中华病理学杂志最新文献

{"title":"[Primary ovarian mesonephric-like adenocarcinoma: a clinicopathological analysis of 17 cases].","authors":"J Yuan, T T Chen, X C Chen, Y Ning, X Tao, W Y Gu","doi":"10.3760/cma.j.cn112151-20241113-00752","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20241113-00752","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinicopathological characteristics, diagnosis, origin, and prognosis of primary ovarian mesonephric-like adenocarcinoma. <b>Methods:</b> A total of 17 cases of primary ovarian mesonephric-like adenocarcinoma diagnosed at the Obstetrics and Gynecology Hospital of Fudan University and Jiaxing Maternal and Child Health Care Hospital between January 2018 and September 2024 were included in this study. Histopathological sections were retrospectively reviewed, and clinicopathological data were systematically analyzed. Immunohistochemical analysis, molecular profiling, and clinical follow-up were performed to further characterize the cases. <b>Results:</b> The patients' age was (57.1±9.3) years. Tumor involvement included 1 bilateral case, 9 left-sided cases, and 7 right-sided cases. Nine cases originated from endometrioid cysts, and 8 cases exhibited coexisting tumor components of other types. Gross examination revealed gray-yellow solid masses or solid components within cysts. Microscopically, the tumors displayed diverse architectural patterns, including papillary, glandular, cystic, tubular, and solid structures, with eosinophilic secretions within glandular lumens and mild to moderate nuclear atypia. Immunohistochemically, the tumors showed variable expression of TTF1, GATA3, CD10, and Calretinin. ER and PR were focally positive in only 2 cases, while others were negative. All cases demonstrated intact DNA mismatch repair proteins expression and wild-type p53 staining patterns. Molecular analysis performed in 10 cases identified pathogenic KRAS mutations in all tested samples. During a follow-up period of 1 to 75 months, 5 cases had recurrence, 1 patient remained alive with disease, and no disease-related death was reported. <b>Conclusions:</b> Ovarian mesonephric-like adenocarcinoma is an aggressive malignancy with a high potential for early recurrence and metastasis. Its frequent association with endometriosis and coexistence with other Müllerian tumors suggest a potential Müllerian origin. The tumor's diverse morphological spectrum and common admixture with other tumor types often pose diagnostic challenges, making it difficult to distinguish from other gynecological malignancies. Therefore, accurate diagnosis of ovarian mesonephric-like adenocarcinoma is crucial for appropriate clinical management and prognostication.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"494-499"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in gynecological pathology in China over the past ten years: retrospect and prospect].","authors":"A J Liu","doi":"10.3760/cma.j.cn112151-20250216-00102","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250216-00102","url":null,"abstract":"<p><p>In the past decade, great progress has been made in the field of gynecological pathology in China, especially in the field of pathology of female reproductive tract tumors. Gynecological pathologists have not only made a lot of research work in pathological diagnosis and its clinical application, but also issued several expert consensus and guidelines, and edited and translated a number of monographs. All above efforts have made a positive contribution to improving the level of gynecological pathology nationwide.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"435-440"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathological characteristics of high-grade succinate dehydrogenase-deficient renal cell carcinoma].","authors":"T Tang, Y X Li, Y Liu, W J Yu, Y X Jiang, Y J Li, W Zhang","doi":"10.3760/cma.j.cn112151-20240831-00584","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240831-00584","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinicopathological characteristics and diagnosis of high-grade succinate dehydrogenase-deficient renal cell carcinoma (SDH-RCC). <b>Methods:</b> Three cases of high-grade SDH-RCC diagnosed by immunohistochemical staining and/or molecular testing were collected from Affiliated Hospital of Qingdao University and 971 Hospital of Navy of Chinese People's Liberation Army from January 2015 to December 2023. The clinicopathological characteristics and immunohistochemical features were summarized using light microscopy. Two cases were tested for gene mutations by next-generation sequencing. <b>Results:</b> Of the 3 cases, 2 were male and 1 was female. The ages were 49, 61, and 53 years, respectively. Gross examination revealed that all tumors were single nodules with diameters of 7.0, 4.5, and 5.2 cm, respectively, grayish white in color with irregular borders. Cases 1 and 2 exhibited solid cut sections, whereas case 3 had cystic and solid cut sections. Microscopically, all cases had high WHO/ISUP nuclear grade (3 or 4) and overt invasion. Case 1 exhibited a solid, sheet-like growth pattern with numerous scattered glandular ducts or acinar structures. Case 2 displayed a diffusely growth pattern reminiscent of sarcoma. Case 3 demonstrated intracystic papillary and nodular infiltrative growth patterns. Large clear cytoplasmic vacuoles could be observed in the focal areas of case 1 and case 3. Prominent peritumoral lymphocytes in stroma were noted in case 1. Case 1 was diagnosed with regional lymph node metastasis, and case 2 was diagnosed with renal vein thrombosis. Immunohistochemical staining revealed that SDHB and SDHA were deficiently expressed in 3 cases, while PAX8, FH, and INI-1 exhibited diffuse expression. CD10 (1/3), CA9 (1/3), and CK20 (1/3) were occasionally expressed. The Ki-67 proliferation index ranged from 10% to 50%. Two cases underwent next-generation sequencing and were both found to harbor pathogenic mutations in SDHA (case 2 had a frameshift mutation, and case 3 had a splice site mutation). All 3 cases were followed up for 11 to 112 months. Case 2 died 11 months post-operation, while case 1 and case 3 survived for 19 and 112 months, respectively, without any recurrence or metastasis. <b>Conclusions:</b> High-grade SDH-RCC is a rare subtype of SDH-RCC. The tumor exhibits various architectural patterns and is often misdiagnosed as other types of renal cell carcinoma. The presence of cytoplasmic vacuoles may be indicative for diagnosis. Compared to typical SDH-RCC, the high-grade subtype generally shows a larger tumor size, higher TNM stage, greater invasive potential, and poorer prognosis. For high-grade SDH-RCC, routine SDHB immunohistochemical staining may be necessary. The occurrence of high-grade SDH-RCC may be associated with mutations in SDHA.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"506-511"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Plexiform myofibroblastoma: report of a case].","authors":"R F Xu, P P Zhu, J Wang","doi":"10.3760/cma.j.cn112151-20250124-00064","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20250124-00064","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"536-538"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary kidney GLI1-altered mesenchymal tumor: report of a case].","authors":"M W Xu, Z Z Gao, Z S Li, Z Wang, S P Guo","doi":"10.3760/cma.j.cn112151-20240921-00623","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240921-00623","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"527-529"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Characterization of PIK3CA/AKT1/PTEN gene mutations in hormone receptor- positive/HER2-negative breast cancer].","authors":"M L Liu, S F Wu, Y Y Liu, K M Li, X Huang, X D Liu, L L Zeng, X Zeng","doi":"10.3760/cma.j.cn112151-20240819-00552","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240819-00552","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the mutation of PIK3CA, AKT1 and PTEN genes in hormone receptor (HR)-positive and HER2-negative invasive breast cancer. <b>Methods:</b> A total of 44 formalin-fixed paraffin-embedded samples from HR-positive/HER2-negative female patients with breast cancer obtained between January 2020 and July 2024 in Peking Union Medical College Hospital were selected. The mutations of PIK3CA, AKT1 and PTEN genes were analyzed by next-generation sequencing (NGS), and the related clinicopathological characteristics were summarized. <b>Results:</b> In the cohort, 31 out of 44 cases (70.5%) exhibited alterations in the PIK3CA, AKT1 and PTEN genes. Of these, 83.9% (26/31) tumors harbored genetic abnormalities involving one gene, including 21 (47.7%, 21/44) PIK3CA, 2 (4.5%, 2/44) PTEN and 3 (6.8%, 3/44) AKT1 gene mutations. Mutations of both PIK3CA and PTEN genes were found in 16.1% (5/31) of specimens. Among the 26 cases with PIK3CA gene mutations, 13 variants were identified, including E542K, E545K, Q546K, H1047R, H1047L, G1049R, M1043I, C420R, P447_L455del, N345K, N345I, K711N and H1047L/V346G. In addition, 7 mutants of PTEN gene were determined (T319^*, T321Qfs^*23, Q245^*, Q171H, L108P, Y68Ifs^*6 and V343fs). For AKT1 gene mutation, only E17K was observed.Mutations of PIK3CA/AKT1/PTEN genes are more likely to occur over 40 year-old patients.In this cohort, the PIK3CA V346G mutation (co-existent PIK3CA H1047L) and the PTEN V343fs mutation were not found in previous publications. <b>Conclusion:</b> In addition to the predominance of common loci, PIK3CA and PTEN gene mutations also have rare loci mutations in the breast cancer, warranting further analysis with an expanded sample size.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"500-505"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathological features of early-stage lung adenocarcinomas with co-occurrence of MET exon 14 skipping mutation and gene amplification].","authors":"Y Y Liu, S F Wu, X D Liu, K M Li, M L Liu, L P Lu, X Zeng","doi":"10.3760/cma.j.cn112151-20240828-00578","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240828-00578","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the abnormalities of mesenchymal-epithelial transition factor (MET) gene in early-stage lung adenocarcinomas and to provide genetic bases for related clinical studies. <b>Methods:</b> A total of 630 cases of formalin-fixed and paraffin-embedded lung adenocarcinoma specimens with ALK and EGFR double-negativities were collected at Peking Union Medical College Hospital, Beijing, China between July 2020 and April 2022. Forty-three stage Ⅰ-ⅢA tumors with MET exon 14 skipping mutation identified by reverse transcription droplet digital PCR (RT-ddPCR) were identified and then evaluated for MET amplification using fluorescence in situ hybridization (FISH). MET amplification was determined using the ratio of MET to chromosome 7 enumeration probe (CEP7) or the mean of MET gene copy number (GCN). <b>Results:</b> Among the 43 samples with MET exon 14 skipping mutation, MET amplification was detected in 9 cases (9/43, 20.93%), including 1 case of MET/CEP7 ≥2 and GCN ≥5 (1/9), 8 cases of GCN≥5 (8/9), as well as 10 cases with high level of CEP7 (7.00-9.72) which included 5 cases with MET amplification. There were no significant differences in clinicopathological features between the two subgroups of tumors which harbored MET exon 14 skipping mutation with MET amplification versus those without (<i>P</i>>0.05). <b>Conclusions:</b> Co-occurrence of MET exon 14 skipping mutation and MET amplification or high level of CEP7 is frequently observed in early-stage lung adenocarcinomas. The most common pattern of MET gene amplification is GCN ≥5.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"477-481"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Thyroid follicular origin carcinoma with PPP1R21::ALK gene fusion: report of a case].","authors":"F Liu, Q L Ao","doi":"10.3760/cma.j.cn112151-20240821-00562","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20240821-00562","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"530-532"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Primary breast glomus tumor with uncertain malignant potential: report of a case].","authors":"Z Z Gao, M W Xu, J Y Liang, Z Y Ke, Z Wang, S P Guo","doi":"10.3760/cma.j.cn112151-20241203-00810","DOIUrl":"https://doi.org/10.3760/cma.j.cn112151-20241203-00810","url":null,"abstract":"","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 5","pages":"539-541"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinicopathological features and prognostic value of CD30 expression in EBV-positive diffuse large B cell lymphoma].","authors":"Y X Gong, S N Sun, Y F Yang, G Chen, Z H Zhang","doi":"10.3760/cma.j.cn112151-20240910-00603","DOIUrl":"10.3760/cma.j.cn112151-20240910-00603","url":null,"abstract":"<p><p><b>Objective:</b> To explore the clinical and pathological features of EBV-positive diffuse large B cell lymphoma (EBV⁺DLBCL) and to analyze the prognostic significance of CD30 expression in this entity. <b>Methods:</b> A retrospective analysis was conducted from 34 cases of EBV⁺DLBCL and 198 cases of EBV^-DLBCL diagnosed and treated at the First Affiliated Hospital of Nanjing Medical University, from January 2017 to June 2023. Based on CD30 expression, 34 patients with EBV⁺DLBCL were categorized into CD30-positive and CD30-negative groups. Fisher exact test and Kaplan-Meier survival curves were employed to analyze the relationship between CD30 expression and clinicopathological parameters as well as its prognostic implications. Chi-square tests were used to compare the clinicopathological features between EBV⁺DLBCL and EBV^-DLBCL. <b>Results:</b> There were 19 males and 15 females with a median age of 69.5 (15-83) years in the EBV⁺DLBCL group. Compared with EBV^-DLBCL, EBV⁺DLBCL was more likely to present with clinical features such as B symptoms (<i>χ</i>²=23.818,<i>P</i><0.001), Ann Arbor stage Ⅲ-Ⅳ (<i>χ</i>²=8.540,<i>P</i>=0.003), ECOG (Eastern Cooperative Oncology Group Performance Status) score 2-4 (<i>χ</i>²=6.722,<i>P</i>=0.010), IPI score 3-5 (<i>χ</i>²=9.953,<i>P</i>=0.002), and involvement of more than one extranodal site (<i>χ</i>²=6.825,<i>P</i>=0.009). Additionally, EBV⁺DLBCL exhibited higher frequencies of elevated LDH (<i>χ</i>²=4.307,<i>P</i>=0.038), CRP (<i>χ</i>²=5.596,<i>P</i>=0.018), and β2-MG (<i>χ</i>²=7.008,<i>P</i>=0.008) levels. Histopathologically, EBV⁺DLBCL was more commonly of the non-GCB subtype (<i>χ</i>²=12.421,<i>P</i><0.001), with higher frequencies of CD30-positive (<i>χ</i>²=62.706,<i>P</i><0.001),CD10-negative (<i>χ</i>²=8.687,<i>P</i>=0.003),bcl-6-negative (<i>χ</i>²=11.123,<i>P</i><0.001), and bcl-2-negative (<i>χ</i>²=22.779,<i>P</i>=0.003) expression. Using 20% as the positive threshold for CD30, the CD30-positive group had a higher proliferation index (<i>P</i>=0.045). No significant differences were observed in overall survival between the two groups. <b>Conclusions:</b> EBV⁺DLBCL is more prevalent in the elderly and often exhibits aggressive clinical features. The expression of CD30 is not associated with the overall prognosis of EBV⁺DLBCL.</p>","PeriodicalId":35997,"journal":{"name":"中华病理学杂志","volume":"54 4","pages":"354-360"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}