>Globally, in 2022, 30,871 children were diagnosed with CNS-tumors. Many have been treated with radiotherapy, and a significant number suffer from chronic late effects, including fatigue. This study aims to investigate previous research on the impact of cancer-related fatigue for neurocognitive function that can be related to radiotherapy in patients who have undergone primary brain radiotherapy before the age of 18.</div></div><div><h3>Methods</h3><div>Conducted under PRISMA-S framework, this systematic review searched MEDLINE ALL (Ovid), EMBASE (Ovid), CINAHL (EBSCO), and PsycINFO (Ovid) for relevant studies. Criteria for inclusion were children under 18 who underwent radiotherapy for primary brain cancer, focusing on late cognitive side effects, published 2000–2023.</div></div><div><h3>Results</h3><div>From 4,067 records, 10 studies were included, examining Proton Radiation Therapy (n = 4), X-ray Radiation Therapy (n = 3), and their comparisons (n = 3). The studies used various cognitive tests, and late effects that emerged were neurocognitive functions and disorders, intellectual functioning, specific cognitive functions and daily life, social functioning, and performance. These themes can be encompassed by cancer-related fatigue.</div></div><div><h3>Conclusions</h3><div>The findings underscore critical need for more in-depth research to understand the health perception variations among children post-primary brain radiotherapy. Furthermore, detailed insights of treatment specifics, disease progression, target volume sizes, and doses to surrounding organs at risk are imperative.</div></div>","PeriodicalId":36328,"journal":{"name":"Technical Innovations and Patient Support in Radiation Oncology","volume":"33 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}