Critical Pathways in Cardiology最新文献

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Clinician Perception of Risk As a Barrier to Implementation of a High-sensitivity Troponin Accelerated Diagnostic Protocol. 临床医生对风险的认知是实施高灵敏度肌钙蛋白加速诊断方案的障碍。
Critical Pathways in Cardiology Pub Date : 2022-06-01 DOI: 10.1097/HPC.0000000000000287
Andrew J Matuskowitz, John P Hall, Mathew J Gregoski, Steven H Saef
{"title":"Clinician Perception of Risk As a Barrier to Implementation of a High-sensitivity Troponin Accelerated Diagnostic Protocol.","authors":"Andrew J Matuskowitz,&nbsp;John P Hall,&nbsp;Mathew J Gregoski,&nbsp;Steven H Saef","doi":"10.1097/HPC.0000000000000287","DOIUrl":"https://doi.org/10.1097/HPC.0000000000000287","url":null,"abstract":"<p><strong>Background: </strong>To assess emergency department (ED) clinician perception of patient risk, we measured willingness to discharge patients categorized as increased risk by traditional risk stratification modalities for acute coronary syndrome but low risk by a validated high-sensitivity troponin accelerated diagnostic protocol (HST-ADP).</p><p><strong>Methods: </strong>This was a cross-sectional descriptive survey study distributed to ED clinicians at an urban academic medical center. Four clinical vignettes classified hypothetical patients as low risk for 30-day acute coronary syndrome according to the 0-/1-hour HST-ADP. Vignettes additionally identified patients with History, Electrocardiogram, Age, Risk factors, and initial Troponin (HEART) scores of 4 or 6 (2 cases each). One patient in each subset had preexisting coronary artery disease (CAD). ED clinicians self-reported willingness to discharge patients from the ED on a 10-point Likert scale.</p><p><strong>Results: </strong>Among 66 eligible participants, 36 (55%) participated in the survey. ED clinicians reported a mean willingness to discharge patients of 6.07 (95% confidence interval, 5.34-6.80). They reported higher mean willingness to discharge patients with HEART scores of 4 compared with those with HEART scores of 6 (mean difference, 3.61; 95% confidence interval, 2.19-5.03). There were no differences in willingness to discharge regarding presence or absence of CAD or between clinician types (attending, resident, advanced practice provider).</p><p><strong>Conclusions: </strong>ED clinicians accustomed to the HEART Pathway demonstrated limited willingness to discharge patients from the ED categorized as moderate risk by the HEART score despite simultaneous classification as low risk by the 0-/1-hour HST-ADP. Willingness to discharge was higher with lower HEART scores but not affected by the presence of CAD and did not vary between clinician types.</p>","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309064/pdf/nihms-1905710.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10205517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning to Assess for Acute Myocardial Infarction Within 30 Minutes. 机器学习在30分钟内评估急性心肌梗死。
Critical Pathways in Cardiology Pub Date : 2022-06-01 DOI: 10.1097/HPC.0000000000000281
James McCord, Joseph Gibbs, Michael Hudson, Michele Moyer, Gordon Jacobsen, Gillian Murtagh, Richard Nowak
{"title":"Machine Learning to Assess for Acute Myocardial Infarction Within 30 Minutes.","authors":"James McCord,&nbsp;Joseph Gibbs,&nbsp;Michael Hudson,&nbsp;Michele Moyer,&nbsp;Gordon Jacobsen,&nbsp;Gillian Murtagh,&nbsp;Richard Nowak","doi":"10.1097/HPC.0000000000000281","DOIUrl":"https://doi.org/10.1097/HPC.0000000000000281","url":null,"abstract":"<p><p>Variations in high-sensitivity cardiac troponin I by age and sex along with various sampling times can make the evaluation for acute myocardial infarction (AMI) challenging. Machine learning integrates these variables to allow a more accurate evaluation for possible AMI. The goal was to test the diagnostic and prognostic utility of a machine learning algorithm in the evaluation of possible AMI. We applied a machine learning algorithm (myocardial-ischemic-injury-index [MI3]) that incorporates age, sex, and high-sensitivity cardiac troponin I levels at time 0 and 30 minutes in 529 patients evaluated for possible AMI in a single urban emergency department. MI3 generates an index value from 0 to 100 reflecting the likelihood of AMI. Patients were followed at 30-45 days for major adverse cardiac events (MACEs). There were 42 (7.9%) patients that had an AMI. Patients were divided into 3 groups by the MI3 score: low-risk (≤ 3.13), intermediate-risk (> 3.13-51.0), and high-risk (> 51.0). The sensitivity for AMI was 100% with a MI3 value ≤ 3.13 and 353 (67%) ruled-out for AMI at 30 minutes. At 30-45 days, there were 2 (0.6%) MACEs (2 noncardiac deaths) in the low-risk group, in the intermediate-risk group 4 (3.0%) MACEs (3 AMIs, 1 cardiac death), and in the high-risk group 4 (9.1%) MACEs (4 AMIs, 2 cardiac deaths). The MI3 algorithm had 100% sensitivity for AMI at 30 minutes and identified a low-risk cohort who may be considered for early discharge.</p>","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10205495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The E/e' Ratio: As "Critical" As the Left Ventricular Ejection Fraction? E/ E比值:与左心室射血分数一样“关键”?
Critical Pathways in Cardiology Pub Date : 2022-06-01 DOI: 10.1097/HPC.0000000000000288
Mori J Krantz, Todd Rudo, Blaine Horvath, Elizabeth Gregory, Morteza Farasat, Odette Gore, Philip S Mehler
{"title":"The E/e' Ratio: As \"Critical\" As the Left Ventricular Ejection Fraction?","authors":"Mori J Krantz,&nbsp;Todd Rudo,&nbsp;Blaine Horvath,&nbsp;Elizabeth Gregory,&nbsp;Morteza Farasat,&nbsp;Odette Gore,&nbsp;Philip S Mehler","doi":"10.1097/HPC.0000000000000288","DOIUrl":"https://doi.org/10.1097/HPC.0000000000000288","url":null,"abstract":"<p><p>Ascertainment of the left ventricular ejection fraction is the primary reason for ordering echocardiography in the acute care setting; however, this parameter does not provide information regarding a patient's volume status. As such, it cannot be reliably used to inform decisions regarding intravenous fluid resuscitation or diuresis, particularly in undifferentiated dyspnea and hypotension. This is relevant given a national quality improvement exhortation to provide aggressive fluid resuscitation as part of a \"sepsis bundle.\" This initiative must be tempered by the well-established increase in hospital mortality from providing intravenous fluid to patients with unrecognized heart failure, which may occur if sepsis is misdiagnosed. We describe herein, what is to our knowledge, the first description of a critically elevated Doppler ratio of mitral inflow peak E-wave velocity to the mean mitral annular velocity as a harbinger of sudden death from pulmonary edema in a patient treated with aggressive intravenous fluids as part of the \"sepsis bundle.\" This is utilized as a springboard for proposing a clinical algorithm focused on expedited echocardiography. It emphasized the potential value of advancing markedly the diastolic assessment of filling pressure (ratio of mitral inflow peak E-wave velocity to the mean mitral annular velocity) in the acute care setting to a level of import comparable to the left ventricular ejection fraction.</p>","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10207565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a Risk Prediction Model for Early Atrial Fibrillation Recurrence After Maze Procedure. 建立迷宫术后早期房颤复发的风险预测模型。
Critical Pathways in Cardiology Pub Date : 2022-06-01 DOI: 10.1097/HPC.0000000000000286
Amirhosein Seyedhoseinpour, Ali Vasheghani-Farahani, Kyomars Abbasi, Arash Jalali, Farbod Zahed Tajreshi, Amir Fazeli, Seyyed Mojtaba Ghorashi, Negar Omidi
{"title":"Developing a Risk Prediction Model for Early Atrial Fibrillation Recurrence After Maze Procedure.","authors":"Amirhosein Seyedhoseinpour,&nbsp;Ali Vasheghani-Farahani,&nbsp;Kyomars Abbasi,&nbsp;Arash Jalali,&nbsp;Farbod Zahed Tajreshi,&nbsp;Amir Fazeli,&nbsp;Seyyed Mojtaba Ghorashi,&nbsp;Negar Omidi","doi":"10.1097/HPC.0000000000000286","DOIUrl":"https://doi.org/10.1097/HPC.0000000000000286","url":null,"abstract":"<p><strong>Background: </strong>The efficiency of maze is a safe procedure in AF patients who underwent concomitant mitral valve surgery was more than 60%. The aim of this study was to define predictors of early AF recurrence after concomitant maze procedure with valvular surgery.</p><p><strong>Methods: </strong>In this retrospective study, 234 patients with AF underwent concomitant valvular replacement and maze procedure. Patients were classified into 2 groups of sinus and atrial fibrillation (AF). Baseline characteristics of patients were then compared between 2 groups.</p><p><strong>Results: </strong>Totally, 234 patients were enrolled, 148 of which maintained sinus rhythm during hospitalization. Left atrial diameter and type of valvular surgery were similar in both groups. Age, number of replaced valves, concomitant coronary artery bypass grafting, and history of preoperative persistent AF and beta-blocker therapy were independent predictors of in-hospital AF recurrence. We used these variables to build a model to anticipate early AF recurrence.</p><p><strong>Conclusions: </strong>Being older, multivalvular surgery, and persistent preoperative AF were the predictors of higher risk of early recurrent AF, whereas concomitant coronary artery bypass grafting and using beta-blocker had a protective effect. This model based on preoperative and operative characteristics can help us to better evaluate if the patient benefits from maze procedure coincide with valvular surgery.</p>","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10202392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Very Low Risk for In-hospital Adverse Outcome Such as ST-elevation or Non-ST-elevation Myocardial Infarction in Patients Undergoing Knee Surgery. 膝关节手术患者发生st段抬高或非st段抬高心肌梗死等院内不良结局的风险极低。
Critical Pathways in Cardiology Pub Date : 2022-06-01 DOI: 10.1097/HPC.0000000000000282
Armin Talle, Mehrtash Hashemzadeh, Mohammad Reza Movahed
{"title":"Very Low Risk for In-hospital Adverse Outcome Such as ST-elevation or Non-ST-elevation Myocardial Infarction in Patients Undergoing Knee Surgery.","authors":"Armin Talle,&nbsp;Mehrtash Hashemzadeh,&nbsp;Mohammad Reza Movahed","doi":"10.1097/HPC.0000000000000282","DOIUrl":"https://doi.org/10.1097/HPC.0000000000000282","url":null,"abstract":"<p><strong>Background: </strong>Knee surgery is a very common surgery. The risk of cardiac events is thought to be low. The goal of this study was to evaluate inpatients adverse outcomes such as ST-elevation myocardial infarction (STEMI) or Non-ST-elevation myocardial infarction in patients undergoing knee surgery.</p><p><strong>Method: </strong>Using the nation inpatient sample database, we evaluated the occurrence of STEMI and Non-STEMI in a very large population.</p><p><strong>Results: </strong>Using 2 random samples from 2005 to 2014, 10 years apart involving 7444 knee surgeries, the occurrence of STEMI and Non-STEMI were very low. In 2005, only 1 STEMI (0.0%) and 4 non-STEMI (0.1%) events occurred in inpatient knee-surgery patients. In the 2014 group, 0 STEMI (0.0%) and 5 non-STEMI (0.16%) events occurred in inpatient knee-surgery patients. Overall, STEMI or non-STEMI events occurred in 0.13% of inpatient knee-surgery procedures.</p><p><strong>Conclusions: </strong>Inpatients' adverse outcome of patients undergoing knee surgery is very low suggesting that extensive cardiac workup for knee surgery may not be warranted.</p>","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10205502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Features and Prognoses of Middle-Aged Women With ST-Elevation Myocardial Infarction With a Focus on Spontaneous Coronary Artery Dissection: erratum. 以自发性冠状动脉夹层为重点的ST段抬高型心肌梗死中年妇女的临床特征和预后:勘误表。
Critical Pathways in Cardiology Pub Date : 2022-06-01 Epub Date: 2022-05-20 DOI: 10.1097/HPC.0000000000000285
Somayeh Yadangi
{"title":"Clinical Features and Prognoses of Middle-Aged Women With ST-Elevation Myocardial Infarction With a Focus on Spontaneous Coronary Artery Dissection: erratum.","authors":"Somayeh Yadangi","doi":"10.1097/HPC.0000000000000285","DOIUrl":"10.1097/HPC.0000000000000285","url":null,"abstract":"","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10222267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-hospital and 1-Year Outcomes of Repeated Percutaneous Coronary Intervention for In-stent Restenosis With Acute Coronary Syndrome Presentation 多次经皮冠状动脉介入治疗支架内再狭窄伴急性冠状动脉综合征的住院和1年预后
Critical Pathways in Cardiology Pub Date : 2022-03-03 DOI: 10.1097/HPC.0000000000000283
Y. Nozari, Seyyed Mojtaba Ghorashi, Mostafa Alidoust, S. Hamideh Mortazavi, A. Jalali, N. Omidi, Amir Fazeli, H. Aghajani, M. Salarifar, Ali Reza Amirzadegan
{"title":"In-hospital and 1-Year Outcomes of Repeated Percutaneous Coronary Intervention for In-stent Restenosis With Acute Coronary Syndrome Presentation","authors":"Y. Nozari, Seyyed Mojtaba Ghorashi, Mostafa Alidoust, S. Hamideh Mortazavi, A. Jalali, N. Omidi, Amir Fazeli, H. Aghajani, M. Salarifar, Ali Reza Amirzadegan","doi":"10.1097/HPC.0000000000000283","DOIUrl":"https://doi.org/10.1097/HPC.0000000000000283","url":null,"abstract":"Background: In-stent restenosis (ISR) is the Achilles’ heel of percutaneous coronary intervention (PCI). There have been controversial data about outcomes of repeated PCI (redo-PCI) for ISR. This study aims to determine the predictors of major adverse cardiac events (MACE) in patients underwent redo-PCI for ISR. Methods: In this retrospective study, all patients with acute coronary syndrome who were underwent successful PCI for ISR at Tehran Herat Center (between 2004 and 2019) were eligible for inclusion. Patients with moderate to severe valvular heart disease and/or hematological disorders were excluded. Participants were divided into 2 groups based on the occurrence of the MACE [composite of cardiovascular death, myocardial infarction (MI), coronary artery bypass grafting, target vessel revascularization, and target lesion revascularization]; then, the study variables were compared between the 2 groups. Finally, the predictors of MACE were identified using Cox regression analysis. Results: Of 748 redo-PCI patients (mean age: 65.2 ± 10.1; 71.0% males), 631 patients had met the inclusion criteria. Fifty-four patients (9.8%) developed MACE within a 1-year follow-up period. Multivessel disease, primary PCI, Ad-hoc PCI, history of non–ST-segment elevation MI, and diabetes mellitus were independent predictors for MACE. In a subgroup analysis, 30 patients who experienced third PCI (target lesion revascularization/target vessel revascularization) were followed more as 1-year MACE. Among these patients, 14 MACEs were observed during the last follow-up (till June 2020). Conclusions: Multivessel disease, primary PCI, and history of non–ST-segment elevation MI were the predictors of higher 1-year MACE, whereas Ad-hoc PCI and diabetes mellitus had a protective effect on MACE.","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90105548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Impact of Accelerated Diagnostic Protocol Implementation on Chest Pain Observation Unit Utilization. 加速诊断方案实施对胸痛观察单元使用的影响。
Critical Pathways in Cardiology Pub Date : 2022-03-01 DOI: 10.1097/HPC.0000000000000254
Iltifat Husain, Simon A Mahler, Brian C Hiestand, Chadwick D Miller, Jason P Stopyra
{"title":"The Impact of Accelerated Diagnostic Protocol Implementation on Chest Pain Observation Unit Utilization.","authors":"Iltifat Husain,&nbsp;Simon A Mahler,&nbsp;Brian C Hiestand,&nbsp;Chadwick D Miller,&nbsp;Jason P Stopyra","doi":"10.1097/HPC.0000000000000254","DOIUrl":"https://doi.org/10.1097/HPC.0000000000000254","url":null,"abstract":"<p><strong>Background: </strong>Data evaluating the impact of the history, ECG, age, risk factors, and troponin (HEART) Pathway on observation unit (OU) use is limited. The objective of this study is to determine how HEART Pathway implementation affects OU use.</p><p><strong>Methods: </strong>An analysis of OU registry data from October 2012 to October 2016, 2 years before and after HEART Pathway implementation at an academic medical center, was conducted. Adult patients placed in the OU for chest pain were included. The proportion of patients placed in the OU chest pain protocol per total OU volume and hospitalization and myocardial infarction (MI) rates were determined. Proportions before versus after implementation were compared using χ2 tests and age was compared using a Mann-Whitney U test.</p><p><strong>Results: </strong>During the study period, 1688 patients with chest pain before HEART Pathway implementation and 1692 after were included. The proportion of chest pain patients in the OU per total OU volume decreased following implementation from (57% [1688/2968] to 43.6% [1692/3882]; P < 0.001). Before HEART Pathway implementation, the hospitalization rate was 10.4% (175/1688) versus 12.4% (210/1692) after (P = 0.07). More patients were diagnosed with MI following implementation (0.8% [14/1665] vs. 2.0% [33/1686]; P = 0. 008). Median age was older postimplementation (52 years [IQR: 45-59 years] vs. 54 years [IQR: 48-64 years]; P < 0. 001).</p><p><strong>Conclusions: </strong>HEART Pathway implementation resulted in management of higher risk patients in the OU. Following implementation, OU chest pain patients were older and were more likely to be hospitalized or diagnosed with MI.</p>","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014373/pdf/nihms-1794627.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10204120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Perioperative Cardiac Troponin T and Risk of Postoperative Atrial Fibrillation in Coronary Artery Bypass Graft Surgery. 围术期心肌肌钙蛋白T与冠状动脉搭桥术术后房颤的风险
Critical Pathways in Cardiology Pub Date : 2022-03-01 DOI: 10.1097/HPC.0000000000000276
Ali Vasheghani Farahani, Abbas Salehi Omran, Kyomars Abbasi, Ali Gholamrezaei, Pejman Mansouri, Seyed Hossein Ahmadi Tafti, Mansour Jahangiri
{"title":"Perioperative Cardiac Troponin T and Risk of Postoperative Atrial Fibrillation in Coronary Artery Bypass Graft Surgery.","authors":"Ali Vasheghani Farahani,&nbsp;Abbas Salehi Omran,&nbsp;Kyomars Abbasi,&nbsp;Ali Gholamrezaei,&nbsp;Pejman Mansouri,&nbsp;Seyed Hossein Ahmadi Tafti,&nbsp;Mansour Jahangiri","doi":"10.1097/HPC.0000000000000276","DOIUrl":"https://doi.org/10.1097/HPC.0000000000000276","url":null,"abstract":"<p><strong>Background: </strong>Postoperative atrial fibrillation (AF) is a common complication after cardiac surgery. We investigated whether perioperative cardiac troponin T (cTnT) is associated with the risk of AF after coronary artery bypass grafting (CABG).</p><p><strong>Methods: </strong>Two thousand four hundred twenty-one patients with isolated CABG were studied. High sensitivity cTnT (hs-cTnT) was assessed before and then at 80 hour and 24 hour after the operation. Logistic regression models were applied to investigate the association of perioperative hs-cTnT with postoperative AF. The ROC curve analysis was applied to determine the optimal cutoff values.</p><p><strong>Results: </strong>Postoperative AF was occurred in 356 (14.7%) patients. Age (adjusted odds ratio [ORs] 1.087-1.090), male gender (OR 1.390), left atrium size (ORs 1.055-1.111), on-pump coronary bypass (OR 1.561), and application of intra-aortic balloon pump (ORs 2.890-2.966) were independently associated with AF. Preoperative hs-cTnT was associated with AF in patients with off-pump coronary bypass (ORs 1.997-2.375). However, the area under the curve for preoperative hs-cTnT was 0.625 in this group. On-pump coronary bypass had major influence on postoperative hs-cTnT levels regardless of the occurrence of AF.</p><p><strong>Conclusions: </strong>Preoperative hs-cTnT level is associated with the risk of AF after isolated CABG in patients undergoing off-pump coronary bypass, but the accuracy of this biomarker is yet inadequate. Postoperative levels of hs-cTnT have no predictive value considering large influence by the surgical technique and the cardiac surgery itself. Therefore, perioperative hs-cTnT is not a clinically useful biomarker for predicting AF following CABG.</p>","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10207539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Features and Prognoses of Middle-Aged Women With ST-Elevation Myocardial Infarction With a Focus on Spontaneous Coronary Artery Dissection. 以自发性冠状动脉夹层为重点的ST段抬高型心肌梗死的中年妇女的临床特征和预后。
Critical Pathways in Cardiology Pub Date : 2022-03-01 DOI: 10.1097/HPC.0000000000000275
Aliasghar Almasi, Pejman Mansouri, Mana Jameie, Somayeh Yadangi, Saeed Haghighi Parapary, Seyed Abolfazl Mohsenizadeh, Peiman Jamshidi, Yaser Jenab
{"title":"Clinical Features and Prognoses of Middle-Aged Women With ST-Elevation Myocardial Infarction With a Focus on Spontaneous Coronary Artery Dissection.","authors":"Aliasghar Almasi, Pejman Mansouri, Mana Jameie, Somayeh Yadangi, Saeed Haghighi Parapary, Seyed Abolfazl Mohsenizadeh, Peiman Jamshidi, Yaser Jenab","doi":"10.1097/HPC.0000000000000275","DOIUrl":"10.1097/HPC.0000000000000275","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous coronary artery dissection (SCAD) has become an increasingly recognized cause of acute coronary syndrome, particularly in young women, over the last decade. The goal of this study was to determine the prognoses and characteristics of adult women with SCAD who presented with ST-elevation myocardial infarction (STEMI).</p><p><strong>Methods: </strong>This retrospective cohort study enrolled all adult women under the age of 60 who had undergone coronary artery angiography in the setting of STEMI. The patients were divided into 3 groups based on their angiographic characteristics: STEMI-SCAD (STEMI due to SCAD), STEMI-ATH (STEMI caused by an atherosclerotic lesion), and STEMI-others (STEMI due to other etiologies including Takotsubo cardiomyopathy and myopericarditis, as well as STEMI despite a normal epicardial coronary angiography).</p><p><strong>Results: </strong>Fifteen women out of 311 female patients aged below 60 years with STEMI were diagnosed with SCAD (4.8%). There were no significant differences in body mass index, hypertension, dyslipidemia, smoking status, opium addiction status, family history, previous percutaneous coronary intervention, coronary artery bypass grafting, and cerebrovascular accidents between the STEMI-SCAD and STEMI-ATH groups. Nevertheless, the STEMI-SCAD and STEMI-others groups were more likely to be younger, less likely to be diabetic, and less likely to have 3 cardiovascular risk factors or more than was the STEMI-ATH group. The left anterior descending artery was the most common culprit lesion in the STEMI-SCAD group (80%) and the other 2 groups. Out of the 311 patients, 7 patients died during the index hospitalization: 1 patient in the STEMI-SCAD group, 6 patients in the STEMI-ATH group, and 0 patients in the STEMI-others group. None of the patients in the STEMI-others group experienced any major adverse cardiac events during the follow-up. In the other 2 groups, the most experienced outcomes were myocardial infarction and in-hospital cardiac death, followed by target lesion revascularization and target vessel revascularization.</p><p><strong>Conclusions: </strong>STEMI-SCAD is one of the known causes of STEMI in young women. Still, despite the complexity of revascularization in our patients with STEMI-SCAD, they had more favorable prognoses in both conservative and revascularization management modalities than our patients with STEMI-ATH.</p>","PeriodicalId":35914,"journal":{"name":"Critical Pathways in Cardiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10207541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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