Global Epidemiology最新文献

{"title":"Evaluating algorithms for identifying incident Guillain-Barré Syndrome in Medicare fee-for-service claims","authors":"Samantha R. Eiffert ,&nbsp;Brad Wright ,&nbsp;Joshua Nardin ,&nbsp;James F. Howard ,&nbsp;Rebecca Traub","doi":"10.1016/j.gloepi.2024.100145","DOIUrl":"https://doi.org/10.1016/j.gloepi.2024.100145","url":null,"abstract":"<div><h3>Objective</h3><p>Claims data can be leveraged to study rare diseases such as Guillain-Barré Syndrome (GBS), a neurological autoimmune condition. It is difficult to accurately measure and distinguish true cases of disease with claims without a validated algorithm. Our objective was to identify the best-performing algorithm for identifying incident GBS cases in Medicare fee-for-service claims data using chart reviews as the gold standard.</p></div><div><h3>Study design and setting</h3><p>This was a multi-center, single institution cohort study from 2015 to 2019 that used Medicare-linked electronic health record (EHR) data. We identified 211 patients with a GBS diagnosis code in any position of an inpatient or outpatient claim in Medicare that also had a record of GBS in their electronic medical record. We reported the positive predictive value (PPV = number of true GBS cases/total number of GBS cases identified by the algorithm) for each algorithm tested. We also tested algorithms using several prevalence assumptions for false negative GBS cases and calculated a ranked sum for each algorithm's performance.</p></div><div><h3>Results</h3><p>We found that 40 patients out of 211 had a true case of GBS. Algorithm 17, a GBS diagnosis in the primary position of an inpatient claim and a diagnostic procedure within 45 days of the inpatient admission date, had the highest PPV (PPV = 81.6%, 95% CI (69.3, 93.9). Across three prevalence assumptions, Algorithm 15, a GBS diagnosis in the primary position of an inpatient claim, was favored (PPV = 79.5%, 95% CI (67.6, 91.5).</p></div><div><h3>Conclusions</h3><p>Our findings demonstrate that patients with incident GBS can be accurately identified in Medicare claims with a chart-validated algorithm. Using large-scale administrative data to study GBS offers significant advantages over case reports and patient repositories with self-reported data, and may be a potential strategy for the study of other rare diseases.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000117/pdfft?md5=0dfb6efc036ab03fd73bfec5b44947a7&pid=1-s2.0-S2590113324000117-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140879056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does recall bias explain the association of mood disorders with workplace harassment?","authors":"Igor Burstyn ,&nbsp;Jean-Michel Galarneau ,&nbsp;Nicola Cherry","doi":"10.1016/j.gloepi.2024.100144","DOIUrl":"https://doi.org/10.1016/j.gloepi.2024.100144","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the contribution of recall bias to the observed excess in mental ill-health in those reporting harassment at work.</p></div><div><h3>Methods</h3><p>A prospective cohort of 1885 workers in welding and electrical trades was contacted every six months for up to 5 years, asking whether they were currently anxious or depressed and whether this was made worse by work. Only at the end of the study did we ask about any workplace harassment they had experienced at work. We elicited sensitivity and specificity of self-reported bullying from published reliability studies and formulated priors that reflect the possibility of over-reporting of workplace harassment (exposure) by those whose anxiety or depression was reported to be made worse by work (cases). We applied the resulting misclassification models to probabilistic bias analysis (PBA) of relative risks.</p></div><div><h3>Results</h3><p>We observe that PBA implies that it is unlikely that biased misclassification due to the study subjects' states of mind could have caused the entire observed association. Indeed, the results demonstrated that doubling of risk of anxiety or depression following workplace harassment is plausible, with the unadjusted relative risk attenuated with understated uncertainty.</p></div><div><h3>Conclusions</h3><p>It seems unlikely that risk of anxiety or depression following workplace harassment can be explained by the form of recall bias that we proposed.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000105/pdfft?md5=3fc7d2022eca921077b72024765c5435&pid=1-s2.0-S2590113324000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140818302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triangulation of epidemiological evidence and risk of bias evaluation: A proposed framework and applied example using formaldehyde exposure and risk of myeloid leukemias","authors":"Daniel J. Lauer ,&nbsp;Anthony J. Russell ,&nbsp;Heather N. Lynch ,&nbsp;William J. Thompson ,&nbsp;Kenneth A. Mundt ,&nbsp;Harvey Checkoway","doi":"10.1016/j.gloepi.2024.100143","DOIUrl":"https://doi.org/10.1016/j.gloepi.2024.100143","url":null,"abstract":"<div><p>Evidence triangulation may help identify the impact of study design elements on study findings and to tease out biased results when evaluating potential causal relationships; however, methods for triangulating epidemiologic evidence are evolving and have not been standardized. Building upon key principles of epidemiologic evidence triangulation and risk of bias assessment, and responding to the National Academies of Sciences, Engineering, and Medicine (NASEM) call for applied triangulation examples, the objective of this manuscript is to propose a triangulation framework and to apply it as an illustrative example to epidemiologic studies examining the possible relationship between occupational formaldehyde exposure and risk of myeloid leukemias (ML) including acute (AML) and chronic (CML) types.</p><p>A nine-component triangulation framework for epidemiological evidence was developed incorporating study quality and ROB guidance from various federal health agencies (i.e., US EPA TSCA and NTP OHAT). Several components of the triangulation framework also drew from widely used epidemiological analytic tools such as stratified meta-analysis and sensitivity analysis. Regarding the applied example, fourteen studies were identified and assessed using the following primary study quality domains to explore potential key sources of bias: 1) study design and analysis; 2) study participation; 3) exposure assessment; 4) outcome assessment; and 5) potential confounding. Across studies, methodological limitations possibly contributing to biased results were observed within most domains. Interestingly, results from one study – often providing the largest and least-precise relative risk estimates, likely reflecting study biases, deviated from most primary study findings indicating no such associations. Triangulation of epidemiological evidence appears to be helpful in exploring inconsistent results for the identification of study results possibly reflecting various biases. Nonetheless, triangulation methodologies require additional development and application to real-world examples to enhance objectivity and reproducibility.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000099/pdfft?md5=1a7ead941966ce9014523a5ba67690c0&pid=1-s2.0-S2590113324000099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the effect of realistic improvements of metformin adherence on COVID-19 mortality using targeted machine learning","authors":"Sky Qiu ,&nbsp;Alan E. Hubbard ,&nbsp;Juan Pablo Gutiérrez ,&nbsp;Ganesh Pimpale ,&nbsp;Arturo Juárez-Flores ,&nbsp;Rakesh Ghosh ,&nbsp;Iván de Jesús Ascencio-Montiel ,&nbsp;Stefano M. Bertozzi","doi":"10.1016/j.gloepi.2024.100142","DOIUrl":"https://doi.org/10.1016/j.gloepi.2024.100142","url":null,"abstract":"<div><h3>Background</h3><p>Type 2 diabetes elevates the risk of severe outcomes in COVID-19 patients, with multiple studies reporting higher case fatality rates. Metformin is a widely used medication for glycemic management. We hypothesize that improved adherence to metformin may lower COVID-19 post-infection mortality risk in this group. Utilizing data from the Mexican Social Security Institute (IMSS), we investigate the relationship between metformin adherence and mortality following COVID-19 infection in patients with chronic metformin prescriptions.</p></div><div><h3>Methods</h3><p>This is a retrospective cohort study consisting of 61,180 IMSS beneficiaries who received a positive polymerase chain reaction (PCR) or rapid test for SARS-CoV-2 and had at least two consecutive months of metformin prescriptions prior to the positive test. The hypothetical intervention is improved adherence to metformin, measured by proportion of days covered (PDC), with the comparison being the observed metformin adherence values. The primary outcome is all-cause mortality following COVID-19 infection. We defined the causal parameter using shift intervention, an example of modified treatment policies. We used the targeted learning framework for estimation of the target estimand.</p></div><div><h3>Findings</h3><p>Among COVID-19 positive patients with chronic metformin prescriptions, we found that a 5% and 10% absolute increase in metformin adherence is associated with a respective 0.26% (95% CI: −0.28%, 0.79%) and 1.26% (95% CI: 0.72%, 1.80%) absolute decrease in mortality risk.</p></div><div><h3>Interpretation</h3><p>Subject to the limitations of a real-world data study, our results indicate a causal association between improved metformin adherence and reduced COVID-19 post-infection mortality risk.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000087/pdfft?md5=a6ec9ca0bb8638bd123b2d043132b7e9&pid=1-s2.0-S2590113324000087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140339685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative recall bias analysis of the talc and ovarian cancer association","authors":"Julie E. Goodman,&nbsp;Leon M. Espira,&nbsp;Ke Zu ,&nbsp;Denali Boon","doi":"10.1016/j.gloepi.2024.100140","DOIUrl":"https://doi.org/10.1016/j.gloepi.2024.100140","url":null,"abstract":"","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100140"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000063/pdfft?md5=64e99086dc1b3d0a104e4bd42a503427&pid=1-s2.0-S2590113324000063-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population attributable fraction of gas cooking and childhood asthma: What was missed?","authors":"Wenchao Li,&nbsp;Julie E. Goodman,&nbsp;Christopher Long","doi":"10.1016/j.gloepi.2024.100141","DOIUrl":"https://doi.org/10.1016/j.gloepi.2024.100141","url":null,"abstract":"","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000075/pdfft?md5=5fa3deb72e12e1602f6c1ca53740219f&pid=1-s2.0-S2590113324000075-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factors associated with anxiety disorder among married women exposed to violence in rural area, Ismailia, Egypt: A cross-sectional study","authors":"Almaza A. Salim ,&nbsp;Mona Elsayed ,&nbsp;Mohamed Hafez Mohamed ,&nbsp;Heba Yousef ,&nbsp;Mohamed S. Hemeda ,&nbsp;Alaa Ramadan ,&nbsp;Nathan Ezie Kengo ,&nbsp;Noha M. Abu Bakr Elsaid","doi":"10.1016/j.gloepi.2024.100139","DOIUrl":"10.1016/j.gloepi.2024.100139","url":null,"abstract":"<div><h3>Background</h3><p>Domestic abuse is a widespread health issue that negatively impacts both mental health and quality of life.</p></div><div><h3>Objectives</h3><p>To determine the prevalence of domestic violence and anxiety among women visiting primary healthcare facilities in the rural Ismailia governorate.</p></div><div><h3>Methods</h3><p>Between October 2021 and December 2021, a cross-sectional study was conducted. Simple random methods were used to choose the participants from those who attended a clinic. 350 married women were included in the estimated sample size. By using an interview questionnaire, data were gathered including the following parts: The socio-demographic data, designed scale for assessment of violence and anxiety symptoms were assessed by the Hamilton anxiety scale.</p></div><div><h3>Results</h3><p>The prevalence of domestic violence was 41% and both physical and sexual abuse was 43%. The most predominant sexual abuse was practice without consent (63%). The prevalence of anxiety was 76%, the predominance was mild degree 46% followed by mild to moderate 18%. The significant predictors for anxiety in the total sample were the increase in age of women, rural residence, and exposure to abuse (OR = 11.2 (4.9–25.4). The use of the husband's stimulant drugs was the most predictor factor for women's abuse (OR = 2.3 (1.4–3.9).</p></div><div><h3>Conclusion</h3><p>forty-one of the women exposed to every form of violence, anxiety was present in more than three-quarters of the studied women. It is essential to screen any wife attending primary health care for the manifestation of domestic violence especially in rural areas and increase the awareness of family physicians towards screening of mental health problems.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000051/pdfft?md5=e89ce5f6223f4f0afce6ed1f277aa822&pid=1-s2.0-S2590113324000051-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139874970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of different forms of coconut on the lipid profile in normal free-living healthy subjects: A randomized controlled trial (Phase II)","authors":"Ruvan A.I. Ekanayaka ,&nbsp;P.G.S.M. de Silva ,&nbsp;Medhani K.I. Ekanayaka ,&nbsp;W.M.M. Jayathilake ,&nbsp;R.P.M.M.R. Pathirana ,&nbsp;Y.N. Amaratunga ,&nbsp;Prasadhini J.D. De Silva ,&nbsp;Bilesha Perera","doi":"10.1016/j.gloepi.2024.100138","DOIUrl":"https://doi.org/10.1016/j.gloepi.2024.100138","url":null,"abstract":"<div><h3>Background</h3><p>It has been postulated that the lipid effects of coconut could be mediated by its fatty acids, fiber and lysine/arginine ratio. Hence, the lipid effects of coconut oil could be different from the effects of the kernel flakes or milk extract because the constituents could be different in each coconut preparation. The present research investigated the lipid effects of different modes of coconut used in food preparation.</p></div><div><h3>Methods</h3><p>This study involved a total of 190 participants, randomized into four groups, which received coconut oil supplement (30 ml) (<em>n</em> = 53), kernel flakes (30 g) (<em>n</em> = 52) or coconut milk powder (30 g) (<em>n</em> = 44) for a period of 8 weeks. The control group (<em>n</em> = 41) received no supplement. Lipid assays were performed at baseline and at the end of the 4th and 8th weeks. The generalized estimating equations (GEE), ANOVA, and paired and independent <em>t-</em>tests were used in the analysis.</p></div><div><h3>Result</h3><p>The age range of the participants was 25–60 years, and 52.6% of them (<em>n</em> = 100) were men. Coconut milk supplementation induced beneficial changes in the lipid profile in that the LDL and non-HDL levels decreased while the HDL levels increased. The subgroup whose baseline LDL level was elevated appeared to benefit most from coconut milk supplementation. Coconut oil and kernel flakes failed to induce favorable lipid changes comparable to coconut milk supplementation.</p></div><div><h3>Conclusion</h3><p>Differing concentrations of protein, fat and fiber in coconut preparations could possibly explain the dissimilar effects on the lipid profile caused by the different coconut preparations. The benefits of coconut milk seen in the high basal LDL subgroup warrant a detailed study.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259011332400004X/pdfft?md5=4d92d8d64db8471c0414ee103b4cfbe3&pid=1-s2.0-S259011332400004X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139710145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of COVID-19 and serum per- and polyfluoroalkyl substances: A case-control study among workers with a wide range of exposures","authors":"Anna K. Porter ,&nbsp;Sarah E. Kleinschmidt ,&nbsp;Kara L. Andres ,&nbsp;Courtney N. Reusch ,&nbsp;Ryan M. Krisko ,&nbsp;Oyebode A. Taiwo ,&nbsp;Geary W. Olsen ,&nbsp;Matthew P. Longnecker","doi":"10.1016/j.gloepi.2024.100137","DOIUrl":"https://doi.org/10.1016/j.gloepi.2024.100137","url":null,"abstract":"<div><p><em>Per</em>- and polyfluoroalkyl substances (PFAS) are a broad class of synthetic chemicals; some are present in most humans in developed countries. Some studies suggest that certain PFAS may have immunotoxic effects in humans, which could put individuals with high levels of exposure at increased risk for infectious diseases such as COVID-19. We conducted a case-control study to examine the association between COVID-19 diagnosis and PFAS serum concentrations among employees and retirees from two 3 M facilities, one of which historically generated perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS). Participants completed enrollment and follow-up study visits in the Spring of 2021. Participants were categorized as cases if they reported a COVID-19 diagnosis or became sick with at least one symptom of COVID-19 when someone else in their household was diagnosed, otherwise they were categorized as a control. COVID-19 diagnosis was modeled in relation to concentration of serum PFAS measured at enrollment after adjusting for covariates. The analytic sample comprised 573 individuals, 111 cases (19.4%) and 462 controls (80.6%). In adjusted models, the odds ratio of COVID-19 was 0.94 per interquartile range (14.3 ng/mL) increase in PFOS (95% confidence interval 0.85, 1.04). Results for PFOA, PFHxS, and perfluorononanoic acid (PFNA) were similar. Other PFAS present at lower concentrations were examined as categorical variables (above the limit of quantification [LOQ], yes vs. no [referent category]), and also showed no positive associations. In our study, which used individual-level data and included people with high occupational exposure, the serum concentrations of all PFAS examined were not associated with an increased odds ratio for COVID-19. At this point, the epidemiologic data supporting no association of COVID-19 occurrence with PFAS exposure are stronger than those suggesting a positive association.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000038/pdfft?md5=0b41e758ae31284c9f51cb049c716f3f&pid=1-s2.0-S2590113324000038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139436464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of vasovagal syncope: A systematic review and meta-analysis","authors":"Nader Salari ,&nbsp;Zohre Karimi ,&nbsp;Mahvan Hemmati ,&nbsp;Ali Mohammadi ,&nbsp;Shamarina Shohaimi ,&nbsp;Masoud Mohammadi","doi":"10.1016/j.gloepi.2024.100136","DOIUrl":"10.1016/j.gloepi.2024.100136","url":null,"abstract":"<div><h3>Background</h3><p>Today, vasovagal syncope is a common problem that has become a significant health and social challenge. The present study investigated the global prevalence of vasovagal syncope using a systematic review and meta-analysis.</p><p>Methods: In this systematic review and meta-analysis study, the global prevalence of vasovagal syncope using the keywords Prevalence, Epidemiology, Vasovagal syncope, and Reflex syncope in PubMed, WoS, Scopus, ScienceDirect databases, and Google scholar search engine without time limit until July 20, 2022, was extracted and transferred to the information management software (EndNote). Then the repeated studies were excluded, and researchers evaluated the remaining studies during three stages (i.e., screening, eligibility, and qualitative assessment). The heterogeneity of studies was investigated using the I² index, and the analysis of eligible studies was performed using the random effects model.</p></div><div><h3>Results</h3><p>In the review of 12 studies with a sample size of 36,156 people, the global prevalence of vasovagal syncope was reported as 16.4 (95%CI: 6–37.5), and the study of publication bias in the studies through the Egger test shows the absence of publication bias in the studies.</p></div><div><h3>Conclusion</h3><p>The prevalence reported in the studies shows a high prevalence of vasovagal syncope, which requires serious intervention and preventive, diagnostic, and therapeutic measures. It is necessary for health policymakers to take effective measures in this field.</p></div>","PeriodicalId":36311,"journal":{"name":"Global Epidemiology","volume":"7 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590113324000026/pdfft?md5=b0863b1ef4032b11730b61751dc55dcb&pid=1-s2.0-S2590113324000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}