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Listeriosis and the COVID-19 pandemic 李斯特菌病与COVID-19大流行
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-1-102-112
E. Klimova, O. Voronina, G. Karetkina, E.A. Posukhovsky, N. Ryzhova, M. Kunda, E. Aksenova, A. Kutuzova, T. Karpova, I. Tartakovskiy, A.Yu. Pokidysheva, T. Pronina, A. Melkumyan, O. E. Orlova, E. Burmistrova, A.A. Syrochev, S. Smetanina, N. D. Yushchuk
{"title":"Listeriosis and the COVID-19 pandemic","authors":"E. Klimova, O. Voronina, G. Karetkina, E.A. Posukhovsky, N. Ryzhova, M. Kunda, E. Aksenova, A. Kutuzova, T. Karpova, I. Tartakovskiy, A.Yu. Pokidysheva, T. Pronina, A. Melkumyan, O. E. Orlova, E. Burmistrova, A.A. Syrochev, S. Smetanina, N. D. Yushchuk","doi":"10.33029/2305-3496-2022-11-1-102-112","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-1-102-112","url":null,"abstract":"Listeriosis is a saprozoonotic infection that occurs when eating foods contaminated with Listeria. Invasive forms of listeriosis can have extremely severe consequences. Respiratory viral diseases predispose to the occurrence of combined viral-bacterial infections. With a mixed infection of listeriosis and COVID-19, a severe course of the disease is observed, which has a serious prognosis. The aim of the study was to analyze the frequency of various variants of invasive listeriosis and their outcomes in the period before the COVID-19 pandemic and against the background of its development, as well as to determine the genetic diversity of L. monocytogenes isolates. Material and methods. We analyzed 55 cases of invasive listeriosis in patients observed in 2018-2021 in various medical organizations in Moscow. The diagnosis was established on the basis of epidemiological, clinical and laboratory data, listeriosis was confirmed by bacteriological and molecular genetic methods, COVID-19 was confirmed by the detection of SARS-CoV-2 RNA in an oropharyngeal swab using real-time RT-PCR, as well as computed tomography of the lungs. Results. During the current COVID-19 pandemic (2020-2021), the incidence of listeriosis in pregnant women and invasive listeriosis occurring in the form of sepsis and/or lesions of the central nervous system did not differ significantly from similar indicators registered in 2018-2019. Listeria sepsis and/or meningitis/meningoencephalitis in association with severe SARS-CoV-2 novel coronavirus infection are at high risk of death. During the years of the COVID-19 pandemic, the diversity and range of L. monocytogenes genotypes in invasive listeriosis changed, new genotypes appeared that were not previously characteristic of the Russian Federation. Conclusion. The likelihood of developing listeriosis sepsis and/or meningitis/meningoencephalitis against the background of a severe course of COVID-19, and a high risk of an adverse outcome, require increased awareness of medical workers in the field of diagnosis and treatment of invasive listeriosis in order to conduct the earliest and most adequate antibiotic therapy. © 2022 Geotar Media Publishing Group. All Rights Reserved.","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Trace elements: role in the development of severe forms of COVID-19 and the possibility of correction 微量元素:在COVID-19严重形式发展中的作用和纠正的可能性
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-4-91-98
A. O. Romanov, M. M. Sharipova, I. A. Popova, A. Arkhangelskaia, K. Gurevich, N. Shimanovskiy
{"title":"Trace elements: role in the development of severe forms of COVID-19 and the possibility of correction","authors":"A. O. Romanov, M. M. Sharipova, I. A. Popova, A. Arkhangelskaia, K. Gurevich, N. Shimanovskiy","doi":"10.33029/2305-3496-2022-11-4-91-98","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-4-91-98","url":null,"abstract":"The COVID-19 pandemic has set tasks for health professionals, in particular, related to the rapid diagnosis of the disease and the provision of medical care to patients with a new coronavirus infection. All over the world, scientific work is being carried out on the study of the clinical and epidemiological characteristics of the dis-ease, the development of new means of its prevention and treatment. Epidemiological studies have identified a number of physiological and other factors that increase the risk of developing severe forms of the disease. Among them: old age, as well as concomitant diseases, including diabetes mellitus, cardiovascular diseases, chronic kidney disease and others. Changes in the balance of trace elements (ME) are considered as a risk factor for the development of severe forms of COVID-19. It is especially important that this factor can potentially be influenced, especially given the potential for replenishing the ME deficit in patients with COVID-19 for the purpose of early recovery and faster rehabilitation. © 2022 Tomsk Polytechnic University, Publishing House. All rights reserved.","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of regional varicella vaccination programmes 区域水痘疫苗接种规划的有效性
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-3-95-103
N. M. Afonina, I. Mikheeva
{"title":"Effectiveness of regional varicella vaccination programmes","authors":"N. M. Afonina, I. Mikheeva","doi":"10.33029/2305-3496-2022-11-3-95-103","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-3-95-103","url":null,"abstract":"The article presents data on the epidemic process of varicella (chickenpox) in Moscow and the Sverdlovsk region against the background of many years of use of varicella vaccines in the implementation of regional programs for children's immunization against varicella. An estimate of the volume of varicella vaccination in these regions is given. Aim. Evaluation of the effectiveness of varicella vaccination within the framework of regional vaccination schedules in Moscow and the Sverdlovsk region for the scientific substantiation of recommendations for expanding the National Immunization Schedule of the Russian Federation. Material and methods. To assess the epidemic situation in terms of the incidence of varicella in 2006–2021, data from forms No. 2 of the Federal State Statistical Observation \"Information on infectious and parasitic diseases” and forms No. 23-17 \"Information on outbreaks of infectious diseases” in Moscow in 2017–2021 were used. To assess the volume of vaccination against chickenpox, we took into account the data of form No. 5 of the Federal State Statistical Observation \"Information on preventive vaccinations” in the Russian Federation and certain territories in 2013–2021. We have carried out a retrospective epidemiological analysis of the distribution of the incidence of chickenpox in general on the territory of the Russian Federation, Moscow and the Sverdlovsk region. Results and discussion. In the regions of the Russia where the planned varicella vaccination of children is carried out with low coverage and the use of a single-dose immunization scheme, after the success of regional programs in the first years of their implementation, the \"growing up” of infection, an increase in the incidence of varicella of children of the first year of life, and an increase in the probability of congenital forms were revealed. Against the background of a decrease in the incidence of varicella in 2020–2021, as a result of restrictive measures in organized groups, as part of the response to the COVID-19 epidemic, susceptible individuals accumulate, which allows predicting another epidemic increase in incidence. Conclusion. Based on regional experience, it is recommended to introduce 2 doses of varicella vaccination into the National Vaccination Schedule with at least 90% coverage. © Eco-Vector, 2022.","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical and laboratory manifestations and pathological anatomical picture of a severe course of a new coronavirus infection COVID-19 with a fatal outcome 新型冠状病毒感染COVID-19致死性重症病程的临床、实验室表现及病理解剖图
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-4-30-37
R. Abdullaev, O. Komissarova, M. Rybka, E.M. Greсov, L. A. Semenova, Y. Berezovsky
{"title":"Clinical and laboratory manifestations and pathological anatomical picture of a severe course of a new coronavirus infection COVID-19 with a fatal outcome","authors":"R. Abdullaev, O. Komissarova, M. Rybka, E.M. Greсov, L. A. Semenova, Y. Berezovsky","doi":"10.33029/2305-3496-2022-11-4-30-37","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-4-30-37","url":null,"abstract":"Aim - to study the clinical and laboratory manifestations of a severe course of COVID-19 in a lethal outcome with an assessment of the pathomorphological picture based on autopsy material. Material and methods. A retrospective analysis of demographic, clinical and laboratory parameters, as well as the results of a pathoanatomical study of 54 patients with severe COVID-19 who died in the intensive care unit, was carried out. Results. Among the patients included in the study, women and men were equally divided. The mean age was 73.1+/-1.86 years (median 73 years). An increase in body temperature above 38 degreeS was observed in 81.5% of cases, weakness - in 70.4%, dry cough - in 46.3%, a feeling of lack of air - in 46.3%, muscle pain - in 40.7%. The volume of lung damage by the type of bilateral polysegmental pneumonia with areas of compaction of the type of \"frosted glasses\" and consolidation was more than 75.0% and was determined in 68.5% of patients. Concomitant diseases were detected in 94.4% of patients. It was found that all patients had a pronounced systemic inflammatory response, as evidenced by an increase in the level of C-reactive protein and procalcitonin in all patients. A decrease in albumin levels was observed in 88.9% of cases. A hypercoagulable shift with intravascular coagulation was noted. Morphological studies revealed damage to the lungs, liver, kidneys and pancreas with the development of thrombovascular changes. Conclusion. A severe course of COVID-19 with a fatal outcome was observed in older patients with clinical, radiological and laboratory manifestations of a systemic inflammatory response, which was accompanied by damage to various organs and systems.Copyright © Authors, 2022.","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of neutralizing monoclonal antibodies against SARS-CoV-2 in hemodialysis patients 抗SARS-CoV-2中和性单克隆抗体在血液透析患者中的应用
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-4-38-46
E. Volodina, N. Frolova, M. Lysenko, I.G. Kim, A. Ushakova, V. Vinogradov, S. S. Usatiuk, A. Nikitina, U. Markina, V. I. Chervinko, E. Kryukov, M. Zubkin
{"title":"The use of neutralizing monoclonal antibodies against SARS-CoV-2 in hemodialysis patients","authors":"E. Volodina, N. Frolova, M. Lysenko, I.G. Kim, A. Ushakova, V. Vinogradov, S. S. Usatiuk, A. Nikitina, U. Markina, V. I. Chervinko, E. Kryukov, M. Zubkin","doi":"10.33029/2305-3496-2022-11-4-38-46","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-4-38-46","url":null,"abstract":"Patients with end-stage kidney disease undergoing hemodialysis have one of the highest COVID-19 mortality rates. The use of innovative methods capable of optimizing their treatment outcomes is important for clinical practice. Aims – to investigate the efficacy and safety of neutralizing monoclonal antibodies in COVID-19 patients treated with hemodialysis. Material and methods. We conducted a retrospective controlled single-center study with 102 COVID-19 patients on maintenance hemodialysis involved (M: 67;65.7%;W: 35;34.3%), aged 57.2±15.3 years. PCR-detected SARS-CoV-2 infection was diagnosed in all patients. Neutralizing monoclonal antibodies were administered to 69 patients, who formed the study group (group 1). The control group included 33 patients (group 2). The combination of bamlanevimab and etesevimab was the most frequent therapy used (in 59 patients). Results. In the course of the disease, group 1 patients, compared to those of group 2, had statistically significantly higher blood oxygen saturation values (94.2±5.7 vs 89.8±10.7);they required less frequent oxygen support (29.0 vs 54.5%) and ICU treatment (18.8 vs 48.5%), respectively. Fatal outcomes occurred in 4 (5.8%) of 69 patients who received neutralizing antibodies and in 6 (18.2%) of 33 patients who did not receive the therapy, p<0.05. Except for one patient, all other patients in both groups developed an unfavorable outcome due to progressive lung damage. However, only 4 of 6 (2/3) patients with progressive lung damage died in group 1, whereas the similar course of the disease proved fatal in all cases in group 2. Conclusion. The use of neutralizing monoclonal antibodies in hemodialysis patients is safe and effective when the drugs are administered early, the pulmonary process progression is insignificant and dominant SARSCoV-2 variants are sensitive to them. © 2022 Tomsk Polytechnic University, Publishing House. All rights reserved.","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical case of co-infection: COVID19 and invasive meningococcal infection 新冠肺炎合并侵袭性脑膜炎球菌感染临床1例
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-3-151-155
O. Samodova, E. Krieger, N. Rogushina
{"title":"Clinical case of co-infection: COVID19 and invasive meningococcal infection","authors":"O. Samodova, E. Krieger, N. Rogushina","doi":"10.33029/2305-3496-2022-11-3-151-155","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-3-151-155","url":null,"abstract":"In light of the current pandemic, doctors need to raise the suspicion of concurrent SARS-CoV-2 infection with Neisseria meningitides infection. In this article we reported a case of invasive meningococcal infection in an adolescent with COVID-19. Severity of the disease depended on septic shock due to invasive meningococcal infection associated with sepsis and meningitis. The differential diagnosis with a multisystem inflammatory syndrome was tricky considering the fever, shock, meningeal symptoms, elevated levels of C-reactive protein and D-dimer, patient age, and a positive test for SARS-CoV-2. The disease outcome was good. Given the risk of invasive forms of meningococcal infection, the possible synergy of SARS-CoV-2 and Neisseria meningitidis, the complexity of differential diagnosis in patients in critical condition, immunization against meningococcal infection should be carried out according to epidemic indications, despite the COVID-19 pandemic. © 2022 Sorbtsionnye i Khromatograficheskie Protsessy. All rights reserved.","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of the diagnosis and course of COVID-19 in HIV-infected patients hospitalized in a hospital 某医院hiv感染者COVID-19诊断及病程特点
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-3-44-51
A. S. Sycheva, M. Nagibina, K.A. Uryanskaya, A. Solodov, A. L. Kebinа, I. Semeniakin, O. Levchenko, O. Yanushevich
{"title":"Features of the diagnosis and course of COVID-19 in HIV-infected patients hospitalized in a hospital","authors":"A. S. Sycheva, M. Nagibina, K.A. Uryanskaya, A. Solodov, A. L. Kebinа, I. Semeniakin, O. Levchenko, O. Yanushevich","doi":"10.33029/2305-3496-2022-11-3-44-51","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-3-44-51","url":null,"abstract":"The global pandemic of coronavirus infection (COVID-19) has set complex diagnostic tasks for doctors of polyclinics and hospitals. Considering the simultaneous pandemic spread of two infectious diseases – COVID-19 and HIV infection, the problem of studying the clinical features of combined COVID-19/HIV infection becomes urgent. The aim of the study was to determine the features of the diagnosis and course of COVID-19 against the background of HIV infection in patients undergoing inpatient treatment. Material and methods. The study was conducted on the basis of the temporary Clinical Medical Center COVID-19 of the A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation in Moscow from October 2020 to January 2022. The study included 31 233 patients with COVID-19 complicated by pneumonia. To analyze the features of the course of combined COVID-19/HIV infection, a group of 51 HIV-infected patients was identified. The diagnosis of COVID-19 was determined based on the detection of SARS-CoV-2 RNA by PCR in nasal/oropharyngeal smears and/or according to computed tomography of the lungs (CT). During the study, age, gender, anamnesis, objective examination data were analyzed, taking into account the results of CT scans of the chest organs, data from routine laboratory blood tests, oxygen support regimens, treatment outcomes and duration of detection of SARS-CoV-2 RNA. All patients were treated according to the Temporary Clinical Guidelines for the Diagnosis and Treatment of COVID-19, 14 version dated 12/27/2021. Results. The number of patients with combined HIV infection and SARS-CoV-2 out of the total number of hospitalized COVID-19 patients (n=31 233) was 0.16%. Upon admission, 30 (59%) patients reported having HIV infection and receiving antiretroviral therapy (ART). HIV infection was first diagnosed in 21 patients at 2–3 weeks of inpatient treatment. The average age of patients with SARS-Cov-2/HIV co-infection was 1.5 times less than in patients without HIV (41.1±5.3 and 64.4±10.1, respectively) (p≤0.05). Concomitant pathology (hypertension, type 2 diabetes mellitus, chronic kidney disease and chronic lung diseases) was less common (51%) in the group of combined infection than in the group without HIV (83%). However, in 41% of patients with coinfection, chronic viral hepatitis B, C was detected, in contrast to 0.3% of cases of COVID-19 patients without HIV. 26 (51%) patients were discharged with improvement, while the average bed-day did not differ from patients without HIV infection (13.4±4.5 days and 11.7±5.2, respectively) (p≥0.05). 7 (24%) patients at the time of discharge (16.8±4.2 days) with clinical and laboratory improvement maintained a positive result of PCR RNA on SARS-Cov-2. In 22 (43%) patients with coinfection, hospitalization was fatal for 3 to 21 days of treatment, with ARDS with respiratory and multiple organ failure, which is 3.6 times higher than in patients without HI","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of olfactory impairment in COVID-19: a systematic review COVID-19嗅觉损伤机制的系统综述
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-2-8-13
A. Medeulova, K. Zhapar, D. Kussainova
{"title":"Mechanisms of olfactory impairment in COVID-19: a systematic review","authors":"A. Medeulova, K. Zhapar, D. Kussainova","doi":"10.33029/2305-3496-2022-11-2-8-13","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-2-8-13","url":null,"abstract":"One of the symptoms of a new coronavirus infection (COVID-19) is a complete or partial violation of the sense of smell. The aim of the work is to analyze the published results of scientific research on the mechanisms of olfactory impairment in COVID-19. Material and methods. Research was conducted for publications in Pubmed on the problem of olfactory impairment in COVID-19 using terms indexed by MeSH. The systematic review was compiled in accordance with the checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA). Results. Publication’s analysis has shown that the existing ideas about conductive anosmia are insufficient to explain the causes of olfactory impairment caused by SARS-CoV-2. It has been established that ACE2 and TMPRSS2 receptors located on the surface of target cells are necessary for the penetration of a new coronavirus. It is known that these receptors are mainly located on the cells of the olfactory epithelium. The main hypothesis of olfactory impairment in COVID-19 is that anosmia/hyposmia is caused by damage not to neuronal cells (as previously assumed), but to the olfactory epithelium. There is no confirmation of the point of view about the damage of SARS-CoV-2 olfactory bulbs and olfactory neurons, since they do not express receptor proteins for the virus on their surface. © 2022 by the authors.","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of screening examination of employees of a medical hospital for antibodies to SARS-CoV-2 某医院职工SARS-CoV-2抗体筛查检查结果
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-1-28-33
R. F. Sayfullin, S. K. Pylaeva, D. O. Sinyavkin
{"title":"Results of screening examination of employees of a medical hospital for antibodies to SARS-CoV-2","authors":"R. F. Sayfullin, S. K. Pylaeva, D. O. Sinyavkin","doi":"10.33029/2305-3496-2022-11-1-28-33","DOIUrl":"https://doi.org/10.33029/2305-3496-2022-11-1-28-33","url":null,"abstract":"While providing medical care to patients with a new coronavirus infection, medical workers are at risk of developing COVID-19 significantly more often than the general population. In addition to morbidity risks, an important question is the duration of the immune response to COVID-19. The aim of our study is to assess the incidence of COVID-19 and the duration of the persistence of anti-SARS-CoV-2 antibodies among hospital medical staff. Material and methods. We conducted a retrospective non-randomized single-center study, based on the analysis of the laboratory database of the Municipal Clinical Hospital No. 52 (Moscow). The results of the 2160 employees were included into analysis. The inclusion criteria were as follows: at least one result of antibody determination to SARS-CoV-2 in period from June 2020 to January 2021;the date of the last antibody determination to SARS-CoV-2 no earlier than November 1, 2020. Additionally, a group of 100 employees were selected for further investigation of the persistence of immunoglobulin G (IgG) antibodies to SARS-CoV-2. Additionally, a group of 100 employees was selected, who had a confirmed fact of seroconversion for IgG and the presence of at least three results of IgG to SARS-CoV-2 determination with an interval of at least 4 weeks. Results. According to IgG determination results, by January 2021, 66.6% of all hospital employees have already been ill with COVID-19. The medical staff who worked with patients with COVID-19 been ill with COVID-19 in 78.2% of cases. The share of sick medical personnel who did not work with this group of patients was 55.3%. The first termination of antibodies persistence to SARS-CoV-2 from employees was marked from 3-4 months of observation. After 7-9 months, 23% of the observed group became seronegative. Odds ratio for the risk of COVID-19 for medical staff, who worked with COVID-19 patients was 2.89 (95% CI 2.34-3.56) to other medical staff and 3.6 (95% CI 2.82-4.59) to non-medical staff. Conclusion. The incidence of COVID-19 and the risk of infection among medical workers is significantly higher than among the general population, which dictates the need of further improvement of COVID-19 prevention measures among medical workers. © 2022 by the authors.","PeriodicalId":36113,"journal":{"name":"Infectious Diseases: News, Opinions, Training","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69484369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Diversity of circulating rotavirus strains before and after the introduction of rotavirus vaccine 引入轮状病毒疫苗前后循环轮状病毒株的多样性
Infectious Diseases: News, Opinions, Training Pub Date : 2022-01-01 DOI: 10.33029/2305-3496-2022-11-4-77-81
A. Nazurdinov, F. Tishkova, R. Tursunov
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