American Journal of Obstetrics & Gynecology Mfm最新文献

{"title":"Fetal surgery for severe left congenital diaphragmatic hernia: a cost-effectiveness analysis","authors":"Fiona Stefanik MD, Afsoon Ghafari-Saravi MD, Claire H. Packer MD, MPH, Sarina Chaiken MD, Uma Doshi MD, Aaron B. Caughey MD, PhD","doi":"10.1016/j.ajogmf.2025.101683","DOIUrl":"10.1016/j.ajogmf.2025.101683","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 7","pages":"Article 101683"},"PeriodicalIF":3.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic role of miRNAs in identifying placenta Accreta: a systematic review","authors":"Mohammad Haddadi MD,&nbsp;Roxana Safari MD,&nbsp;Sedigheh Hantoushzadeh MD","doi":"10.1016/j.ajogmf.2025.101682","DOIUrl":"10.1016/j.ajogmf.2025.101682","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review evaluates the diagnostic accuracy of circulating microRNAs (miRNAs) as potential biomarkers for detecting placenta accreta spectrum (PAS) disorders, a condition characterized by abnormal placental adherence with significant maternal health risks.</div></div><div><h3>Data Sources</h3><div>A comprehensive literature search was conducted in PubMed, Embase, and Scopus databases up to October 30, 2024, using predefined keywords such as \"miRNA\" and “placenta accreta.”</div></div><div><h3>Study Eligibility</h3><div>Studies investigating miRNA expression in PAS cases compared to controls, using either blood or placental tissue, were included. Articles were screened independently by 2 reviewers, with discrepancies resolved by consensus.</div></div><div><h3>Study Appraisal and Synthesis Methods</h3><div>The methodological quality of eligible studies was assessed using the Newcastle-Ottawa Scale. Extracted data were synthesized to identify miRNAs with diagnostic potential for PAS disorders. Due to significant variations in the comparisons conducted across studies and the diverse outcome measures reported, a meta-analysis of the included studies was not feasible.</div></div><div><h3>Results</h3><div>Out of 82 articles identified, 14 met the inclusion criteria after duplicate removal and screening. The studies reported distinct differential expression patterns of miRNAs in PAS cases. Notably, a combination of miR-26a-5p and miR-17-5p demonstrated 100% sensitivity and 82% specificity for predicting PAS in the first-trimester of pregnancy.</div></div><div><h3>Conclusions</h3><div>PAS disorders are typically diagnosed during the third trimester through imaging techniques like ultrasonography. However, miRNAs exhibit promise as non-invasive, early biomarkers, potentially enabling earlier diagnosis and improved clinical management. These findings support the incorporation of miRNA analysis into diagnostic guidelines for PAS.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 8","pages":"Article 101682"},"PeriodicalIF":3.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and neonatal outcomes after delayed vs early cord clamping at cesarean delivery: a systematic review and meta-analysis","authors":"Anubha Arora MD ,&nbsp;Bracha Pollack MD ,&nbsp;Maytal Babajanian MD ,&nbsp;Rebecca Friedman-Ciment MD ,&nbsp;Mikaela Glass MD ,&nbsp;Madison Kasoff MD ,&nbsp;Moses Bibi MD ,&nbsp;Margaret Magovern MD ,&nbsp;Rosa Soto MD ,&nbsp;Rahim Hirani MD ,&nbsp;Olivia Nussbaum MD ,&nbsp;Adi Steinhart MD ,&nbsp;Elizabeth D. Drugge PhD, MPH ,&nbsp;Angela Silber MD ,&nbsp;Cara L. Grimes MD, MAS","doi":"10.1016/j.ajogmf.2025.101680","DOIUrl":"10.1016/j.ajogmf.2025.101680","url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>This study aimed to systematically review maternal and neonatal outcomes after delayed cord clamping compared with early cord clamping at the time of cesarean delivery.</div></div><div><h3>DATA SOURCES</h3><div>MEDLINE, Embase, and ClinicalTrials.gov were searched from inception through October 5, 2023.</div></div><div><h3>STUDY ELIGIBILITY CRITERIA</h3><div>Our population included childbearing people undergoing cesarean delivery, and neonates delivered via cesarean delivery after 23 weeks of gestation. Our intervention was delayed cord clamping (&gt;30 seconds after birth) compared with early cord clamping. Randomized controlled trials and prospective and retrospective comparative studies were included.</div></div><div><h3>METHODS</h3><div>Abstracts and potentially relevant full-text articles were doubly screened, and accepted articles were doubly extracted. Of the 736 abstracts screened, 222 full-text articles were assessed, and 25 studies were included. Fifteen studies reported maternal outcomes, 20 reported neonatal outcomes, and 10 assessed both neonatal and maternal outcomes. Data were extracted by 9 reviewers, and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed. Random-effects meta-analyses of pooled proportions were conducted. Maternal outcomes included were estimated blood loss, postoperative hematocrit reduction, total surgical time, postpartum hemorrhage, blood transfusion, uterotonic administration, postoperative hemoglobin reduction, and incidence of hysterectomy. Neonatal outcomes included bilirubin levels, hematocrit change, phototherapy, neonatal intensive care unit admissions, Apgar scores at 1 and 5 minutes, mean hemoglobin, cord pH, mortality, need for resuscitation, and blood transfusion.</div></div><div><h3>RESULTS</h3><div>No difference was noted between delayed and early cord clamping at cesarean delivery for any maternal outcome, including estimated blood loss, postpartum hemorrhage, blood transfusion, surgical time, additional uterotonic administration, change in hemoglobin/hematocrit, and incidence of hysterectomy. Delayed cord clamping was favored for neonatal hematocrit change and bilirubin levels. No difference was noted in the need for phototherapy, neonatal intensive care unit admissions, and Apgar scores.</div></div><div><h3>CONCLUSION</h3><div>In agreement with robust physiological evidence, our data suggest that delayed cord clamping improves some neonatal outcomes (including hematocrit and bilirubin levels) for both term and preterm infants born via cesarean delivery compared with early cord clamping, without increasing the risk of adverse maternal outcomes, including maternal bleeding.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 6","pages":"Article 101680"},"PeriodicalIF":3.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a bilingual patient-reported outcome measure for patient trust during pregnancy care","authors":"Rose L. Molina MD, MPH,&nbsp;Daniela Reyes MD,&nbsp;Michele R. Hacker ScD, MSPH,&nbsp;Anjali J. Kaimal MD, MAS,&nbsp;Margarita Alegría PhD,&nbsp;Leonor Fernández MD,&nbsp;Jeanne-Marie Guise MD, MPH, MBA,&nbsp;Maria O. Edelen PhD","doi":"10.1016/j.ajogmf.2025.101681","DOIUrl":"10.1016/j.ajogmf.2025.101681","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 7","pages":"Article 101681"},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional block vs acupuncture for post-cesarean delivery pain control","authors":"Fu-Shan Xue MD,&nbsp;Dan-Feng Wang MD,&nbsp;Xiao-Chun Zheng MD","doi":"10.1016/j.ajogmf.2025.101678","DOIUrl":"10.1016/j.ajogmf.2025.101678","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 6","pages":"Article 101678"},"PeriodicalIF":3.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral labetalol versus nifedipine in preterm preeclampsia with severe features: a multicenter study evaluating pregnancy latency","authors":"Jessica A. Meyer MD,&nbsp;Anthony M. Torres MD,&nbsp;Steven Friedman MS,&nbsp;Celia A. Muoser MD, MPH,&nbsp;Itamar Futterman MD,&nbsp;Jessica Peterson MD,&nbsp;Meralis L. Martinez MD,&nbsp;Kavita Vani MD,&nbsp;Angela Bianco MD,&nbsp;Erinn M. Hade PhD,&nbsp;Ashley S. Roman MD, MPH,&nbsp;Christina A. Penfield MD, MPH","doi":"10.1016/j.ajogmf.2025.101677","DOIUrl":"10.1016/j.ajogmf.2025.101677","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 6","pages":"Article 101677"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal sleep-associated hypoxemia is common during pregnancy in sickle cell disease: a retrospective review","authors":"Mofiyin A. Obadina MD, MSCR,&nbsp;Ada Chang BA,&nbsp;Iman Owens BS,&nbsp;Jane A. Little MD","doi":"10.1016/j.ajogmf.2025.101676","DOIUrl":"10.1016/j.ajogmf.2025.101676","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 6","pages":"Article 101676"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of uterine rupture in individuals attempting trial of labor after cesarean in the setting of stillbirth","authors":"Alyssa Savelli Binsted MD, MS,&nbsp;Elizabeth Miller MD,&nbsp;George Saade MD,&nbsp;Tetsuya Kawakita MD, MS","doi":"10.1016/j.ajogmf.2025.101675","DOIUrl":"10.1016/j.ajogmf.2025.101675","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 6","pages":"Article 101675"},"PeriodicalIF":3.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose time in range trajectories during pregnancy and association with adverse perinatal outcomes: a joint latent-class trajectory modeling approach","authors":"Sara M. Sauer PhD ,&nbsp;Isabel Fulcher PhD ,&nbsp;Ayodeji Sanusi MD ,&nbsp;Ashley N. Battarbee MD","doi":"10.1016/j.ajogmf.2025.101669","DOIUrl":"10.1016/j.ajogmf.2025.101669","url":null,"abstract":"<div><h3>Background</h3><div>While time in range (TIR) summarized over pregnancy is associated with adverse outcomes among individuals with preexisting type 1 or 2 diabetes, the impact of TIR trajectories with advancing gestation is unknown.</div></div><div><h3>Objective</h3><div>To identify glucose TIR trajectories across pregnancy and evaluate their association with perinatal outcomes among patients with preexisting diabetes.</div></div><div><h3>Study Design</h3><div>Retrospective, single-center cohort study of pregnant patients with type 1 or 2 diabetes who used continuous glucose monitoring (CGM) and delivered in 2019 to 2023. Weekly TIR (65-140 mg/dL) was computed starting at 10 weeks’ gestation, and joint latent-class trajectory modeling identified discrete TIR trajectory groups. Patients were classified into groups, and multivariable logistic regression estimated the associations between groups and perinatal outcomes.</div></div><div><h3>Results</h3><div>Of 179 pregnant patients, 91 had type 1 and 88 had type 2 diabetes. We identified four TIR trajectory groups using data from over 5.1 million CGM measurements: (1) good control, stable (<em>n</em>=48), (2) moderate control, initial improvement, and late decline (<em>n</em>=22), (3) moderate control, late improvement (<em>n</em>=63), and (4) poor control, initial worsening and late improvement (<em>n</em>=46). All perinatal outcomes differed by TIR trajectory. Groups 2, 3, and 4 with suboptimal control in early pregnancy were associated with higher odds of preterm birth, indicated preterm birth, and NICU admission, compared to group 1. Groups 3 and 4, which had the lowest TIR during second and early third trimesters, were associated with higher odds of large-for-gestational-age (LGA). Only group 4 was associated with higher odds of preeclampsia and neonatal hypoglycemia.</div></div><div><h3>Conclusion</h3><div>Achieving glycemic control in the second and early third trimesters during fetal and placental growth and development is important to reduce the risk of adverse pregnancy outcomes, particularly LGA. Third-trimester TIR decline may impact risk of preterm birth and NICU admission.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 6","pages":"Article 101669"},"PeriodicalIF":3.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of an informative video on anxiety levels in women undergoing term induction of labor: a randomized controlled trial","authors":"Matan Friedman MD,&nbsp;Liat Mor MD,&nbsp;Irit Segman MD,&nbsp;Yossi Mizrachi MD,&nbsp;Noa Ben Shushan MD,&nbsp;Hagit Eisenberg MD,&nbsp;Tamar Shieldkrot MD,&nbsp;Eran Weiner MD,&nbsp;Giulia Barda MD","doi":"10.1016/j.ajogmf.2025.101667","DOIUrl":"10.1016/j.ajogmf.2025.101667","url":null,"abstract":"<div><h3>Background</h3><div>Induction of labor (IOL) is frequently performed worldwide. While IOL is often medically necessary to improve maternal and neonatal outcomes, the process can be associated with considerable anxiety, particularly for nulliparous women.</div></div><div><h3>Objective</h3><div>To evaluate the impact of an informative educational video on anxiety levels among women undergoing term IOL.</div></div><div><h3>Methods</h3><div>This randomized controlled trial included 167 women who underwent term IOL at a single medical center between April 2024 and August 2024. Participants in the “video group” (<em>n</em>=81) watched an 8-minute animated video detailing IOL methods and risks in addition to standard counseling. Participants in the control group (<em>n</em>=86) only received standard counseling. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) before and after the procedure. The primary outcome was the change in STAI scores. Secondary outcomes including patient satisfaction, as reported on a scale of one to five.</div></div><div><h3>Results</h3><div>Baseline STAI scores before receiving any counseling regarding IOL were similar between the study groups. Postprocedure, women allocated to the video group demonstrated lower anxiety levels compared to women in the control group (38.9±11.0 vs 44.1±11.3, <em>P</em>=.002). Moreover, the decrease in STAI scores was greater in the video group (4.4±7.9 vs 0.6±10.0, <em>P</em>=.007). Multivariate analysis confirmed that the video intervention was independently associated with reduced anxiety (<em>β</em> –7.8, 95% CI –15.1 to –0.5). Finally, Patient satisfaction was also higher in the video group (4.4±0.6 vs 4.1±0.9, <em>P</em>=.018).</div></div><div><h3>Conclusion</h3><div>An informative educational video prior to IOL is an effective, low-cost intervention for reducing patient anxiety and improving satisfaction during labor induction.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 6","pages":"Article 101667"},"PeriodicalIF":3.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}