Clinical and Experimental Morphology最新文献

{"title":"Myocardial lesions in patients with COVID-19. Autopsy case series","authors":"Yu. A. Yermola, A. A. Galyshevskaya, A. Davydova, A. Beketov, T. Makalish, M. Kriventsov","doi":"10.31088/cem2022.11.4.59-69","DOIUrl":"https://doi.org/10.31088/cem2022.11.4.59-69","url":null,"abstract":"Introduction. Morphological data on SARS-CoV-2-associated heart damage and its mechanisms are rather limited. However, clinical and morphological features of myocardial lesions in COVID-19 patients have been described and include myocardial ischemia, acute coronary syndrome, and acute myocarditis. The prevailing features of myocardial lesions and their consequences are still controversial. The aim of our research was to evaluate the morphological features of myocardial lesions in patients with severe COVID-19, using routine histological examination and immunohistochemistry (CD45) to confirm myocardial inflam-matory infiltration. Materials and methods. We analyzed samples of the left ventricular myocardium obtained during autopsy examination of 48 patients with severe COVID-19 who died from SARS-CoV-2-associated pneumonia. We used histological description and immunohistochemical methods. Results. The results revealed several histopathological features of COVID-19-associated myocardial lesions, including acute ischemia (25% of cases) and mild inflammatory changes termed borderline myocarditis (18.75% of cases). Other significant findings in the myocardium included microcirculatory vessel thrombosis. Conclusion. The study confirms the existing data on damage to myocardium in severe COVID-19. However, further studies are warranted. It may contribute to the development of new management strategies for severe COVID-19 patients. Keywords: SARS-CoV-2, heart, ischemia, myocarditis","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69280731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung changes in a patient with combination of HIv infection and COvID-19","authors":"Y. Parkhomenko, A. Chernyaev, P. Vedyapin, N. Mozgaleva, Zh.R. Omarova, O. A. Tishkevich, E. A. Gomzikova, M. Samsonova, A. Zhilenkova, Y. Lebedin","doi":"10.31088/CEM2022.11.2.71-77","DOIUrl":"https://doi.org/10.31088/CEM2022.11.2.71-77","url":null,"abstract":"The COVID-19 pandemic is now a global medical and social problem. Little is known about COVID-19 impact on some vulnerable subgroups, such as immunocompromised patients. Therefore, scientists worldwide show interest in studying the impact of SARS-CoV-2 infection on HIV-positive individuals. We report an autopsy clinical case of a deceased 60-year-old HIV-infected patient with lung damage caused by a combination of the SARS-CoV-2 virus, human herpesvirus 6, cytomegalovirus, and pneumocystis with severe fatal respiratory failure. Keywords: COVID-19, HIV, SARS-CoV-2, herpes virus, cytomegalovirus, pneumocystis, pathological anatomy","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69280789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence of glomerulopathies in kidney neoplasms in Krasnoyarsk","authors":"T. Garkusha, E.A. Bykhanova, V. Khorzhevskii, S. V. Gappoev, M. A. Firsov, S. V. Ivliev","doi":"10.31088/cem2022.11.3.15-21","DOIUrl":"https://doi.org/10.31088/cem2022.11.3.15-21","url":null,"abstract":"Introduction. Renal malignancies accounted for 3.9% of all malignant neoplasms in Russia in 2019 and were among the top ten most common. Paraneoplastic syndrome can occur in malignant neoplasms and manifest as paraneoplastic nephropathies and glomerulopathies. The aim of the study was to analyze archival renal specimens to assess the incidence of glomerulopathies in renal neoplasms. Materials and methods. We analyzed 122 kidney samples with a tumor after nephrectomy in Krasnoyarsk regional clinical oncologic hospital named after A.I. Kryzhanovsky. To assess the cellular composition of the glomeruli and basement membrane structure, the following histochemical stains were used: PAS reaction, Masson’s trichrome stain, methenamine silver, and congo red stain. Results. The age of the patients ranged from 28 to 84 years. Malignant neoplasms were diagnosed in 114 cases (93.4%), whereas benign neoplasms were detected in 8 patients (6.6%). Fifty-six cases (45.9%) showed glomerulopathies. In 55 cases, glomerulopathies were found in malignant neoplasms (98.2%) and one case was found in a patient with a benign neoplasm (1.8%). Diabetic nephropathy was detected in 43 cases, ac-counting for 76.8%. Glomerulonephritis was diagnosed in 7 patients (12.5%) and focal segmental glomerulosclerosis was revealed in 6 cases (10.7%). Conclusion. Glomerulopathies in renal tumors are rather common and therefore their diagnosis is important in the study of the operative material. Keywords: kidney, tumour, glomerulopathies, paraneoplastic syndrome, diabetic nephropathy, glomerulonephritis","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69280824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration approach to study placental vessels in preeclampsia","authors":"O. Voronova, A. Milovanov, L. Mikhaleva","doi":"10.31088/cem2022.11.3.30-44","DOIUrl":"https://doi.org/10.31088/cem2022.11.3.30-44","url":null,"abstract":"Introduction. Preeclampsia is key in obstetric pathology, which is one of the causes of maternal and perinatal morbidity and mortality. It is due to the difficulties of diagnosis, variable clinical picture, severity, and high risk of an unfavorable outcome. This problem requires special attention not only from obstetricians and gynecologists, but also from pathologists who make intravital morphological diagnosis ofplacenta in women with preeclampsia. The purpose of the study was to perform amorphological, morphometric, and immunohistochemical analysis of obliterative angiopathy in the vessels of placental stem villi with preeclampsia of varying severity. Materials and methods.We studied 60 placentas, 40 of which were from women having preeclampsia of varying severity, as well as 20 healthy placentas (the comparison group). For morphometric studies, an automated histological analysis system Leica Application Suite hardware and software module based on a Leica DM4000B microscope was used. The immunohistochemical study was carried out with markers CD34, VEGF-A, and endothelial NOS. Results. We established a directly proportional relationship between the degree of preeclampsia and the severity of arteriole lumen obliteration of the stem villi, and accordingly the degree of placental insufficiency. The most pronounced disorders of fetoplacental circulation were observed in combined severe preeclampsia and extragenital pathology. Conclusion. The data obtained allow us to confirm the significance of obliterative angiopathy in preeclamptic placentas as an integral component. Prevention of ischemic changes in the placenta, where obliterative angiopathy of the villus vessels plays a leading role, is an urgent medical problem that requires an objective approach to predict the condition of the newborn. Keywords: preeclampsia, placenta, obliterative angiopathy, morphometric, immunohistochemical study","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69280881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osseointegration properties of titanium implants with different pore diameters: experimental study","authors":"N. Orlinskaya, S. A. Gerasimov, D. Aleynik, D. Zakharova, K. Kulakova, I. Charykova, E. Morozova","doi":"10.31088/cem2023.12.2.69-76","DOIUrl":"https://doi.org/10.31088/cem2023.12.2.69-76","url":null,"abstract":"Introduction. Additive technologies make it possible to create implants to replace bone defects. Determining the optimal parameters of a porous structure remains an urgent issue. The experimental research aimed to study the biocompatibility of implants made of titanium alloy with different pore diameters. Materials and methods. The study was carried out in two stages. The first stage included an in vitro study carried out on test cultures of diploid human fibroblasts to assess the cytotoxicity of the titanium alloy, from which samples were made for the second stage in vivo. The in vivo study was performed on three groups of rabbits (n=18), which received samples of the developed implants. The average age of subjects was 7±1 months, the weight being 4.675±258 g. All samples were 4 mm in diameter and 6 mm high. In group 1, the pore size was 100 μm; in group 2 – 200 μm; and in group 3 – 400 μm; the porosity was 55%, 62%, and 70%, respectively. The animals were sacrificed on day 90 after placement of the samples. Histological, morphological, and electron microscopic studies were performed to assess the osseointegrative properties of the implants. Results. In the in vitro study, we detected no toxic effects of the material on the test culture. In the in vivo study, the histological analysis did not reveal inflammation in peri-implant tissues in any of the groups. The morphological study showed a newly formed tissue in the area of the formed defect which consisted of young bone trabeculae with osteoblasts located on their surface. In group 3, we found the greatest prevalence of mature bone trabeculae. The samples with a 400-μm pore diameter revealed the largest area of filling the implant with newly formed bone tissue. Conclusion. Samples with a pore diameter of 400 μm have the highest osteointegrative properties. Keywords: osteointegration, biocompatibility, titanium implants, additive technologies, 3D-printing","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69281400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of morphological changes in the kidney and ureter of a rabbit with various methods of infection","authors":"M. Tusupbekova, Y. Sharapatov, E. Pronkin, A. Lavrinenko, Y. Turgunov","doi":"10.31088/cem2022.11.1.62-72","DOIUrl":"https://doi.org/10.31088/cem2022.11.1.62-72","url":null,"abstract":"Introduction. There are two main routes of urinary tract infection: ascending and hematogenous. In the ascending route, the infectious agent penetrates from the external environment through the external openings of the urinary organs. The role of bacterial translocation in the development of the inflammatory process in the urinary organs is still poorly understood. Materials and methods. We conducted an experiment on rabbits (n=45) and studied the structural changes in the kidneys and ureter depending on the pathogenesis of acute pyelonephritis. The animals were randomly divided into 5 groups: 2 experimental and 3 control. In experimental groups I and II , we modeled obstructive pyelonephritis by ligation of the ureter. In control groups III and IV, an infectious agent was administered similarly to that in the experimental groups, but without creating a model of obstructive pyelonephritis. In control group V, a laparotomy was performed without ligation of the ureter and without injection of bacteria. The morphological study was carried out with optical microscopy. Results. In group I, on day 3, the inflammatory infiltration was detected in 80% of cases and on day 5, in 100%. In group II , on days 3 and 5, the inflammatory process in the ureteral tissue developed in all cases. There were no morphological changes in the kidneys and ureter in groups III and V. In group IV, on days 3 and 5, the frequency of inflammatory infiltration was 80%. Conclusion. The nature of morphological changes in the kidneys and ureter in acute pyelonephritis depends on both the ways of infection and the timing of ureteral obstruction. In enterorenal translocation, the severity of morphological changes occurs later. Keywords: urinary tract obstruction, acute pyelonephritis, intestinal translocation, ascending infection","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69279866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intercellular junctions, proliferation, and apoptosis of the gingival epithelium in patients with periodontitis after laser therapy","authors":"E. Speranskaya, E. V. Moskvichev, O. Kostrova, E. Luzikova, L. M. Merkulova, G. Struchko","doi":"10.31088/cem2022.11.3.22-29","DOIUrl":"https://doi.org/10.31088/cem2022.11.3.22-29","url":null,"abstract":"Introduction. E-cadherin participates in the formation of intercellular junctions and protects the epitheliocytes of the gums from apoptosis and regulates proliferation in them. The effect of a diode laser on intercellular contacts, proliferation, and apoptosis of gum epitheliocytes at various ages remains poorly studied. The purpose of the paper was to conduct a comparative analysis of the proliferative and apoptotic activity of human gingival epitheliocytes and their intercellular interaction in chronic inflammation, as well as in age-related diode laser therapy. Materials and methods.The study included patients with and without periodontal inflammation (30 patients in each group). The subjects were divided into 2 age groups: group I included patients aged 20–40 years, whereas group II – 41–60 years. Each age group was divided into subgroups: the control subgroup (patients without gingival inflammation); subgroup with periodontal inflammation (patients with chronic periodontitis); and subgroup after laser therapy (patients after therapy with 940-nm Prometey diode laser). We performed immunohistochemical studies using monoclonal antibodies to Ki-67, p53, E-cadherin; as well as computer morphometry and statistical data analysis. Results. Periodontitis combines a decrease in the number of both proliferating epitheliocytes and E-cadherin-positive intercellular contacts in the basal and spiny layers of the gum epithelium in both young and mature adults (p=0.00002). Exposure of a diode laser has a positive effect on the proliferative activity of epithelial cells and significantly increases the number of E-cadherin-positive intercellular contacts in the basal layer (p=0.00002), but does not affect the expression of p53 (p=0.9) in the gum epithelium in all age groups. Conclusion. Exposure of a diode laser increases the proliferation/apoptosis index in the gingival epithelium and brings the expression of E-cadherin closer to the control values. Keywords: gingival epithelium, chronic periodontitis, diode laser, Ki-67, p53, E-cadherin","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69280872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoration of the microvasculature and hemodynamics in the oral mucosa wound defects area with and without a piezoelectric polymer membrane","authors":"A. Koniaeva, E. Varakuta, A. Leiman, E. Bolbasov, K. Stankevich","doi":"10.31088/cem2022.11.3.56-66","DOIUrl":"https://doi.org/10.31088/cem2022.11.3.56-66","url":null,"abstract":"Introduction. Restoration of blood supply to tissues is crucial for the regeneration of wound defects. The purpose of this research was to study the effect of piezoelectric polymers on the restoration of microcirculation and hemodynamics in the area of oral mucosa wound defects. Materials and methods. The study was carried out on 60 Wistar rats divided into four groups (15 rats each): control (intact) and 3 experimental groups. In group 1, the animals had an open wound defect. In groups 3 and 2, the rats had a wound defect covered with a membrane with and without copper modification, respectively. The specimens for subsequent light and electron microscopy were collected on days 3, 7, and 12. We studied qualitative and quantitative indicators of microcirculation and hemodynamics restoration. Results. Day 3: in all experimental groups, the arteriolo-venular relationship and the pericapillary diffusion index significantly decreased, while the Kernogan index increased. We also observed a significant increase in VEGF expression. Day 7: in experimental group 3, the values of the Kernogan index and the arteriolo-venular relationship were restored, and the pericapillary diffusion index remained significantly higher than in the control group. In the groups 1 and 2, none of the indicators reached the control values. VEGF expression decreased in all groups. On day 12 in group 1, the arteriolo-venular relationship, the Kernogan index and the index of pericapillary diffusion differed from the control group, in contrast to groups 2 and 3, where all the studied parameters were restored. Expression of VEGF in group 1 was significantly less than the control values, and in groups 2 and 3 it was significantly higher. Conclusion. We revealed that closing of oral mucosa wound defects by a piezoelectric polymer membrane led to the restoration of hemodynamic parameters and promoted active vascular formation. Keywords: wound defect, oral cavity, inflammation, regeneration, microcirculation, neoangiogenesis","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69280957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokeratin expression in reactive cylindrical ciliated epithelium of the sinonasal tract in chronic inflammation","authors":"A. A. Bakhtin, E. Tumanova","doi":"10.31088/cem2023.12.2.14-24","DOIUrl":"https://doi.org/10.31088/cem2023.12.2.14-24","url":null,"abstract":"Introduction. Currently, there are limited papers on changes in the pseudostratified ciliated columnar epithelium of the sinonasal tract in chronic inflammatory processes, particularly in basal cell hyperplasia. The latter is similar to dysplasia of varying severity of the stratified squamous nonkeratinized epithelium. Studying of changes in the pseudostratified ciliated columnar epithelium can clarify the histogenesis of various epithelial tumors of the sinonasal tract, including sinonasal papillomas. The research is aimed at studying the cytokeratin profile of reactive cylindrical ciliated epithelium in a chronic nonspecific inflammatory process. Materials and methods. We analyzed surgical materials obtained from 567 patients diagnosed with chronic rhinosinusitis with nasal polyps. We performed an immunohistochemical study in 20 cases using the panel of antibodies to Ki-67, Stathmin, Cytokeratin 7, Cytokeratin 10/13, Cytokeratin 14, Cytokeratin 17, Cytokeratin 18, and Cytokeratin 19. Results. Using hematoxylin and eosin staining, we detected basal cell hyperplasia of different severity in 74% (419 cases). In 13% (73 cases), basal cell hyperplasia was combined with foci of squamous metaplasia. Based on the results, we identified 4 types of morphological changes in the epithelial layer with a specific cytokeratin profile: mild basal cell hyperplasia, moderate basal cell hyperplasia, severe basal cell hyperplasia, and areas of squamous metaplasia. Conclusion. Simultaneous expression of cytokeratins in the areas with severe hyperplasia of basal cells, specific for both simple and compound epithelia, allows us to consider this area to have the highest potential for the development of various epithelial tumors of the sinonasal tract, including various types of sinonasal papillomas. Keywords: basal cell hyperplasia, sinonasal papilloma, pseudostratified columnar ciliated epithelium","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69281204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABC transporters in the development of platinum drug resistance in serous ovarian carcinoma","authors":"E. Ulianova, E. Nepomnyashchaya, G. Zhukova, A. B. Sagakyants, D. Yakubova, O. G. Shulgina","doi":"10.31088/cem2022.11.2.13-21","DOIUrl":"https://doi.org/10.31088/cem2022.11.2.13-21","url":null,"abstract":"Introduction. Serous ovarian carcinoma is a group of extremely aggressive malignant tumors with high mortality rates; today, it remains the most prognostically unfavorable gynecologic cancer in the world. One of the causes is the development of multidrug resistance after administration of various chemotherapy regimens. Therefore, the search for effective markers of resistance to chemotherapy in this disease is promising. The purpose of this study was to analyze expressions of ABC transporters Pgp (ABCB1) and BCRP (ABCG2) in cells of high-grade serous ovarian carcinomas in patients with varying sensitivity to platinum-based polychemotherapy. Materials and methods. Tumor tissues of 100 patients aged 29–79 years with high-grade serous ovarian carcinomas and stages IIIC–IV were studied with immunohistochemical method with rabbit P-glycoprotein 1 (Pgp or MDR1) polyclonal antibodies and by the Reveal Polyvalent HRP-DAB Detection System with mouse monoclonal BCRP antibodies (JF0994 clone). We used the Statistica 13.0 program (StatSoftInc., USA) to analyze the results. We determined the Mann–Whitney U and Pearson’s χ² values, as well as odds ratios with CI. Results. In groups with platinum resistance and platinum sensitivity, there prevailed patients with Pgp+ (98% and 68%) and BCRP+ (90% and 81.4%). Mann–Whitney U-test showed that in cancer cells in platinum-resistant patients, the expression of Pgp and BCRP (70;40–100 and 65;45–90) was 1.8 (p=0.003) and 1.9 times (p=0.013) higher, respectively, than in platinum-sensitive patients (40;4–65 and 35;10–60). Conclusion. The results on the Pgp marker show that it can be used as a predictive factor in high-grade serous ovarian carcinomas. Keywords: serous ovarian carcinoma, multidrug resistance, ABC transporters, Pgp, BCRP","PeriodicalId":36062,"journal":{"name":"Clinical and Experimental Morphology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69280246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}