European Journal of Hybrid Imaging最新文献

{"title":"Suspicious cold thyroid nodule with intense focal 68Ga-DOTATATE uptake: a case report","authors":"Ringo Manta, Wendy Delbart, I. Duran Derijckere, M. Quiriny, P. Demetter, P. Flamen, I. Karfis","doi":"10.1186/s41824-022-00126-5","DOIUrl":"https://doi.org/10.1186/s41824-022-00126-5","url":null,"abstract":"","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41653338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-parametric PET/MRI for enhanced tumor characterization of patients with cervical cancer","authors":"S. Ahangari, Flemming Littrup Andersen, Naja Liv Hansen, T. Jakobi Nøttrup, A. Berthelsen, J. Folsted Kallehauge, I. Richter Vogelius, A. Kjaer, Adam Espe Hansen, B. Fischer","doi":"10.1186/s41824-022-00129-2","DOIUrl":"https://doi.org/10.1186/s41824-022-00129-2","url":null,"abstract":"","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43142734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical experience with 18F-JK-PSMA-7 when using a digital PET/CT","authors":"I. Vierasu, N. Trotta, S. Albisinni, C. Mathey, G. Leurquin-Sterk, S. Lacroix, G. Van Simaeys, T. Quackels, T. Roumeguère, S. Goldman","doi":"10.1186/s41824-022-00128-3","DOIUrl":"https://doi.org/10.1186/s41824-022-00128-3","url":null,"abstract":"","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46006289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 68Ga-PSMA PET/CT with fluoride PET/CT for detection of bone metastatic disease in prostate cancer","authors":"N. Regula, V. Kostaras, S. Johansson, C. Trampal, Elin Lindström, M. Lubberink, V. Iyer, I. Velikyan, J. Sörensen","doi":"10.1186/s41824-022-00127-4","DOIUrl":"https://doi.org/10.1186/s41824-022-00127-4","url":null,"abstract":"","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41774557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically viable myocardial CCTA segmentation for measuring vessel-specific myocardial blood flow from dynamic PET/CCTA hybrid fusion.","authors":"Marina Piccinelli,&nbsp;Navdeep Dahiya,&nbsp;Jonathon A Nye,&nbsp;Russell Folks,&nbsp;C David Cooke,&nbsp;Daya Manatunga,&nbsp;Doyeon Hwang,&nbsp;Jin Chul Paeng,&nbsp;Sang-Geon Cho,&nbsp;Joo Myung Lee,&nbsp;Hee-Seung Bom,&nbsp;Bon-Kwon Koo,&nbsp;Anthony Yezzi,&nbsp;Ernest V Garcia","doi":"10.1186/s41824-021-00122-1","DOIUrl":"https://doi.org/10.1186/s41824-021-00122-1","url":null,"abstract":"<p><strong>Background: </strong>Positron emission tomography (PET)-derived LV MBF quantification is usually measured in standard anatomical vascular territories potentially averaging flow from normally perfused tissue with those from areas with abnormal flow supply. Previously we reported on an image-based tool to noninvasively measure absolute myocardial blood flow at locations just below individual epicardial vessel to help guide revascularization. The aim of this work is to determine the robustness of vessel-specific flow measurements (MBF^vs) extracted from the fusion of dynamic PET (dPET) with coronary computed tomography angiography (CCTA) myocardial segmentations, using flow measured from the fusion with CCTA manual segmentation as the reference standard.</p><p><strong>Methods: </strong>Forty-three patients' ¹³NH₃ dPET, CCTA image datasets were used to measure the agreement of the MBF^vs profiles after the fusion of dPET data with three CCTA anatomical models: (1) a manual model, (2) a fully automated segmented model and (3) a corrected model, where major inaccuracies in the automated segmentation were briefly edited. Pairwise accuracy of the normality/abnormality agreement of flow values along differently extracted vessels was determined by comparing, on a point-by-point basis, each vessel's flow to corresponding vessels' normal limits using Dice coefficients (DC) as the metric.</p><p><strong>Results: </strong>Of the 43 patients CCTA fully automated mask models, 27 patients' borders required manual correction before dPET/CCTA image fusion, but this editing process was brief (2-3 min) allowing a 100% success rate of extracting MBF^vs in clinically acceptable times. In total, 124 vessels were analyzed after dPET fusion with the manual and corrected CCTA mask models yielding 2225 stress and 2122 rest flow values. Forty-seven vessels were analyzed after fusion with the fully automatic masks producing 840 stress and 825 rest flow samples. All DC coefficients computed globally or by territory were ≥ 0.93. No statistical differences were found in the normal/abnormal flow classifications between manual and corrected or manual and fully automated CCTA masks.</p><p><strong>Conclusion: </strong>Fully automated and manually corrected myocardial CCTA segmentation provides anatomical masks in clinically acceptable times for vessel-specific myocardial blood flow measurements using dynamic PET/CCTA image fusion which are not significantly different in flow accuracy and within clinically acceptable processing times compared to fully manually segmented CCTA myocardial masks.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":" ","pages":"4"},"PeriodicalIF":1.7,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39924634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary role of computed tomography angiography with fixed perfusion defects on SPECT myocardial perfusion imaging.","authors":"Rami M Abazid,&nbsp;Yasmine T Sallam,&nbsp;Jonathan G Romsa,&nbsp;James C Warrington,&nbsp;Cigdem Akincioglu,&nbsp;Sabe De,&nbsp;Nikolaos Tzemos,&nbsp;William C Vezina","doi":"10.1186/s41824-021-00124-z","DOIUrl":"https://doi.org/10.1186/s41824-021-00124-z","url":null,"abstract":"<p><strong>Purpose: </strong>We present this case series exploring the complementary role of coronary computed tomography angiography (CCTA) to SPECT myocardial perfusion imaging (MPI) in the detection of myocardial necrosis.</p><p><strong>Methods: </strong>A cardiac hybrid imaging database search identified 144 patients with a previous history of ST-segment elevation myocardial infarction treated with coronary revascularization. CCTA and MPI scans were evaluated to determine whether CCTA had an added value to MPI in detecting myocardial necrosis.</p><p><strong>Results: </strong>Five patients with patent stents and/or bypass grafts and both fixed perfusion defects on MPI and sub-endocardial hypo-perfusion on CCTA were identified. The extent and location of the perfusion defects were closely correlated between the CCTA and SPECT MPI images.</p><p><strong>Conclusion: </strong>In this series, CCTA and SPECT MPI were found to play a complementary role in the assessment of fixed perfusion defect, with CCTA adding specificity to the diagnosis of myocardial necrosis.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":" ","pages":"3"},"PeriodicalIF":1.7,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39876576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional uptakes from early-frame amyloid PET and ¹⁸F-FDG PET scans are comparable independent of disease state.","authors":"Alison Myoraku,&nbsp;Gregory Klein,&nbsp;Susan Landau,&nbsp;Duygu Tosun","doi":"10.1186/s41824-021-00123-0","DOIUrl":"https://doi.org/10.1186/s41824-021-00123-0","url":null,"abstract":"<p><strong>Purpose: </strong>Positron emission tomography (PET) imaging with amyloid-beta (Aβ) tracers and 2-[18F] fluoro-2-Deoxy-D-glucose (¹⁸F-FDG) is extensively employed in Alzheimer's disease (AD) studies as biomarkers of AD pathology and neurodegeneration. To reduce cost and additional burdens to the patient, early-frame uptake during Aβ PET scanning has been proposed as a surrogate measure of regional glucose metabolism. Considering the disease state specific impact of AD on neurovascular coupling, we investigated to what extent the information captured in the early frames of an Aβ-PET (¹⁸F-florbetapir or ¹⁸F-florbetaben) scan is comparable to that of a ¹⁸F-FDG PET scan, independent of disease state.</p><p><strong>Method: </strong>A partial correlation was performed on early-frame ¹⁸F-florbetapir and ¹⁸F-FDG regional data from 100 participants. In a secondary analysis, we compared 92 ¹⁸F-florbetapir and 21 ¹⁸F-florbetaben early-frame Aβ scans from cognitively unimpaired and mild cognitive impairment participants to ascertain if regional early-frame information was similar across different Aβ-PET radioligands.</p><p><strong>Results: </strong>The partial correlation of early-frame ¹⁸F-florbetapir with ¹⁸F-FDG was significant in all 84 brain ROIs, with correlation values ranging from 0.61 to 0.94. There were no significant differences between early-frame ¹⁸F-florbetapir and ¹⁸F-florbetaben images.</p><p><strong>Conclusion: </strong>Overall, we find that the regional uptake measurements from early-frame ¹⁸F-florbetapir are strongly correlated with regional glucose metabolism as measured in ground-truth ¹⁸F-FDG PET scans, regardless of disease state. Future studies should focus on longitudinal early-frame amyloid PET imaging studies to further assess the value of early-frame imaging as a marker of brain metabolic decline.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":" ","pages":"2"},"PeriodicalIF":1.7,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39828601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static CT myocardial perfusion imaging: image quality, artifacts including distribution and diagnostic performance compared to ⁸²Rb PET.","authors":"João R Inácio,&nbsp;Sriraag Balaji Srinivasan,&nbsp;Terrence D Ruddy,&nbsp;Robert A deKemp,&nbsp;Frank Rybicki,&nbsp;Rob S Beanlands,&nbsp;Benjamin J W Chow,&nbsp;Girish Dwivedi","doi":"10.1186/s41824-021-00118-x","DOIUrl":"https://doi.org/10.1186/s41824-021-00118-x","url":null,"abstract":"<p><strong>Background: </strong>Rubidium-82 positron emission tomography (⁸²Rb PET) MPI is considered a noninvasive reference standard for the assessment of myocardial perfusion in coronary artery disease (CAD) patients. Our main goal was to compare the diagnostic performance of static rest/ vasodilator stress CT myocardial perfusion imaging (CT-MPI) to stress/ rest ⁸²Rb PET-MPI for the identification of myocardial ischemia.</p><p><strong>Methods: </strong>Forty-four patients with suspected or diagnosed CAD underwent both static CT-MPI and ⁸²Rb PET-MPI at rest and during pharmacological stress. The extent and severity of perfusion defects on PET-MPI were assessed to obtain summed stress score, summed rest score, and summed difference score. The extent and severity of perfusion defects on CT-MPI was visually assessed using the same grading scale. CT-MPI was compared with PET-MPI as the gold standard on a per-territory and a per-patient basis.</p><p><strong>Results: </strong>On a per-patient basis, there was moderate agreement between CT-MPI and PET-MPI with a weighted 0.49 for detection of stress induced perfusion abnormalities. Using PET-MPI as a reference, static CT-MPI had 89% sensitivity (SS), 58% specificity (SP), 71% accuracy (AC), 88% negative predictive value (NPV), and 59% positive predictive value (PPV) to diagnose stress-rest perfusion deficits on a per-patient basis. On a per-territory analysis, CT-MPI had 73% SS, 65% SP, 67% AC, 90.8% NPV, and 34% PPV to diagnose perfusion deficits.</p><p><strong>Conclusions: </strong>CT-MPI has high sensitivity and good overall accuracy for the diagnosis of functionally significant CAD using ⁸²Rb PET-MPI as the reference standard. CT-MPI may play an important role in assessing the functional significance of CAD especially in combination with CCTA.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":" ","pages":"1"},"PeriodicalIF":1.7,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39785109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal and spatial changes in reactive astrogliosis examined by ¹⁸F-THK5351 positron emission tomography in a patient with severe traumatic brain injury.","authors":"Tetsuhiro Hatakeyama,&nbsp;Kenya Kawakita,&nbsp;Nobuyuki Kawai,&nbsp;Hajime Shishido,&nbsp;Yuka Yamamoto,&nbsp;Yoshihiro Nishiyama,&nbsp;Keisuke Miyake","doi":"10.1186/s41824-021-00121-2","DOIUrl":"https://doi.org/10.1186/s41824-021-00121-2","url":null,"abstract":"<p><strong>Background: </strong>The positron emission tomography (PET) radioligand ¹⁸F-THK5351 is now used to evaluate monoamine oxidase B expression in the reactive astrogliosis seen in various central nervous diseases. Traumatic brain injury (TBI) is known to induce reactive astrogliosis in the lesion site. This is a first report to examine the spatial and temporal changes in reactive astrogliosis as evaluated by ¹⁸F-THK5351 after a severe TBI.</p><p><strong>Case presentation: </strong>A 27-year-old man suffering from a severe TBI with multiple brain contusions was examined using ¹⁸F-THK5351 PET/CT in the subacute and chronic phases after the injury. The first PET scan, performed 46 days after the TBI, showed intense uptake of ¹⁸F-THK5351 in and around the brain contusions. The second PET scan, performed 271 days after the TBI, showed reduced uptake of ¹⁸F-THK5351 at the original sites of the brain contusions and increased uptakes in the white matter surrounding the contusions and the corpus callosum. The patient exhibited sustained improvement of neuropsychological impairment between the two PET examinations and remarkable recovery from the severe TBI.</p><p><strong>Conclusions: </strong>There were evident temporal and spatial changes in ¹⁸F-THK5351 uptake in the traumatized brain between the two PET examinations. These changes may have been related to the remarkable neurological recovery in this patient. The degree and distribution of reactive astrogliosis detected by ¹⁸F-THK5351 PET may be useful in assessing pathophysiology and predicting prognosis in TBI patients.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"26"},"PeriodicalIF":1.7,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39749109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical bilateral ventilation/perfusion mismatches in an asymptomatic patient suffering from metastatic thyroid cancer.","authors":"David Kersting,&nbsp;Christoph Rischpler,&nbsp;Till Plönes,&nbsp;Clemens Aigner,&nbsp;Lale Umutlu,&nbsp;Ken Herrmann,&nbsp;Hubertus Hautzel","doi":"10.1186/s41824-021-00120-3","DOIUrl":"https://doi.org/10.1186/s41824-021-00120-3","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary embolism is indicated by ventilation/perfusion (V/P) mismatches in ventilation/perfusion scintigraphy. However, other pathologies may also evoke segmental or lobar mismatches. Thus, diagnosis can be difficult in asymptomatic patients with equivocal clinical presentation.</p><p><strong>Case presentation: </strong>We present a case of multiple bilateral pulmonary ventilation/perfusion mismatches in a poorly differentiated thyroid cancer patient. Exact diagnosis was difficult, as the patient was asymptomatic and pulmonary embolism is commonly unilateral in tumour patients and not typical for thyroid cancer. External pulmonary artery compression by aortic aneurysm, multiple metastases or additional bronchopulmonary malignancies were considered as differential diagnosis. After unilateral pulmonary and hilar metastasectomy, perfusion normalised on the operated side. Pulmonary perfusion defects due to pulmonary artery compression by hilar metastases were finally diagnosed. Pulmonary embolism was deemed unlikely due to the left-sided post-operative normalisation, persistence of right-sided V/P mismatches, and the lack of clinical symptoms.</p><p><strong>Conclusion: </strong>Pulmonary artery compression may mimic pulmonary artery embolism in lung perfusion scintigraphy and should be considered in bronchopulmonary tumour patients with hilar metastases and unilateral ventilation/perfusion mismatches affecting a complete lobe or even lung. Following the presented case, also bilateral segmental and subsegmental mismatches in patients with hilar metastases from non-bronchopulmonary cancer entities should be carefully evaluated.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"25"},"PeriodicalIF":1.7,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39617406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}