The incidence of glomerulopathies in kidney neoplasms in Krasnoyarsk

Abstract

Introduction. Renal malignancies accounted for 3.9% of all malignant neoplasms in Russia in 2019 and were among the top ten most common. Paraneoplastic syndrome can occur in malignant neoplasms and manifest as paraneoplastic nephropathies and glomerulopathies. The aim of the study was to analyze archival renal specimens to assess the incidence of glomerulopathies in renal neoplasms. Materials and methods. We analyzed 122 kidney samples with a tumor after nephrectomy in Krasnoyarsk regional clinical oncologic hospital named after A.I. Kryzhanovsky. To assess the cellular composition of the glomeruli and basement membrane structure, the following histochemical stains were used: PAS reaction, Masson’s trichrome stain, methenamine silver, and congo red stain. Results. The age of the patients ranged from 28 to 84 years. Malignant neoplasms were diagnosed in 114 cases (93.4%), whereas benign neoplasms were detected in 8 patients (6.6%). Fifty-six cases (45.9%) showed glomerulopathies. In 55 cases, glomerulopathies were found in malignant neoplasms (98.2%) and one case was found in a patient with a benign neoplasm (1.8%). Diabetic nephropathy was detected in 43 cases, ac-counting for 76.8%. Glomerulonephritis was diagnosed in 7 patients (12.5%) and focal segmental glomerulosclerosis was revealed in 6 cases (10.7%). Conclusion. Glomerulopathies in renal tumors are rather common and therefore their diagnosis is important in the study of the operative material. Keywords: kidney, tumour, glomerulopathies, paraneoplastic syndrome, diabetic nephropathy, glomerulonephritis