BMC Clinical Pathology最新文献

{"title":"Uterine myometrial mature teratoma presenting as a uterine mass: a review of literature","authors":"Emmanuel Kamgobe, A. Massinde, D. Matovelo, Edgar Ndaboine, P. Rambau, Tito Chaula","doi":"10.1186/s12907-016-0026-8","DOIUrl":"https://doi.org/10.1186/s12907-016-0026-8","url":null,"abstract":"","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-016-0026-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66186969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone metastasis from malignant phyllodes breast tumor: report of two cases","authors":"M. E. El Ochi, M. Toreis, M. Benchekroun, Z. Benkerroum, M. Allaoui, M. Ichou, B. El khannoussi, A. Albouzidi, M. Oukabli","doi":"10.1186/s12907-016-0027-7","DOIUrl":"https://doi.org/10.1186/s12907-016-0027-7","url":null,"abstract":"","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-016-0027-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66187087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological characterization of corrosion product associated adverse local tissue reaction in hip implants: a study of 285 cases","authors":"B. Ricciardi, A. Nocon, S. Jerabek, Gabrielle Wilner, E. Kaplowitz, S. Goldring, P. E. Purdue, G. Perino","doi":"10.1186/s12907-016-0025-9","DOIUrl":"https://doi.org/10.1186/s12907-016-0025-9","url":null,"abstract":"","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-016-0025-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66186887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMC Clinical Pathology Reviewer Acknowledgment 2015","authors":"Elaine Zhang","doi":"10.1186/s12907-016-0024-x","DOIUrl":"https://doi.org/10.1186/s12907-016-0024-x","url":null,"abstract":"","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-016-0024-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66187069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of placental morphology may identify specific causes of stillbirth","authors":"I. Ptacek, Anna Smith, A. Garrod, S. Bullough, N. Bradley, G. Batra, C. Sibley, Rebecca L. Jones, P. Brownbill, A. Heazell","doi":"10.1186/s12907-016-0023-y","DOIUrl":"https://doi.org/10.1186/s12907-016-0023-y","url":null,"abstract":"","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-016-0023-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66187002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary leiomyosarcoma of the submandibular gland: a case report","authors":"M. E. El Ochi, H. Chahdi, I. Rharrassi, A. Albouzidi, M. Oukabli","doi":"10.1186/s12907-015-0022-4","DOIUrl":"https://doi.org/10.1186/s12907-015-0022-4","url":null,"abstract":"","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-015-0022-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66186716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of a-Tocopherol-Associated protein (TAP) is associated with clinical outcome in breast cancer patients.","authors":"Xi Wang, Brian Z Ring, Robert S Seitz, Douglas T Ross, Kirsten Woolf, Rodney A Beck, David G Hicks, Shuyuan Yeh","doi":"10.1186/s12907-015-0021-5","DOIUrl":"10.1186/s12907-015-0021-5","url":null,"abstract":"<p><strong>Background: </strong>The role of vitamin E in breast cancer prevention and treatment has been widely investigated, and the different tocopherols that comprise this nutrient have been shown to have divergent associations with cancer outcome. Our previous studies have shown that α-Tocopherol-associated protein (TAP), a vitamin E binding protein, may function as a tumor suppressor-like factor in breast carcinogenesis. The current study addresses the association of TAP expression with breast cancer clinical outcomes.</p><p><strong>Methods: </strong>Immunohistochemical stain for TAP was applied to a tissue microarray from a breast cancer cohort consisting of 271 patients with a median follow-up time of 5.2 years. The expression of TAP in tumor cells was compared with patient's clinical outcome at 5 years after diagnosis. The potential role of TAP in predicting outcome was also assessed in clinically relevant subsets of the cohort. In addition, we compared TAP expression and Oncotype DX scores in an independent breast cancer cohort consisting of 71 cases.</p><p><strong>Results: </strong>We demonstrate that the expression of TAP was differentially expressed within the breast cancer cohort, and that ER+/PR ± tumors were more likely to exhibit TAP expression. TAP expression was associated with an overall lower recurrence rate and a better 5-year survival rate. This association was primarily in patients with ER+ tumors; exploratory analysis showed that this association was strongest in patients with node-positive tumors and was independent of stage and treatment with chemotherapy. TAP expression in ER/PR negative or triple negative tumors had no association with clinical outcome. In addition, we did not observe an association between TAP expression and Oncotype DX recurrence score.</p><p><strong>Conclusions: </strong>The significant positive association we found for α-Tocopherol-associated protein with outcome in breast cancer may help to better define and explain studies addressing α-tocopherol's association with cancer risk and outcome. Additionally, further studies to validate and extend these findings may allow TAP to serve as a breast-specific prognostic marker in breast cancer patients, especially in those patients with ER+ tumors.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66186652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of targeted next-generation sequencing and Sanger sequencing for the detection of PIK3CA mutations in breast cancer","authors":"R. Arsenić, D. Treue, A. Lehmann, M. Hummel, M. Dietel, C. Denkert, J. Budczies","doi":"10.1186/s12907-015-0020-6","DOIUrl":"https://doi.org/10.1186/s12907-015-0020-6","url":null,"abstract":"","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-015-0020-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66186446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membranous CD24 expression as detected by the monoclonal antibody SWA11 is a prognostic marker in non-small cell lung cancer patients","authors":"M. Majores, A. Schindler, A. Fuchs, J. Stein, L. Heukamp, P. Altevogt, G. Kristiansen","doi":"10.1186/s12907-015-0019-z","DOIUrl":"https://doi.org/10.1186/s12907-015-0019-z","url":null,"abstract":"","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-015-0019-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66186384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enrichment of the embryonic stem cell reprogramming factors Oct4, Nanog, Myc, and Sox2 in benign and malignant vascular tumors.","authors":"Clarissa N Amaya,&nbsp;Brad A Bryan","doi":"10.1186/s12907-015-0018-0","DOIUrl":"https://doi.org/10.1186/s12907-015-0018-0","url":null,"abstract":"<p><strong>Background: </strong>The \"stem cell theory of cancer\" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component.</p><p><strong>Methods: </strong>In this study, the expression levels of the embryonic stem cell reprogramming factors Oct4, Nanog, Myc, Sox2, and Klf4 were examined via immunohistochemistry in a panel of 71 benign, borderline, and malignant vascular tumors including capillary hemangioma, cavernous hemangioma, granulomatous hemangioma, venous hemangioma, hemangioendothelioma, hemangiopericytoma, and angiosarcoma. Antigenicity for each protein was quantified based on staining intensity and percentage of tissue positive for each antigen, and subsequently compared to data obtained from two control tissue sets: 10 vascular tissues and a panel of 58 various malignant sarcomas.</p><p><strong>Results and discussion: </strong>With the exception of Myc (which was only present in a subset of benign, borderline, and malignant tumors), Oct4, Nanog, Sox2, and Klf4 were detectable at variable levels across both normal and diseased tissues. Semi-quantitative evaluation of our immunohistochemical staining revealed that protein expression of Oct4, Nanog, Myc, and Sox2, but not Klf4, was significantly increased in benign, borderline, and malignant vascular tumors relative to non-diseased vascular tissue controls. Interestingly, the enhanced levels of Oct4, Nanog, Myc, and Sox2 protein were approximately equivalent between benign, borderline, and malignant vascular tumors.</p><p><strong>Conclusions: </strong>These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the \"stem cell theory of cancer\", but additionally extends to common benign vascular tumors such as hemangiomas.</p>","PeriodicalId":35804,"journal":{"name":"BMC Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12907-015-0018-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34211809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}