Journal of Health Science and Medical Research最新文献

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Predictors of Nonadherence to Planned Coronary Angiography: A Retrospective Analysis 不遵守计划冠状动脉造影的预测因素:回顾性分析
Journal of Health Science and Medical Research Pub Date : 2023-04-25 DOI: 10.31584/jhsmr.2023949
Sutida Petsuwan, K. Maneewat, W. Sae-Sia, V. Chittithavorn
{"title":"Predictors of Nonadherence to Planned Coronary Angiography: A Retrospective Analysis","authors":"Sutida Petsuwan, K. Maneewat, W. Sae-Sia, V. Chittithavorn","doi":"10.31584/jhsmr.2023949","DOIUrl":"https://doi.org/10.31584/jhsmr.2023949","url":null,"abstract":"Objective: This study aimed to determine the predictive power of patient-related factors, socio-economic factors, condition-related factors, treatment-related factors, and health care system-related factors for nonadherence to planned coronary angiography (CAG). Material and Methods: A retrospective analysis was conducted on electronic medical records (EMR) of 665 patients appointed for elective CAG at Naradhiwas Rajanagarindra Heart Center from January 2018 to December 2019. One hundred and thirty-three patients with nonadherence to planned CAG were assigned to the study group; the control group consisted of 532 patients with adherence to planned CAG. Results: The retrospective data analysis revealed that divorced or widowed status (OR=3.07; 95% CI 1.54, 6.12), cerebrovascular disease comorbidity (OR=4.37; 95% CI 1.74, 10.96), prescribed diuretics (OR=2.24; 95% CI 1.26, 3.97), CAG wait time three months or longer (OR=3.34; 95% CI 1.46, 7.64) and history of parental cardiovascular disease or death from heart disease (OR=0.12; 95% CI 0.01, 0.95) were co-predictors of nonadherence to planned CAG. Socioeconomic- related factors had no predictive power for planned CAG nonadherence. Conclusion: The findings of this study may contribute to the improvement of nursing service by screening groups at high risk of nonadherence and developing appropriate interventions aimed at increasing adherence to planned CAG as well the rate of positive health outcomes.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42186948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Initial International Prostate Symptom Score (IPSS) and Complications of Benign Prostatic Hyperplasia 初始国际前列腺症状评分(IPSS)与良性前列腺增生并发症的相关性
Journal of Health Science and Medical Research Pub Date : 2023-04-18 DOI: 10.31584/jhsmr.2023948
Santapon Chamnarnprai, Keerati Laowanichwith, Akachai Sinsophonphap, Nol Chuntanaparb, Chatporn Boonyapalanant
{"title":"Correlation between Initial International Prostate Symptom Score (IPSS) and Complications of Benign Prostatic Hyperplasia","authors":"Santapon Chamnarnprai, Keerati Laowanichwith, Akachai Sinsophonphap, Nol Chuntanaparb, Chatporn Boonyapalanant","doi":"10.31584/jhsmr.2023948","DOIUrl":"https://doi.org/10.31584/jhsmr.2023948","url":null,"abstract":"Objective: Benign prostatic hyperplasia (BPH) is a common disease in elderly men, and some of them are suffering from its complications. Early detection and management of complications of BPH will lead to optimal results of treatment. The International Prostate Symptom Score (IPSS) is a disease and symptom-specific scoring system used for initial evaluations of BPH patients. This study aims to determine the correlation between initial IPSS and complications resulting from BPH. Material and Methods: This hospital-based cross-sectional study enrolled all male patients, aged 60 years and above having complained of lower urinary tract symptoms (LUTS), at the outpatient clinic. Patients’ demographic data (age), IPSS, and history of complications from BPH; including urinary tract infection (UTI), hematuria, urinary retention and prostate related surgery were collected. Results: In total, 301 patients were recruited in this study, with a mean age of 70.1 years old. There was significant correlation between age and IPSS (p-value 0.034), by using correlation coefficients. Sub-group analysis demonstrates a significant correlation of IPSS (both mean and severity group classifications) and complications from BPH (UTI, hematuria, urinary retention, and prostate surgery due to BPH) (p-value<0.001). Conclusion: The rate of complications, due to BPH including UTI, hematuria, urinary retention, and BPH-related surgery, correlate with higher initial IPSS. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45417504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-epiglottic Space and Epiglottis to Vocal Cord Ratio in Order to Predict Difficult Intubation in Adults: A Multivariate Analysis 预测成人插管困难的会厌前间隙和声门与声带比率的多变量分析
Journal of Health Science and Medical Research Pub Date : 2023-04-12 DOI: 10.31584/jhsmr.2023947
{"title":"Pre-epiglottic Space and Epiglottis to Vocal Cord Ratio in Order to Predict Difficult Intubation in Adults: A Multivariate Analysis","authors":"","doi":"10.31584/jhsmr.2023947","DOIUrl":"https://doi.org/10.31584/jhsmr.2023947","url":null,"abstract":"Objective: We aimed to enhance the prediction of difficult intubation by using ultrasonographic parameters (pre-epiglottic space (Pre-E), distance between epiglottis to middle part of vocal cord (E-VC) and Pre-E/E-VC) adjusting for traditional airway assessments. Material and Methods: This prospective cohort study was conducted at a super-tertiary care hospital in Thailand. Participants aged 18-65 years with ASA classification I-III and who required general anesthesia with endotracheal intubation were included. Preoperative traditional and ultrasonographic airway assessments were performed by two investigators. The outcome was difficult intubations as diagnosed by laryngoscopic view grade 3 or 4. Multivariate logistic regression was used to identify predictors for difficult intubation presented by adjusted odds ratio (OR) and 95% confidence interval (CI). Results: A total of 94 patients were recruited. The incidence of difficult intubation was 15%. The median Pre-E/E-VC ratio among this group was 0.8 compared with 1.0 in the control group (p-value 0.124). The cut-off point of <1.0 of Pre- E/E-VC was not associated with difficult intubation after adjusting for sex and other traditional parameters (p-value 0.11). Predictors of difficult intubation were female sex (OR [95% CI]: 13.8 [2.8, 68.3]), sternomental distance ≤175 mm (OR [95% CI]: 11.6 [1.9, 71.4]) and interincisor gap <4 cm (OR [95% CI]: 19.8 [1.1, 373.8]) with the area under the receiver operating characteristic curve at 0.88 and a specificity of 90.0%. Conclusion: There was no association between the Pre-E/E-VC in predicting difficult intubation in low-risk patients. The ultrasonographic measurements of Pre-E/E-VC were not helpful in predicting difficult intubations in our setting. Trial registration: thaiclinicaltrials.org: TCTR20180115002, Registered 9 January 2018 - Prospectively registered, https:// www.thaiclinicaltrials.org/#","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49068919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Oral Health Status among the Kutia Kandha Tribe - A Particularly Vulnerable Group Residing in Kandhamal District, Odisha 居住在奥里萨邦Kandhamal区的Kutia Kandha部落的口腔健康状况评估
Journal of Health Science and Medical Research Pub Date : 2023-03-30 DOI: 10.31584/jhsmr.2023946
Payal Dash, G.Ranjith Kumar
{"title":"Assessment of Oral Health Status among the Kutia Kandha Tribe - A Particularly Vulnerable Group Residing in Kandhamal District, Odisha","authors":"Payal Dash, G.Ranjith Kumar","doi":"10.31584/jhsmr.2023946","DOIUrl":"https://doi.org/10.31584/jhsmr.2023946","url":null,"abstract":"Objective: In Odisha, the Kandha tribal group is numerically the most populous tribe. Among the several sections of the Kandha communities, two sub-sections, the Kutia Kandha and Dongria Kandha, have been identified as Particularly Vulnerable Tribal Groups (PVTGs). As a result, the study’s aim was to assess the oral health status of the Kutia Kandha tribe. Material and Methods: A cross-sectional survey was carried out among 850 Kutia Kandhas using a multistage randomised sampling method in the Tumudibandha Block of Kandhamal District. Data were collected using the World Health Organization (WHO) Oral Health Assessment Form, 2013. Numbers and percentages were analyzed using Microsoft Excel and Statistical Package for the Social Science (SPSS) package version 26.0. Comparisons between discrete and continuous data were done using the Chi-square test and ANOVA. A p-value of 0.05 was considered to be statistically significant. Results: The study population consisted of 850 subjects stratified into seven different age groups. The mean DMFT (permanent) and dmft (deciduous) scores of were 4.06±3.55 and 0.12±0.56 respectively. One hundred fifty-one (16.0%) subjects had bleeding. Three hundred and sixty-two (42.6%) subjects had pockets 4-6 mm and 276 (32.5%) had pockets more than 6 mm. Four hundred and seventy-six (56%) of the study participants had 4-5 mm of loss of attachment followed by 303 (35.6%) with 6-8 mm loss of attachment. Conclusion: The prevalence of caries and periodontal diseases was high. Due to a lack of knowledge about oral hygiene maintenance, proper health education should be provided to the Kutia Kandha tribals.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47722731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunometabolic Profile of Nigerian COVID-19 Patients 尼日利亚COVID-19患者免疫代谢谱
Journal of Health Science and Medical Research Pub Date : 2023-03-28 DOI: 10.31584/jhsmr.2023945
G. Arinola, A. A. Onifade, V. F. Edem, S. Rahamon, O. Alonge
{"title":"Immunometabolic Profile of Nigerian COVID-19 Patients","authors":"G. Arinola, A. A. Onifade, V. F. Edem, S. Rahamon, O. Alonge","doi":"10.31584/jhsmr.2023945","DOIUrl":"https://doi.org/10.31584/jhsmr.2023945","url":null,"abstract":"Objective: Existence of crosstalk between metabolic and immune response against severe, acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicates that its full understanding could facilitate therapeutic insights for Coronavirus disease 2019 (COVID-19) management. Therefore, selected immunometabolic indices were determined in COVID-19 patients at a Nigerian Isolation Centre. Material and Methods: Haematological parameters (Total White Blood Cell [TWBC] and Differential White Blood Cell Counts), inflammation indices (C-Reactive Protein [CRP], Albumin, Pre-albumin and Neutrophil/Lymphocyte ratio [NLR]), anti-SARS-CoV-2 specific immunoglobulin (Ig) M and IgG, respiratory burst factors, lipid profile as well as renal and liver functions were determined in COVID-19 patients and controls. Results: Seventy percent of the COVID-19 patients were less than 40 years of age and largely had mild COVID-19. The mean TWBC, neutrophil, NLR and CRP levels were significantly higher, while the lymphocyte count was significantly lower in COVID-19 patients compared with the controls. Also, the mean plasma levels of anti-SARS-CoV-2 specific IgG and IgM in addition to superoxide dismutase (SOD) activity were significantly higher, while the mean plasma levels of nitric oxide, hydrogen peroxide and myeloperoxidase activity were significantly lower in COVID-19 patients compared with the controls. High proportions of COVID-19 patients had values of the liver (59%-96%) and renal (43%-97%) function test parameters within the normal reference intervals. Similarly, high proportions of COVID-19 patients had values of lipid profile (71%-86%) within the normal reference intervals. Conclusion: The infrequent alteration in lipid metabolism as well as liver and renal functions suggest mild COVID-19. However, hyper-inflammation remains a significant observation in COVID-19 patients, irrespective of the form of the disease.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45947439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of Burn Injury in the Southern Border Provinces of Thailand 泰国南部边境省份烧伤流行病学研究
Journal of Health Science and Medical Research Pub Date : 2023-03-27 DOI: 10.31584/jhsmr.2023942
Saranyoo Suwansa-Ard
{"title":"Epidemiology of Burn Injury in the Southern Border Provinces of Thailand","authors":"Saranyoo Suwansa-Ard","doi":"10.31584/jhsmr.2023942","DOIUrl":"https://doi.org/10.31584/jhsmr.2023942","url":null,"abstract":"Objective: This study aimed to investigate burns, from any situation, and the treatment in the Burn Center of Yala Hospital. Material and Methods: This research was a retrospective study in the Burn Center of Yala Hospital; from April 1, 2019 to May 31, 2021. Results: Enrollment consisted of 161 burn patients (male 65.8%, female 34.2%). Most burns in children were scalds (67.3%); whereas, in adults and the elderly they were flame burns (51.0% in adults and 66.7% in the elderly) (p-value<0.001), which were usually <20% of total body surface area (p-value<0.001). Most burns were superficial second degree burns. Patients in all age groups required surgical intervention (p-value=0.003). The median length of hospital stay was approximately seven days (IQR4-17); however, the elderly required intensive care more often than other age groups (p-value=0.003). All enrolled cases survived. Conclusion: The most common cause of burns in adults and the elderly was burning from flames, while burns from scalds occurred most in children. Burns in the elderly were more severe, and required admission to the intensive care unit more than any other age group.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43005320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity and Reliability of the Vietnamese Version of Diabetic Selfcare Knowledge Questionnaire-30 Used for Assessing Self-care Knowledge of Patients with Type 2 Diabetes Mellitus in Vietnam 越南版糖尿病自我护理知识问卷-30用于评估越南2型糖尿病患者自我护理知识的有效性和可靠性
Journal of Health Science and Medical Research Pub Date : 2023-03-27 DOI: 10.31584/jhsmr.2023943
Phung Van Loi, Ngô Huy Hoàng, Pham Tuan Vu, Dao Thanh Xuyen
{"title":"Validity and Reliability of the Vietnamese Version of Diabetic Selfcare Knowledge Questionnaire-30 Used for Assessing Self-care Knowledge of Patients with Type 2 Diabetes Mellitus in Vietnam","authors":"Phung Van Loi, Ngô Huy Hoàng, Pham Tuan Vu, Dao Thanh Xuyen","doi":"10.31584/jhsmr.2023943","DOIUrl":"https://doi.org/10.31584/jhsmr.2023943","url":null,"abstract":"Objectives: To translate and adapt the Diabetic Self-care Knowledge Questionnaire-30 (DSCKQ-30) questionnaire to be suitable for Vietnamese conditions and culture. To examine the reliability and validity of the Vietnamese version of the DSCKQ-30 questionnaire. Material and Methods: The questionnaire was forward translated, from English into Vietnamese and vice versa, by four independent translators. After that, an expert panel resolved any disagreements in translation regarding 4 criteria: semantics, idioms, experiences and concepts. The questionnaire then underwent a pilot study, on a sample of 100 DM patients to assess its clarity and readability; from June 1, 2021, to June 15, 2021. Finally, a test-retest study was conducted on a sample of 279 patients, over one month to examine internal consistency, stability and construct validity of the questionnaire; from July 1, 2021 to July 30, 2021. This study was approved by the Research Ethics Committee of the Thai Nguyen National Hospital. Results: The Vietnamese translated diabeté self-care knowledge questionnaire had content validity of 1.00, Cronbach’s alpha of 0.899 and Kappa coefficient of 0.700 or greater, except for question 15: with a Kappa coefficient of 0.658 (acceptable). Conclusion: The translated, adapted version of the DSCKQ-30 is valid, reliable and a feasible tool for practice, education and research in the future.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45014712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Surgery and Anesthesia Services and Patients’ Attitude Towards Informed Consent: The Case of a Specialized and Comprehensive University Hospital in Northern Ethiopia 手术和麻醉服务与患者知情同意态度的评估——以埃塞俄比亚北部一所专业综合大学医院为例
Journal of Health Science and Medical Research Pub Date : 2023-03-27 DOI: 10.31584/jhsmr.2023944
Mussie Tesfay Atsbeha, Mengistu Mitiku
{"title":"Assessment of Surgery and Anesthesia Services and Patients’ Attitude Towards Informed Consent: The Case of a Specialized and Comprehensive University Hospital in Northern Ethiopia","authors":"Mussie Tesfay Atsbeha, Mengistu Mitiku","doi":"10.31584/jhsmr.2023944","DOIUrl":"https://doi.org/10.31584/jhsmr.2023944","url":null,"abstract":"Objective: Healthcare providers need to establish close relationships with patients planning to undergo major elective surgery as this helps produce positive patient outcomes. This study aimed at investigating surgery and anesthesia services and patients’ attitude toward informed consent at Ayder comprehensive specialized university hospital, in Northern Ethiopia. Material and Methods: A facility-based cross-sectional study was conducted in the biggest health facility in Northern Ethiopia. Four hundred ten patients with major elective surgery were recruited. A structured questionnaire was used to collect socio-demographics, anesthesia and surgery services and the attitude of patients toward informed consent. Descriptive results were presented using frequencies and tables. Regression analysis was accompanied by an odds ratio and a 95% confidence interval was run to identify factors associated with the outcome variable. Results: Study participants’ mean age was 36.1+11.7. Around two-thirds (71.7%) and one-fourth (26.6%) of the study participants were informed about their proposed surgical procedure and its possible complications, respectively. Two hundred ninety four (66.8%) and 88 (21.5%) were made aware of the type of anesthesia that was going to be administered and possible complications. About half (50.7%) had expressed a positive attitude towards informed consent. Rural residents have about twice (AOR=1.9; 95% CI: 1.06-2.73) higher odds of expressing a positive attitude towards the informed consent than their counterparts. Conclusion: The study revealed that the proportion of patients who were informed about their anesthesia-surgery services was moderate. Besides, patients’ attitude toward informed consent was poor. The residence was a good predictor of positive patients’ attitudes toward informed consent. Thus, healthcare professionals in the surgery department should establish clear and transparent communication with patients about surgery and anesthesia-related services.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49039948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Prosthetic Status and Oral Frailty among The Geriatric Population Residing in Old Age Homes of Bhubaneswar City-a Cross Sectional Study 居住在布巴内斯瓦尔市养老院的老年人口中假肢状态和口腔虚弱的评估-一项横断面研究
Journal of Health Science and Medical Research Pub Date : 2023-03-16 DOI: 10.31584/jhsmr.2023941
G. Kumar, Payal Dash, Samikshya Jena
{"title":"Assessment of Prosthetic Status and Oral Frailty among The Geriatric Population Residing in Old Age Homes of Bhubaneswar City-a Cross Sectional Study","authors":"G. Kumar, Payal Dash, Samikshya Jena","doi":"10.31584/jhsmr.2023941","DOIUrl":"https://doi.org/10.31584/jhsmr.2023941","url":null,"abstract":"Objective: The aim of this study was to assess the prosthetic status and oral frailty of the elderly population residing in old age homes of Bhubaneswar city. Material and Methods: A cross-sectional questionnaire study was conducted among 310 geriatric patients aged 60 years and above residing in old age homes of Bhubaneswar city. Data collection was done using a modified World Health Organization (WHO) 1997 and oral frailty index 8. Descriptive statistics, chi-square test, Pearsons correlation and multinomial logistic regression were used. Results: The mean age of the study population was 66.72±6.86 years. Forty-seven percent of the study population required multiple units in the upper arch and approximately 30% in the lower arch. There was a significant positive correlation between the prosthetic status of the upper teeth and oral frailty (Pearson correlation coefficient: 0.315, p-value <0.0001). A ~1.751-fold risk of oral frailty was detected in participants with increasing age (p-value=0.049). Conclusions: The results of this study suggest that most of the need for prostheses in the aged population was inadequate. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70018978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Levels of Interleukin-12 and Interferon Gamma in Pediatric Tuberculosis: A Clinico-Microbiological Correlation 儿童结核患者血清白细胞介素-12和干扰素γ水平:临床微生物学相关性
Journal of Health Science and Medical Research Pub Date : 2023-03-13 DOI: 10.31584/jhsmr.2023940
N. Gupta, B. Kashyap, P. Dewan, Puneeta Hyanki
{"title":"Serum Levels of Interleukin-12 and Interferon Gamma in Pediatric Tuberculosis: A Clinico-Microbiological Correlation","authors":"N. Gupta, B. Kashyap, P. Dewan, Puneeta Hyanki","doi":"10.31584/jhsmr.2023940","DOIUrl":"https://doi.org/10.31584/jhsmr.2023940","url":null,"abstract":"Objective: The interleukin-12/interferon-γ (IL-12/IFN-γ) pathway is the most validated cytokine pathway regulating Mycobacterium tuberculosis infection. The role of IL-12/IFN-γ axis in protecting against tuberculosis (TB) is exhibited in people having mutations in genes encoding these cytokines. We aimed to study the serum levels of IL-12 and IFN-γ in pediatric tuberculosis and their correlation with clinical and microbiological features. Material and Methods: A case-control study was conducted on 60 microbiologically confirmed (smear and/or culture and/or cartridge-based nucleic acid amplification test) or clinically diagnosed (based on clinical features and radiography and/or contact history and/or Mantoux test with/without microbiological confirmation) pediatric TB patients ≤12 years. Serum interleukin-12 and interferon-gamma levels were estimated using enzyme-linked immunosorbent assays.Thirty age- and sex-matched controls were also included in the study. Results: The median IL-12 levels were lower in our pediatric TB patients (488.1 pg/ml) compared to controls (784.8 pg/ml). However, the IFN-γ/IL-12 ratios were significantly higher among the TB patients as compared to the controls. Moreover, the levels of interleukin-12 and interferon gamma were significantly lower in cases with no evidence of TB on chest radiography. IL-12 was significantly lower in patients with hydrocephalus and enlarged ventricles. Higher levels of IL-12 and IFN-γ were associated with positive results by conventional microbiological techniques. Conclusion: The serum IFN-γ level and the IFN-γ/IL-12 ratio were significantly higher in children with TB compared to the controls in this study. Higher IL-12 and IFN-γ levels as well as IFN-γ/IL-12 ratios were associated with positive results by conventional microbiological techniques. Further studies on larger sample sizes could help evaluate the usefulness of interleukin-12 and interferon-γ as potential markers of severity and prognosis in pediatric TB. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46063167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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