Global Epidemiology最新文献

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Critical concern of tobacco consumption among pregnant and lactating women in India: A call for comprehensive data and intervention strategies 对印度孕妇和哺乳期妇女烟草消费的严重关切:呼吁提供综合数据和干预战略
Global Epidemiology Pub Date : 2023-10-23 DOI: 10.1016/j.gloepi.2023.100125
Shruti Singh , Gargi Sarode , Rahul Anand , Namrata Sengupta , Sachin C. Sarode
{"title":"Critical concern of tobacco consumption among pregnant and lactating women in India: A call for comprehensive data and intervention strategies","authors":"Shruti Singh , Gargi Sarode , Rahul Anand , Namrata Sengupta , Sachin C. Sarode","doi":"10.1016/j.gloepi.2023.100125","DOIUrl":"https://doi.org/10.1016/j.gloepi.2023.100125","url":null,"abstract":"","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113323000287/pdfft?md5=65bb830cc6dc221ff3b62a8b1f84f2a1&pid=1-s2.0-S2590113323000287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91591652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Nipah outbreak in India: A plea for immediate action 印度尼帕疫情的管理:呼吁立即采取行动。
Global Epidemiology Pub Date : 2023-10-12 DOI: 10.1016/j.gloepi.2023.100123
Poonam Suryawanshi , Sachin Sarode , Srikant Tripathy
{"title":"Management of Nipah outbreak in India: A plea for immediate action","authors":"Poonam Suryawanshi , Sachin Sarode , Srikant Tripathy","doi":"10.1016/j.gloepi.2023.100123","DOIUrl":"10.1016/j.gloepi.2023.100123","url":null,"abstract":"","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/f2/main.PMC10585320.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 224
Estimating the prevalence of COVID-19 cases through the analysis of SARS-CoV-2 RNA copies derived from wastewater samples from North Dakota 通过分析来自北达科他州废水样本的SARS-CoV-2 RNA拷贝,估计新冠肺炎病例的流行率。
Global Epidemiology Pub Date : 2023-10-12 DOI: 10.1016/j.gloepi.2023.100124
Bong-Jin Choi , Scott Hoselton , Grace N. Njau , I.G.C.G. Idamawatta , Paul Carson , John McEvoy
{"title":"Estimating the prevalence of COVID-19 cases through the analysis of SARS-CoV-2 RNA copies derived from wastewater samples from North Dakota","authors":"Bong-Jin Choi ,&nbsp;Scott Hoselton ,&nbsp;Grace N. Njau ,&nbsp;I.G.C.G. Idamawatta ,&nbsp;Paul Carson ,&nbsp;John McEvoy","doi":"10.1016/j.gloepi.2023.100124","DOIUrl":"10.1016/j.gloepi.2023.100124","url":null,"abstract":"<div><p>The SARS-CoV-2 virus was first detected in December 2019, which prompted many researchers to investigate how the virus spreads. SARS-CoV-2 is mainly transmitted through respiratory droplets. Symptoms of the SARS-CoV-2 virus appear after an incubation period. Moreover, the asymptomatic infected individuals unknowingly spread the virus. Detecting infected people requires daily tests and contact tracing, which are expensive. The early detection of infectious diseases, including COVID-19, can be achieved with wastewater-based epidemiology, which is timely and cost-effective. In this study, we collected wastewater samples from wastewater treatment plants in several cities in North Dakota and then extracted viral RNA copies. We used log-RNA copies in the model to predict the number of infected cases using Quantile Regression (QR) and K-Nearest Neighbor (KNN) Regression. The model's performance was evaluated by comparing the Mean Absolute Percentage Error (MAPE). The QR model performs well in cities where the population is &gt;<span><math><mn>10000</mn></math></span>. In addition, the model predictions were compared with the basic Susceptible-Infected-Recovered (SIR) model which is the golden standard model for infectious diseases.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/0e/main.PMC10594563.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hysterectomy and thyroid cancer risk: A systematic review and meta-analysis 子宫切除术与甲状腺癌症风险的系统回顾和荟萃分析
Global Epidemiology Pub Date : 2023-10-05 DOI: 10.1016/j.gloepi.2023.100122
Roberto Fabiani , Patrizia Rosignoli , Irene Giacchetta , Manuela Chiavarini
{"title":"Hysterectomy and thyroid cancer risk: A systematic review and meta-analysis","authors":"Roberto Fabiani ,&nbsp;Patrizia Rosignoli ,&nbsp;Irene Giacchetta ,&nbsp;Manuela Chiavarini","doi":"10.1016/j.gloepi.2023.100122","DOIUrl":"10.1016/j.gloepi.2023.100122","url":null,"abstract":"<div><h3>Background</h3><p>Incidence rates of thyroid cancer have increased. Recent studies findings suggest that women who underwent a hysterectomy have an elevated relative risk of thyroid cancer. The aim of our meta-analysis is to summarize the evidence about the association between hysterectomy and thyroid cancer risk.</p></div><div><h3>Methods</h3><p>PubMed, Web of Science, and Scopus database were searched for studies published up to 5 September 2023. The PRISMA statement was followed. Heterogeneity was explored with Q statistic and the I2 statistic. Publication bias was assessed with Begg's and Egger's tests.</p></div><div><h3>Results</h3><p>Sixteen studies met the criteria. The pooled analysis showed a significantly 64% increment of thyroid cancer risk in association with any hysterectomy (OR 1.64, 95% CI 1.48–1.81; I2 = 28.68%, <em>p</em> = 0.156). Hysterectomy without oophorectomy was a stronger predictor of risk than hysterectomy with oophorectomy. The pooled analysis of data regarding hysterectomy without oophorectomy showed a statistically significant increment of thyroid cancer risk by 59%. Hysterectomy with oophorectomy was associated with an increase of thyroid cancer risk of 39% (OR 1.39, 95% CI 1.16–1.67; I2 = 42.10%, <em>p</em> = 0.049). Significant publication bias was not detected.</p></div><div><h3>Conclusions</h3><p>Our findings help with decision making around these surgeries.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Literature landscape of neurodevelopment and pesticides: A scoping review of methodologies 神经发育与杀虫剂的文献综述:方法学的范围综述
Global Epidemiology Pub Date : 2023-09-20 DOI: 10.1016/j.gloepi.2023.100121
Jennifer E. Reed , Carol J. Burns , Federica Pisa
{"title":"Literature landscape of neurodevelopment and pesticides: A scoping review of methodologies","authors":"Jennifer E. Reed ,&nbsp;Carol J. Burns ,&nbsp;Federica Pisa","doi":"10.1016/j.gloepi.2023.100121","DOIUrl":"10.1016/j.gloepi.2023.100121","url":null,"abstract":"<div><p>Pesticides are highly tested and regulated chemicals. There is currently great interest in the role that pesticides may play in childhood neurodevelopment. The objective was to identify and describe the body of evidence and to assess the ability to synthesize effect estimates. The epidemiologic literature from 2011 to 2022 was searched for publications on the association between pesticide exposure and neurodevelopment, behavior, and/or cognition in children. We identified 114 publications, representing 67 unique studies. While organochlorine and other insecticides were the most common classes of pesticides studied, up to 159 different metabolites or active ingredients were reported. Nine pesticides or their metabolites were reported in &gt;10 publications. Similarly, multiple assessment methods were administered across studies to evaluate outcomes in neurodevelopment at ages which ranged from birth to 18 years of age. This scoping review reveals the heterogeneity among published studies with respect to exposures and health outcomes, in the methods used to assess and classify them, and in combinations of the two. This limits the adequacy of the evidence to evaluate specific risk estimates for a particular exposure-outcome pair. Intentional coordination among researchers to increase consistency in methodologies would facilitate the synthesis of results across studies. Research opportunities also exist to validate assumptions in exposure and outcome assessment which are implicit in many of the studies reviewed. In conclusion, there are many ongoing epidemiologic studies with a focus on pesticides and neurodevelopment. The variety of exposures, exposure assessment methods and tests for each outcome can be overwhelming. Interdisciplinary collaboration is recommended to harmonize data collection and to enable meaningful interpretation of the study results across populations.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/b6/main.PMC10539886.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjustment for collider bias in the hospitalized Covid-19 setting 新冠肺炎住院环境中对撞机偏差的调整
Global Epidemiology Pub Date : 2023-08-23 DOI: 10.1016/j.gloepi.2023.100120
Moslem Taheri Soodejani , Seyyed Mohammad Tabatabaei , Mohammad Hassan Lotfi , Maryam Nazemipour , Mohammad Ali Mansournia
{"title":"Adjustment for collider bias in the hospitalized Covid-19 setting","authors":"Moslem Taheri Soodejani ,&nbsp;Seyyed Mohammad Tabatabaei ,&nbsp;Mohammad Hassan Lotfi ,&nbsp;Maryam Nazemipour ,&nbsp;Mohammad Ali Mansournia","doi":"10.1016/j.gloepi.2023.100120","DOIUrl":"10.1016/j.gloepi.2023.100120","url":null,"abstract":"<div><h3>Background</h3><p>Causal directed acyclic graphs (cDAGs) are frequently used to identify confounding and collider bias. We demonstrate how to use causal directed acyclic graphs to adjust for collider bias in the hospitalized Covid-19 setting.</p></div><div><h3>Materials and methods</h3><p>According to the cDAGs, three types of modeling have been performed. In model 1, only vaccination is entered as an independent variable. In model 2, in addition to vaccination, age is entered the model to adjust for collider bias due to the conditioning of hospitalization. In model 3, comorbidities are also included for adjustment of collider bias due to the conditioning of hospitalization in different biasing paths intercepting age and comorbidities.</p></div><div><h3>Results</h3><p>There was no evidence of the effect of vaccination on preventing death due to Covid-19 in model 1. In the second model, where age was included as a covariate, a protective role for vaccination became evident. In model 3, after including chronic diseases as other covariates, the protective effect was slightly strengthened.</p></div><div><h3>Conclusion</h3><p>Studying hospitalized patients is subject to collider-stratification bias. Like confounding, this type of selection bias can be adjusted for by inclusion of the risk factors of the outcome which also affect hospitalization in the regression model.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47703643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Moral controversies and academic public health: Notes on navigating and surviving academic freedom challenges 道德争议与学术公共卫生:关于应对和应对学术自由挑战的说明
Global Epidemiology Pub Date : 2023-08-15 DOI: 10.1016/j.gloepi.2023.100119
Tyler J. VanderWeele
{"title":"Moral controversies and academic public health: Notes on navigating and surviving academic freedom challenges","authors":"Tyler J. VanderWeele","doi":"10.1016/j.gloepi.2023.100119","DOIUrl":"10.1016/j.gloepi.2023.100119","url":null,"abstract":"<div><p>Schools of public health often serve both as public health advocacy organizations and as academic units within a university. These two roles, however, can sometimes come into conflict. I experienced this conflict directly at the Harvard T. H. Chan School of Public Health in holding and expressing unpopular minority viewpoints on certain moral controversies. In this essay I describe my experiences and their relation to questions of academic freedom, population health promotion, and efforts at working together across differing moral systems.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41663477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Incidence trend analysis of tuberculosis in Khuzestan Province, southwest of Iran: 2010–2019 伊朗西南部胡齐斯坦省2010-2019年结核病发病趋势分析
Global Epidemiology Pub Date : 2023-08-04 DOI: 10.1016/j.gloepi.2023.100118
Seyed Mohammad Alavi , Mostafa Enayatrad , Bahman Cheraghian , Neda Amoori
{"title":"Incidence trend analysis of tuberculosis in Khuzestan Province, southwest of Iran: 2010–2019","authors":"Seyed Mohammad Alavi ,&nbsp;Mostafa Enayatrad ,&nbsp;Bahman Cheraghian ,&nbsp;Neda Amoori","doi":"10.1016/j.gloepi.2023.100118","DOIUrl":"10.1016/j.gloepi.2023.100118","url":null,"abstract":"<div><h3>Objectives</h3><p>Identifying the trend of diseases and its changes over time can be highly important in evaluating the extent and method of achieving strategies for controlling them, developing health indicators, and health planning. This study aimed to investigate the incidence of tuberculosis.</p></div><div><h3>Methods</h3><p>As a repeated cross-sectional study in which the population under study was a census, this study involved all tuberculosis cases registered in 21 cities of Southwest of Iran, from 2010 to 2019. Data were obtained from the National System of Notification of Tuberculosis and included variables related to age, sex and Disease consequence. Segmented regression models were used to analyze the trend of tuberculosis changes. Also, data analysis software- Join Point Regression version 5.0.2 was used for data analysis.</p></div><div><h3>Results</h3><p>The results of evaluating the trend of tuberculosis from 2010 to 2019 showed no change in the general trend of tuberculosis and an annual 0.84% (95% CI: ‐5.17 to 6.82) increase in incidence rate is observed in the trend. Also, the findings of join point regression analysis show that between 2010 and 2013, an annual 18.10% (95% CI: 8.78 to 34.89) increase in the incidence of tuberculosis, and between 2013 and 2019, annual −5.42% (95% CI: −10.04 to −2.22) decrease in the incidence of tuberculosis was observed. From 2010 to 2012, a 33.10% (95% CI: 15.77 to 48.06) annual increase in the incidence of tuberculosis in males and − 9.47% (95%CI: −14.02 to −6.33) annual decrease in the incidence of tuberculosis in females was observed.</p></div><div><h3>Conclusions</h3><p>The results of this study showed that the incidence of tuberculosis had an upward trend from 2010 to 2013 and a downward trend from 2013 onwards.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspectives on recent reviews of aspartame cancer epidemiology 阿斯巴甜癌症流行病学研究进展
Global Epidemiology Pub Date : 2023-08-03 DOI: 10.1016/j.gloepi.2023.100117
Julie E. Goodman , Denali N. Boon , Maia M. Jack
{"title":"Perspectives on recent reviews of aspartame cancer epidemiology","authors":"Julie E. Goodman ,&nbsp;Denali N. Boon ,&nbsp;Maia M. Jack","doi":"10.1016/j.gloepi.2023.100117","DOIUrl":"10.1016/j.gloepi.2023.100117","url":null,"abstract":"<div><p>Aspartame is a dipeptide non-sugar sweetener that was first marketed in the US in carbonated beverages in 1983, before gaining prominence globally. The Joint Food and Agriculture Organization of the United Nations (FAO)/World Health Organization (WHO) Expert Committee on Food Additives (JECFA) and the WHO International Agency for Research on Cancer (IARC) completed evaluations of aspartame and cancer in July 2023. JECFA reaffirmed the safety of aspartame, stating that epidemiology evidence is “not convincing,” and that there are no consistent associations between aspartame and cancer (JECFA/IARC, 2023; JECFA, 2023). JECFA also noted “reverse causality, chance, bias and confounding by socioeconomic or lifestyle factors, or consumption of other dietary components, could not be completely ruled out” in relevant epidemiology studies (JECFA/IARC, 2023). In contrast, IARC stated that there are three “high quality” studies on liver cancer (Riboli, 2023), but that the evidence is limited because “chance, bias or confounding could not be ruled out as an explanation for the positive findings” (JECFA/IARC, 2023). IARC does not provide an explanation as to how these studies can be both high quality and have these weaknesses, most notably potential exposure misclassification, or how inconsistent associations from studies with these weaknesses constitute limited evidence. Further, when IARC concludes an agent has limited or inadequate human evidence (and no sufficient animal or strong mechanistic evidence), it classifies that agent as either Group 2B, a possible human carcinogen, or Group 3, not classifiable as to its carcinogenicity. Ultimately, the interpretations of Group 2B and Group 3 classifications are intended to be similar. However, a Group 2B designation may make it appear to scientists and non-scientists alike that the evidence is pointing in the direction of causality. This can lead to unnecessary confusion with respect to the evidence, as well as a perception of a disagreement within WHO regarding aspartame. This apparent contradiction could have been avoided by assigning the IARC classification most consistent with the conclusion that the human evidence for cancer is inadequate: Group 3.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/54/main.PMC10446002.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of corticosteroids types, dexamethasone, and methylprednisolone in patients hospitalized with COVID-19: A systematic review and network meta-analysis 新冠肺炎住院患者皮质类固醇类型、地塞米松和甲基强的松龙的比较:系统综述和网络荟萃分析
Global Epidemiology Pub Date : 2023-07-31 DOI: 10.1016/j.gloepi.2023.100116
Mina Morsali , Amin Doosti-Irani , Shahideh Amini , Maryam Nazemipour , Mohammad Ali Mansournia , Rasoul Aliannejad
{"title":"Comparison of corticosteroids types, dexamethasone, and methylprednisolone in patients hospitalized with COVID-19: A systematic review and network meta-analysis","authors":"Mina Morsali ,&nbsp;Amin Doosti-Irani ,&nbsp;Shahideh Amini ,&nbsp;Maryam Nazemipour ,&nbsp;Mohammad Ali Mansournia ,&nbsp;Rasoul Aliannejad","doi":"10.1016/j.gloepi.2023.100116","DOIUrl":"10.1016/j.gloepi.2023.100116","url":null,"abstract":"<div><h3>Background</h3><p>COVID-19 is associated with severe pneumonia lung damage, acute respiratory distress syndrome (ARDS), and mortality. In this study, we aimed to compare corticosteroids' effect on the mortality risk in patients hospitalized with COVID-19.</p></div><div><h3>Methods</h3><p>PubMed, Web of Science, Scopus, Cochrane Library, and Embase, were searched using a predesigned search strategy. Randomized controlled trials (RCTs) that had compared the corticosteroid drugs were included. The hazard ratio (HR) with a 95% confidence interval (CI) was used to summarize the effect size from the network meta-analysis (NMA).</p></div><div><h3>Results</h3><p>Out of 329 retrieved references, 12 RCTs with 11,455 participants met the eligibility criteria in this review. The included RCTs formed one network with six treatments. In addition, five treatments in two RCTs were not connected to the network. Methylprednisolone + usual care (UC) versus UC decreased the risk of death by 0.65 (95% CI: 0.47, 0.90). Among treatments in the network the highest P-score (0.89) was related to Methylprednisolone + UC.</p></div><div><h3>Conclusion</h3><p>Based on the results of this NMA it seems Methylprednisolone + UC to be the best treatment option in patients with COVID-ARDS and COVID pneumonia.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"6 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/75/main.PMC10445991.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10304041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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