Stomatologiya最新文献

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[Dynamics of expression of NOD-like receptors of periodontal tissue cells in patients with aggressive periodontitis]. [侵袭性牙周炎患者牙周组织细胞nod样受体表达的动态变化]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410306210
E V Fomenko, A I Grudyanov, O V Kalyuzhin, I I Babichenko
{"title":"[Dynamics of expression of NOD-like receptors of periodontal tissue cells in patients with aggressive periodontitis].","authors":"E V Fomenko, A I Grudyanov, O V Kalyuzhin, I I Babichenko","doi":"10.17116/stomat202410306210","DOIUrl":"10.17116/stomat202410306210","url":null,"abstract":"<p><strong>The aim of the study: </strong>To study the expression of NOD receptors of immunotropic periodontal tissue cells in patients with aggressive periodontitis before and after complex treatment.</p><p><strong>Materials and methods: </strong>15 patients aged 22 to 36 years with aggressive periodontitis were examined before and 21 days after the start of complex treatment. 15 patients with fibroids of the oral mucosa without signs of inflammation served as controls. Samples of the gingival mucosa after surgical treatment were sent to a routine histological and immunohistochemical (IHC) method with polyclonal rabbit antibodies. The expression of pro- and anti-inflammatory receptors was studied: NOD receptors - NLRP3 and NLRP12 as the most significant. The criterion for evaluating the expression of NLRP12 and NLRP3 receptors was the staining of nuclei and cytoplasm of cells of the multilayer squamous epithelium and cytoplasm of inflammatory infiltrate cells in the own plate of the mucous membrane. The intensity of staining was assessed as: no staining (0), weak staining (1+), medium (2+) and intense (3+).</p><p><strong>Results: </strong>In the control group of patients diagnosed with fibroma without signs of inflammation in the oral mucosa, expression of NOD receptors was not observed. The maximum expression of NOD receptors was detected during exacerbation of the aggressive form of periodontitis in the nuclei and cytoplasm of stratified squamous epithelial cells and in the lamina propria of the gingival mucosa in the cells of the inflammatory infiltrate. After complex treatment of patients with an aggressive form of periodontitis, there is a significant (<i>p</i><0.05) decrease in the expression of NLRP12 receptors in the cells of the inflammatory infiltrate, which inhibit the inflammatory response in periodontal tissues.</p><p><strong>Conclusion: </strong>The expression of NMDA receptors in the multilayer squamous epithelium characterizes the activity of the inflammatory process in the oral mucosa and can be recommended for use in evaluating the effectiveness of the treatment of an aggressive form of periodontitis.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 6. Vyp. 2","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of the antimicrobial efficacy of active components in wound dressings under in vitro conditions]. [体外条件下创面敷料中活性成分抗菌效果评价]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410306233
T Z Chkadua, L E Smirnova, O S Vladimirskaya, O E Medusheva, Yu S Fiodorovskaya, E V Azarenkov
{"title":"[Evaluation of the antimicrobial efficacy of active components in wound dressings under in vitro conditions].","authors":"T Z Chkadua, L E Smirnova, O S Vladimirskaya, O E Medusheva, Yu S Fiodorovskaya, E V Azarenkov","doi":"10.17116/stomat202410306233","DOIUrl":"10.17116/stomat202410306233","url":null,"abstract":"<p><strong>Objective: </strong>Study on the impact of medical wound dressing compositions on reference strains of microorganisms in vitro conditions.</p><p><strong>Materials and methods: </strong>The study compared the antimicrobial activity of three types of dressing materials (DM): iodoform gauze bandage, DM with furagin and sodium alginate, DM from hydrogel with dimexide and silver nitrates. Gauze bandage with chlorhexidine was used as a control. Their impact on various strains of bacteria and fungi was investigated by measuring zones of growth inhibition of microorganisms over several days at different temperatures.</p><p><strong>Results: </strong>Iodoform showed short-term action: the inhibition of microorganism growth ranged from 6 to 9 mm during the first few days, and then disappeared. The sample with furagin and sodium alginate demonstrated stable activity throughout the entire period; the largest inhibition of growth was observed for <i>S. aureus</i> (up to 13.5 mm) and <i>P. aeruginosa</i> (up to 12 mm), and the smallest for <i>C. albicans</i> (5.5 mm). The hydrogel with dimexide and silver nitrate was the most effective, showing antimicrobial activity against all strains, especially against <i>C. albicans</i> (up to 12 mm). The control bandage with chlorhexidine was twice as effective as the furagin sample in antimicrobial activity against <i>E. cloacae</i> and <i>S. pyogenes</i> and on average 2.6 mm against <i>P. aeruginosa</i>.</p><p><strong>Conclusion: </strong>The hydrogel from sodium alginate with dimexide and silver nitrates is effective against all the studied microorganisms, including yeast fungi of the genus Candida. The antimicrobial activity remains for 7 days, which can reduce the frequency of dressing changes and minimize wound surface trauma, improving the quality and safety of medical care.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 6. Vyp. 2","pages":"33-36"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Risk-oriented approach to predicting external inflammatory resorption in children with permanent teeth injuries]. [以风险为导向的方法预测儿童恒牙损伤的外部炎症吸收]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410306242
L Yu Kharkova, M V Korolenkova
{"title":"[Risk-oriented approach to predicting external inflammatory resorption in children with permanent teeth injuries].","authors":"L Yu Kharkova, M V Korolenkova","doi":"10.17116/stomat202410306242","DOIUrl":"10.17116/stomat202410306242","url":null,"abstract":"<p><strong>The aim of the study: </strong>Was to determine the risk factors for pulp necrosis and external inflammatory resorption in children with permanent teeth trauma.</p><p><strong>Materials and methods: </strong>The study involved 68 pediatric patients aged 6 to 16 years (mean age 10.9±2.9 years) with a history of trauma to 152 permanent teeth. Of the 152 teeth, 55 had unformed roots, and 97 teeth had formed roots. Multiple trauma was observed in 43 teeth, and isolated trauma was observed in 109 teeth. All patients were assessed for the risks of pulp necrosis and external inflammatory root resorption in traumatized permanent teeth depending on a number of factors. The patients were observed clinically and radiographically from 6 months to 9 years.</p><p><strong>Results: </strong>The probability of external inflammatory resorption in case of pulp necrosis in permanent teeth with unformed roots is 2.3 times higher than in formed ones. Multiple trauma (30.9%) is more common in patients with unformed roots of permanent teeth, while combined trauma (87.6%) is more common in patients with formed roots. The probability of pulp necrosis in case of multiple trauma of a permanent tooth is higher (67.4%) than in case of isolated trauma (36.7%). Of all types of trauma, avulsion and impaction of a permanent tooth most often lead to pulp necrosis and development of external inflammatory root resorption.</p><p><strong>Conclusion: </strong>Multiple trauma, which is more typical for permanent teeth with unformed roots, is a risk factor for pulp necrosis and, consequently, external inflammatory root resorption of a tooth. A risk-based approach can be an effective tool for a dentist in choosing the tactics of managing children with permanent tooth trauma. Evaluation of risk factors for pulp necrosis and external inflammatory resorption in a specific permanent tooth in a child will allow the dentist to provide a personalized way to prevent these complications, and therefore increase the likelihood of tooth survival after trauma.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 6. Vyp. 2","pages":"42-46"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Distinctions in molecular composition of the dental biofilm in a dependence of method of exo/endogeneous caries prevention and cariogenic condition of a patient]. [牙齿生物膜分子组成的差异取决于外源性/内源性防龋方法和患者的致龋情况]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat20241030515
P V Seredin, Yu A Ippolitov, Y A Peshkov, D L Goloshchapov, I Yu Ippolitov, O G Avraamova
{"title":"[Distinctions in molecular composition of the dental biofilm in a dependence of method of exo/endogeneous caries prevention and cariogenic condition of a patient].","authors":"P V Seredin, Yu A Ippolitov, Y A Peshkov, D L Goloshchapov, I Yu Ippolitov, O G Avraamova","doi":"10.17116/stomat20241030515","DOIUrl":"10.17116/stomat20241030515","url":null,"abstract":"<p><strong>Objective: </strong>Comparative study of changes in the secondary structure of dental biofilm proteins in people with cariesogenic and cariesoprotective status using synchrotron IR microspectroscopy.</p><p><strong>Materials and methods: </strong>Dental biofilm samples from 50 patients without caries (group 1) and with carious lesions of tooth enamel (group 2) were studied. The molecular composition of biofilms was studied using IR microspectroscopy. Changes in the secondary structure of dental biofilm proteins were evaluated based on deconvolution of Amide I or Amide II amide bands. using the analysis of variance. Patients of both groups took tablets containing a mineral complex with calcium glycerophosphate.</p><p><strong>Results: </strong>Based on the deconvolution of the IR spectral profile of the Amide I and Amide II bands, the changes occurring in the secondary structure of dental biofilm proteins have been studied. Using a large set of spectra, it was shown that the prediction of the secondary structure of the biofilm protein network is influenced by both the cariesogenic situation in the oral cavity (with initial carious lesions of the enamel) and the fact that patients use a modulator - calcium glycerophosphate (a tableted mineral complex with calcium glycerophosphate). Significant intra-group and intergroup differences in the secondary structure of dental biofilm proteins were established for patients in normal and carisogenic situations in the mouth, including after the use of a tableted mineral complex with calcium glycerophosphate. This allowed us to give a mathematical assessment of shifts in the secondary structure of proteins depending on the activity of caries and external modulation.</p><p><strong>Conclusion: </strong>The results obtained can form the basis of a technique for spectroscopic diagnosis of changes (shifts) in the oral microbiome leading to the development of the carious process, as well as become the basis for choosing the optimal therapeutic ways to treat enamel caries, including through preventive measures aimed at restoring the microflora of the patient's oral cavity.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 5","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Impact of chemical surface treatment of samples made of domestic zirconium dioxide on adhesive strength]. [国产二氧化锆样品的化学表面处理对粘合强度的影响]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410303139
F F Losev, I B Axelrod, A A Romanenko, V P Chuev
{"title":"[Impact of chemical surface treatment of samples made of domestic zirconium dioxide on adhesive strength].","authors":"F F Losev, I B Axelrod, A A Romanenko, V P Chuev","doi":"10.17116/stomat202410303139","DOIUrl":"https://doi.org/10.17116/stomat202410303139","url":null,"abstract":"<p><p>Ceramic based on zirconium dioxide (ZD) is a modern, durable material for the manufacture of dentures. It is known that ZD is not etched as glass-ceramic, making it difficult to prepare this material before fixing.</p><p><strong>Objective: </strong>To study the impact of various methods of surface treatment of ZD-based ceramic on adhesive strength.</p><p><strong>Materials and methods: </strong>Sandblasting with Al<sub>2</sub>O<sub>3</sub> particles sized 50 μm and application of primers with 10-MDP phosphate monomer were used. Adhesive strength values for following 4 groups of samples were obtained: 1st group - RelyX U200 + sandblasting + Compofix new primer (<i>n</i>=9); 2nd group - Compofix + sandblasting + Compofix new primer (<i>n</i>=9); 3rd group - Panavia F 2.0 + sandblasting (<i>n</i>=9); 4th group (control) - Variolink Esthetic DC + sandblasting + Monobond Plus primer (<i>n</i>=9).</p><p><strong>Results: </strong>The highest strength of adhesion was in the 4th group - 48.71±5.71MPa, the smallest in the 3rd group - 9.49±35.24 MPa. Fully domestic components used in the 2nd group allowed to obtain values of 42.50±9.79 MPa. Adhesive strength in the 1st group was 34.11±4.78 MPa.</p><p><strong>Conclusion: </strong>The absence of the 10-MDP-based primers application in the preparation of ZD ceramic reduces the adhesive strength between resin cement and its surface. The domestic set for fixation of dentures can be effectively used for ZD on the same basis as European analogue.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 3","pages":"39-41"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The syndrome of psycho-sensory-anatomical-functional auto-desadaptation in patients with malignant tumors of the maxillofacial region]. [颌面部恶性肿瘤患者的心理-感觉-解剖-功能自动失调综合征]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410304120
A A Matchin, A A Chetverova
{"title":"[The syndrome of psycho-sensory-anatomical-functional auto-desadaptation in patients with malignant tumors of the maxillofacial region].","authors":"A A Matchin, A A Chetverova","doi":"10.17116/stomat202410304120","DOIUrl":"https://doi.org/10.17116/stomat202410304120","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to evaluate the syndrome of PSAF-autoadaptation in patients with tumors of maxillofacial localization based on the analysis of the results of a survey of the patient's Voluntary Confidential Information Sheet (DDIV Sheet).</p><p><strong>Material and methods: </strong>The object of the study was 110 patients (39 men and 71 women (average age 58 years) with malignant neoplasms of the skin, tongue, bottom of the oral cavity, parotid salivary gland, upper jaw, submandibular salivary gland (stage II-IV of the disease). Rapid diagnostics of psycho-sensory-anatomical-functional-autoadaptation (PSAF) was performed by analyzing self-filled patient lists of DDIV with its self-assessment of the main complaints. After distributing complaints and manifestations of the disease into 4 clusters, the severity and structure of autoadaptation were calculated in points.</p><p><strong>Results: </strong>It was found that in the majority of cancer patients in the preoperative period, complaints related to mental and functional clusters prevailed. At the same time, 80% of patients rated the degree of concern for their health as extremely alarming, and 20% as very anxious. In the postoperative period, the number of psychological complaints decreased and the number of complaints corresponding to anatomical, sensory and functional clusters increased.</p><p><strong>Conclusion: </strong>The study of personal response to the disease according to PSAF-autoadaptation of cancer patients showed that the presence of a tumor lesion not only affects the internal picture of the disease, adversely affects the physical, mental and social well-being of patients, but also requires the involvement of psychologists, psychotherapists, clinical pharmacologists in the treatment of cognitive behavioral psychotherapy.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 4","pages":"20-27"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Medication-related osteonecrosis of the jaws associated with the use of bone-modifying agents]. [与使用骨改良剂有关的药物性颌骨坏死]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410301159
I G Shelegova, N S Nurieva
{"title":"[Medication-related osteonecrosis of the jaws associated with the use of bone-modifying agents].","authors":"I G Shelegova, N S Nurieva","doi":"10.17116/stomat202410301159","DOIUrl":"10.17116/stomat202410301159","url":null,"abstract":"<p><p>The relevance of the study is associated with the widespread use of osteomodifying agents in patients with bone metastases and osteoporosis. Bisphosphonates and other osteo-modifying agents are widely used in oncology and prevention of age-related changes in the human bone system. The use, therapeutic effects and complications of therapy with osteo modifying agents are being investigated all over the world. However, the etiology and pathogenesis of drug-induced osteonecrosis of the jaws (MONCH) have not been fully studied, in this regard, the study of risk factors and mechanisms of its development remains relevant. New data on the etiology and pathogenesis of drug-induced osteonecrosis are presented. The literature review is carried out on the electronic resource PubMed.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Methods of treatment of patients with skeletal forms of distal occlusion using dental alveolar compensation. The role of digital technologies and the approach to treatment]. [利用牙槽骨补偿治疗骨骼型远端咬合患者的方法。数字技术的作用和治疗方法]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410305124
N V Popova, O I Arsenina, S I Abakarov, A V Popova
{"title":"[Methods of treatment of patients with skeletal forms of distal occlusion using dental alveolar compensation. The role of digital technologies and the approach to treatment].","authors":"N V Popova, O I Arsenina, S I Abakarov, A V Popova","doi":"10.17116/stomat202410305124","DOIUrl":"https://doi.org/10.17116/stomat202410305124","url":null,"abstract":"<p><strong>Objective: </strong>Improving the effectiveness of complex treatment in patients with distal occlusion of the dentition during the period of active skeletal growth.</p><p><strong>Material and methods: </strong>202 patients with skeletal distal occlusion were examined and treated. Patients are divided into three subgroups depending on the position/size of the jaw bones and the main link of pathogenesis. The parameters of TRG and CBCT sections were measured before and after treatment. Various parameters were used for the analysis: skeletal (SNA, SNB, ANB, etc.), dental (II/SN, II/ii, APog-I, APog-i, etc.), skeletal profile and soft tissue parameters.</p><p><strong>Results: </strong>Various orthodontic techniques have been applied, including FNTA, the Damon bracket system, the Biederman apparatus and others. In the retention period, non-removable retainers in the frontal section and removable night retention devices of various structures were used. Patients were monitored for up to 15 years after the completion of the active orthodontic treatment stage. The analysis of the X-ray examination data indicates the normalization of the mutual position of the jaw bones in relation to the base of the skull, optimization of the ratios of the bone elements of the TMJ. An algorithm has been developed for the treatment of patients with dental anomalies in the sagittal plane, with narrowing of the upper jaw during the bite of permanent teeth.</p><p><strong>Conclusion: </strong>Comprehensive treatment of patients with distal occlusion during the period of active skeletal growth makes it possible to achieve significant improvements in dentition, position and closure of teeth, as well as skeletal parameters of X-ray examinations. The results indicate the importance of early intervention using modern orthodontic techniques. Long-term follow-up in the retention period shows the stability of the results and the effectiveness of the treatment.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 5","pages":"24-36"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A retrospective cohort study of the effect of zolendronic acid on mandibular bone optical density in cancer patients]. [唑仑膦酸对癌症患者下颌骨骨光学密度影响的回顾性队列研究]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410303121
I G Shelegova, N S Nurieva, M A Izosimova, A V Privalov
{"title":"[A retrospective cohort study of the effect of zolendronic acid on mandibular bone optical density in cancer patients].","authors":"I G Shelegova, N S Nurieva, M A Izosimova, A V Privalov","doi":"10.17116/stomat202410303121","DOIUrl":"https://doi.org/10.17116/stomat202410303121","url":null,"abstract":"<p><strong>The aim the study: </strong>To analyze the density of the mandible in cancer patients during treatment with zoledronic acid.</p><p><strong>Materials and methods: </strong>A retrospective cohort study included 45 patients with cancer aged 26-81 years (average age 55±12.88 years), of whom 14 patients had bone metastases (<i>n</i>=14) and took 4 mg of zolendronic acid once every 28 days. The patients underwent standard PET-CT examinations in the «whole body» mode, and the density of the mandible was examined on CT. Radiation therapy was performed by intracavitary administration of strontium 89 chloride; remote radiation therapy with cisplatin radiomodification. In the presence of bone metastases, patients received complex supportive therapy with zolendronic acid. The effect of zolendronic acid on the density of the mandible in the frontal and lateral sections was studied by multidimensional dispersion analysis.</p><p><strong>Results: </strong>Statistically significant differences (<i>p</i>=0.002) were revealed for density indicators according to CT scans of the mandible in the frontal region against the background of zolendronic acid therapy. We attribute the absence of statistically significant differences for the density of the mandible in the lateral sections (<i>p</i>=0.101 and <i>p</i>=0.082) against the background of zolendronic acid therapy to a measurement bias. We attribute the absence of statistically significant differences in density indices against the background of hormonal, radiation, targeted and chemotherapy to the design of the study.</p><p><strong>Conclusion: </strong>Density measurement based on CT examination data can be recommended for use as an additional tool in assessing the effect of zolendronic acid on the density of the mandible. However, the method of measuring the density of the mandible in the lateral sections requires improvement to prevent measurement bias.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 3","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study of the kinetics of accumulation and distribution of the photosensitizer photoditazin in the oral mucosa in patients with lichen planus]. [研究光敏剂 photoditazin 在扁平苔藓患者口腔黏膜中的蓄积和分布动力学]。
Stomatologiya Pub Date : 2024-01-01 DOI: 10.17116/stomat202410301112
O F Rabinovich, I M Rabinovich, K V Umarova
{"title":"[Study of the kinetics of accumulation and distribution of the photosensitizer photoditazin in the oral mucosa in patients with lichen planus].","authors":"O F Rabinovich, I M Rabinovich, K V Umarova","doi":"10.17116/stomat202410301112","DOIUrl":"10.17116/stomat202410301112","url":null,"abstract":"<p><strong>The aim of the study: </strong>Was to explore the accumulation and distribution of the photosensitizer Photoditazine in the oral mucosa when applied to pathological lesions in patients with severe forms of lichen planus.</p><p><strong>Material and methods: </strong>A clinical and laboratory examination was carried out in 50 patients with severe forms of lichen planus (bullous and erosive-ulcerative) aged 18 to 70 years, including 6 men and 44 women. For autofluorescent imaging a LED device with a wavelength in the violet region of the spectrum (400±10 nm) was used. Quantitative registration of the kinetics of accumulation and distribution of the photosensitizer was carried out using the method of local fluorescence spectroscopy by measuring the fluorescence spectra.</p><p><strong>Results: </strong>The measurements were made before applying the photosensitizer, 10, 20 and 30 minutes after application. The study showed that in most patients with erosive-ulcerative and bullous forms of lichen planus, the accumulation of the photosensitizer in the lesions on the oral mucosa increased as the exposure time increased from 20 to 30 minutes. The fastest accumulation of the photosensitizer occurred in the areas of mucosal lesions with the most pronounced vascularization, namely, in the area of the tongue and the bottom of the oral cavity.</p><p><strong>Conclusion: </strong>Using the method of local fluorescence spectroscopy, the kinetics of accumulation and destruction of photosensitizer in pathological areas of the oral mucosa was determined, and therefore the optimal time of laser exposure to the lesion was determined.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 1","pages":"12-15"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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