European Journal of Hybrid Imaging最新文献

{"title":"Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis.","authors":"Edward Cheung, Sarah Ahmad, Matthew Aitken, Rosanna Chan, Robert M Iwanochko, Meyer Balter, Ur Metser, Patrick Veit-Haibach, Filio Billia, Yasbanoo Moayedi, Heather J Ross, Kate Hanneman","doi":"10.1186/s41824-021-00119-w","DOIUrl":"10.1186/s41824-021-00119-w","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the diagnostic and prognostic significance of combined cardiac ¹⁸F-fluorodeoxyglucose (FDG) PET/MRI with T1/T2 mapping in the evaluation of suspected cardiac sarcoidosis.</p><p><strong>Methods: </strong>Patients with suspected cardiac sarcoidosis were prospectively enrolled for cardiac ¹⁸F-FDG PET/MRI, including late gadolinium enhancement (LGE) and T1/T2 mapping with calculation of extracellular volume (ECV). The final diagnosis of cardiac sarcoidosis was established using modified JMHW guidelines. Major adverse cardiac events (MACE) were assessed as a composite of cardiovascular death, ventricular tachyarrhythmia, bradyarrhythmia, cardiac transplantation or heart failure. Statistical analysis included Cox proportional hazard models.</p><p><strong>Results: </strong>Forty-two patients (53 ± 13 years, 67% male) were evaluated, 13 (31%) with a final diagnosis of cardiac sarcoidosis. Among patients with cardiac sarcoidosis, 100% of patients had at least one abnormality on PET/MRI: FDG uptake in 69%, LGE in 100%, elevated T1 and ECV in 100%, and elevated T2 in 46%. FDG uptake co-localized with LGE in 69% of patients with cardiac sarcoidosis compared to 24% of those without, p = 0.014. Diagnostic specificity for cardiac sarcoidosis was highest for FDG uptake (69%), elevated T2 (79%), and FDG uptake co-localizing with LGE (76%). Diagnostic sensitivity was highest for LGE, elevated T1 and ECV (100%). After median follow-up duration of 634 days, 13 patients experienced MACE. All patients who experienced MACE had LGE, elevated T1 and elevated ECV. FDG uptake (HR 14.7, p = 0.002), elevated T2 (HR 9.0, p = 0.002) and native T1 (HR 1.1 per 10 ms increase, p = 0.044) were significant predictors of MACE even after adjusting for left ventricular ejection fraction and immune suppression treatment. The presence of FDG uptake co-localizing with LGE had the highest diagnostic performance overall (AUC 0.73) and was the best predictor of MACE based on model goodness of fit (HR 14.9, p = 0.001).</p><p><strong>Conclusions: </strong>Combined cardiac FDG-PET/MRI with T1/T2 mapping provides complementary diagnostic information and predicts MACE in patients with suspected cardiac sarcoidosis.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"24"},"PeriodicalIF":1.7,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39729918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial experience in staging primary oesophageal/gastro-oesophageal cancer with 18F-FDG PET/MRI.","authors":"Amy R Sharkey, Bert-Ram Sah, Samuel J Withey, Shaheel Bhuva, Radhouene Neji, Sami Jeljeli, Adrian Green, Gary J R Cook, Vicky Goh","doi":"10.1186/s41824-021-00117-y","DOIUrl":"10.1186/s41824-021-00117-y","url":null,"abstract":"<p><strong>Background: </strong>¹⁸F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) may improve cancer staging by combining sensitive cancer detection with high-contrast resolution and detail. We compared the diagnostic performance of 18F-FDG PET/MRI to ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging oesophageal/gastro-oesophageal cancer. Following ethical approval and informed consent, participants with newly diagnosed primary oesophageal/gastro-oesophageal cancer were enrolled. Exclusions included prior/concurrent malignancy. Following 324 ± 28 MBq 18F-FDG administration and 60-min uptake, PET/CT was performed, immediately followed by integrated PET/MRI from skull base to mid-thigh. PET/CT was interpreted by two dual-accredited nuclear medicine physicians and PET/MRI by a dual-accredited nuclear medicine physician/radiologist and cancer radiologist in consensus. Per-participant staging was compared with the tumour board consensus staging using the McNemar test, with statistical significance at 5%.</p><p><strong>Results: </strong>Out of 26 participants, 22 (20 males; mean ± SD age 68.8 ± 8.7 years) completed 18F-FDG PET/CT and PET/MRI. Compared to the tumour board, the primary tumour was staged concordantly in 55% (12/22) with PET/MRI and 36% (8/22) with PET/CT; the nodal stage was concordant in 45% (10/22) with PET/MRI and 50% (11/22) with PET/CT. There was no statistical difference in PET/CT and PET/MRI staging performance (p > 0.05, for T and N staging). The staging of distant metastases was concordant with the tumour board in 95% (21/22) with both PET/MRI and PET/CT. Of participants with distant metastatic disease, PET/MRI detected additional metastases in 30% (3/10).</p><p><strong>Conclusion: </strong>In this preliminary study, compared to 18F-FDG PET/CT, 18F-FDG PET/MRI showed non-significant higher concordance with T-staging, but no difference with N or M-staging. Additional metastases detected by 18F-FDG PET/MRI may be of additive clinical value.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"23"},"PeriodicalIF":1.7,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39718986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallium-68-somatostatin receptor PET/CT parameters as potential prognosticators for clinical time to progression after peptide receptor radionuclide therapy: a cohort study.","authors":"Sander C Ebbers,&nbsp;Muriël Heimgartner,&nbsp;Maarten W Barentsz,&nbsp;Rachel S van Leeuwaarde,&nbsp;Mark J C van Treijen,&nbsp;Marnix M E G Lam,&nbsp;Arthur J A T Braat","doi":"10.1186/s41824-021-00116-z","DOIUrl":"https://doi.org/10.1186/s41824-021-00116-z","url":null,"abstract":"<p><strong>Background: </strong>Early [⁶⁸Ga]Ga-DOTA-TOC PET/CT imaging after peptide receptor radionuclide therapy (PRRT) in neuroendocrine neoplasm patients is often used as a prognosticator for survival, but lacks validity. This study investigates the prognostic value of changes in PET parameters after PRRT.</p><p><strong>Methods: </strong>Baseline and follow-up [⁶⁸Ga]Ga-DOTA-TOC PET/CT scans of all patients treated with PRRT were delineated automatically. Total lesion somatostatin receptor expression (TL-SSTR) and somatostatin receptor expressing tumor volume (SSTR-TV) were used as covariates in Cox proportional hazard models to predict time-to-new treatment.</p><p><strong>Results: </strong>In twenty patients, median time-to-new treatment was 19.3 months (range [3.8; 36.2]). Absolute and percentual changes in both PET parameters were not associated with time-to-new treatment. A significant relation between independent baseline and follow-up SSTR-TV and follow-up TL-SSTR, and time-to-new treatment was identified.</p><p><strong>Conclusions: </strong>Automatically derived [⁶⁸Ga]Ga-DOTA-TOC PET/CT parameters are easy to acquire and may be of prognostic value after completing PRRT. Acquiring SSTR-TV or TL-SSTR parameters at baseline and during follow-up can be of value in identifying a patient's prognosis.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"22"},"PeriodicalIF":1.7,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39704343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative ¹⁸F-FET PET/CT in brain metastasis recurrence: a teaching case report.","authors":"Samirah Alshehri,&nbsp;John Prior,&nbsp;Mohammed Moshebah,&nbsp;Luis Schiappacasse,&nbsp;Vincent Dunet","doi":"10.1186/s41824-021-00115-0","DOIUrl":"https://doi.org/10.1186/s41824-021-00115-0","url":null,"abstract":"<p><p>Positron emission tomography (PET) using O-(2-[¹⁸F]fluoroethyl)-L-tyrosine (¹⁸F-FET) PET has been shown to be a useful tool for differentiating radiation therapy outcomes, such as brain metastasis recurrence or radiation necrosis. We present the case of a female patient with brain metastases from pulmonary mucinous adenocarcinoma with suspicion of tumor recurrence on follow-up magnetic resonance imaging (MRI) after radiosurgery. ¹⁸F-FET PET/computed tomography (CT) was indicative of radiation necrosis. Due to the patient's medical history and the discrepancy between the brain MRI and PET/CT results, surgical biopsies were decided, which were positive for brain metastasis recurrence. The diagnosis of metastasis recurrence may also be challenging on ¹⁸F-FET PET/CT. In case of discrepancies between MRI and PET/CT results, false-negative ¹⁸F-FET PET/CT remains a possibility and requires careful follow-up or biopsy.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"21"},"PeriodicalIF":1.7,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39645157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study.","authors":"Ana Carolina Trevisan,&nbsp;Leonardo Alexandre-Santos,&nbsp;Rodrigo Luppino Assad,&nbsp;Emerson Nobuyuki Itikawa,&nbsp;Felipe Arriva Pitella,&nbsp;Mery Kato,&nbsp;José Henrique Silvah,&nbsp;Antonio Carlos Santos,&nbsp;Paulo Louzada-Junior,&nbsp;Lauro Wichert-Ana","doi":"10.1186/s41824-021-00112-3","DOIUrl":"https://doi.org/10.1186/s41824-021-00112-3","url":null,"abstract":"<p><p>This study was addressed to evaluate the temporal and spatial changes in regional cerebral blood flow (rCBF) of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Our objective was to correlate the subtracted SPECT coregistered to MRI features (SISCOM) with demographic, clinical and laboratory findings to shed light upon the pathophysiological evolution of the NPSLE. Twenty-six NPSLE patients with MRI and pre- and post-treatment brain SPECT with [99mTc]Tc-ECD. SISCOM features were categorized as improvement, worsening, activation and/or deactivation of rCBF findings. Patients mean age of 43.19 years and 65.38% white were evaluated. The patients mean age at onset of SLE was 26.05 and 42.29 for NPSLE. The mean time between the onset of SLE and first NPSLE symptoms was 05.57 years. The disease has already been initiated as NPSLE in 4 patients. The SLEDAI average score was 31.69 and the SLICC/ACR-DI score was 06.96. The patients underwent an average of 09.23 cyclophosphamide. The SISCOM findings showed functional and pathological states on different brain regions. The rCBF changes were not associated with index scores. There was, however, a trend towards an association between lower SLEDAI scores with improvement and higher SLEDAI with worsening in SISCOM, Also a trend of association between lower SLICC score with improvement, and higher SLICC with worsening. The female gender was predictive of activation and worsening, separately, and deactivation and worsening in a set. Non-white patients were predictive of worsening. The seizure was predictive of deactivation separately, and deactivation and worsening in a set. Finally, normal C3 was a predictor of improvement. The present study showed dynamic brain changes in NPSLE patients. SISCOM technique showed improved rCBF in some brain areas, and worsening, activation and deactivation in others. There were associations between rCBF changes and gender, skin colour and complement C3 and association trends with SLEDAI and SLICC scores.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"19"},"PeriodicalIF":1.7,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39694146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/CT uncovers cranial giant cell arteritis.","authors":"Tamer Anati,&nbsp;Michal Hoffman Ben Shabat","doi":"10.1186/s41824-021-00114-1","DOIUrl":"https://doi.org/10.1186/s41824-021-00114-1","url":null,"abstract":"<p><strong>Background: </strong>Giant cell arteritis (GCA) is an inflammation of large and medium sized vessels, mainly affecting people over 50 years of age. Diagnosis needs to be made quickly to prevent complications. Steroids treatment should be started once diagnosis is made.</p><p><strong>Case presentation: </strong>Here we reported a case of cranial GCA in a 82-year-old man. [18F]FDG PET/CT imaging demonstrated higher FDG uptake in medium sized and cranial vessels. Glucocorticoid treatment was started, followed by a rapid and marked improvement of symptoms and inflammatory markers.</p><p><strong>Conclusions: </strong>This case report supports the role of PET/CT hybrid imaging as a useful noninvasive tool in the evaluation of cranial GCA.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"20"},"PeriodicalIF":1.7,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39538776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma.","authors":"C Van Bogaert,&nbsp;C Mathey,&nbsp;I Vierasu,&nbsp;N Trotta,&nbsp;L Rocq,&nbsp;A Wolfromm,&nbsp;V De Wilde,&nbsp;S Goldman","doi":"10.1186/s41824-021-00113-2","DOIUrl":"https://doi.org/10.1186/s41824-021-00113-2","url":null,"abstract":"<p><p>A 73-year-old man with a history of marginal zone lymphoma was admitted to the emergency room for diplopia and ipsilateral headache. The Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) demonstrated intense and symmetrical hypermetabolism of the cavernous sinuses, and hypermetabolic lesions diffusely in the lymph nodes and bones. The diagnosis of high-grade relapse of lymphomatous disease was made. In this context, the homogenous and symmetric lesion of the cavernous sinuses, without any other encephalic or meningeal lesions, raised the hypothesis of a paraneoplastic origin. A plausible paraneoplastic link between the neuro-ophthalmological lesion and the malignant disorder is IgG4-related disease, a condition that may be associated with lymphoma. As in our case, this diagnosis is often presumptive because histopathological confirmation is difficult to obtain.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"18"},"PeriodicalIF":1.7,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39493292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of 99mTc sulphur colloid lymphoscintigraphy in a rare case of chylothorax and lymphocele formation post esophageal duplication cyst excision.","authors":"Naveen Yadav,&nbsp;Sameer Taywade,&nbsp;Rajesh Kumar,&nbsp;Arun Prashanth,&nbsp;Rahul Saxena","doi":"10.1186/s41824-021-00111-4","DOIUrl":"https://doi.org/10.1186/s41824-021-00111-4","url":null,"abstract":"<p><p>We report a rare case of chylothorax with lymphocele formation post esophageal duplication cyst (EDC) excision in a 2 year old male child. Patient developed chylothorax after excision of EDC. Pleural fluid cytology showed increased triglycerides and cholesterol levels. Filtered Tc-99m Sulphur colloid lymphoscintigraphy showed abnormal radiotracer uptake in the lower thoracic region on right side corresponding to lymphocele on SPECT-CT images with possible site of leak medially. In addition, Tc-99m pertechnetate scan was done to rule out possibility of residual duplication cyst revealed no abnormality. Patient underwent open and en-masse ligation of the duct. Patient recovered completely post-surgery. This case highlights the importance of lymphoscintigraphy with SPECT-CT in the evaluation of patients with post-operative complications of chylothorax with detection of site of chyle leak.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"17"},"PeriodicalIF":1.7,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39435575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of baseline ¹⁸F-FDG PET/CT in soft tissue sarcomas.","authors":"Rafael Hernando Reyes Marlés,&nbsp;José Luis Navarro Fernández,&nbsp;José Pablo Puertas García-Sandoval,&nbsp;Fernando Santonja Medina,&nbsp;Laroussi Mohamed Salem,&nbsp;Laura Frutos Esteban,&nbsp;José Fulgencio Contreras Gutiérrez,&nbsp;María Isabel Castellón Sánchez,&nbsp;Guadalupe Ruiz Merino,&nbsp;María Antonia Claver Valderas","doi":"10.1186/s41824-021-00110-5","DOIUrl":"https://doi.org/10.1186/s41824-021-00110-5","url":null,"abstract":"<p><strong>Background: </strong>The use of ¹⁸F-FDG Positron emission tomography/Computed tomography (PET/CT) in the initial staging of many cancers is clearly established. Most soft tissue sarcoma (STS) has a high affinity for ¹⁸F-FDG, which is why ¹⁸F-FDG PET/CT has been proposed as a non-invasive method, useful in diagnosis and follow-up. The standardized uptake value values (SUV), the volume-based metabolic parameters MTV (metabolic tumor volume), and TLG (total lesion glycolysis) determine tumor viability and provide its total volume and the total activity of metabolically active tumor cells. The histological grade is the most important predictor of metastases and mortality associated with STS, and a significant relationship between the metabolic parameters of ¹⁸F-FDG PET/CT and the histological grade has been described.</p><p><strong>Methods: </strong>A retrospective study was conducted on STS patients, who had histological grade according to the FNCLCC (Fédération Nationale des Centres de Lutte Contre Le Cancer) criteria, as well as a baseline PET/CT. SUV (SUV_max, SUV_mean, and SUV_peak), MTV, and TLG were quantified. A T-student test was performed to establish the relationship between the metabolic biomarkers and the histological grade. Their usefulness as predictors of the histological grade was verified using receiver operator characteristic (ROC) curves. A survival function study was performed using the Kaplan-Meier method. To assess the prognostic utility of the metabolic biomarkers we use the Log-Rank method.</p><p><strong>Results: </strong>The SUV values were useful to discriminate high-grade STS. We found a significant relationship between the histological grade and the SUV values. SUV_max, SUV_peak, MTV, and TLG were predictors of overall survival (OS). There were no significant differences in the OS for the SUV_mean, or in the disease-free survival (DFS) for SUV_max, SUV_mean, SUV_peak, MTV, and TLG.</p><p><strong>Conclusions: </strong>The SUV_max, SUV_mean, and SUV_peak values correlate with the HG and are useful to discriminate high-grade from low-grade STS. Patients with high SUV_max, SUV_peak, MTV, and TLG have a significantly lower OS.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"16"},"PeriodicalIF":1.7,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39379851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined amino acid PET-MRI for identifying recurrence in post-treatment gliomas: together we grow.","authors":"Shumyla Jabeen,&nbsp;Arpana Arbind,&nbsp;Dinesh Kumar,&nbsp;Pardeep Kumar Singh,&nbsp;Jitender Saini,&nbsp;Nishanth Sadashiva,&nbsp;Uday Krishna,&nbsp;Arivazhagan Arimappamagan,&nbsp;Vani Santosh,&nbsp;Chandana Nagaraj","doi":"10.1186/s41824-021-00109-y","DOIUrl":"https://doi.org/10.1186/s41824-021-00109-y","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study is to compare the diagnostic accuracy of amino acid PET, MR perfusion and diffusion as stand-alone modalities and in combination in identifying recurrence in post-treatment gliomas and to qualitatively assess spatial concordance between the three modalities using simultaneous PET-MR acquisition.</p><p><strong>Methods: </strong>A retrospective review of 48 cases of post-treatment gliomas who underwent simultaneous PET-MRI using C11 methionine as radiotracer was performed. MR perfusion and diffusion sequences were acquired during the PET study. The following parameters were obtained: TBR_max, TBR_mean, SUV_max, and SUV_mean from the PET images; rCBV from perfusion; and ADC_mean and ADC_ratio from the diffusion images. The final diagnosis was based on clinical/imaging follow-up and histopathology when available. ROC curve analysis in combination with logistic regression analysis was used to compare the diagnostic performance. Spatial concordance between modalities was graded as 0, 1, and 2 representing discordance, < 50% and > 50% concordance respectively.</p><p><strong>Results: </strong>There were 35 cases of recurrence and 13 cases of post-treatment changes without recurrence. The highest area under curve (AUC) was obtained for TBR_max followed by rCBV and ADC_ratio. The AUC increased significantly with a combination of rCBV and TBR_max. Amino acid PET showed the highest diagnostic accuracy and maximum agreement with the final diagnosis. There was discordance between ADC and PET in 22.9%, between rCBV and PET in 16.7% and between PET and contrast enhancement in 14.6% cases.</p><p><strong>Conclusion: </strong>Amino acid PET had the highest diagnostic accuracy in identifying recurrence in post-treatment gliomas. Combination of PET with MRI further increased the AUC thus improving the diagnostic performance.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"15"},"PeriodicalIF":1.7,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39320749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}