Samirah Alshehri, John Prior, Mohammed Moshebah, Luis Schiappacasse, Vincent Dunet
{"title":"Negative <sup>18</sup>F-FET PET/CT in brain metastasis recurrence: a teaching case report.","authors":"Samirah Alshehri, John Prior, Mohammed Moshebah, Luis Schiappacasse, Vincent Dunet","doi":"10.1186/s41824-021-00115-0","DOIUrl":null,"url":null,"abstract":"<p><p>Positron emission tomography (PET) using O-(2-[<sup>18</sup>F]fluoroethyl)-L-tyrosine (<sup>18</sup>F-FET) PET has been shown to be a useful tool for differentiating radiation therapy outcomes, such as brain metastasis recurrence or radiation necrosis. We present the case of a female patient with brain metastases from pulmonary mucinous adenocarcinoma with suspicion of tumor recurrence on follow-up magnetic resonance imaging (MRI) after radiosurgery. <sup>18</sup>F-FET PET/computed tomography (CT) was indicative of radiation necrosis. Due to the patient's medical history and the discrepancy between the brain MRI and PET/CT results, surgical biopsies were decided, which were positive for brain metastasis recurrence. The diagnosis of metastasis recurrence may also be challenging on <sup>18</sup>F-FET PET/CT. In case of discrepancies between MRI and PET/CT results, false-negative <sup>18</sup>F-FET PET/CT remains a possibility and requires careful follow-up or biopsy.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"5 1","pages":"21"},"PeriodicalIF":1.7000,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606481/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Hybrid Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41824-021-00115-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Positron emission tomography (PET) using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET has been shown to be a useful tool for differentiating radiation therapy outcomes, such as brain metastasis recurrence or radiation necrosis. We present the case of a female patient with brain metastases from pulmonary mucinous adenocarcinoma with suspicion of tumor recurrence on follow-up magnetic resonance imaging (MRI) after radiosurgery. 18F-FET PET/computed tomography (CT) was indicative of radiation necrosis. Due to the patient's medical history and the discrepancy between the brain MRI and PET/CT results, surgical biopsies were decided, which were positive for brain metastasis recurrence. The diagnosis of metastasis recurrence may also be challenging on 18F-FET PET/CT. In case of discrepancies between MRI and PET/CT results, false-negative 18F-FET PET/CT remains a possibility and requires careful follow-up or biopsy.
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