American Journal of Obstetrics & Gynecology Mfm最新文献

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Postpartum readmissions among patients with adult congenital heart disease 成人先天性心脏病患者产后再入院的研究
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2024.101580
Lisa D. Levine MD, MSCE , Alexander M. Friedman MD, MPH , Yuli Y. Kim MD , Stephanie E. Purisch MD , Timothy Wen MD, MPH
{"title":"Postpartum readmissions among patients with adult congenital heart disease","authors":"Lisa D. Levine MD, MSCE , Alexander M. Friedman MD, MPH , Yuli Y. Kim MD , Stephanie E. Purisch MD , Timothy Wen MD, MPH","doi":"10.1016/j.ajogmf.2024.101580","DOIUrl":"10.1016/j.ajogmf.2024.101580","url":null,"abstract":"<div><h3>BACKGROUND</h3><div>Given the risks associated with congenital heart disease in the postpartum period, epidemiologic data identifying risk factors and timing of complications may be useful in improving postpartum care.</div></div><div><h3>OBJECTIVE</h3><div>This study aimed to determine the timing of, risk factors for, and complications associated with 60-day postpartum readmissions following deliveries with maternal congenital heart disease.</div></div><div><h3>STUDY DESIGN</h3><div>The 2010–2020 Nationwide Readmissions Database was used for this retrospective cohort study. Postpartum readmissions occurring within 60 days of delivery hospitalization discharge were ascertained. Clinical, demographic, and hospital risk factors associated with postpartum readmission were analyzed using logistic regression models, with unadjusted and adjusted odds ratios as measures of association. Among patients with congenital heart disease, the role of additional cardiac risk factors in the likelihood of readmission was analyzed. Risks for adverse maternal outcomes during readmission were analyzed, including severe maternal morbidity, cardiac severe maternal morbidity, and a critical care composite.</div></div><div><h3>RESULTS</h3><div>Of an estimated 40,780,439 delivery hospitalizations, 35,242 had an associated congenital heart disease diagnosis (8.6 per 10,000), including 2279 (6.5%) with complex congenital heart disease and 32,963 (93.5%) with noncomplex congenital heart disease. The proportion of deliveries with a maternal congenital heart disease diagnosis increased significantly from 6.7 per 10,000 in 2010 to 11.8 in 2020. Overall risk for 60-day postpartum readmission was 1.6% among women without congenital heart disease and 3.1% among women with congenital heart disease (<em>P</em><.01). Among women with congenital heart disease, 36.0% of 60-day postpartum readmissions occurred 1 to 5 days after discharge, 18.0% 5 to 10 days after discharge, and 14.5% 10 to 20 days after discharge. In adjusted models for the entire population, congenital heart disease retained a significant association with 60-day postpartum readmission (adjusted odds ratio, 1.73; 95% confidence interval, 1.55–1.94). When the cohort was restricted to deliveries with congenital heart disease, adjusted analyses demonstrated increased odds associated with additional cardiac risk factors (congestive heart failure: adjusted odds ratio, 1.72; 95% confidence interval, 1.13–2.62; arrhythmia: adjusted odds ratio, 1.68; 95% confidence interval, 1.27–2.21; pulmonary circulation disorders: adjusted odds ratio, 1.57; 95% confidence interval, 1.10–2.24; and chronic hypertension: adjusted odds ratio, 1.88; 95% confidence interval, 1.26–2.80), hypertensive disorders of pregnancy (adjusted odds ratio, 1.97; 95% confidence interval, 1.49–2.61), and cesarean delivery (primary adjusted odds ratio, 1.82; 95% confidence interval, 1.39–2.38; repeat cesarean: adjusted odds ratio, 1.91; 95% confidenc","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 2","pages":"Article 101580"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe maternal morbidity contributed by obstetric hemorrhage: Maryland, 2020-2022 由产科出血导致的严重孕产妇发病率:马里兰州,2020-2022年。
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2024.101589
Carrie Wolfson PHD , Jessica Tsipe Angelson MS, CNM , Robert Atlas MD , Irina Burd MD, PHD , Pamela Chin MS, PA-C , Cathy Downey BSN, RN , Jenifer Fahey CNM, PhD , Susan Hoffman BSN , Clark T. Johnson MD , Monica B. Jones MD , Kimberly Jones-Beatty DNP, MSN, CNM , Jennifer Kasirsky MD , Daniel Kirsch MD , Ichchha Madan MD , Donna Neale MD , Joanne Olaku MSN , Michelle Phillips BSN , Amber Richter MSN , Jeanne Sheffield MD , Danielle Silldorff MS , Andreea Creanga MD, PHD
{"title":"Severe maternal morbidity contributed by obstetric hemorrhage: Maryland, 2020-2022","authors":"Carrie Wolfson PHD ,&nbsp;Jessica Tsipe Angelson MS, CNM ,&nbsp;Robert Atlas MD ,&nbsp;Irina Burd MD, PHD ,&nbsp;Pamela Chin MS, PA-C ,&nbsp;Cathy Downey BSN, RN ,&nbsp;Jenifer Fahey CNM, PhD ,&nbsp;Susan Hoffman BSN ,&nbsp;Clark T. Johnson MD ,&nbsp;Monica B. Jones MD ,&nbsp;Kimberly Jones-Beatty DNP, MSN, CNM ,&nbsp;Jennifer Kasirsky MD ,&nbsp;Daniel Kirsch MD ,&nbsp;Ichchha Madan MD ,&nbsp;Donna Neale MD ,&nbsp;Joanne Olaku MSN ,&nbsp;Michelle Phillips BSN ,&nbsp;Amber Richter MSN ,&nbsp;Jeanne Sheffield MD ,&nbsp;Danielle Silldorff MS ,&nbsp;Andreea Creanga MD, PHD","doi":"10.1016/j.ajogmf.2024.101589","DOIUrl":"10.1016/j.ajogmf.2024.101589","url":null,"abstract":"<div><h3>Background</h3><div>Obstetric hemorrhage is the leading cause of maternal mortality and severe maternal morbidity (SMM) in Maryland and nationally. Currently, through a quality collaborative, the state is implementing the Alliance for Innovation on Maternal Health (AIM) patient safety bundle on obstetric hemorrhage.</div></div><div><h3>Objective</h3><div>To describe SMM events contributed by obstetric hemorrhage and their preventability in Maryland.</div></div><div><h3>Study Design</h3><div>This cross-sectional study used data from hospital-based SMM surveillance and review program in Maryland. Hospital-based SMM criteria include admission to an intensive care unit and/or transfusion of 4 or more units of blood products (of any type) during pregnancy or within 42 days postpartum. A total of 193 obstetric hemorrhage events that met the surveillance definition were identified in hospitals participating in SMM surveillance since inception on August 1, 2020 until December 31, 2022. We compared patient and delivery characteristics, practices done well, and recommendations for care improvement among patients with severe obstetric hemorrhage deemed preventable and non-preventable by hospital-based review committees. For obstetric hemorrhage events deemed preventable, we further identified factors that contributed to the SMM outcome at the provider, system, and patient levels.</div></div><div><h3>Results</h3><div>Uterine atony was the leading cause of obstetric hemorrhage events (37.8%), followed by uterine rupture, laceration and intra-abdominal bleeding (23.8%). Sixty-six (34.2%) obstetric hemorrhage events were preventable. Patients with preventable obstetric hemorrhage were significantly more likely to have an emergency than planned cesarean delivery and less likely to have a placental complication or &gt;1500 mL blood loss volume. Hospital-based review committees determined that 81.8%, 30.3%, and 22.7% of preventable events could have been prevented or made less severe through changes to provider, system, or patient factors, respectively. Recommendations following event reviews aligned with the Alliance for Innovation on Maternal Health Obstetric Hemorrhage Patient Safety Bundle, particularly regarding elements in the Recognition and Prevention and Response domains.</div></div><div><h3>Conclusion</h3><div>About one-third of SMM events contributed by obstetric hemorrhages were deemed preventable. Of AIM bundle elements, assessing hemorrhage risk on admission to labor and delivery, peripartum, and upon transition to postpartum care together with rapid, unit-standardized management of hemorrhage are likely to benefit more than half of patients with preventable SMM contributed by obstetric hemorrhage.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 2","pages":"Article 101589"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined vaginal progesterone and cervical cerclage in the prevention of preterm birth: A systematic review and meta-analysis 阴道孕酮联合宫颈环扎术预防早产:一项系统综述和荟萃分析
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2024.101553
Anne-Marie Aubin MD , Liam McAuliffe MD , Kimberley Williams MD , Ashad Issah MD , Rosanna Diacci MD , Jack E. McAuliffe BSc , Salma Sabdia MD , Jason Phung MD , Carol A. Wang BSc(Hons) , Craig E. Pennell PhD
{"title":"Combined vaginal progesterone and cervical cerclage in the prevention of preterm birth: A systematic review and meta-analysis","authors":"Anne-Marie Aubin MD ,&nbsp;Liam McAuliffe MD ,&nbsp;Kimberley Williams MD ,&nbsp;Ashad Issah MD ,&nbsp;Rosanna Diacci MD ,&nbsp;Jack E. McAuliffe BSc ,&nbsp;Salma Sabdia MD ,&nbsp;Jason Phung MD ,&nbsp;Carol A. Wang BSc(Hons) ,&nbsp;Craig E. Pennell PhD","doi":"10.1016/j.ajogmf.2024.101553","DOIUrl":"10.1016/j.ajogmf.2024.101553","url":null,"abstract":"<div><h3>Background</h3><div>Vaginal progesterone and cervical cerclage are both effective interventions for reducing preterm birth (PTB). It is currently unclear whether combined therapy offers superior effectiveness compared to single therapy.</div></div><div><h3>Objective</h3><div>To determine the efficacy of combining cervical cerclage and vaginal progesterone in the prevention of PTB.</div></div><div><h3>Data sources</h3><div>We searched Medline (Ovid), EMBASE (Ovid), PsycINFO (Ovid), CINAHL (EBSCOhost), Cochrane Library (Wiley) and Scopus (from their inception to 2020).</div></div><div><h3>Study eligibility criteria</h3><div>The review accepted randomized and pseudo-randomized control trials, non-randomized experimental control trials, and cohort studies. High risk patients (shortened cervical length &lt;25mm or prior PTB) who were assigned cervical cerclage, vaginal progesterone, or both for the prevention of PTB were included. Only singleton pregnancies were assessed.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>The primary outcome was birth &lt;37 weeks. Secondary outcomes included birth &lt;28, &lt;32 and &lt;34 weeks, gestational age (GA) at delivery, days between intervention and delivery, preterm premature rupture of membranes, neonatal mortality, neonatal intensive care unit admission, intubation and birthweight. Following title and full-text screening, eight papers were included in the final analysis. Risk of bias was assessed using the Cochrane Collaboration tool for assessing the risk of bias (ROBINS-I and RoB-2). Quality of evidence was assessed using the GRADE tool.</div></div><div><h3>Results</h3><div>Combined therapy was associated with lower risk of PTB &lt;37 weeks compared to progesterone alone (RR 0.75, 95% CI 0.58, 0.96). Compared to cerclage only, combined therapy was associated with less PTB &lt;32 weeks, decreased neonatal mortality, increased GA and a longer interval between intervention and delivery. Compared to progesterone alone, combined therapy was associated with less PTB &lt;32 weeks, less PTB&lt;28 weeks, increased GA, decreased neonatal mortality and decreased neonatal intensive care unit admissions.</div></div><div><h3>Conclusions</h3><div>Combined treatment of cervical cerclage and vaginal progesterone could potentially result in a greater reduction in PTB compared to single therapy. Further well-conducted and adequately powered randomized controlled trials are needed to assess these promising findings.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 2","pages":"Article 101553"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cesarean delivery classification system 剖宫产分类系统。
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2025.101624
Clodagh Mullen MD, Marcos Izquierdo MD, Nicolas Mas D' Alessandro MD, Matthew Sikora MD
{"title":"Cesarean delivery classification system","authors":"Clodagh Mullen MD,&nbsp;Marcos Izquierdo MD,&nbsp;Nicolas Mas D' Alessandro MD,&nbsp;Matthew Sikora MD","doi":"10.1016/j.ajogmf.2025.101624","DOIUrl":"10.1016/j.ajogmf.2025.101624","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 4","pages":"Article 101624"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of GLP-1 medication exposure prior to, during, and after pregnancy using state-wide data from 2017 to 2023 使用2017年至2023年全州数据分析妊娠前、妊娠期间和妊娠后GLP-1药物暴露的患病率
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2024.101596
Katherine A. Ahrens MPH, PhD, Kristin Palmsten ScD, Heather S. Lipkind MD, MS, Christina M. Ackerman-Banks MD
{"title":"Prevalence of GLP-1 medication exposure prior to, during, and after pregnancy using state-wide data from 2017 to 2023","authors":"Katherine A. Ahrens MPH, PhD,&nbsp;Kristin Palmsten ScD,&nbsp;Heather S. Lipkind MD, MS,&nbsp;Christina M. Ackerman-Banks MD","doi":"10.1016/j.ajogmf.2024.101596","DOIUrl":"10.1016/j.ajogmf.2024.101596","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 2","pages":"Article 101596"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effectiveness of low molecular weight heparin on live birth for recurrent spontaneous abortion: systematic review and network meta-analysis 低分子量肝素对复发性自然流产活产的比较效果:系统综述和网络荟萃分析:低分子量肝素对 RSA 活产的有效性。
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2024.101572
Wenrui Huang PhD , Yue Yu BD , Lei Chen MD , Xiaoxuan Tang MD , Xingzi Fang MD , Xingyan Ou MD , XueLian Du PhD
{"title":"Comparative effectiveness of low molecular weight heparin on live birth for recurrent spontaneous abortion: systematic review and network meta-analysis","authors":"Wenrui Huang PhD ,&nbsp;Yue Yu BD ,&nbsp;Lei Chen MD ,&nbsp;Xiaoxuan Tang MD ,&nbsp;Xingzi Fang MD ,&nbsp;Xingyan Ou MD ,&nbsp;XueLian Du PhD","doi":"10.1016/j.ajogmf.2024.101572","DOIUrl":"10.1016/j.ajogmf.2024.101572","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effectiveness and safety of low molecular weight heparins (LMWHs) on live birth rates and adverse pregnancy outcomes in individuals experiencing recurrent spontaneous abortion (RSA).</div></div><div><h3>Data sources</h3><div>PubMed, Web of Science, the Cochrane Library, and Embase from database inception to July 1, 2024.</div></div><div><h3>Study eligibility criteria</h3><div>Eligible randomized controlled trials enrolled women with RSA who received LMWH, with a follow-up duration of at least 12 weeks. The treatment was either monotherapy with LMWH or added LMWH to nonrandomized background anticoagulant treatments, with the control group being placebo and other anticoagulant treatments. Trials with a crossover design or involving withdrawn drugs were also excluded.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>We assessed bias using the Risk of Bias 2.0 tool and evaluated evidence quality with the Confidence in Network Meta-Analysis framework. The network meta-analysis employed a Bayesian framework to integrate direct and indirect evidence, calculating risk ratios and 95% confidence intervals. Markov chain Monte Carlo methods generated posterior distributions, allowing comparison and ranking of treatments. Subgroup, regression, and sensitivity analyses assessed the impact of various factors on the results.</div></div><div><h3>Results</h3><div>This network meta-analysis included 22 trials involving 4773 participants across five different LMWH drugs, with all comparisons made against the control group. Among the five drugs, enoxaparin showed significant benefits. It notably improved live birth rates (LBR) (Risk Ratios 1.19, (95% confidence intervals 1.06 to 1.36), surface under the cumulative ranking curve 73%; moderate confidence of evidence), reduced the risk of pre-eclampsia (0.53, (0.28–0.92), 85%), lowered preterm delivery (0.59, [0.41–0.86], 85%), and decreased pregnancy loss (0.55, [0.38–0.76], 82%). Further analysis of 7 different LMWH doses revealed that both enoxaparin 20mg (1.53, [1.08–2.25], 89%) and 40mg (1.18, [1.04–1.38], 59%) significantly improved LBR, with the 20mg dose proving more effective. Both doses also significantly reduced the risk of pregnancy loss.</div></div><div><h3>Conclusion</h3><div>Enoxaparin proved to be the most effective LMWH in increasing LBR compared to the control group. It also significantly lowered the risks of pre-eclampsia, preterm delivery, and pregnancy loss. A dosage-based subgroup analysis showed that both 20mg and 40mg of enoxaparin improved LBR, with the 20mg dose demonstrating greater effectiveness.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 2","pages":"Article 101572"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal exome sequencing for the structurally normal fetus: ready or not? 结构正常胎儿的产前外显子组测序:准备好了吗?
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2024.101513
Teresa N. Sparks MD, MAS
{"title":"Prenatal exome sequencing for the structurally normal fetus: ready or not?","authors":"Teresa N. Sparks MD, MAS","doi":"10.1016/j.ajogmf.2024.101513","DOIUrl":"10.1016/j.ajogmf.2024.101513","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 2","pages":"Article 101513"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis 高剂量与低剂量催产素方案用于助产:一项系统回顾和荟萃分析。
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2025.101604
Teresa C. Logue MD, MPH , Fabrizio Zullo MD , Fiamma van Biema MA , Moeun Son MD, MSCI , Lauren London MD , Sneha Paranandi MD , Anthony C. Sciscione DO , Giuseppe Rizzo MD , Daniele Di Mascio MD , Suneet P. Chauhan MD, Hon DSc
{"title":"High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis","authors":"Teresa C. Logue MD, MPH ,&nbsp;Fabrizio Zullo MD ,&nbsp;Fiamma van Biema MA ,&nbsp;Moeun Son MD, MSCI ,&nbsp;Lauren London MD ,&nbsp;Sneha Paranandi MD ,&nbsp;Anthony C. Sciscione DO ,&nbsp;Giuseppe Rizzo MD ,&nbsp;Daniele Di Mascio MD ,&nbsp;Suneet P. Chauhan MD, Hon DSc","doi":"10.1016/j.ajogmf.2025.101604","DOIUrl":"10.1016/j.ajogmf.2025.101604","url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>This study aimed to assess whether high- vs low-dose oxytocin regimens for labor augmentation are associated with differential risk of low Apgar score, neonatal acidosis, and other adverse labor outcomes.</div></div><div><h3>DATA SOURCES</h3><div>We searched electronic databases (MEDLINE, Embase, the Cochrane Library, CINAHL, Scopus, ClinicalTrials.gov) from inception up to March 2024 using combinations of the following key words: “oxytocin,” “oxytocin regimen,” “oxytocin protocol,” “oxytocin dosage,” “active management,” “high dose protocol,” “low dose protocol,” and “augmentation of labor.”</div></div><div><h3>STUDY ELIGIBILITY CRITERIA</h3><div>We included quasi-randomized and randomized controlled trials comparing continuous oxytocin infusion with high-dose regimens (intervention group) vs low-dose regimens (control group) in nulliparous or multiparous patients undergoing labor augmentation. High-dose regimens were defined as a starting oxytocin dose of ≥4 mU/min, increasing in increments of 3 to 7 mU/min every 15 to 40 minutes. Low-dose regimens were defined as a starting oxytocin dose of &lt;4 mU/min, increasing in increments of 1 to 2 mU/min every 15 to 40 minutes (PROSPERO CRD42024500197).</div></div><div><h3>METHODS</h3><div>The coprimary outcomes were incidence of Apgar score &lt;7 at 5 minutes and umbilical arterial pH &lt;7.00. The secondary outcomes included cesarean delivery and chorioamnionitis. We performed random-effects head-to-head meta-analyses to compare high-dose with low-dose strategies, and reported summary risk ratios with 95% confidence intervals.</div></div><div><h3>RESULTS</h3><div>Ten randomized and quasi-randomized controlled trials of 5508 pregnancies met the inclusion criteria and were included in this meta-analysis. There was no difference in risk for the coprimary outcomes of Apgar score &lt;7 at 5 minutes (relative risk, 0.94; 95% confidence interval, 0.60–1.46) and umbilical arterial pH &lt;7.00 (relative risk, 0.77; 95% confidence interval, 0.50–1.20). There was also no difference in risk for cesarean delivery (relative risk, 0.83; 95% confidence interval, 0.67–1.02). High-dose oxytocin regimens were associated with significantly lower risk of chorioamnionitis (relative risk, 0.70; 95% confidence interval, 0.57–0.84; number needed to treat=25) and higher risk of tachysystole (relative risk, 1.32; 95% confidence interval, 1.21–1.43; <em>P</em>&lt;.001).</div></div><div><h3>CONCLUSION</h3><div>When used for labor augmentation, high-dose oxytocin regimens decreased the risk of chorioamnionitis compared with low-dose regimens without affecting the risk of low Apgar scores, neonatal acidosis, or cesarean delivery.</div></div>","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 2","pages":"Article 101604"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Labor roulette: the probability of achieving spontaneous labor in normal-risk nulliparous patients 产程轮盘赌:正常风险无产患者实现自然分娩的概率。
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2024.101590
Sarah M. Nicholson MB, Susan Hatt MSc, Corina I. Oprescu MD, Sara N. EL Nimr MB, Michael P. Geary MD, Patrick Dicker MSc, Zara E. Molphy PhD, Karen Flood MD, Fergal D. Malone MD
{"title":"Labor roulette: the probability of achieving spontaneous labor in normal-risk nulliparous patients","authors":"Sarah M. Nicholson MB,&nbsp;Susan Hatt MSc,&nbsp;Corina I. Oprescu MD,&nbsp;Sara N. EL Nimr MB,&nbsp;Michael P. Geary MD,&nbsp;Patrick Dicker MSc,&nbsp;Zara E. Molphy PhD,&nbsp;Karen Flood MD,&nbsp;Fergal D. Malone MD","doi":"10.1016/j.ajogmf.2024.101590","DOIUrl":"10.1016/j.ajogmf.2024.101590","url":null,"abstract":"","PeriodicalId":36186,"journal":{"name":"American Journal of Obstetrics & Gynecology Mfm","volume":"7 2","pages":"Article 101590"},"PeriodicalIF":3.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of fixed time–interval and on-demand analgesia protocols for post–cesarean pain on maternal chronic pain and child development–follow-up of randomized controlled trial 剖宫产后镇痛定时间隔和按需镇痛方案对产妇慢性疼痛和儿童发育的影响——随机对照试验随访。
IF 3.8 2区 医学
American Journal of Obstetrics & Gynecology Mfm Pub Date : 2025-02-01 DOI: 10.1016/j.ajogmf.2024.101591
Enav Yefet MD, PhD, Noa Frishman Martsiano MD, Ilanit Elbaz Shchory PhD, Zohar Nachum MD, MHA
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