{"title":"[Recent advances in the treatment of Crohn's disease].","authors":"Shigeki Bamba, Takayuki Imai, Masashi Ohno","doi":"10.11405/nisshoshi.122.486","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.486","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 7","pages":"486-495"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Primary duodenal epithelioid angiosarcoma:a case report].","authors":"Hiromu Kondo, Yusuke Yokoi, Chisaki Ikai, Naruomi Jinno, Keisuke Itoh, Yasuki Hori, Michihiro Yoshida, Shingo Inaguma, Yoichi Matsuo, Kazuki Hayashi","doi":"10.11405/nisshoshi.122.774","DOIUrl":"10.11405/nisshoshi.122.774","url":null,"abstract":"<p><p>A male patient in his 70s was admitted with bloody stool. Upper gastrointestinal endoscopy revealed active bleeding from a submucosal lesion located opposite the duodenal papilla. Hemostasis was difficult to achieve, and histopathological analysis of the biopsy specimen revealed only necrotic tissue and inflammatory changes. Endoscopic ultrasonography (EUS) revealed a 35-mm hypoechoic lesion within the submucosal layer. EUS-guided tissue acquisition suggested a poorly differentiated or undifferentiated tumor. Given these findings, the patient underwent pancreaticoduodenectomy. The final diagnosis was primary duodenal epithelioid angiosarcoma.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 11","pages":"774-781"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuta Tanimoto, Makoto Kadokura, Yuta Kaneko, Tomoki Yasumura, Keisuke Tanaka, Fumitake Amemiya
{"title":"[Analysis of bile culture in acute cholangitis -longitudinal changes in isolated bacterial species and antibiotic resistance].","authors":"Yuta Tanimoto, Makoto Kadokura, Yuta Kaneko, Tomoki Yasumura, Keisuke Tanaka, Fumitake Amemiya","doi":"10.11405/nisshoshi.122.696","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.696","url":null,"abstract":"<p><p>We retrospectively analyzed bile cultures obtained during drainage procedures for acute cholangitis, examining isolated bacteria, their antibiotic susceptibility, and trends over time between January 2019 and December 2023. A total of 416 bacterial strains were identified across 189 cases. Enterococcus spp., Klebsiella spp., and Escherichia coli were the main isolates. While no significant changes were observed in the overall proportions or susceptibilities of isolates, ESBL-producing strains increased significantly. The appropriateness of initial antibiotic therapy did not affect prognosis or length of hospitalization. Healthcare-associated infections were associated with significantly higher resistance rates.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 10","pages":"696-704"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Recent advances in pharmacological treatment of gastric cancer].","authors":"Yoshito Komatsu","doi":"10.11405/nisshoshi.122.684","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.684","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 10","pages":"684-688"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Up to date on indication for liver transplantation].","authors":"Yoshihide Ueda, Yasuhiro Ogura, Hideki Ohdan","doi":"10.11405/nisshoshi.122.596","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.596","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 9","pages":"596-600"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The cutting edge of the management of primary sclerosing cholangitis].","authors":"Hiroyuki Isayama, Taito Fukuma, Toshio Fujisawa","doi":"10.11405/nisshoshi.122.227","DOIUrl":"https://doi.org/10.11405/nisshoshi.122.227","url":null,"abstract":"","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 4","pages":"227-234"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A case of severe liver injury associated with erythropoietic protoporphyria].","authors":"Hironori Nakamura, Seiji Adachi, Hiroki Nagai, Taisei Iwasa, Yuki Itoh, Masatoshi Mabuchi, Makoto Shimazaki, Shinji Nishiwaki, Tomohiro Kanayama","doi":"10.11405/nisshoshi.122.873","DOIUrl":"10.11405/nisshoshi.122.873","url":null,"abstract":"<p><p>A man in his 60s presented to our hospital with decreased appetite and approximately 10-kg weight loss over the past year. He was found to have chronic liver dysfunction and jaundice, prompting a thorough evaluation, including hepatitis virus markers. Three weeks after the initial visit, he was hospitalized with acute exacerbation of liver injury and persistent nausea. Given his personal and family history of photosensitivity, porphyria was suspected. Blood testing revealed markedly elevated protoporphyrin level at 4923μg/dL RBC (normal 30-86). Ferrochelatase gene testing identified a heterozygous deletion mutation and a low-expression allele, IVS3-48C/C, in both alleles, suggesting erythropoietic protoporphyria (EPP). Liver biopsy revealed deposits with birefringence under polarized light, confirming EPP-related hepatopathy. The patient's symptoms improved temporarily with hemin therapy, and he was discharged from the hospital, but liver injury worsened after relapse. Despite multidisciplinary management-including repeat hemin, phlebotomy, and plasma exchange-he died just over two weeks later. An autopsy performed with the family's consent revealed a markedly cirrhotic liver with a smooth black surface. Microscopy revealed dark-brown matrix deposits with birefringence under polarized light, along with perivascular deposits of acidophilic, PAS-positive substrates in the papillary dermis, consistent with EPP pathology. Comparison of the liver biopsy and autopsy specimens showed marked fibrosis progression. This was a severe case of EPP-related liver failure with no established treatment, although temporary benefit was achieved with hemin therapy.</p>","PeriodicalId":35808,"journal":{"name":"Japanese Journal of Gastroenterology","volume":"122 12","pages":"873-881"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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