Acta medica (Hradec Kralove)最新文献

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Sexual Behavior of Men Who Have Sex with Men and Its Relationship to Sexually Transmitted Infections during an Outbreak of the Human Monkeypox Virus. 人类猴痘病毒爆发期间男男性行为及其与性传播感染的关系。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2023.3
Raúl Montalvo Otivo, Sonia Crisostomo, Liz Zevallos, Carina Ninahuanca, Miguel Montalvo
{"title":"Sexual Behavior of Men Who Have Sex with Men and Its Relationship to Sexually Transmitted Infections during an Outbreak of the Human Monkeypox Virus.","authors":"Raúl Montalvo Otivo, Sonia Crisostomo, Liz Zevallos, Carina Ninahuanca, Miguel Montalvo","doi":"10.14712/18059694.2023.3","DOIUrl":"10.14712/18059694.2023.3","url":null,"abstract":"<p><strong>Background: </strong>There is a high frequency of monkeypox (MPOX) and sexually transmitted infections (STIs) in men who have sex with men (MSM).</p><p><strong>Aim: </strong>To identify the sexual behavior of MSM during the MPOX infection period.</p><p><strong>Methods: </strong>We conducted an observational study of cases and controls were carried out.</p><p><strong>Results: </strong>A total of 171 participants were considered, two heterosexual male controls (MSW) were included for each case of MSM with a consecutive selection of people who attended the STI prevention and control center from January to July 2022. The results revealed that the mean number of sexual partners reported in the last year was higher in cases (4.2) compared to controls 1.9 (p < 0.05). The related conditions for MSM to acquire some type of STI were sexual intercourse under the influence of alcohol (OR 2.42; 95% CI: 1.11-3.96), forgetting to use a protection method (condom) (OR 3.16; 95%: 1.73-7.48) and sexual intercourse with casual couples (OR 1.4; 95% CI: 1.01-2.16).</p><p><strong>Conclusion: </strong>Our findings demonstrated a link between the sexual behavior of men who have sex with men and the high prevalence of sexually transmitted infections during the human monkeypox virus outbreak.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An Investigation of the Accuracy and Reproducibility of 3D Printed Transparent Endodontic Blocks. 3D打印透明根管块的准确性和可重复性研究。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.19
Martin Smutný, Martin Kopeček, Aleš Bezrouk
{"title":"An Investigation of the Accuracy and Reproducibility of 3D Printed Transparent Endodontic Blocks.","authors":"Martin Smutný,&nbsp;Martin Kopeček,&nbsp;Aleš Bezrouk","doi":"10.14712/18059694.2022.19","DOIUrl":"https://doi.org/10.14712/18059694.2022.19","url":null,"abstract":"Due to a broad spectrum of endodontic rotary instruments on the market and no standardised protocol for comparing their mechanical properties, it can be challenging for clinician to choose proper instruments. In vitro studies using resin blocks with artificial canals can offer many valuable information because of their uniformity compared to studies performed on extracted teeth. To improve precision and reproducibility of artificial canals, 3D printing was used in this study to manufacture endodontic test block samples. 20 commercially available endodontic blocks Endo-Training-Bloc-J by Dentsply Sirona were tested. The mean values of the measured parameters were used for a 3D CAD model of their replicas. 20 copies of the endodontic training blocks were printed from acrylic resin (VeroClear-RGD810, Stratasys, Eden Prairie, USA) using the 3D printer Objet30 Pro (Stratasys, Eden Prairie, USA). The key dimensions of the commercial blocks and the 3D printed blocks were measured under and compared using t - test and Levene's test for equality of variances. The profiles of the 3D printed artificial canals showed significantly lower dimensional variability when compared with the commercial blocks. 3D polyjet printing proved to be a precise and reproducible method for production of blocks for testing endodontic rotary instruments.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40548072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral Mature Ovarian Teratoma with Torsion in a Premenarchal Girl. 女童双侧成熟卵巢畸胎瘤伴扭转。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.14
Jana Lešková, Jaroslav Thierry Kříž, Radek Štichhauer
{"title":"Bilateral Mature Ovarian Teratoma with Torsion in a Premenarchal Girl.","authors":"Jana Lešková,&nbsp;Jaroslav Thierry Kříž,&nbsp;Radek Štichhauer","doi":"10.14712/18059694.2022.14","DOIUrl":"https://doi.org/10.14712/18059694.2022.14","url":null,"abstract":"<p><p>Mature cystic teratoma is the most common type of ovarian tumor in children. Adnexal torsion is the main complication of mature ovarian teratoma. The synchronous bilateral incidence of mature cystic teratoma in premenarchal girls is known to be rare. However, the incidence of adnexal torsion is higher in young girls. A 10-year-old girl presenting with acute abdomen was managed by emergency laparotomy. Bilateral mature ovarian teratoma with adnexal torsion of the right ovary was found. The right ovarian tissue was not viable due to torsion and an oophorectomy was necessary. Cystectomy with preservation of the ovarian tissue of the left ovary was performed. Histopathological diagnosis was bilateral synchronous mature teratoma with necrosis of the right adnexa. Although the risk of malignancy of torsed ovaries and mature teratomas in premenarchal girls is low, their removal is recommended to prevent adnexal torsion. Decision between ovarian tissue sparing surgery or oophorectomy depends on the risk of malignancy, fertility preservation and the avoidance of early menopause.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40564591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Efficacy of Prednisone in Children with Acute Nonspecific Mesenteric Lymphadenitis: A Pilot Study. 强的松治疗儿童急性非特异性肠系膜淋巴结炎的疗效:一项初步研究。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.12
Momcilo Pavlovic, Zeljko Rokvic, Karolina Berenji
{"title":"Efficacy of Prednisone in Children with Acute Nonspecific Mesenteric Lymphadenitis: A Pilot Study.","authors":"Momcilo Pavlovic,&nbsp;Zeljko Rokvic,&nbsp;Karolina Berenji","doi":"10.14712/18059694.2022.12","DOIUrl":"https://doi.org/10.14712/18059694.2022.12","url":null,"abstract":"<p><strong>Background: </strong>Acute nonspecific mesenteric lymphadenitis (ANML) is a common cause of acute abdominal pain in children with no specific treatment.</p><p><strong>Methods: </strong>A total of 13 patients (6 boys, 7 girls) aged 7.3 (5-13.5) years with severe acute abdominal pain were evaluated using ultrasonography and laboratory tests to establish the diagnosis of ANML. They were treated with prednisone 1 mg/kg (max 40 mg daily) for a maximum of 5 days. The intensity of abdominal pain was evaluated before and after treatment using a numeric rating scale.</p><p><strong>Results: </strong>All patients had pain scores above 6/10 before, and below 4/10 after treatment with prednisone. Intensity of abdominal pain after treatment for 1-5 days decreased significantly (p &lt; 0.001), with no recurrence at follow-up within 3 months. All other pre-existing signs and symptoms, such as nausea, vomiting, anorexia, fever, diarrhea, and constipation were found to disappear with no adverse effects of corticosteroid therapy.</p><p><strong>Conclusion: </strong>These results suggest that the treatment with prednisone in selective patients with ANML can reduce the duration of abdominal pain.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40564589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progressive Worsening of Snoring as a Rare Presentation of HPV-Positive Oropharyngeal Squamous Cell Carcinoma. hpv阳性口咽鳞状细胞癌的罕见表现:打鼾的进行性恶化。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.13
V Sha Kri Eh Dam, Azliana Aziz, Sarah Zulkarnain, Nur Asyilla Che Jalil, Irfan Mohamad
{"title":"Progressive Worsening of Snoring as a Rare Presentation of HPV-Positive Oropharyngeal Squamous Cell Carcinoma.","authors":"V Sha Kri Eh Dam,&nbsp;Azliana Aziz,&nbsp;Sarah Zulkarnain,&nbsp;Nur Asyilla Che Jalil,&nbsp;Irfan Mohamad","doi":"10.14712/18059694.2022.13","DOIUrl":"https://doi.org/10.14712/18059694.2022.13","url":null,"abstract":"<p><p>The incidence of oropharyngeal squamous cell carcinoma (OPSCC) especially human papillomavirus (HPV) associated type is increasing in trend despite reducing in other head and neck squamous cell carcinoma. Muffled voice, dysphagia, neck mass and pain over the throat are among the common presentations; however, health care professional should be aware of unusual presentation to avoid delay in management. We present a case of HPV-positive OPSCC with a rare presentation; progressive worsening of snoring for 6 months duration. Patient sougth medical attention at the some of private clinics for the past 2 months, however, was told to have a normal tonsillar enlargement. Subsequently, patient was referred to our center with impression of obstructive sleep apnea. We highlight the important of early referral to appropriate center and otorhinolaryngology for assessment in cases presented with worsening snoring.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40564590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Citrulline and Ornithine: Potential Markers of Coeliac Disease Activity. 血清瓜氨酸和鸟氨酸:乳糜泻活动性的潜在标志物。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.22
Ladislav Douda, Radomír Hyšpler, Martin Mžik, Doris Vokurková, Marcela Drahošová, Vít Řeháček, Eva Čermáková, Tomáš Douda, Jiří Cyrany, Tomáš Fejfar, Václav Jirkovský, Marcela Kopáčová, Blanka Kupková, Tomáš Vašátko, Ilja Tachecí, Jan Bureš
{"title":"Serum Citrulline and Ornithine: Potential Markers of Coeliac Disease Activity.","authors":"Ladislav Douda,&nbsp;Radomír Hyšpler,&nbsp;Martin Mžik,&nbsp;Doris Vokurková,&nbsp;Marcela Drahošová,&nbsp;Vít Řeháček,&nbsp;Eva Čermáková,&nbsp;Tomáš Douda,&nbsp;Jiří Cyrany,&nbsp;Tomáš Fejfar,&nbsp;Václav Jirkovský,&nbsp;Marcela Kopáčová,&nbsp;Blanka Kupková,&nbsp;Tomáš Vašátko,&nbsp;Ilja Tachecí,&nbsp;Jan Bureš","doi":"10.14712/18059694.2022.22","DOIUrl":"https://doi.org/10.14712/18059694.2022.22","url":null,"abstract":"<p><strong>Introduction: </strong>To date, there is not generally accepted and universal indicator of activity, and functional integrity of the small intestine in patients with coeliac disease. The aim of our study was to investigate whether serum concentrations of the non-essential amino acids citrulline and ornithine might have this function.</p><p><strong>Methods: </strong>We examined serum citrulline and ornithine concentrations in a subgroup of patients with proven coeliac disease and healthy controls (blood donors).</p><p><strong>Results: </strong>A total of 94 patients with coeliac disease (29 men, mean age 53 ± 18 years; 65 women, mean age 44 ± 14 years) and 35 healthy controls (blood donors) in whom coeliac disease was serologically excluded (10 men, mean age 51 ± 14 years; 25 women, mean age 46 ± 12 years) were included in the study. Significantly lower concentrations of serum ornithine were found in patients with coeliac disease (mean 65 ± 3 μmol/L; median 63 μmol/L, IQR 34 μmol/L, p < 0.001). No statistically nor clinically significant differences were found in the citrulline concentrations between the study and control group.</p><p><strong>Conclusions: </strong>Serum ornithine (but not citrulline) may be useful for assessing the functional status of the small intestine in uncomplicated coeliac disease. Further studies involving more detailed analysis of dietary and metabolic changes in patients will be needed to reach definitive conclusions.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9212621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Missed Diagnosis of Laryngotracheal Injury Secondary to Emergency Intubation: Lessons Learned. 急诊插管后喉气管损伤的漏诊:经验教训。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.27
V Sha Kri Eh Dam, Sakinah Mohamad, Nik Fariza Husna Nik Hassan, Mohd Zulfakar Mazlan
{"title":"A Missed Diagnosis of Laryngotracheal Injury Secondary to Emergency Intubation: Lessons Learned.","authors":"V Sha Kri Eh Dam,&nbsp;Sakinah Mohamad,&nbsp;Nik Fariza Husna Nik Hassan,&nbsp;Mohd Zulfakar Mazlan","doi":"10.14712/18059694.2022.27","DOIUrl":"https://doi.org/10.14712/18059694.2022.27","url":null,"abstract":"<p><p>Iatrogenic laryngotracheal trauma is a potentially fatal complication of endotracheal intubation, especially in an emergency setting. Symptoms are almost always related to speech, breathing, and swallowing. Hoarseness being the commonest symptom, while shortness of breath and stridor always signify more devastating injury. We present a case of iatrogenic subglottic and tracheal stenosis, which was misdiagnosed in the emergency department during the first visit. This case report highlights the importance of salient history and thorough examination with a high index of suspicion in a stridorous case with a recent history of intubation. Early detection and management are vital to avoid a life-threatening event.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10715540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Flow Nasal Cannula Therapy in the Emergency Department: Main Benefits in Adults, Pediatric Population and against COVID-19: A Narrative Review. 急诊科高流量鼻插管治疗:成人、儿科人群和COVID-19的主要益处:叙述性综述
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.17
Eduardo Esteban-Zubero, Cristina García-Muro, Moisés Alejandro Alatorre-Jiménez, Vickramjeet Johal, Carlos Arturo López-García, Alejandro Marín-Medina
{"title":"High Flow Nasal Cannula Therapy in the Emergency Department: Main Benefits in Adults, Pediatric Population and against COVID-19: A Narrative Review.","authors":"Eduardo Esteban-Zubero,&nbsp;Cristina García-Muro,&nbsp;Moisés Alejandro Alatorre-Jiménez,&nbsp;Vickramjeet Johal,&nbsp;Carlos Arturo López-García,&nbsp;Alejandro Marín-Medina","doi":"10.14712/18059694.2022.17","DOIUrl":"https://doi.org/10.14712/18059694.2022.17","url":null,"abstract":"<p><p>This review aims to summarize the literature's main results about high flow nasal cannula therapy (HFNC) HFNC benefits in the Emergency Department (ED) in adults and pediatrics, including new Coronavirus Disease (COVID-19). HFNC has recently been established as the usual treatment in the ED to provide oxygen support. Its use has been generalized due to its advantages over traditional oxygen therapy devices, including decreased nasopharyngeal resistance, washing out of the nasopharyngeal dead space, generation of positive pressure, increasing alveolar recruitment, easy adaptation due to the humidification of the airways, increased fraction of inspired oxygen and improved mucociliary clearance. A wide range of pathologies has been studied to evaluate the potential benefits of HFNC; some examples are heart failure, pneumonia, chronic pulmonary obstructive disease, asthma, and bronchiolitis. The regular use of this oxygen treatment is not established yet due to the literature's controversial results. However, several authors suggest that it could be useful in several pathologies that generate acute respiratory failure. Consequently, the COVID-19 irruption has generated the question of HFNC as a safety and effective treatment. Our results suggested that HFNC seems to be a useful tool in the ED, especially in patients affected by acute hypoxemic respiratory failure, acute heart failure, pneumonia, bronchiolitis, asthma and acute respiratory distress syndrome in patients affected by COVID-19. Its benefits in hypercapnic respiratory failure are more discussed, being only observed benefits in patients with mild-moderate disease. These results are based in clinical as well as cost-effectiveness outcomes. Future studies with largest populations are required to confirm these results as well as establish a practical guideline to use this device.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40557511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Necrotizing Fasciitis in the Immediate Post-Operative Period Following Resection and Free Flap Reconstruction for Oral Cancer. 口腔癌症切除和游离皮瓣重建术后即刻坏死性筋膜炎。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2022.21
Alice Rigby, Paul Sexton, Preetha Chengot, Anastasios Kanatas
{"title":"Necrotizing Fasciitis in the Immediate Post-Operative Period Following Resection and Free Flap Reconstruction for Oral Cancer.","authors":"Alice Rigby,&nbsp;Paul Sexton,&nbsp;Preetha Chengot,&nbsp;Anastasios Kanatas","doi":"10.14712/18059694.2022.21","DOIUrl":"https://doi.org/10.14712/18059694.2022.21","url":null,"abstract":"<p><p>Necrotising fasciitis (NF) is a rapidly spreading bacterial infection of the fascial planes and can be fatal if is not treated urgently. Here, we present the case of a 65-year-old female, with oral squamous cell carcinoma, treated surgically with curative intent. On the second post-operative day from a mandibulectomy, selective neck dissection and reconstruction with a fibula free flap, she developed rapidly progressing NF, at the surgical site.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40568962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Primary Duodenal Melanoma: Challenges in Diagnosis and Management of a Rare Entity. 原发性十二指肠黑色素瘤:罕见疾病诊断与治疗的挑战。
Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI: 10.14712/18059694.2023.2
Konstantina Dimopoulou, Anastasia Dimopoulou, Dimitra Dimopoulou, Eleni Panopoulou, Andriani Zacharatou, Paul Patapis, Nikolaos Zavras
{"title":"Primary Duodenal Melanoma: Challenges in Diagnosis and Management of a Rare Entity.","authors":"Konstantina Dimopoulou,&nbsp;Anastasia Dimopoulou,&nbsp;Dimitra Dimopoulou,&nbsp;Eleni Panopoulou,&nbsp;Andriani Zacharatou,&nbsp;Paul Patapis,&nbsp;Nikolaos Zavras","doi":"10.14712/18059694.2023.2","DOIUrl":"https://doi.org/10.14712/18059694.2023.2","url":null,"abstract":"<p><p>Primary melanoma of the duodenum is an extremely rare, aggressive and life-threatening malignant neoplasm. Published data regarding the effectiveness of current treatment strategies is limited, and our knowledge relies mostly on sporadic case reports. The diagnosis of primary duodenal melanoma is challenging and is based on the patient's medical history and findings from physical examination and radiological and endoscopic imaging as well as proper and careful pathological examinations of the tumor. Despite the many advances in cancer treatment, the prognosis for patients with this type of melanoma remains extremely poor. Delayed diagnosis at advanced disease stage, the general aggressive behavior of this neoplasm, the technical difficulty in achieving complete surgical resection, along with the rich vascular and lymphatic drainage of the intestinal mucosa, all have a negative impact on patients' outcome. In the present review, we aimed to collect and summarize the currently available data in the literature regarding the pathogenesis, clinical features, diagnosis, management and long-term outcomes of this rare, malignant tumor, in order to expand knowledge of its biological behavior and investigate optimal therapeutic options for these patients. Additionally, we present our experience of a case involving a 73-year-old female with primary duodenal melanoma, who was successfully treated with complete surgical resection.</p>","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9150357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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